A Rashid

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi CpG island methylation in colorectal adenomas
    A Rashid
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Am J Pathol 159:1129-35. 2001
  2. ncbi CpG island methylation in gastroenterologic neoplasia: a maturing field
    Asif Rashid
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Gastroenterology 127:1578-88. 2004
  3. ncbi Cellular and molecular biology of biliary tract cancers
    Asif Rashid
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 85, Houston, TX 77030 4095, USA
    Surg Oncol Clin N Am 11:995-1009. 2002
  4. ncbi K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China
    Asif Rashid
    Department of Pathology and Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Cancer Res 8:3156-63. 2002
  5. ncbi Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia
    A S Fleisher
    Department of Medicine, Gastroenterology Division, University of Maryland School of Medicine and Baltimore VA Hospital, Baltimore, Maryland, MD 21201, USA
    Oncogene 20:329-35. 2001
  6. ncbi Expression of epidermal growth factor receptor in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome
    Kim L Wang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 109:658-67. 2007
  7. ncbi Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations
    A Rashid
    Department of Pathology, The Johns Hopkins Oncology Center, The John Hopkins School of Medicine, Baltimore, MD 21205 2196, USA
    Br J Cancer 80:59-66. 1999
  8. ncbi Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries
    Annie O Chan
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 11:8281-7. 2005
  9. ncbi Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma
    Changhyeok An
    Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4096
    Clin Cancer Res 11:656-63. 2005
  10. ncbi CpG island methylation in aberrant crypt foci of the colorectum
    Annie On-On Chan
    Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4095, USA
    Am J Pathol 160:1823-30. 2002

Detail Information

Publications85

  1. ncbi CpG island methylation in colorectal adenomas
    A Rashid
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Am J Pathol 159:1129-35. 2001
    ..Methylation is distinct from microsatellite instability and develops in individual adenomas rather than resulting from a field defect in an individual patient...
  2. ncbi CpG island methylation in gastroenterologic neoplasia: a maturing field
    Asif Rashid
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Gastroenterology 127:1578-88. 2004
    ..It is likely that epigenetic pathways will be integrated in the routine management of gastrointestinal malignancies over the next decade...
  3. ncbi Cellular and molecular biology of biliary tract cancers
    Asif Rashid
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 85, Houston, TX 77030 4095, USA
    Surg Oncol Clin N Am 11:995-1009. 2002
    ..Advances in the understanding of the genetics of this disease will help in diagnosing biliary tract cancer, screening at-risk patients, and developing therapies...
  4. ncbi K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China
    Asif Rashid
    Department of Pathology and Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Cancer Res 8:3156-63. 2002
    ..These genetic alterations were compared with patient demographics and clinicopathological characteristics of the tumors...
  5. ncbi Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia
    A S Fleisher
    Department of Medicine, Gastroenterology Division, University of Maryland School of Medicine and Baltimore VA Hospital, Baltimore, Maryland, MD 21201, USA
    Oncogene 20:329-35. 2001
    ..MSI and hypermethylation-associated inactivation of hMLH1 are more prevalent in early gastric cancers than in gastric adenomas. Thus, hypermethylation-associated inactivation of the hMLH1 gene can occur early in gastric carcinogenesis...
  6. ncbi Expression of epidermal growth factor receptor in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome
    Kim L Wang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 109:658-67. 2007
    ..It is not known whether EGFR plays a similar role in esophageal and EGJ adenocarcinomas...
  7. ncbi Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations
    A Rashid
    Department of Pathology, The Johns Hopkins Oncology Center, The John Hopkins School of Medicine, Baltimore, MD 21205 2196, USA
    Br J Cancer 80:59-66. 1999
    ..01). These data indicate a possible interaction between p53 gene mutation and 4q loss in the pathogenesis of HCC...
  8. ncbi Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries
    Annie O Chan
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 11:8281-7. 2005
    ..These molecular differences could affect prevention strategies, therapeutic efficacy, and transferability of clinical trial results...
  9. ncbi Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma
    Changhyeok An
    Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4096
    Clin Cancer Res 11:656-63. 2005
    ..Concordant methylation of multiple genes/loci (CIMP-H) is associated with better survival but is not an independent predictor of prognosis in resected gastric cancer...
