A J Roberts

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Operant self-administration of sweetened versus unsweetened ethanol: effects on blood alcohol levels
    A J Roberts
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Alcohol Clin Exp Res 23:1151-7. 1999
  2. pmc Alteration of Methamphetamine-induced stereotypic behaviour in transgenic mice expressing HIV-1 envelope protein gp120
    Amanda J Roberts
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Road, SV142 La Jolla, CA 92037, USA
    J Neurosci Methods 186:222-5. 2010
  3. ncbi request reprint mu-Opioid receptor knockout mice do not self-administer alcohol
    A J Roberts
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 293:1002-8. 2000
  4. ncbi request reprint Increased ethanol self-administration in delta-opioid receptor knockout mice
    A J Roberts
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 25:1249-56. 2001
  5. ncbi request reprint Substance dependence as a compulsive behavior
    G F Koob
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Psychopharmacol 12:39-48. 1998
  6. ncbi request reprint Intravenous self-administration of heroin, cocaine, and the combination in Balb/c mice
    A J Roberts
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Pharmacol 326:119-25. 1997
  7. ncbi request reprint Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor
    Glenn R Valdez
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 26:1494-501. 2002
  8. pmc Robust and stable drinking behavior following long-term oral alcohol intake in rhesus macaques
    Simon N Katner
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    Drug Alcohol Depend 91:236-43. 2007
  9. pmc Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout
    Kathleen Chu
    Molecular and Integrative Neurosciences Department, SV 142, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92036, USA
    Pharmacol Biochem Behav 86:813-21. 2007
  10. ncbi request reprint Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41)
    Deborah A Finn
    Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon Veterans Affairs Medical Center, Oregon, USA
    Alcohol Clin Exp Res 31:939-49. 2007

Research Grants

  1. Role of Amygdala in Ethanol Reinforcement and Anxiety
    Amanda Roberts; Fiscal Year: 2005
  2. Mouse Animal Models Core
    Amanda Roberts; Fiscal Year: 2007

