Lubica Rauova

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. pmc Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia
    Lubica Rauova
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 116:5021-31. 2010
  2. pmc Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications
    Lubica Rauova
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 107:2346-53. 2006
  3. pmc Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT
    M Anna Kowalska
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 118:2882-8. 2011
  4. pmc Dynamic antibody-binding properties in the pathogenesis of HIT
    Bruce S Sachais
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 120:1137-42. 2012
  5. pmc Diminished adhesion and activation of platelets and neutrophils with CD47 functionalized blood contacting surfaces
    Matthew J Finley
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Biomaterials 33:5803-11. 2012
  6. pmc Infusion of mature megakaryocytes into mice yields functional platelets
    Rudy Fuentes
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 120:3917-22. 2010
  7. doi request reprint Role of the platelet chemokine platelet factor 4 (PF4) in hemostasis and thrombosis
    M Anna Kowalska
    Department of Pediatrics, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Thromb Res 125:292-6. 2010
  8. ncbi request reprint Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia
    Lubica Rauova
    Division of Hematology, Children s Hospital of Philadelphia, PA, USA
    Blood 105:131-8. 2005
  9. pmc Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice
    Donna S Woulfe
    Center for Translational Research, Department of Medicine, Thomas Jefferson University, Philadelphia, and Department of Pediatrics, Children s Hospital of Pennsylvania 19107, USA
    Blood 111:3458-67. 2008
  10. pmc Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications
    Michele P Lambert
    Department of Pediatrics, Children s Hospital of Philadelphia, PA 19104, USA
    Blood 110:1153-60. 2007

Detail Information

Publications13

  1. pmc Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia
    Lubica Rauova
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 116:5021-31. 2010
    ....
  2. pmc Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications
    Lubica Rauova
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 107:2346-53. 2006
    ..We believe that this focus on surface PF4 advances our understanding of the pathogenesis of HIT, suggests ways to identify patients at high risk to develop HIT upon heparin exposure, and offers new therapeutic strategies...
  3. pmc Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT
    M Anna Kowalska
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 118:2882-8. 2011
    ..Recognition of these complexes by HIT antibodies reverses the PF4-dependent enhancement in aPC generation and may contribute to the prothrombotic nature of HIT...
  4. pmc Dynamic antibody-binding properties in the pathogenesis of HIT
    Bruce S Sachais
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 120:1137-42. 2012
    ..These differences suggest the potential importance of epitope specificity in the pathogenesis of HIT...
  5. pmc Diminished adhesion and activation of platelets and neutrophils with CD47 functionalized blood contacting surfaces
    Matthew J Finley
    Division of Cardiology, Department of Pediatrics, The Children s Hospital of Philadelphia, PA 19104 4318, USA
    Biomaterials 33:5803-11. 2012
    ..In addition, ethylene oxide gas sterilization did not inhibit the efficacy of the CD47 modification. In conclusion, CD47 modified PVC inhibits both the adhesion and activation of platelets and neutrophils...
  6. pmc Infusion of mature megakaryocytes into mice yields functional platelets
    Rudy Fuentes
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 120:3917-22. 2010
    ..These data suggest that it may be unnecessary to generate platelets from ex vivo grown megakaryocytes to achieve clinically relevant increases in platelet numbers...
  7. doi request reprint Role of the platelet chemokine platelet factor 4 (PF4) in hemostasis and thrombosis
    M Anna Kowalska
    Department of Pediatrics, University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Thromb Res 125:292-6. 2010
    ....
  8. ncbi request reprint Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia
    Lubica Rauova
    Division of Hematology, Children s Hospital of Philadelphia, PA, USA
    Blood 105:131-8. 2005
    ....
  9. pmc Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice
    Donna S Woulfe
    Center for Translational Research, Department of Medicine, Thomas Jefferson University, Philadelphia, and Department of Pediatrics, Children s Hospital of Pennsylvania 19107, USA
    Blood 111:3458-67. 2008
    ..We propose that SG-/- platelet function deficiencies are related to inadequate packaging and secretion of selected alpha-granule proteins and reduced secretion of dense granule contents critical for platelet activation...
  10. pmc Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications
    Michele P Lambert
    Department of Pediatrics, Children s Hospital of Philadelphia, PA 19104, USA
    Blood 110:1153-60. 2007
    ..These individuals with high levels of platelet PF4 may be especially sensitive to developing thrombocytopenia after bone marrow injury and may benefit from approaches that block the effects of released PF4...
  11. ncbi request reprint Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin
    Don E Eslin
    Division of Hematology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Blvd, ARC Rm 316I, Philadelphia, PA 19104, USA
    Blood 104:3173-80. 2004
    ..The mechanisms underlying these observations of PF4 biology and their clinical implications remain to be determined...
  12. doi request reprint "Radical" model of thrombosis
    Lubica Rauova
    Children s Hospital of Philadelphia, USA
    Blood 119:1798-9. 2012
    ..This new in vivo model involving a novel injury, minimally invasive vessel preparation, and advanced data collection may be particularly useful in dissecting the role of inflammation in thrombosis...
  13. ncbi request reprint Surface heparinization of polyurethane via bromoalkylation of hard segment nitrogens
    Ivan S Alferiev
    Children s Hospital of Philadelphia, Divisions of Cardiology and Hematology, Abramson Research Center, Suite 702, 3516 Civic Center Blvd, Philadelphia, PA 19104 4318, USA
    Biomacromolecules 7:317-22. 2006
    ....