Matthias Riewald

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    Matthias Riewald
    Department of Immunology, C204, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 296:1880-2. 2002
  2. ncbi request reprint Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling
    Matthias Riewald
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 280:19808-14. 2005
  3. ncbi request reprint Activated protein C signals through the thrombin receptor PAR1 in endothelial cells
    Matthias Riewald
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Endotoxin Res 9:317-21. 2003
  4. pmc Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1
    Reto A Schuepbach
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA
    Thromb Haemost 101:724-33. 2009
  5. pmc Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin
    Reto A Schuepbach
    Department of Immunology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 111:2667-73. 2008
  6. pmc Activated protein C up-regulates procoagulant tissue factor activity on endothelial cells by shedding the TFPI Kunitz 1 domain
    Reto A Schuepbach
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA
    Blood 117:6338-46. 2011
  7. ncbi request reprint Orchestration of coagulation protease signaling by tissue factor
    Matthias Riewald
    Department of Immunology C204, The Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Cardiovasc Med 12:149-54. 2002
  8. pmc Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant
    Laurent O Mosnier
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 113:5970-8. 2009
  9. ncbi request reprint Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells
    Clemens Feistritzer
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 281:20077-84. 2006
  10. ncbi request reprint Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
    Clemens Feistritzer
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 105:3178-84. 2005

Research Grants

  1. Protease activated receptor-1 signaling by protein C
    Matthias Riewald; Fiscal Year: 2010
  2. Protease activated receptor-1 signaling by protein C
    Matthias Riewald; Fiscal Year: 2006

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    Matthias Riewald
    Department of Immunology, C204, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 296:1880-2. 2002
    ..Thus, the prototypical thrombin receptor is the target for EPCR-dependent APC signaling, suggesting a role for this receptor cascade in protection from sepsis...
  2. ncbi request reprint Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling
    Matthias Riewald
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 280:19808-14. 2005
    ..These data may explain how APC can be therapeutically protective through the EPCR-PAR1 signaling despite ongoing thrombin generation due to disseminated intravascular coagulopathy...
  3. ncbi request reprint Activated protein C signals through the thrombin receptor PAR1 in endothelial cells
    Matthias Riewald
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Endotoxin Res 9:317-21. 2003
    ..These data demonstrate unexpected protective functions of the major thrombin receptor PAR1 in endothelial cells...
  4. pmc Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1
    Reto A Schuepbach
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA
    Thromb Haemost 101:724-33. 2009
    ..Our data in vitro and in vivo support the paradigm that PAR1 contributes to protective effects of APC on vascular barrier integrity in sepsis...
  5. pmc Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin
    Reto A Schuepbach
    Department of Immunology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Blood 111:2667-73. 2008
    ..The data suggest that different trafficking of activated PAR1 might explain how PAR1 signaling by APC can be relevant when thrombin is present...
  6. pmc Activated protein C up-regulates procoagulant tissue factor activity on endothelial cells by shedding the TFPI Kunitz 1 domain
    Reto A Schuepbach
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA
    Blood 117:6338-46. 2011
    ....
  7. ncbi request reprint Orchestration of coagulation protease signaling by tissue factor
    Matthias Riewald
    Department of Immunology C204, The Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Cardiovasc Med 12:149-54. 2002
    ..Targeting inflammatory cell signaling events of the coagulation system may become an important aspect of efforts to improve antithrombotic therapy...
  8. pmc Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant
    Laurent O Mosnier
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 113:5970-8. 2009
    ..Protein engineering can provide APC mutants that permit definitive mechanism of action studies for APC's multiple activities, and may also provide safer and more effective second-generation APC mutants with reduced bleeding risk...
  9. ncbi request reprint Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells
    Clemens Feistritzer
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 281:20077-84. 2006
    ..WE may have powerful protective effects in systemic inflammation through signaling by the endogenously generated APC...
  10. ncbi request reprint Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
    Clemens Feistritzer
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 105:3178-84. 2005
    ....
  11. pmc Science review: role of coagulation protease cascades in sepsis
    Matthias Riewald
    Department of Immunology C204, The Scripps Research Institute, La Jolla, California, USA
    Crit Care 7:123-9. 2003
    ..This dichotomy is of relevance for the interpretation of preclinical and clinical data that document nonuniform responses to anticoagulant strategies in sepsis therapy...
  12. ncbi request reprint Tissue factor-dependent coagulation protease signaling in acute lung injury
    Wolfram Ruf
    Department of Immunology, C204, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Crit Care Med 31:S231-7. 2003
    ..To interpret preclinical and clinical data on therapeutic intervention of the coagulation cascade, focusing on the principles of proteolytic cell signaling of the coagulant and anticoagulant pathways...
  13. ncbi request reprint Endothelial protein C receptor-dependent inhibition of migration of human lymphocytes by protein C involves epidermal growth factor receptor
    Clemens Feistritzer
    Division of General Internal Medicine, Department of Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria
    J Immunol 176:1019-25. 2006
    ..Exposure of lymphocytes to protein C or activated protein C stimulates phosphorylation of Tyr845 of epidermal growth factor receptor, which may be relevant for cytoprotective effects of the protein C pathway...
  14. ncbi request reprint Thrombin affects eosinophil migration via protease-activated receptor-1
    Clemens Feistritzer
    Division of General Internal Medicine, Department of Internal Medicine, Medical University of Innsbruck, Anichstrasse 35, AT 6020 Innsbruck, Austria
    Int Arch Allergy Immunol 135:12-6. 2004
    ..Thus we investigated whether thrombin affects eosinophil migration in vitro...
  15. ncbi request reprint Protective signaling pathways of activated protein C in endothelial cells
    Matthias Riewald
    Arterioscler Thromb Vasc Biol 28:1-3. 2008

Research Grants7

  1. Protease activated receptor-1 signaling by protein C
    Matthias Riewald; Fiscal Year: 2010
    ..The results will have important implications for novel treatment strategies for diseases where the inflammatory response plays a key role, including myocardial infarction and stroke. ..
  2. Protease activated receptor-1 signaling by protein C
    Matthias Riewald; Fiscal Year: 2006
    ..abstract_text> ..