Robert A Rissman

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi request reprint Age-related alterations in GABA(A) receptor subunits in the nonhuman primate hippocampus
    Robert A Rissman
    Department of Neurobiology and Anatomy, Graduate Program in Neuroscience, MCP Hahnemann University School of Medicine, Philadelphia, PA 19102 1192, USA
    Brain Res 1073:120-30. 2006
  2. ncbi request reprint GABA(A) receptors in aging and Alzheimer's disease
    Robert A Rissman
    Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, California, USA
    J Neurochem 103:1285-92. 2007
  3. ncbi request reprint Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation
    Robert A Rissman
    Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, California 92037, USA
    J Neurosci 27:6552-62. 2007
  4. pmc Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation
    Robert A Rissman
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0624, USA
    Proc Natl Acad Sci U S A 109:6277-82. 2012
  5. pmc Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors
    Allyson D Roe
    Department of Neurosciences, University of California, San Diego School of Medicine, La Jolla, CA, USA
    Eur J Neurosci 34:448-56. 2011
  6. ncbi request reprint Subregional analysis of GABA(A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment
    Robert A Rissman
    Department of Neurobiology and Anatomy, Graduate Program in Neuroscience, MCP Hahnemann University School of Medicine, Philadelphia, PA, USA
    J Chem Neuroanat 28:17-25. 2004
  7. pmc Detection and quantification of 8-hydroxy-2'-deoxyguanosine in Alzheimer's transgenic mouse urine using capillary electrophoresis
    Cheng Zhang
    Department of Neurosciences, UCSD School of Medicine, La Jolla, CA 92093, USA
    Electrophoresis 34:2268-74. 2013
  8. pmc Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability?
    Robert A Rissman
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92037 0624, USA
    J Alzheimers Dis 18:453-7. 2009
  9. pmc Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease
    Robert A Rissman
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Neurochem 117:613-22. 2011
  10. doi request reprint Longitudinal plasma amyloid beta as a biomarker of Alzheimer's disease
    Robert A Rissman
    Alzheimer s Disease Cooperative Study, Department of Neurosciences, UCSD School of Medicine, La Jolla, CA 92037 0624, USA
    J Neural Transm 119:843-50. 2012

Research Grants

  1. Role of Intracellular ABeta in Tau Pathology
    ROBERT RISSMAN; Fiscal Year: 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Age-related alterations in GABA(A) receptor subunits in the nonhuman primate hippocampus
    Robert A Rissman
    Department of Neurobiology and Anatomy, Graduate Program in Neuroscience, MCP Hahnemann University School of Medicine, Philadelphia, PA 19102 1192, USA
    Brain Res 1073:120-30. 2006
    ....
  2. ncbi request reprint GABA(A) receptors in aging and Alzheimer's disease
    Robert A Rissman
    Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, California, USA
    J Neurochem 103:1285-92. 2007
    ..It is therefore crucial to understand the subunit composition of individual GABA(A) receptors in the diseased brain when developing therapeutics that act at these receptors...
  3. ncbi request reprint Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation
    Robert A Rissman
    Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, California 92037, USA
    J Neurosci 27:6552-62. 2007
    ....
  4. pmc Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation
    Robert A Rissman
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0624, USA
    Proc Natl Acad Sci U S A 109:6277-82. 2012
    ....
  5. pmc Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors
    Allyson D Roe
    Department of Neurosciences, University of California, San Diego School of Medicine, La Jolla, CA, USA
    Eur J Neurosci 34:448-56. 2011
    ..CRFR mediation of stress-induced hippocampal tau-P may be limited to emotional stressors...
  6. ncbi request reprint Subregional analysis of GABA(A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment
    Robert A Rissman
    Department of Neurobiology and Anatomy, Graduate Program in Neuroscience, MCP Hahnemann University School of Medicine, Philadelphia, PA, USA
    J Chem Neuroanat 28:17-25. 2004
    ..Collectively, our data provide evidence for modest reductions in GABA(A) receptor subunit mRNAs, and suggest these changes occur very early in the progression of Alzheimer's disease cognitive impairment...
  7. pmc Detection and quantification of 8-hydroxy-2'-deoxyguanosine in Alzheimer's transgenic mouse urine using capillary electrophoresis
    Cheng Zhang
    Department of Neurosciences, UCSD School of Medicine, La Jolla, CA 92093, USA
    Electrophoresis 34:2268-74. 2013
    ..Collectively, our results indicate that this methodology offers great advantages, such as high separation efficiency, good selectivity, low limit of detection, simplicity and low cost of analysis. ..
  8. pmc Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability?
    Robert A Rissman
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92037 0624, USA
    J Alzheimers Dis 18:453-7. 2009
    ..In this review, the question of whether stress-induced tau-P can be used as a model for examining the relationship between functional neuroplasticity and neuronal vulnerability will be discussed...
  9. pmc Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease
    Robert A Rissman
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Neurochem 117:613-22. 2011
    ..When developing AD therapeutics that modulate GABA it is important to consider how E/I balance impacts AD pathogenesis and the relationship between seizure activity and cognitive decline...
  10. doi request reprint Longitudinal plasma amyloid beta as a biomarker of Alzheimer's disease
    Robert A Rissman
    Alzheimer s Disease Cooperative Study, Department of Neurosciences, UCSD School of Medicine, La Jolla, CA 92037 0624, USA
    J Neural Transm 119:843-50. 2012
    ..In this review, we discuss recent data on plasma β-amyloid (Aβ) and examine the issues that have arisen in establishing it as a reliable biomarker of AD...
  11. ncbi request reprint Plasticity of glutamate and GABAA receptors in the hippocampus of patients with Alzheimer's disease
    David M Armstrong
    Laboratory of Neuronal Vulnerability and Aging, The Lankenau Institute for Medical Research, Jefferson Health System, Wynnewood, Pennsylvania, USA
    Cell Mol Neurobiol 23:491-505. 2003
    ..e., the pathologic hallmarks of AD). Throughout the past several years our laboratory has sought to determine the molecular mechanisms underlying the selective vulnerability of neurons in AD...
  12. ncbi request reprint Biochemical and molecular studies of NMDA receptor subunits NR1/2A/2B in hippocampal subregions throughout progression of Alzheimer's disease pathology
    Amanda J Mishizen-Eberz
    Laboratory of Neuronal Vulnerability and Aging, The Lankenau Institute for Medical Research, Jefferson Health System, Wynnewood, PA, USA
    Neurobiol Dis 15:80-92. 2004
    ..This investigation supports the hypothesis that alterations occur in the expression of specific NMDA receptor subunits with increasing AD pathologic severity, which is hypothesized to contribute to the vulnerability of these neurons...
  13. ncbi request reprint Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain
    Troy T Rohn
    Department of Biology, Boise State University, Idaho 83725, USA
    Neurobiol Dis 11:341-54. 2002
    ..Taken together, these results demonstrate the activation of caspases and cleavage of tau in the AD brain, events which may precede and lead to the formation of NFTs...
  14. ncbi request reprint Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage
    Troy L Carter
    Laboratory of Neuronal Vulnerability and Aging, The Lankenau Institute for Medical Research, Jefferson Health System, Wynewood, PA 19096, USA
    Exp Neurol 187:299-309. 2004
    ....
  15. pmc Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology
    Robert A Rissman
    Institute for Brain Aging and Dementia, University of California, Irvine 92697, USA
    J Clin Invest 114:121-30. 2004
    ..These results suggest that therapeutics aimed at inhibiting tau caspase-cleavage may prove beneficial not only in preventing NFT formation, but also in slowing cognitive decline...
  16. pmc Caspase-mediated degeneration in Alzheimer's disease
    David H Cribbs
    Institute for Brain Aging and Dementia, Irvine CA 92697 4540, USA
    Am J Pathol 165:353-5. 2004
  17. ncbi request reprint Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology
    Jodie Newman
    Department of Biology, Boise State University, Boise, Idaho, USA
    Acta Neuropathol 110:135-44. 2005
    ....
  18. ncbi request reprint The role of caspase cleavage of tau in Alzheimer disease neuropathology
    Carl W Cotman
    Institute for Brain Aging and Dementia, University of California, Irvine, 92697, USA
    J Neuropathol Exp Neurol 64:104-12. 2005
    ..In addition, a model is presented whereby caspase cleavage of tau provides a mechanistic link between the development of amyloid and tangle pathologies...

Research Grants1

  1. Role of Intracellular ABeta in Tau Pathology
    ROBERT RISSMAN; Fiscal Year: 2003
    ..The goals of the proposed studies are to investigate the role of in vitro intracellular beta-amyloid (ABeta) as a potential initiator of the cascade leading to caspase proteolysis of tau. ..