Research Topics
| Marisa RobertoSummaryAffiliation: The Scripps Research Institute Country: USA Publications
Research Grants
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Detail Information
Publications
The central amygdala and alcohol: role of γ-aminobutyric acid, glutamate, and neuropeptidesMarisa Roberto
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Cold Spring Harb Perspect Med 2:a012195. 2012..Alcohol dependence produces plasticity in these neuropeptide systems, reflecting a recruitment of those systems during the transition to alcohol dependence...- Cellular and behavioral interactions of gabapentin with alcohol dependenceMarisa Roberto
Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 28:5762-71. 2008.... 
Actions of acute and chronic ethanol on presynaptic terminalsMarisa Roberto
Molecular and Integrative Neuroscience Department, The Scripps Research Institute, La Jolla, California 92037, USA
Alcohol Clin Exp Res 30:222-32. 2006..The chairs of the session were Marisa Roberto and George Robert Siggins...- Chronic ethanol exposure and protracted abstinence alter NMDA receptors in central amygdalaMarisa Roberto
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
Neuropsychopharmacology 31:988-96. 2006..These data indicate that CET induces reversible neuroadaptations in synaptic function, gene expression, and protein composition of NMDAR at CeA synapses... - Nociceptin/orphanin FQ presynaptically decreases GABAergic transmission and blocks the ethanol-induced increase of GABA release in central amygdalaMarisa Roberto
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 103:9715-20. 2006..Our data suggest that nociceptin has a role in regulating the GABAergic system and opposing the effect elicited by ethanol. Thus, nociceptin may represent a therapeutic target for alleviating alcohol dependence... - Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependenceMarisa Roberto
Committee on the Neurobiology of Addictive Disorders, Scripps Research Institute, La Jolla, California 92037, USA
Biol Psychiatry 67:831-9. 2010..Ethanol augments CeA GABA release in ethanol-naive rats and mice... - The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdalaMarisa Roberto
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
Neuropsychopharmacology 35:1962-72. 2010..Our study points to an important role of CB1 in CeA in which the eCBs tonically regulate neuronal activity, and suggests a potent mechanism for modulating CeA tone during challenge with ethanol... - CRF system recruitment mediates dark side of compulsive eatingPietro Cottone
Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, Harold L Dorris Neurological Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 106:20016-20. 2009.... - Increased GABA release in the central amygdala of ethanol-dependent ratsMarisa Roberto
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 24:10159-66. 2004..These combined findings suggest that acute and chronic ethanol increases GABA release in CeA and support previous reports that the behavioral actions of ethanol are mediated, in part, by increased GABAergic transmission in the CeA... - Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysisMarisa Roberto
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 24:1594-603. 2004.... 
Differential alteration of hippocampal excitatory synaptic transmission by cannabinoid ligandsMichal Bajo
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci Res 87:766-75. 2009..We observed large differences between full (synthetic) and partial (endogenous) CB1 agonists in altering synaptic transmission, notably because of the involvement of active degradation mechanisms...- Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependenceNicholas W Gilpin
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
Biol Psychiatry 69:1091-9. 2011.... - Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdalaMichal Bajo
Molecular and Integrative Neurosciences Department, Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 105:8410-5. 2008..These results identify a PKCepsilon signaling pathway in the CeA that is activated by CRF(1) receptor stimulation, mediates GABA release at nerve terminals, and regulates anxiety and alcohol consumption... - Nociceptin/orphanin FQ blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposureMaureen T Cruz
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Biol Psychiatry 71:666-76. 2012..In the rat, CRF and ethanol significantly augment CeA gamma-aminobutyric acid (GABA) release, whereas nociceptin diminishes it... - Neuroadaptation of GABAergic transmission in the central amygdala during chronic morphine treatmentMichal Bajo
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
Addict Biol 16:551-64. 2011.... - NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdalaPaul J Kenny
Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
Neuropsychopharmacology 34:266-81. 2009..Taken together, these data suggest that NMDA receptors, including those in the CeA and VTA, gate the magnitude and valence of the effects of nicotine on brain reward systems, thereby regulating motivation to consume the drug... - Chronic morphine treatment alters expression of N-methyl-D-aspartate receptor subunits in the extended amygdalaMichal Bajo