  10. ncbi CpG island methylation in aberrant crypt foci of the colorectum
    Annie On-On Chan
    Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4095, USA
    Am J Pathol 160:1823-30. 2002
    ....
  11. ncbi Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors
    Mirela Stancu
    Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Mod Pathol 16:1189-98. 2003
    ..These findings suggest that allelic loss of chromosomes 11q, 16q, and 18q in goblet cell carcinoids and ileal carcinoids may have an important role in the pathogenesis of these tumors...
  12. ncbi Beta-catenin mutations in biliary tract cancers: a population-based study in China
    A Rashid
    Department of Pathology, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4095, USA
    Cancer Res 61:3406-9. 2001
    ..04) and in papillary adenocarcinomas than other histological types of carcinomas (P = 0.02). These results suggest that the molecular pathways of biliary tract neoplasms vary by anatomical subsite and histological subtype...
  13. ncbi Decreased expression of gene cluster at chromosome 1q21 defines molecular subgroups of chemoradiotherapy response in esophageal cancers
    Madan G Luthra
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77054, USA
    Clin Cancer Res 13:912-9. 2007
    ..In the current study, we did an in-depth investigation of the expression of 1q21-1q25 region genes to uncover the role of the EDC and its flanking genes in CTXRT response...
  14. ncbi CpG island methylation in carcinoid and pancreatic endocrine tumors
    Annie On On Chan
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Oncogene 22:924-34. 2003
    ..03). Loss of p16 protein expression correlated with methylation of p16 gene in carcinoid tumors (p = 0.006). Our study indicates that methylation profile of carcinoid tumors differs from PETs, reflecting different molecular pathogenesis...
  15. ncbi Instabilotyping: comprehensive identification of frameshift mutations caused by coding region microsatellite instability
    Y Mori
    Department of Medicine, University of Maryland School of Medicine, Baltimore V. A. Hospital, Baltimore, Maryland 21201, USA
    Cancer Res 61:6046-9. 2001
    ..8%), and EBP1/PA2G4 (20.9%). This genome-wide approach identifies coding region MSI in genes or pathways not implicated previously in colorectal tumorigenesis, which may merit functional study or other additional analysis...
  16. ncbi Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas
    Sang Geol Kim
    Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, USA
    Gastroenterology 124:1300-10. 2003
    ....
  17. ncbi Epigenetic alterations in neuroendocrine tumors: methylation of RAS-association domain family 1, isoform A and p16 genes are associated with metastasis
    Lixia Liu
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 18:1632-40. 2005
    ..044). Our study shows that in neuroendocrine tumors epigenetic alterations vary by tumor subsite and clinicopathologic features, including age of onset, histopathologic type and metastasis status...
  18. ncbi Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors
    Jun Zhang
    Department of Gastrointestinal Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 109:1478-86. 2007
    ..Vascular endothelial growth factor (VEGF) is a critical proangiogenic factor in solid tumors. However, its expression and role in human neuroendocrine tumor development and progression remains unclear...
  19. ncbi Frequent CpG island methylation in precursor lesions and early gastric adenocarcinomas
    Jae-Hyuk Lee
    Department of Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 23:4646-54. 2004
    ..Methylation of the p16 gene may contribute to the malignant transformation of gastric precursor lesions...
  20. ncbi Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma
    Jae Hyuk Lee
    Department of Pathology, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Pathol 161:611-8. 2002
    ..Gastric adenomas or dysplasias without APC mutations but with or without MSI may have a different biological behavior, and are precursors of intestinal-type of gastric adenocarcinomas...
  21. ncbi Concordant CpG island methylation in hyperplastic polyposis
    Annie On-On Chan
    Department of Pathology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4095, USA
    Am J Pathol 160:529-36. 2002
    ..The hypermethylator phenotype is related to patient-specific factors, such as carcinogenic exposure or genetic predisposition...
  22. ncbi Loss of chromosome 18q and DPC4 (Smad4) mutations in appendiceal adenocarcinomas
    Dipen Maru
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 23:859-64. 2004
    ..The presence of chromosome 18q loss and DPC4 mutations in appendiceal adenocarcinomas suggests involvement of DPC4 and nearby genes on chromosome 18q (DCC and/or JV-18) in the pathogenesis of appendiceal adenocarcinomas...