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Operant self-administration of sweetened versus unsweetened ethanol: effects on blood alcohol levels
    A J Roberts
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Alcohol Clin Exp Res 23:1151-7. 1999
    ....
  2. pmc Alteration of Methamphetamine-induced stereotypic behaviour in transgenic mice expressing HIV-1 envelope protein gp120
    Amanda J Roberts
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Road, SV142 La Jolla, CA 92037, USA
    J Neurosci Methods 186:222-5. 2010
    ..Thus this experimental model system may be useful to further study the mechanistic interaction of both the viral envelope protein and the psychostimulant drug in behavioural alterations and neurodegenerative disease...
  3. ncbi request reprint mu-Opioid receptor knockout mice do not self-administer alcohol
    A J Roberts
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 293:1002-8. 2000
    ..These data provide new evidence for a critical role for mu-opioid receptors in ethanol self-administration assessed with a variety of behavioral paradigms and new insights into the neuropharmacological basis for ethanol reinforcement...
  4. ncbi request reprint Increased ethanol self-administration in delta-opioid receptor knockout mice
    A J Roberts
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 25:1249-56. 2001
    ..It is clear that alternative approaches to understanding opioid-receptor involvement in ethanol drinking are needed...
  5. ncbi request reprint Substance dependence as a compulsive behavior
    G F Koob
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Psychopharmacol 12:39-48. 1998
    ..Challenges for the future involve not only elucidation of the neurobiological substrates of the different behavioral components of addiction, but better animal models of these components with which to effect such studies...
  6. ncbi request reprint Intravenous self-administration of heroin, cocaine, and the combination in Balb/c mice
    A J Roberts
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Pharmacol 326:119-25. 1997
    ..It is hypothesized that heroin may interact with effects of cocaine that function to limit self-administration in Balb/c mice, facilitating the acquisition and maintenance of self-administration of cocaine + heroin combinations...
  7. ncbi request reprint Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor
    Glenn R Valdez
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 26:1494-501. 2002
    ..The objective of the present study was to investigate the role of CRF in the regulation of ethanol self-administration and to examine the behavioral stress response during acute withdrawal and protracted abstinence...
  8. pmc Robust and stable drinking behavior following long-term oral alcohol intake in rhesus macaques
    Simon N Katner
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    Drug Alcohol Depend 91:236-43. 2007
    ..It is concluded that models with excellent face validity (flavored beverages) can produce reliable ethanol intake in patterns that are highly consistent with ethanol-seeking behavior...
  9. pmc Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout
    Kathleen Chu
    Molecular and Integrative Neurosciences Department, SV 142, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92036, USA
    Pharmacol Biochem Behav 86:813-21. 2007
    ..In addition, a model is presented that may be useful for studies examining underlying mechanisms of the ethanol addiction process as well as for testing potential therapeutics...
  10. ncbi request reprint Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41)
    Deborah A Finn
    Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon Veterans Affairs Medical Center, Oregon, USA
    Alcohol Clin Exp Res 31:939-49. 2007
    ..The present studies provide additional behavioral validation and initial pharmacological validation of this withdrawal-associated drinking procedure...
  11. ncbi request reprint Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose
    M Rocio A Carrera
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road BCC 582, La Jolla, CA 92037, United States
    Pharmacol Biochem Behav 81:709-14. 2005
    ..Importantly, GNC92H2 prevented death even post-cocaine injection. The results support the important potential of GNC92H2 as a therapeutic tool against cocaine overdose...
  12. ncbi request reprint Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice
    Sandy Ghozland
    Department of Neuropharmacology SP 315, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropharmacology 49:493-501. 2005
    ....
  13. ncbi request reprint Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure
    Laura E O'Dell
    Department of Psychology, The University of Texas at El Paso, El Paso, Texas, USA
    Alcohol Clin Exp Res 28:1676-82. 2004
    ..Ethanol self-administering rats exhibit enhanced responding during withdrawal from continuous exposure to ethanol vapor. This study compared self-administration of ethanol during withdrawal from continuous versus intermittent ethanol vapor...
  14. ncbi request reprint Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure
    Simon N Katner
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 28:873-83. 2004
    ..Flavorant-fading procedures can initiate and maintain oral ethanol intake in rodents. The present study developed a similar procedure to achieve controlled and behaviorally relevant levels of ethanol intake in monkeys...
  15. ncbi request reprint Mice lacking 5-HT receptors show specific impairments in contextual learning
    Amanda J Roberts
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Neurosci 19:1913-22. 2004
    ..The results indicate an important role for the 5-HT(7) receptor in contextual hippocampal-dependent learning and suggest a possible neuronal correlate for such a role is present within the CA1 region of the hippocampus...
  16. ncbi request reprint Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence
    Glenn R Valdez
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Alcohol 29:55-60. 2003
    ..Results of the current experiment demonstrated that continuous exposure to ethanol over a 3-week period leads to an increased behavioral responsiveness to stress, which seems to be regulated by CRF...
  17. ncbi request reprint Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response
    Raphaelle Winsky-Sommerer
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 24:11439-48. 2004
    ..We propose that, after stressor stimuli, CRF stimulates the release of hypocretins and that this circuit contributes to activation and maintenance of arousal associated with the stress response...
  18. ncbi request reprint Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors
    Zhiguo Nie
    Department of Neuropharmacology and Alcohol Research Center, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 303:1512-4. 2004
    ..These data indicate that CRF1 receptors mediate ethanol enhancement of GABAergic synaptic transmission in the CeA, and they suggest a cellular mechanism underlying involvement of CRF in ethanol's behavioral and motivational effects...
  19. ncbi request reprint Neurosteroid consumption has anxiolytic effects in mice
    Deborah A Finn
    Department of Veterans Affairs Medical Center, Portland Alcohol Research Center, 3710 SW U S Veterans Hospital Road, Portland, OR 97239, USA
    Pharmacol Biochem Behav 76:451-62. 2003
    ....
  20. pmc Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo
    Hao Li
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:9397-402. 2008
    ..Our data support a crucial role for MEF2C in programming early neuronal differentiation and proper distribution within the layers of the neocortex...
  21. pmc Myocyte enhancer factor 2C as a neurogenic and antiapoptotic transcription factor in murine embryonic stem cells
    Zhen Li
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Neurosci 28:6557-68. 2008
    ....
  22. ncbi request reprint Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology
    George F Koob
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Recent Dev Alcohol 16:263-81. 2003
    ....
  23. ncbi request reprint Corticotropin-releasing factor receptor-2-deficient mice display abnormal homeostatic responses to challenges of increased dietary fat and cold
    Tracy L Bale
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Endocrinology 144:2580-7. 2003
    ..These results demonstrate that CRFR2 plays a critical role in regulation of energy expenditure and is important for responses to homeostatic challenges...
  24. ncbi request reprint The corticotropin-releasing factor/urocortin system and alcohol
    Andrey E Ryabinin
    Department of Behavioral Neuroscience, Oregon Health and Sciences University, Portland 97201 3098, USA
    Alcohol Clin Exp Res 26:714-22. 2002
    ..Mehmert, R. Camarini, Joseph A. Kim, Heather N. Koenig, Michelle A. Nannini, and Clyde W. Hodge; and (5) Selective sensitivity of urocortin-containing neurons to alcohol self-administration, by Andrey E. Ryabinin and Ryan K. Bachtell...
  25. ncbi request reprint Use of a novel mouse genotype to model acute benzodiazepine withdrawal
    Pamela Metten
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, and Department of Veterans Affairs Medical Center, Portland, OR 97239, USA
    Behav Genet 37:160-70. 2007
    ..Withdrawal convulsions were seen after all of the drugs by at least one method, suggesting that BZR agonists as a class elicit acute physical dependence in this susceptible genotype...
  26. pmc Stress enhancement of craving during sobriety: a risk for relapse
    George R Breese
    Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Alcohol Clin Exp Res 29:185-95. 2005
    ..Collectively, the presentations provided convincing support for an involvement of stress in the cause of relapse and continuing alcohol abuse and suggested novel pharmacological approaches for treating relapse induced by stress...
  27. pmc Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus
    Stefan Kunz
    Molecular and Integrative Neurosciences Department MIND IMM6, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 80:9082-92. 2006
    ..However, since IFNs have also been implicated in adverse effects on neuronal function, the chronic induction of some ISGs may also contribute to the observed cognitive impairment...
  28. ncbi request reprint Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene"
    Antoine Tabarin
    Laboratoire Homéostasie Allostasie Pathologie, EA 3666, University of Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux, France
    Diabetes 54:3510-6. 2005
    ....
  29. ncbi request reprint Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: new insights about an old question
    Carles Sanchis-Segura
    Howard Florey Institute, University of Melbourne, Australia
    Alcohol Clin Exp Res 29:1522-7. 2005
    ..Grisel, Amanda J. Roberts, and George F. Koob; and () The mu-Opioid Receptor Modulates Acute Ethanol Sensitivity and Ethanol Withdrawal Severity by Sandra Ghozland...
  30. ncbi request reprint Presynaptic delta opioid receptors regulate ethanol actions in central amygdala
    Maeng hee Kang-Park
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    J Pharmacol Exp Ther 320:917-25. 2007
    ..This result supports the hypothesis that endogenous opioid peptides modulate the ethanol-induced augmentation of GABA(A) receptor-dependent circuitry in CeA (Roberto et al., 2003)...

Research Grants3

  1. Role of Amygdala in Ethanol Reinforcement and Anxiety
    Amanda Roberts; Fiscal Year: 2005
    ..This INIA makes use of several Genetic Animal Models Core Components, relates well to other INIA UOls, and also will provide input to the Gene Expression, Imaging and the Bioinformatics Cores. ..
  2. Mouse Animal Models Core
    Amanda Roberts; Fiscal Year: 2007
    ..To provide established and refined neuroadaptive models to INIA investigators and Specific Aim 2. To combine neuroadaptive models with genetic models for INIA investigators. ..