Sanjay Rajagopalan

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Use of a constitutively active hypoxia-inducible factor-1alpha transgene as a therapeutic strategy in no-option critical limb ischemia patients: phase I dose-escalation experience
    Sanjay Rajagopalan
    Section of Vascular Medicine, 473 W 12th Ave, Division of Cardiovascular Medicine, Ohio State University, Columbus, OH 43210 1252, USA
    Circulation 115:1234-43. 2007
  2. pmc Effect of co-exposure to nickel and particulate matter on insulin resistance and mitochondrial dysfunction in a mouse model
    Xiaohua Xu
    Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio, USA
    Part Fibre Toxicol 9:40. 2012
  3. pmc Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue
    Xiaohua Xu
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Toxicol Sci 124:88-98. 2011
  4. ncbi request reprint Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent cl
    Sanjay Rajagopalan
    Department of Internal Medicine, Section of Vascular Medicine, Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, USA
    Circulation 108:1933-8. 2003
  5. pmc In vivo targeting of inflammation-associated myeloid-related protein 8/14 via gadolinium immunonanoparticles
    Andrei Maiseyeu
    Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, USA
    Arterioscler Thromb Vasc Biol 32:962-70. 2012
  6. pmc Diesel exhaust exposure induces angiogenesis
    Xiaohua Xu
    Division of Environmental Health Sciences, Colleges of Medicine and Public Health, The Ohio State University, Columbus, OH 43210 1240, USA
    Toxicol Lett 191:57-68. 2009
  7. pmc Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue
    Xiaohua Xu
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, 460 W 12th Ave, Columbus, OH 43210, USA
    Am J Physiol Regul Integr Comp Physiol 300:R1115-25. 2011
  8. doi request reprint Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis
    Zubair Shah
    Davis Heart and Lung Research Institute, 473 W 12th Avenue, Columbus, OH 43210, USA
    Circulation 124:2338-49. 2011
  9. pmc Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase
    Zhekang Ying
    Davis Heart Lung Research Institute, The Ohio State Univ, Rm 110, 473 W 12th Ave, Columbus, OH 43210 1252, USA
    Am J Physiol Heart Circ Physiol 296:H1540-50. 2009
  10. doi request reprint A modified sesamol derivative inhibits progression of atherosclerosis
    Zhekang Ying
    Davis Heart Lung Research Institute, Ohio State University, Columbus, OH 43210 1252, USA
    Arterioscler Thromb Vasc Biol 31:536-42. 2011

Detail Information

Publications88

  1. ncbi request reprint Use of a constitutively active hypoxia-inducible factor-1alpha transgene as a therapeutic strategy in no-option critical limb ischemia patients: phase I dose-escalation experience
    Sanjay Rajagopalan
    Section of Vascular Medicine, 473 W 12th Ave, Division of Cardiovascular Medicine, Ohio State University, Columbus, OH 43210 1252, USA
    Circulation 115:1234-43. 2007
    ....
  2. pmc Effect of co-exposure to nickel and particulate matter on insulin resistance and mitochondrial dysfunction in a mouse model
    Xiaohua Xu
    Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, Ohio, USA
    Part Fibre Toxicol 9:40. 2012
    ..5) exposure...
  3. pmc Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue
    Xiaohua Xu
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Toxicol Sci 124:88-98. 2011
    ..These findings suggest that long-term ambient PM₂.₅ exposure induces impaired glucose tolerance, IR, inflammation, and mitochondrial alteration, and thus, it is a risk factor for the development of type 2 diabetes...
  4. ncbi request reprint Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent cl
    Sanjay Rajagopalan
    Department of Internal Medicine, Section of Vascular Medicine, Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, USA
    Circulation 108:1933-8. 2003
    ....
  5. pmc In vivo targeting of inflammation-associated myeloid-related protein 8/14 via gadolinium immunonanoparticles
    Andrei Maiseyeu
    Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, USA
    Arterioscler Thromb Vasc Biol 32:962-70. 2012
    ..Myeloid-related protein (Mrp) 8/14 complex (is a highly expressed extracellularly secreted protein, implicated in atherosclerosis. In this study, we evaluated the feasibility of targeting Mrp in vivo through synthetic immuno-nanoprobes...