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci Res 83:532-7. 2006..In addition, our results indicate a region-specific response of NMDA receptor subunits to chronic morphine administration at the gene and protein levels... - The tipsy terminal: presynaptic effects of ethanolGeorge Robert Siggins
Department of Neuropharmacology and Alcohol Research Center, The Scripps Research Institute, CVN 12, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Pharmacol Ther 107:80-98. 2005..Such studies could lead to the formulation of new treatment strategies for alcohol intoxication, alcohol abuse, and alcoholism... - Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neuronsMarisa Roberto
Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 100:2053-8. 2003..These findings add further support to the contention that the ethanol-GABA interaction in CeA plays an important role in the reinforcing effects of ethanol... - Endocannabinoids restrict hippocampal long-term potentiation via CB1Kristen A Slanina
Department of Neuropharmacology, CVN 12, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Neuropharmacology 49:660-8. 2005..Inhibition of COX-1 or other routes of eCB degradation did not affect LTP. We conclude that COX-2 regulates the formation of CB1 ligands that negatively regulate LTP... - Glutamatergic transmission in opiate and alcohol dependenceGeorge Robert Siggins
Department of Neuropharmacology, Department of Molecular Biology, The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, California 92037, USA
Ann N Y Acad Sci 1003:196-211. 2003..These combined findings suggest that changes in glutamatergic transmission in NAcc and CeA may underlie the neuroadaptions that lead to opiate and ethanol dependence... - Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter miceMelissa A Herman
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 33:3284-98. 2013..Together, these data demonstrate subunit-specific tonic signaling and provide mechanistic insight into the specific effects of ethanol on CeA microcircuitry... - gamma-hydroxybutyrate increases a potassium current and decreases the H-current in hippocampal neurons via GABAB receptorsPaul Schweitzer
The Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037, USA
J Pharmacol Exp Ther 311:172-9. 2004.... - Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: Alcohol and CRF effectsMelissa A Herman
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, SP30 1150, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Neuropharmacology 67:337-48. 2013..The elevated GABAergic transmission observed in naïve msP rats is consistent with the neuroadaptations reported in Sprague Dawley rats after the development of ethanol dependence... - Type 7 Adenylyl Cyclase is Involved in the Ethanol and CRF Sensitivity of GABAergic Synapses in Mouse Central AmygdalaMaureen T Cruz
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute La Jolla, CA, USA
Front Neurosci 4:207. 2011..These electrophysiological data suggest that AC7 plays an important role in ethanol and CRF modulation of presynaptic GABA release in CeA and thus may underlie ethanol-related behaviors such as anxiety and dependence... - Ghrelin increases GABAergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdalaMaureen T Cruz
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
Neuropsychopharmacology 38:364-75. 2013..These studies implicate a potential role for the ghrelin system in regulating GABAergic transmission and a complex interaction with ethanol at CeA GABAergic synapses... - From blue states to up states: a regional view of NMDA-ethanol interactionsJohn J Woodward
Department of Neurosciences and Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Alcohol Clin Exp Res 30:359-67. 2006..In the third presentation, Marisa Roberto described adaptations in the expression and function of NMDA receptors in the central nucleus of the amygdala .. - Time-dependent inhibition of hippocampal LTP in vitro following contextual fear conditioning in the ratBenedetto Sacchetti
Department of Neuroscience, University of Turin, Corso Raffaello 30, I-10125 Turin, Italy
Eur J Neurosci 15:143-50. 2002....
Research Grants
- Synaptic and peptidergic neuroadaptations associated with alcohol dependenceMarisa Roberto; Fiscal Year: 2009..A better understanding of the neuroadaptations shaping the synaptic networks involved in ethanol dependence will be useful toward revealing new therapeutic agents to alleviate alcohol dependence. ..
- Synaptic and peptidergic neuroadaptations associated with alcohol dependenceMarisa Roberto; Fiscal Year: 2010..A better understanding of the neuroadaptations shaping the synaptic networks involved in ethanol dependence will be useful toward revealing new therapeutic agents to alleviate alcohol dependence. ..
- Regulation of Ethanol Effects on Synaptic TransmissionMarisa Roberto; Fiscal Year: 2010..abstract_text> ..
- Regulation of Ethanol Effects on Synaptic TransmissionMarisa Roberto; Fiscal Year: 2009..abstract_text> ..
- Regulation of Ethanol Effects on Synaptic TransmissionMarisa Roberto; Fiscal Year: 2007....
- Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsMarisa Roberto; Fiscal Year: 2010..Insight into the nature and influence of these interactions may be invaluable in the development of pharmacotherapeutics for alcoholism. ..