Robert A Rissman
Affiliation: The Salk Institute
- Age-related alterations in GABA(A) receptor subunits in the nonhuman primate hippocampusRobert A Rissman
Department of Neurobiology and Anatomy, Graduate Program in Neuroscience, MCP Hahnemann University School of Medicine, Philadelphia, PA 19102 1192, USA
Brain Res 1073:120-30. 2006....
- GABA(A) receptors in aging and Alzheimer's diseaseRobert A Rissman
Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, California, USA
J Neurochem 103:1285-92. 2007..It is therefore crucial to understand the subunit composition of individual GABA(A) receptors in the diseased brain when developing therapeutics that act at these receptors...
- Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylationRobert A Rissman
Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, California 92037, USA
J Neurosci 27:6552-62. 2007....
- Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregationRobert A Rissman
Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0624, USA
Proc Natl Acad Sci U S A 109:6277-82. 2012....
- Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptorsAllyson D Roe
Department of Neurosciences, University of California, San Diego School of Medicine, La Jolla, CA, USA
Eur J Neurosci 34:448-56. 2011..CRFR mediation of stress-induced hippocampal tau-P may be limited to emotional stressors...
- Subregional analysis of GABA(A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairmentRobert A Rissman
Department of Neurobiology and Anatomy, Graduate Program in Neuroscience, MCP Hahnemann University School of Medicine, Philadelphia, PA, USA
J Chem Neuroanat 28:17-25. 2004..Collectively, our data provide evidence for modest reductions in GABA(A) receptor subunit mRNAs, and suggest these changes occur very early in the progression of Alzheimer's disease cognitive impairment...
- Detection and quantification of 8-hydroxy-2'-deoxyguanosine in Alzheimer's transgenic mouse urine using capillary electrophoresisCheng Zhang
Department of Neurosciences, UCSD School of Medicine, La Jolla, CA 92093, USA
Electrophoresis 34:2268-74. 2013..Collectively, our results indicate that this methodology offers great advantages, such as high separation efficiency, good selectivity, low limit of detection, simplicity and low cost of analysis. ..
- Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability?Robert A Rissman
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92037 0624, USA
J Alzheimers Dis 18:453-7. 2009..In this review, the question of whether stress-induced tau-P can be used as a model for examining the relationship between functional neuroplasticity and neuronal vulnerability will be discussed...
- Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's diseaseRobert A Rissman
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
J Neurochem 117:613-22. 2011..When developing AD therapeutics that modulate GABA it is important to consider how E/I balance impacts AD pathogenesis and the relationship between seizure activity and cognitive decline...
- Longitudinal plasma amyloid beta as a biomarker of Alzheimer's diseaseRobert A Rissman
Alzheimer s Disease Cooperative Study, Department of Neurosciences, UCSD School of Medicine, La Jolla, CA 92037 0624, USA
J Neural Transm 119:843-50. 2012..In this review, we discuss recent data on plasma β-amyloid (Aβ) and examine the issues that have arisen in establishing it as a reliable biomarker of AD...
- Plasticity of glutamate and GABAA receptors in the hippocampus of patients with Alzheimer's diseaseDavid M Armstrong
Laboratory of Neuronal Vulnerability and Aging, The Lankenau Institute for Medical Research, Jefferson Health System, Wynnewood, Pennsylvania, USA
Cell Mol Neurobiol 23:491-505. 2003..e., the pathologic hallmarks of AD). Throughout the past several years our laboratory has sought to determine the molecular mechanisms underlying the selective vulnerability of neurons in AD...
- Biochemical and molecular studies of NMDA receptor subunits NR1/2A/2B in hippocampal subregions throughout progression of Alzheimer's disease pathologyAmanda J Mishizen-Eberz
Laboratory of Neuronal Vulnerability and Aging, The Lankenau Institute for Medical Research, Jefferson Health System, Wynnewood, PA, USA
Neurobiol Dis 15:80-92. 2004..This investigation supports the hypothesis that alterations occur in the expression of specific NMDA receptor subunits with increasing AD pathologic severity, which is hypothesized to contribute to the vulnerability of these neurons...
- Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brainTroy T Rohn
Department of Biology, Boise State University, Idaho 83725, USA
Neurobiol Dis 11:341-54. 2002..Taken together, these results demonstrate the activation of caspases and cleavage of tau in the AD brain, events which may precede and lead to the formation of NFTs...
- Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stageTroy L Carter
Laboratory of Neuronal Vulnerability and Aging, The Lankenau Institute for Medical Research, Jefferson Health System, Wynewood, PA 19096, USA
Exp Neurol 187:299-309. 2004....
- Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathologyRobert A Rissman
Institute for Brain Aging and Dementia, University of California, Irvine 92697, USA
J Clin Invest 114:121-30. 2004..These results suggest that therapeutics aimed at inhibiting tau caspase-cleavage may prove beneficial not only in preventing NFT formation, but also in slowing cognitive decline...
- Caspase-mediated degeneration in Alzheimer's diseaseDavid H Cribbs
Institute for Brain Aging and Dementia, Irvine CA 92697 4540, USA
Am J Pathol 165:353-5. 2004
- Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathologyJodie Newman
Department of Biology, Boise State University, Boise, Idaho, USA
Acta Neuropathol 110:135-44. 2005....
- The role of caspase cleavage of tau in Alzheimer disease neuropathologyCarl W Cotman
Institute for Brain Aging and Dementia, University of California, Irvine, 92697, USA
J Neuropathol Exp Neurol 64:104-12. 2005..In addition, a model is presented whereby caspase cleavage of tau provides a mechanistic link between the development of amyloid and tangle pathologies...
- Role of Intracellular ABeta in Tau PathologyROBERT RISSMAN; Fiscal Year: 2003..The goals of the proposed studies are to investigate the role of in vitro intracellular beta-amyloid (ABeta) as a potential initiator of the cascade leading to caspase proteolysis of tau. ..