  6. pmc Diesel exhaust exposure induces angiogenesis
    Xiaohua Xu
    Division of Environmental Health Sciences, Colleges of Medicine and Public Health, The Ohio State University, Columbus, OH 43210 1240, USA
    Toxicol Lett 191:57-68. 2009
    ..The angiogenic effects may occur through increasing HIF-1alpha and VEGF while decreasing PHD2 expression...
  7. pmc Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue
    Xiaohua Xu
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, 460 W 12th Ave, Columbus, OH 43210, USA
    Am J Physiol Regul Integr Comp Physiol 300:R1115-25. 2011
    ....
  8. doi request reprint Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis
    Zubair Shah
    Davis Heart and Lung Research Institute, 473 W 12th Avenue, Columbus, OH 43210, USA
    Circulation 124:2338-49. 2011
    ..Because DPP-4 is expressed in inflammatory cells, we hypothesized that its inhibition will exert favorable effects in atherosclerosis...
  9. pmc Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase
    Zhekang Ying
    Davis Heart Lung Research Institute, The Ohio State Univ, Rm 110, 473 W 12th Ave, Columbus, OH 43210 1252, USA
    Am J Physiol Heart Circ Physiol 296:H1540-50. 2009
    ..In conclusion, PM(2.5) potentiates cardiac remodeling in response to ANG II through RhoA/Rho kinase-dependent mechanisms. These findings have implications for the chronic cardiovascular health effects of air pollution...
  10. doi request reprint A modified sesamol derivative inhibits progression of atherosclerosis
    Zhekang Ying
    Davis Heart Lung Research Institute, Ohio State University, Columbus, OH 43210 1252, USA
    Arterioscler Thromb Vasc Biol 31:536-42. 2011
    ..In the present study, we synthesized a modified form of sesamol (INV-403) to enhance its properties and assessed its effects on atherosclerosis...
  11. pmc Detection of macrophages via paramagnetic vesicles incorporating oxidatively tailored cholesterol ester: an approach for atherosclerosis imaging
    Andrei Maiseyeu
    Davis Heart and Lung Research Institute, Room 110, 473 W 12th Avenue, Columbus, OH 43210 1252, USA
    Nanomedicine (Lond) 5:1341-56. 2010
    ..In this article we describe the synthesis of biocompatible, paramagnetic, fluorescent phosphatidylserine vesicles containing cholesterol ester with a free carboxylic acid function and its use for targeted imaging of macrophages...
  12. doi request reprint Initial feasibility of a multi-station high resolution three-dimensional dark blood angiography protocol for the assessment of peripheral arterial disease
    Georgeta Mihai
    Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA
    J Magn Reson Imaging 30:785-93. 2009
    ....
  13. pmc Cardiovascular remodeling in response to long-term exposure to fine particulate matter air pollution
    Loren E Wold
    Center for Cardiovascular and Pulmonary Research, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics Physiology and Cell Biology, The Ohio State University, 700 Children s Drive, Columbus, OH 43205, USA
    Circ Heart Fail 5:452-61. 2012
    ..We therefore tested the hypothesis that exposure over a considerable portion of the lifespan would induce maladaptive cardiovascular responses...
  14. pmc Sustained release of multiple growth factors from injectable polymeric system as a novel therapeutic approach towards angiogenesis
    Qinghua Sun
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio 43210 1252, USA
    Pharm Res 27:264-71. 2010
    ....
  15. pmc A mouse model of yellow fluorescent protein (YFP) expression in hematopoietic cells to assess leukocyte-endothelial interactions in the microcirculation
    Thomas Kampfrath
    Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, 473 W 12th Avenue, Room 110, Columbus, OH 43210, USA
    Microvasc Res 78:294-300. 2009
    ..Taken together, these data demonstrate the use of c-fms(YFP+) mice in identifying distinct monocyte subsets and highlight the potential of this model for real-time monocyte-endothelial interactions using intravital microscopy...