  23. ncbi MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers
    R Luthra
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Oncogene 27:6667-78. 2008
    ..This study demonstrated a novel mechanism of post-transcriptional regulation of ANXA1 expression and identified miR-196a as a marker of esophageal cancer...
  24. ncbi Mylotarg (gemtuzumab ozogamicin) therapy is associated with hepatic venoocclusive disease in patients who have not received stem cell transplantation
    F J Giles
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
    Cancer 92:406-13. 2001
    ..Hepatic venoocclusive disease (VOD) has been reported in patients who have undergone stem cell transplantation (SCT) after Mylotarg therapy. Outside of the SCT setting, VOD has been associated very rarely with cytotoxic therapy...
  25. ncbi Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiation
    Rajyalakshmi Luthra
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    J Clin Oncol 24:259-67. 2006
    ..Currently, however, there are no tools to help select optimum therapy. We hypothesized that gene expression profiling could provide clues and biomarkers for selection of therapy...
  26. ncbi Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors)
    In Seon Choi
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Mod Pathol 20:802-10. 2007
    ....
  27. ncbi Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma
    John J Liang
    Department of Pathology, The University of Texas M D Anderson Cancer, Houston, TX 77030, USA
    Clin Cancer Res 14:7043-9. 2008
    ..MAP4K4 plays an important role in transformation, invasiveness, adhesion, and cell migration. However, the expression of MAP4K4 and its significance in pancreatic ductal adenocarcinoma (PDA) has not been studied...
  28. ncbi Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low- to intermediate-grade neuroendocrine tumors: results of a phase II study
    James C Yao
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 26:4311-8. 2008
    ..Evaluate the activity of everolimus (RAD001) in combination with octreotide long-acting repeatable (LAR) in patients with advanced low- to intermediate-grade neuroendocrine tumors...
  29. ncbi Retrospective study of clinicopathologic features and prognosis of high-grade neuroendocrine carcinoma of the esophagus
    Dipen M Maru
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 32:1404-11. 2008
    ..031). There was no difference in prognosis between patients with large-cell NEC and those with small-cell neuroendocrine carcinoma. Esophageal NEC is an aggressive tumor, and patients with mix NEC have better outcome...
  30. ncbi One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States
    James C Yao
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 26:3063-72. 2008
    ..Clinicians need to be become familiar with the natural history and patterns of disease progression, which are characteristic of these tumors...
  31. ncbi Clinical and in vitro studies of imatinib in advanced carcinoid tumors
    James C Yao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:234-40. 2007
    ..Effective systemic therapy options for carcinoid tumors are lacking. We conducted in vitro studies and a phase II clinical trial to explore the activity of imatinib in carcinoid tumors...
  32. ncbi Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma
    Melanie B Thomas
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 110:1059-67. 2007
    ..The primary objective of this study was to determine the proportion of hepatocellular carcinoma (HCC) patients treated with erlotinib who were alive and progression-free (PFS) at 16 weeks of continuous treatment...
  33. ncbi Population-based study of islet cell carcinoma
    James C Yao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Ann Surg Oncol 14:3492-500. 2007
    ..We examine the epidemiology, natural history, and prognostic factors that affect the duration of survival for islet cell carcinoma by using population-based registries...
  34. ncbi Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma
    Yutaka Suehiro
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 14:2560-9. 2008
    ....
  35. ncbi Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis
    Chongjuan Wei
    Department of Epidemiology, The University of Texas, MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11297-303. 2005
    ..These results strongly suggested that mutations of p53 and Lkb1 gene cooperate in the acceleration of tumorigenesis...
  36. ncbi Hypomethylation of long interspersed nuclear element-1 in hepatocellular carcinomas
    Mi Jung Kim
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 22:442-9. 2009
    ..In hepatocellular carcinomas, hypermethylation of CpG islands, and CpG island methylator phenotype status seems to correlate with levels of long interspersed nuclear element-1 hypomethylation...
  37. ncbi Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer
    Marsha L Frazier
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:4805-8. 2003
    ..Patients with methylation at all four loci were 14 times more likely to have a family history of cancer than patients with methylation at none of the four loci. These findings suggest that there may be a genetic component to CIMP in CRC...
  38. ncbi Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas
    Sang Geol Kim
    Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030-4095, USA
    Mod Pathol 16:1086-94. 2003
    ..The differences in genetic alterations but not epigenetic alterations may explain the pathogenesis and progression to malignancy of these cystic tumors of pancreas...
  39. ncbi Molecular biomarkers correlate with disease-free survival in patients with anal canal carcinoma treated with chemoradiation
    Jaffer A Ajani
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA
    Dig Dis Sci 55:1098-105. 2010
    ..Upon further expansion and validation, these results may provide a biomarker-based understanding of heterogeneous clinical biology of patients with anal carcinoma...
  40. ncbi Alterations of p16 and prognosis in biliary tract cancers from a population-based study in China
    Takashi Ueki
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 10:1717-25. 2004
    ..Biliary tract cancer is an uncommon malignancy with a poor survival rate. We evaluated p16 gene alteration as a prognostic marker for this disease...
  41. ncbi Anti-phosphorylated histone H3 expression in Barrett's esophagus, low-grade dysplasia, high-grade dysplasia, and adenocarcinoma
    Mahmoud Goodarzi
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 22:1612-21. 2009
    ..In addition, phosphorylated histone H3 is a potential supportive marker to histology in differentiating low-grade dysplasia from indefinite for dysplasia and high-grade dysplasia from adenocarcinoma in the mucosal biopsy samples...
  42. ncbi Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin
    Roy S Herbst
    Department of Thoracic and Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Clin Oncol 20:3804-14. 2002
    ..We present the initial results of a dose-finding clinical trial of recombinant human endostatin (rh-Endo) that examined potential surrogates for response to antiangiogenic therapy...
  43. ncbi Frequent loss of heterozygosity of chromosome 1q in esophageal adenocarcinoma: loss of chromosome 1q21.3 is associated with shorter overall survival
    Dipen M Maru
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 115:1576-85. 2009
    ..It was unclear whether this difference was due to loss of heterozygosity (LOH) or to other genetic alterations at this locus...
  44. ncbi Allelic alterations in pancreatic endocrine tumors identified by genome-wide single nucleotide polymorphism analysis
    Yasuhiko Nagano
    Department of Pathology, MD Anderson Cancer Center, The University of Texas, 1515 Holcombe Boulevard, Box 85, Houston, Texas 77030 4095, USA
    Endocr Relat Cancer 14:483-92. 2007
    ..4 +/- 3.1 cm compared with 2.3 +/- 1.3 cm for low AI (P = 0.03). Our study shows that genome-wide allelotyping is a powerful new tool for the analysis of AI in PETs...
  45. ncbi DNA methylation and environmental exposures in human hepatocellular carcinoma
    Lanlan Shen
    Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, USA
    J Natl Cancer Inst 94:755-61. 2002
    ..6%; P<.001). CONCLUSION: Geographic variations in the methylation status of various CpG islands indicate that environmental factors may influence the frequent and concordant degree of hypermethylation in multiple genes in HCC tumors...
  46. ncbi Simplified staging for hepatocellular carcinoma
    Jean Nicolas Vauthey
    International Cooperative Study Group on Hepatocellular Carcinoma, Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Clin Oncol 20:1527-36. 2002
    ..The current American Joint Committee on Cancer (AJCC) staging system for hepatocellular carcinoma (HCC) fails to stratify patients adequately with respect to prognosis...
  47. ncbi Signet-ring cell or mucinous histology after preoperative chemoradiation and survival in patients with esophageal or esophagogastric junction adenocarcinoma
    Lucian R Chirieac
    Department of Pathology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 11:2229-36. 2005
    ..04). CONCLUSIONS: Our study showed that patients with esophageal or EGJ adenocarcinoma who have signet-ring cell or mucinous histology benefited substantially from preoperative chemoradiation and esophagectomy...
  48. ncbi Mucinous and nonmucinous appendiceal adenocarcinomas: different clinicopathological features but similar genetic alterations
    Wareef Kabbani
    Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, USA
    Mod Pathol 15:599-605. 2002
    ..0002). Our findings suggest that mucinous and nonmucinous carcinomas of appendix have similar genetic alterations, but different clinical presentation and prognosis...
  49. ncbi The significance of neuroendocrine differentiation in adenocarcinoma of the esophagus and esophagogastric junction after preoperative chemoradiation
    Kim L Wang
    Departments of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
    Cancer 107:1467-74. 2006
    ..The presence of NE differentiation in residual tumor was associated with poor survival after preoperative neoadjuvant therapy...
  50. ncbi Excellent interobserver agreement on grading the extent of residual carcinoma after preoperative chemoradiation in esophageal and esophagogastric junction carcinoma: a reliable predictor for patient outcome
    Tsung Teh Wu
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Surg Pathol 31:58-64. 2007
    ..The extent of residual carcinoma is a reliable and reproducible predictor of survival; this grading system may allow a novel and early means of comparing outcomes after different neoadjuvant treatment regimens...
  51. ncbi Lymphovascular invasion as a tool to further subclassify T1b esophageal adenocarcinoma
    Putao Cen
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 112:1020-7. 2008
    ..The authors hypothesized that LVI status would subclassify T1b cancers and facilitate new therapeutic strategies...
  52. ncbi Human telomerase reverse transcriptase (hTERT) and Ki-67 are better predictors of survival than established clinical indicators in patients undergoing curative hepatic resection for colorectal metastases
    David L Smith
    Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Ann Surg Oncol 11:45-51. 2004
    ..CONCLUSIONS: In patients undergoing curative resection of hepatic colorectal metastases, hTERT and Ki-67 are better predictors of survival than is a score based on clinical features...
  53. ncbi Overexpression of caspase-3 in hepatocellular carcinomas
    Rajendra Persad
    Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Mod Pathol 17:861-7. 2004
    ..01). Caspase-3 overexpression in HCCs by immunohistochemistry was associated with serum alpha-fetoprotein (AFP) levels (P=0.01). In conclusion, caspase-3 is frequently overexpressed in HCCs and is associated with high serum levels of AFP...
  54. ncbi Posttherapy pathologic stage predicts survival in patients with esophageal carcinoma receiving preoperative chemoradiation
    Lucian R Chirieac
    Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 103:1347-55. 2005
    ..The findings in the current study supported the concept of downstaging by preoperative therapy...
  55. ncbi Histopathological identification of colon cancer with microsatellite instability
    J Alexander
    Department of Pathology, Division of Gastrointestinal Liver Pathology, The Johns Hopkins University School of Medicine and Hospital, Baltimore, Maryland, USA
    Am J Pathol 158:527-35. 2001
    ..Our findings indicate that histopathological evaluation can be used to prioritize sporadic colon cancers for MSI studies, but morphological prediction of MSI-H has low sensitivity, requiring molecular analysis for therapeutic decisions...
  56. ncbi Biallelic inactivation of the APC gene is associated with hepatocellular carcinoma in familial adenomatous polyposis coli
    L K Su
    Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 92:332-9. 2001
    ..CONCLUSIONS: To the authors' knowledge, this study provides the first evidence that biallelic inactivation of the APC gene may contribute to the development of HCC in patients with FAP...
  57. ncbi Detection of 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP)-DNA adducts in human pancreatic tissues
    J Zhu
    Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    Biomarkers 11:319-28. 2006
    ..Although limited by the small sample size, these preliminary results suggest that PhIP exposure may contribute to human pancreatic cancer development...
  58. ncbi Significance of post-chemoradiation biopsy in predicting residual esophageal carcinoma in the surgical specimen
    Q Yang
    Department of Pathology, The University of Texas M.D, Anderson Cancer Center, Houston, Texas, USA
    Dis Esophagus 17:38-43. 2004
    ..The utility of PCEB in predicting residual cancer in the lymph nodes needs to be explored further along with molecular predictors of response to preoperative therapy...
  59. ncbi The development and characterization of a human midgut carcinoid cell line
    George van Buren
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230, USA
    Clin Cancer Res 13:4704-12. 2007
    ..The scarcity of good gastrointestinal NET models has limited the ability to study potential therapeutic agents. We describe and characterize the establishment of a human midgut carcinoid tumor cell line carcinoid tumor 2 (CNDT2)...
  60. ncbi Invasive ductal adenocarcinoma arising from pancreatic heterotopia in rectum: case report and review of literature
    Mahmoud Goodarzi
    Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 41:1809-13. 2010
    ..Although our literature search found 31 documented reports of tumors arising in the heterotopic pancreas, the present case is the first case of ductal adenocarcinoma arising in a focus of pancreatic heterotopia in the rectum...
  61. ncbi Value of endoscopic ultrasound staging in conjunction with the evaluation of lymphovascular invasion in identifying low-risk esophageal carcinoma
    Putao Cen
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 112:503-10. 2008
    ..It was hypothesized that endoscopic ultrasonography (EUS) in concert with detailed histopathologic evaluation would identify low-risk cancers for an appropriate but organ-preserving strategy...
  62. ncbi Allelic alterations in well-differentiated neuroendocrine tumors (carcinoid tumors) identified by genome-wide single nucleotide polymorphism analysis and comparison with pancreatic endocrine tumors
    Do Ha Kim
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Genes Chromosomes Cancer 47:84-92. 2008
    ..001). Our study shows that genome-wide allelotyping using SNP array is a powerful new tool for the analysis of allelic imbalances in WDNTs, and some of these alterations are tumor site-dependent and are different than in PETs...
  63. ncbi Significance of the depth of tumor invasion and lymph node metastasis in superficially invasive (T1) esophageal adenocarcinoma
    Lixia Liu
    Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 29:1079-85. 2005
    ....
  64. ncbi Frequent CpG island methylation in serrated adenomas of the colorectum
    Seun-Ja Park
    Department of Pathology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030-4095, USA
    Am J Pathol 162:815-22. 2003
    ..Our results indicate that CpG island methylation is common in sporadic serrated adenomas and may play an important role in their pathogenesis...
  65. ncbi Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance
    Sue S Yom
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 18:315-9. 2005
    ....
  66. ncbi Reduced expression of cytokeratin 20 in colorectal carcinomas with high levels of microsatellite instability
    David K McGregor
    Departments of Pathology and Hematopathology, Division of Pathology and Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 28:712-8. 2004
    ..Our results also indicate that regulation of CK20 gene expression involves molecular pathways that are altered by MSI-H...
  67. ncbi Expression of annexin A1 in esophageal and esophagogastric junction adenocarcinomas: association with poor outcome
    Kim L Wang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Clin Cancer Res 12:4598-604. 2006
    ..However, the role of ANXA1 in esophageal adenocarcinoma is unclear. Our goal was to evaluate ANXA1 expression and determine its prognostic significance in adenocarcinoma of the esophagus and esophagogastric junction...
  68. ncbi Comparison of genetic alterations in neuroendocrine tumors: frequent loss of chromosome 18 in ileal carcinoid tumors
    Gordon G Wang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 18:1079-87. 2005
    ..02). Our study indicates that genetic alterations vary by tumor subsite and clinicopathologic features, and ileal carcinoid tumors have distinctive clinicopathologic and genetic profiles...
  69. ncbi The number of lymph nodes with metastasis predicts survival in patients with esophageal or esophagogastric junction adenocarcinoma who receive preoperative chemoradiation
    Yan Gu
    Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:1017-25. 2006
    ..The authors suggest modification of the tumor-lymph node-metastasis (TNM) staging classification (ypTNM) to include the number of positive LNs in the ypN1 category...
  70. ncbi Prognostic value of response after upfront therapy for acute GVHD
    R M Saliba
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Bone Marrow Transplant 47:125-31. 2012
    ..Our data confirm the validity of using day-28 response as a primary end point in clinical trials for upfront therapy for aGVHD...
  71. ncbi Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668
    Darren W Davis
    Department of Cancer Biology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 11:678-89. 2005
    ..CONCLUSIONS: SU5416 and SU6668 displayed biological activity in xenografts. However, neither drug produced marked biological activity in primary patient tumors...
  72. ncbi High levels of nucleolar expression of nucleolin are associated with better prognosis in patients with stage II pancreatic ductal adenocarcinoma
    Lan Peng
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:3734-42. 2010
    ..However, the expression and significance of nucleolin in pancreatic ductal adenocarcinoma (PDA) have not been studied...
  73. ncbi P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53
    Lanlan Shen
    Department of Leukemia, The University of Texas at M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Gastroenterology 124:626-33. 2003
    ..The results provide a possible explanation for the paucity of p53 mutations in colon cancers with microsatellite instability...
  74. ncbi Correlation of staining for LKB1 and COX-2 in hamartomatous polyps and carcinomas from patients with Peutz-Jeghers syndrome
    Chongjuan Wei
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Histochem Cytochem 51:1665-72. 2003
    ..These results suggest that COX-2 plays a role in tumorigenesis in PJS and may therefore be considered as a potential target for PJS chemoprevention...
  75. ncbi An inverse correlation between Interleukin-6 and select gene promoter methylation in patients with gastric cancer
    Li Ping Tang
    Department of Medicine, University of Hong Kong, Hong Kong, SAR, China
    Digestion 74:85-90. 2006
    ..002) and signet cell histology (p = 0.001). Conclusion: IL-6 is of prognostic value for patients of gastric cancer. Low serum IL-6 levels were associated with p16 or DAPK gene methylation in patients with gastric cancer...
  76. ncbi CpG island methylation in precursors of gastrointestinal malignancies
    Annie On On Chan
    Department of Medicine, The University of Hong Kong, Hong Kong
    Curr Mol Med 6:401-8. 2006
    ..Targeting of the epigenetic changes that occur before the development of frank malignancy offers a potential chemopreventive strategy...
  77. ncbi Loss of cooperative function of transforming growth factor-beta signaling proteins, smad3 with embryonic liver fodrin, a beta-spectrin, in primary biliary cirrhosis
    Bibhuti Mishra
    GI Developmental Biology, Medicine, Surgical Sciences, Lombardi Cancer Center, Georgetown University and DVAMC, Washington, DC, USA
    Liver Int 24:637-45. 2004
    ..CONCLUSIONS: These results suggest that a compromised cytoarchitecture and polarized trafficking of TGF-beta signaling molecules, ELF and Smad3 are involved in the pathogenesis of PBC as well as HCC...
  78. ncbi Association between Helicobacter pylori infection and interleukin 1beta polymorphism predispose to CpG island methylation in gastric cancer
    Annie On On Chan
    Gut 56:595-7. 2007
  79. ncbi [A survey on the diagnosis and treatment of biliary tract cancers in Shanghai]
    Bing Sheng Wang
    Department of Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
    Zhonghua Wai Ke Za Zhi 43:455-9. 2005
    ..To survey the status of diagnosis and treatment of biliary tract cancer in Shanghai...
  80. ncbi Catalytic subunit of human telomerase reverse transcriptase is an independent predictor of survival in patients undergoing curative resection of hepatic colorectal metastases: a multicenter analysis
    Julien Domont
    Institut Gustave Roussy, Division of Cancer Médecine, 39 rue Camille Desmoulins, 94805 Villejuif, France
    J Clin Oncol 23:3086-93. 2005
    ..To determine the role of the catalytic subunit of human telomerase reverse transcriptase (hTERT) in predicting survival after resection of hepatic colorectal metastases (CRM)...
  81. ncbi Associations of Ki-ras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics
    Janine G Einspahr
    Department of Medicine, Arizona Cancer Center, P O Box 245024, Tucson, AZ 85724, USA
    Cancer Epidemiol Biomarkers Prev 15:1443-50. 2006
    ....
  82. ncbi E-cadherin promoter hypermethylation induced by interleukin-1beta treatment or H. pylori infection in human gastric cancer cell lines
    Xuemin Qian
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Hong Kong, Hong Kong
    Cancer Lett 263:107-13. 2008
    ..pylori. Treatment of IL-1ra could reverse the phenomena. Our study indicated that IL-1beta is an important step in mediating E-cadherin methylation...
  83. ncbi [Tea consumption and risk of biliary tract cancers and gallstone disease: a population-based case-control study in Shanghai, China]
    Xue-Hong Zhang
    Department of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China
    Zhonghua Zhong Liu Za Zhi 27:667-71. 2005
    ..CONCLUSION: Tea consumption may decrease the risk of cancers of the gallbladder and extrahepatic bile duct among females. The protective effect appears to be independent of gallstone disease...
  84. ncbi Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China
    Shih Chen Chang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 29:944-8. 2008
    ..Results from this population-based study suggest that certain genetic variants involved in the regulation of obesity-related insulin sensitivity may increase susceptibility to bile duct cancer and gallstones...
  85. ncbi Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling
    Yi Tang
    Cancer Genetics, Digestive Diseases and Developmental Molecular Biology, Institute of Transplant Surgery, Department of Surgery, Lombardi Comprehensive Cancer Center, Georgetown University, Medical Dental Building, Washington, DC 20007, USA
    Proc Natl Acad Sci U S A 105:2445-50. 2008
    ..These experiments suggest an important therapeutic role for targeting IL-6 in HCCs lacking a functional TGF-beta pathway...