Marisa Roberto

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Type 7 Adenylyl Cyclase is Involved in the Ethanol and CRF Sensitivity of GABAergic Synapses in Mouse Central Amygdala
    Maureen T Cruz
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute La Jolla, CA, USA
    Front Neurosci 4:207. 2011
  2. pmc The central amygdala and alcohol: role of γ-aminobutyric acid, glutamate, and neuropeptides
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cold Spring Harb Perspect Med 2:a012195. 2012
  3. pmc Actions of acute and chronic ethanol on presynaptic terminals
    Marisa Roberto
    Molecular and Integrative Neuroscience Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 30:222-32. 2006
  4. pmc Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 67:831-9. 2010
  5. pmc Cellular and behavioral interactions of gabapentin with alcohol dependence
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 28:5762-71. 2008
  6. pmc Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase of GABA release in central amygdala
    Marisa Roberto
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:9715-20. 2006
  7. ncbi request reprint Chronic ethanol exposure and protracted abstinence alter NMDA receptors in central amygdala
    Marisa Roberto
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 31:988-96. 2006
  8. pmc The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdala
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Neuropsychopharmacology 35:1962-72. 2010
  9. pmc CRF system recruitment mediates dark side of compulsive eating
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, Harold L Dorris Neurological Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20016-20. 2009
  10. ncbi request reprint Increased GABA release in the central amygdala of ethanol-dependent rats
    Marisa Roberto
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 24:10159-66. 2004

Detail Information

Publications33

  1. pmc Type 7 Adenylyl Cyclase is Involved in the Ethanol and CRF Sensitivity of GABAergic Synapses in Mouse Central Amygdala
    Maureen T Cruz
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute La Jolla, CA, USA
    Front Neurosci 4:207. 2011
    ..These electrophysiological data suggest that AC7 plays an important role in ethanol and CRF modulation of presynaptic GABA release in CeA and thus may underlie ethanol-related behaviors such as anxiety and dependence...
  2. pmc The central amygdala and alcohol: role of γ-aminobutyric acid, glutamate, and neuropeptides
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cold Spring Harb Perspect Med 2:a012195. 2012
    ..Alcohol dependence produces plasticity in these neuropeptide systems, reflecting a recruitment of those systems during the transition to alcohol dependence...
  3. pmc Actions of acute and chronic ethanol on presynaptic terminals
    Marisa Roberto
    Molecular and Integrative Neuroscience Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 30:222-32. 2006
    ..The chairs of the session were Marisa Roberto and George Robert Siggins...
  4. pmc Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 67:831-9. 2010
    ..Ethanol augments CeA GABA release in ethanol-naive rats and mice...
  5. pmc Cellular and behavioral interactions of gabapentin with alcohol dependence
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 28:5762-71. 2008
    ....
  6. pmc Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase of GABA release in central amygdala
    Marisa Roberto
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:9715-20. 2006
    ..Our data suggest that nociceptin has a role in regulating the GABAergic system and opposing the effect elicited by ethanol. Thus, nociceptin may represent a therapeutic target for alleviating alcohol dependence...
  7. ncbi request reprint Chronic ethanol exposure and protracted abstinence alter NMDA receptors in central amygdala
    Marisa Roberto
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 31:988-96. 2006
    ..These data indicate that CET induces reversible neuroadaptations in synaptic function, gene expression, and protein composition of NMDAR at CeA synapses...
  8. pmc The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdala
    Marisa Roberto
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Neuropsychopharmacology 35:1962-72. 2010
    ..Our study points to an important role of CB1 in CeA in which the eCBs tonically regulate neuronal activity, and suggests a potent mechanism for modulating CeA tone during challenge with ethanol...
  9. pmc CRF system recruitment mediates dark side of compulsive eating
    Pietro Cottone
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, Harold L Dorris Neurological Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:20016-20. 2009
    ....
  10. ncbi request reprint Increased GABA release in the central amygdala of ethanol-dependent rats
    Marisa Roberto
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 24:10159-66. 2004
    ..These combined findings suggest that acute and chronic ethanol increases GABA release in CeA and support previous reports that the behavioral actions of ethanol are mediated, in part, by increased GABAergic transmission in the CeA...
  11. ncbi request reprint Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis
    Marisa Roberto
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 24:1594-603. 2004
    ....
  12. pmc Differential alteration of hippocampal excitatory synaptic transmission by cannabinoid ligands
    Michal Bajo
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 87:766-75. 2009
    ..We observed large differences between full (synthetic) and partial (endogenous) CB1 agonists in altering synaptic transmission, notably because of the involvement of active degradation mechanisms...
  13. pmc Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence
    Nicholas W Gilpin
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 69:1091-9. 2011
    ....
  14. pmc Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala
    Michal Bajo
    Molecular and Integrative Neurosciences Department, Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:8410-5. 2008
    ..These results identify a PKCepsilon signaling pathway in the CeA that is activated by CRF(1) receptor stimulation, mediates GABA release at nerve terminals, and regulates anxiety and alcohol consumption...
  15. pmc Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors
    Roberto Ciccocioppo
    School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino 62032, Italy, Institute of Psychopharmacology at the Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg, Heidelberg 68159, Germany, Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, and National Institutes of Health National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892 1108
    J Neurosci 34:363-72. 2014
    ..These combined results demonstrate that acute stress increases N/OFQ systems in the CeA and that N/OFQ has antistress properties. ..
  16. pmc Nociceptin/orphanin FQ blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposure
    Maureen T Cruz
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Biol Psychiatry 71:666-76. 2012
    ..In the rat, CRF and ethanol significantly augment CeA gamma-aminobutyric acid (GABA) release, whereas nociceptin diminishes it...
  17. pmc Neuroadaptation of GABAergic transmission in the central amygdala during chronic morphine treatment
    Michal Bajo
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Addict Biol 16:551-64. 2011
    ....
  18. pmc NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala
    Paul J Kenny
    Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
    Neuropsychopharmacology 34:266-81. 2009
    ..Taken together, these data suggest that NMDA receptors, including those in the CeA and VTA, gate the magnitude and valence of the effects of nicotine on brain reward systems, thereby regulating motivation to consume the drug...
  19. pmc Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects
    Melissa A Herman
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, SP30 1150, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropharmacology 67:337-48. 2013
    ..The elevated GABAergic transmission observed in naïve msP rats is consistent with the neuroadaptations reported in Sprague Dawley rats after the development of ethanol dependence...
  20. ncbi request reprint Chronic morphine treatment alters expression of N-methyl-D-aspartate receptor subunits in the extended amygdala
    Michal Bajo
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci Res 83:532-7. 2006
    ..In addition, our results indicate a region-specific response of NMDA receptor subunits to chronic morphine administration at the gene and protein levels...
  21. ncbi request reprint The tipsy terminal: presynaptic effects of ethanol
    George Robert Siggins
    Department of Neuropharmacology and Alcohol Research Center, The Scripps Research Institute, CVN 12, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Pharmacol Ther 107:80-98. 2005
    ..Such studies could lead to the formulation of new treatment strategies for alcohol intoxication, alcohol abuse, and alcoholism...
  22. pmc Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons
    Marisa Roberto
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:2053-8. 2003
    ..These findings add further support to the contention that the ethanol-GABA interaction in CeA plays an important role in the reinforcing effects of ethanol...
  23. pmc Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction
    Marsida Kallupi
    School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California
    Biol Psychiatry 74:520-8. 2013
    ..Studies have demonstrated an enhanced dynorphin/kappa-opioid receptor (KOR) system following repeated cocaine exposure, but few reports have focused on neuroadaptations within the central amygdala (CeA)...
  24. pmc Ghrelin increases GABAergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdala
    Maureen T Cruz
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 38:364-75. 2013
    ..These studies implicate a potential role for the ghrelin system in regulating GABAergic transmission and a complex interaction with ethanol at CeA GABAergic synapses...
  25. ncbi request reprint Endocannabinoids restrict hippocampal long-term potentiation via CB1
    Kristen A Slanina
    Department of Neuropharmacology, CVN 12, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropharmacology 49:660-8. 2005
    ..Inhibition of COX-1 or other routes of eCB degradation did not affect LTP. We conclude that COX-2 regulates the formation of CB1 ligands that negatively regulate LTP...
  26. ncbi request reprint Glutamatergic transmission in opiate and alcohol dependence
    George Robert Siggins
    Department of Neuropharmacology, Department of Molecular Biology, The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1003:196-211. 2003
    ..These combined findings suggest that changes in glutamatergic transmission in NAcc and CeA may underlie the neuroadaptions that lead to opiate and ethanol dependence...
  27. pmc Innate immune factors modulate ethanol interaction with GABAergic transmission in mouse central amygdala
    Michal Bajo
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines, La Jolla, CA 92037, USA Electronic address
    Brain Behav Immun 40:191-202. 2014
    ....
  28. pmc Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter mice
    Melissa A Herman
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 33:3284-98. 2013
    ..Together, these data demonstrate subunit-specific tonic signaling and provide mechanistic insight into the specific effects of ethanol on CeA microcircuitry...
  29. ncbi request reprint gamma-hydroxybutyrate increases a potassium current and decreases the H-current in hippocampal neurons via GABAB receptors
    Paul Schweitzer
    The Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 311:172-9. 2004
    ....
  30. pmc Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats
    Marsida Kallupi
    1 Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA 2 School of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy
    Neuropsychopharmacology 39:1081-92. 2014
    ..Taken together, these studies implicate a potential role for the nociceptin system in regulating glutamatergic transmission and a complex interaction with ethanol at CeA glutamatergic synapses. ..
  31. ncbi request reprint From blue states to up states: a regional view of NMDA-ethanol interactions
    John J Woodward
    Department of Neurosciences and Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 30:359-67. 2006
    ..In the third presentation, Marisa Roberto described adaptations in the expression and function of NMDA receptors in the central nucleus of the amygdala ..
  32. ncbi request reprint Time-dependent inhibition of hippocampal LTP in vitro following contextual fear conditioning in the rat
    Benedetto Sacchetti
    Department of Neuroscience, University of Turin, Corso Raffaello 30, I 10125 Turin, Italy
    Eur J Neurosci 15:143-50. 2002
    ....

Research Grants12

  1. Regulation of Ethanol Effects on Synaptic Transmission
    Marisa Roberto; Fiscal Year: 2006
    ....
  2. Synaptic and peptidergic neuroadaptations associated with alcohol dependence
    Marisa Roberto; Fiscal Year: 2009
    ..A better understanding of the neuroadaptations shaping the synaptic networks involved in ethanol dependence will be useful toward revealing new therapeutic agents to alleviate alcohol dependence. ..
  3. Synaptic and peptidergic neuroadaptations associated with alcohol dependence
    Marisa Roberto; Fiscal Year: 2010
    ..A better understanding of the neuroadaptations shaping the synaptic networks involved in ethanol dependence will be useful toward revealing new therapeutic agents to alleviate alcohol dependence. ..
  4. Regulation of Ethanol Effects on Synaptic Transmission
    Marisa Roberto; Fiscal Year: 2010
    ..abstract_text> ..
  5. Gene-environment interaction: the brain CRF system in alcohol preferring msP rats
    Marisa Roberto; Fiscal Year: 2009
    ..Insight into the nature and influence of these interactions may be invaluable in the development of pharmacotherapeutics for alcoholism. ..
  6. Synaptic and peptidergic neuroadaptations associated with alcohol dependence
    Marisa Roberto; Fiscal Year: 2009
    ..A better understanding of the neuroadaptations shaping the synaptic networks involved in ethanol dependence will be useful toward revealing new therapeutic agents to alleviate alcohol dependence. ..
  7. Regulation of Ethanol Effects on Synaptic Transmission
    Marisa Roberto; Fiscal Year: 2009
    ..abstract_text> ..
  8. Regulation of Ethanol Effects on Synaptic Transmission
    Marisa Roberto; Fiscal Year: 2007
    ....
  9. Gene-environment interaction: the brain CRF system in alcohol preferring msP rats
    Marisa Roberto; Fiscal Year: 2010
    ..Insight into the nature and influence of these interactions may be invaluable in the development of pharmacotherapeutics for alcoholism. ..