  16. ncbi request reprint Adenoviral-mediated gene transfer of vascular endothelial growth factor in critical limb ischemia: safety results from a phase I trial
    Emile R Mohler
    Department of Internal Medicine, Section of Vascular Medicine, Division of Cardiology, University of Pennsylvania Health System, Philadelphia, PA, USA
    Vasc Med 8:9-13. 2003
    ..CI-1023 appears to be well tolerated and safe for single-dose administration in patients with critical limb ischemia due to PAD. Further studies are needed to determine the efficacy of this form of therapeutic angiogenesis...
  17. pmc Modified methylenedioxyphenol analogs lower LDL cholesterol through induction of LDL receptor expression
    Zhekang Ying
    Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, USA
    J Lipid Res 53:879-87. 2012
    ..INV-403 lowered plasma LDL cholesterol levels through LDLR upregulation. These results indicate a role for small molecule approaches other than statins for lowering LDL cholesterol...
  18. pmc Association of systemic inflammation with marked changes in particulate air pollution in Beijing in 2008
    Xiaohua Xu
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, OH, USA
    Toxicol Lett 212:147-56. 2012
    ..Short-term air quality improvements were significantly associated with reduced overall inflammatory responses...
  19. pmc Pulmonary T cell activation in response to chronic particulate air pollution
    Jeffrey A Deiuliis
    Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, USA
    Am J Physiol Lung Cell Mol Physiol 302:L399-409. 2012
    ..Our experiments indicate that PM(2.5) potentiates a proinflammatory Th1 response involving increased homing of CXCR3(+) T effector cells to the lung and modulation of systemic T cell populations...
  20. pmc Improved detection of myocardial involvement in acute inflammatory cardiomyopathies using T2 mapping
    Paaladinesh Thavendiranathan
    The Ohio State University, Columbus, OH 43210, USA
    Circ Cardiovasc Imaging 5:102-10. 2012
    ..We hypothesized that quantitative T2 mapping could better delineate myocardial involvement in these disorders versus T2-weighted imaging...
  21. doi request reprint Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication
    Mark A Creager
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 124:1765-73. 2011
    ....
  22. pmc Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways
    Thomas Kampfrath
    Davis Heart and Lung Research Institute, Ohio State University College of Medicine, Columbus, OH 43210, USA
    Circ Res 108:716-26. 2011
    ..5 μm (PM₂.₅) increases cardiovascular risk. The mechanisms by which inhaled ambient particles are sensed and how these effects are systemically transduced remain elusive...
  23. doi request reprint Feasibility, accuracy, and reproducibility of real-time full-volume 3D transthoracic echocardiography to measure LV volumes and systolic function: a fully automated endocardial contouring algorithm in sinus rhythm and atrial fibrillation
    Paaladinesh Thavendiranathan
    The Ohio State University, 473 West 12th Avenue, Columbus, Ohio 43210, USA
    JACC Cardiovasc Imaging 5:239-51. 2012
    ....
  24. pmc Lipoic acid effects on established atherosclerosis
    Zhekang Ying
    Davis Heart Lung Research Institute, College of Medicine, and Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio 43210 1252, USA
    Life Sci 86:95-102. 2010
    ..We investigated the mechanisms by which LA may confer protection in models of established atherosclerosis...
  25. pmc Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity
    Qinghua Sun
    Wolfe Professor of Medicine and Radiology, Davis Heart and Lung Research Institute, Room 110, 473 W 12th Ave, Columbus, OH 43210 1252, USA
    Circulation 119:538-46. 2009
    ..We hypothesized that exposure to ambient fine particulate matter (<2.5 mum; PM(2.5)) exaggerates diet-induced insulin resistance, adipose inflammation, and visceral adiposity...
  26. ncbi request reprint Design of the Del-1 for therapeutic angiogenesis trial (DELTA-1), a phase II multicenter, double-blind, placebo-controlled trial of VLTS-589 in subjects with intermittent claudication secondary to peripheral arterial disease
    Sanjay Rajagopalan
    Section of Vascular Medicine, Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, