Ofer Reizes

Summary

Affiliation: The Procter and Gamble Company
Country: USA

Publications

  1. ncbi request reprint Syndecan-3 modulates food intake by interacting with the melanocortin/AgRP pathway
    Ofer Reizes
    Procter Gamble Pharmaceuticals, Inc, Health Care Research Center, Mason, Ohio 45040, USA
    Ann N Y Acad Sci 994:66-73. 2003
  2. ncbi request reprint Insulin promotes shedding of syndecan ectodomains from 3T3-L1 adipocytes: a proposed mechanism for stabilization of extracellular lipoprotein lipase
    Ofer Reizes
    Division of Newborn Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    Biochemistry 45:5703-11. 2006
  3. ncbi request reprint The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: a novel class of potent MCH-R1 antagonists
    Jose L Mendez-Andino
    Procter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Mason, OH 45039, USA
    Bioorg Med Chem 15:2092-105. 2007
  4. ncbi request reprint Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists--Increasing selectivity over hERG
    Kenneth M Meyers
    Procter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Mason, OH 45039, USA
    Bioorg Med Chem Lett 17:819-22. 2007
  5. ncbi request reprint Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists
    Kenneth M Meyers
    Procter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Mason, OH 45039, USA
    Bioorg Med Chem Lett 17:657-61. 2007
  6. ncbi request reprint A role for syndecan-3 in the melanocortin regulation of energy balance
    Ofer Reizes
    Procter and Gamble Pharmaceuticals Inc Health Care Research Center, Mason, OH 45040, USA
    Peptides 27:274-80. 2006
  7. pmc Constitutive and accelerated shedding of murine syndecan-1 is mediated by cleavage of its core protein at a specific juxtamembrane site
    Zihua Wang
    Division of Developmental and Newborn Biology, Department of Pediatrics, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 44:12355-61. 2005
  8. ncbi request reprint Inhibition by the soluble syndecan-1 ectodomains delays wound repair in mice overexpressing syndecan-1
    Varpu Elenius
    Department of Pediatrics, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:41928-35. 2004
  9. ncbi request reprint Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG
    Kenneth M Meyers
    Procter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Mason, OH 45039, USA
    Bioorg Med Chem Lett 17:814-8. 2007
  10. ncbi request reprint Design and synthesis of substituted quinolines as novel and selective melanin concentrating hormone antagonists as anti-obesity agents
    Namal C Warshakoon
    Drug Discovery Division, Procter and Gamble Pharmaceuticals Inc, 8700 Mason Montgomery Road, Mason, OH 45040, USA
    Bioorg Med Chem Lett 16:5207-11. 2006

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Syndecan-3 modulates food intake by interacting with the melanocortin/AgRP pathway
    Ofer Reizes
    Procter Gamble Pharmaceuticals, Inc, Health Care Research Center, Mason, Ohio 45040, USA
    Ann N Y Acad Sci 994:66-73. 2003
    ..Collectively, the data suggest that the modulation of melanocortin regulation of energy balance by syndecan-3 is modulated by the action of a TIMP-3-sensitive metalloprotease...
  2. ncbi request reprint Insulin promotes shedding of syndecan ectodomains from 3T3-L1 adipocytes: a proposed mechanism for stabilization of extracellular lipoprotein lipase
    Ofer Reizes
    Division of Newborn Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    Biochemistry 45:5703-11. 2006
    ..These data suggest that syndecan ectodomains, shed by adipocytes in response to insulin, are physiological extracellular chaperones for lipoprotein lipase as it translocates from its site of synthesis to its site of action...
  3. ncbi request reprint The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: a novel class of potent MCH-R1 antagonists
    Jose L Mendez-Andino
    Procter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Mason, OH 45039, USA
    Bioorg Med Chem 15:2092-105. 2007
    ..Compounds within this class promoted significant body weight reduction in mouse diet induced obesity studies. The potential for hERG blockage activity and QT interval studies in anesthetized dogs are discussed...
  4. ncbi request reprint Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists--Increasing selectivity over hERG
    Kenneth M Meyers
    Procter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Mason, OH 45039, USA
    Bioorg Med Chem Lett 17:819-22. 2007
    ..Compounds within this class with greater selectivity over hERG were developed. Compound 4h proved to have the best profile, with MCH-R1 Ki = 16 nm and hERG IC50 = 25 microM...
  5. ncbi request reprint Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists
    Kenneth M Meyers
    Procter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Mason, OH 45039, USA
    Bioorg Med Chem Lett 17:657-61. 2007
    ..The synthesis and biological testing of novel classes of potent melanin-concentrating hormone (MCH-R1) antagonists based on pyrazolopiperazinone and pyrrolopiperazinone scaffolds are described...
  6. ncbi request reprint A role for syndecan-3 in the melanocortin regulation of energy balance
    Ofer Reizes
    Procter and Gamble Pharmaceuticals Inc Health Care Research Center, Mason, OH 45040, USA
    Peptides 27:274-80. 2006
    ..In this review, we present an overview of the biology and potential functions of syndecan-3 and describe a novel hypothesis for its regulation of energy balance...
  7. pmc Constitutive and accelerated shedding of murine syndecan-1 is mediated by cleavage of its core protein at a specific juxtamembrane site
    Zihua Wang
    Division of Developmental and Newborn Biology, Department of Pediatrics, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 44:12355-61. 2005
    ..These results suggest that the same cleavage site is utilized for basal syndecan-1 ectodomain shedding both in vitro from NMuMG and CHO cells and in vivo...
  8. ncbi request reprint Inhibition by the soluble syndecan-1 ectodomains delays wound repair in mice overexpressing syndecan-1
    Varpu Elenius
    Department of Pediatrics, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:41928-35. 2004
    ..These studies indicate that shed syndecan-1 ectodomain may enhance proteolytic activity and inhibit cell proliferation during wound repair...
  9. ncbi request reprint Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG
    Kenneth M Meyers
    Procter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Mason, OH 45039, USA
    Bioorg Med Chem Lett 17:814-8. 2007
    ..SAR studies addressing two distinct alternatives for structural modifications leading to improve hERG selectivity are described...
  10. ncbi request reprint Design and synthesis of substituted quinolines as novel and selective melanin concentrating hormone antagonists as anti-obesity agents
    Namal C Warshakoon
    Drug Discovery Division, Procter and Gamble Pharmaceuticals Inc, 8700 Mason Montgomery Road, Mason, OH 45040, USA
    Bioorg Med Chem Lett 16:5207-11. 2006
    ..These analogs show potent (nM) activity (12a-k) with a moderate selectivity. Conversely, the conformationally constrained thienopyrimidinone analogs (18a-g) showed improved activity in MCH-1R and selectivity over 5HT2C...
  11. ncbi request reprint Unlocking the secrets of syndecans: transgenic organisms as a potential key
    Robert Bellin
    Division of Newborn Medicine, Department of Pediatrics, Children s Hospital, Harvard Medical School, 300 Longwood Ave, Enders 950, Boston, MA 02115, USA
    Glycoconj J 19:295-304. 2002
    ..This review focuses on these diverse functions of the syndecans that have been elucidated by the use of transgenic mice and Drosophila as model systems...
  12. ncbi request reprint Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity
    Nick Kim
    Procter and Gamble Pharmaceuticals, 8700 Mason Montgomery Road, Mason, OH 45040, USA
    Bioorg Med Chem Lett 16:5445-50. 2006
    ....
  13. ncbi request reprint Differential expression of proteoglycans at central and peripheral nodes of Ranvier
    Carmen Melendez-Vasquez
    Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Glia 52:301-8. 2005
    ..These results indicate that the molecular composition and extracellular environment of the PNS and CNS nodes of Ranvier are significantly distinct...
  14. ncbi request reprint The effect of the melanocortin agonist, MT-II, on the defended level of body adiposity
    Randy J Seeley
    Department of Psychiatry, Genome Research Institute, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, Ohio 45226
    Endocrinology 146:3732-8. 2005
    ..These experiments support the hypothesis that melanocortin signaling primarily regulates total body adiposity and that food intake is adjusted as necessary to achieve a specific level of body adiposity...
  15. pmc Mice lacking the syndecan-3 gene are resistant to diet-induced obesity
    April D Strader
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 114:1354-60. 2004
    ..The data implicate syndecan-3 in the regulation of body weight and suggest that inhibition of syndecan-3 may provide a therapeutic approach for the treatment of obesity resulting from exposure to high-fat diets...
  16. ncbi request reprint Small-molecule melanin-concentrating hormone-1 receptor antagonists require brain penetration for inhibition of food intake and reduction in body weight
    X Eric Hu
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC10, Cleveland, OH 44195, USA
    J Pharmacol Exp Ther 324:206-13. 2008
    ..The effect is dose-dependent and appears to be partially driven by a reduction in food intake. Finally, these studies show the utility of a medicinal chemistry approach to address an important biological and pharmacological question...
  17. ncbi request reprint The effects of the melanocortin agonist (MT-II) on subcutaneous and visceral adipose tissue in rodents
    April D Strader
    University of Cincinnati School of Medicine, Cincinnati, Ohio, USA
    J Pharmacol Exp Ther 322:1153-61. 2007
    ..Although the present data suggest that the anorectic effect of MT-II is primarily a consequence of reduced food intake, the body composition data suggest that other mechanisms are involved...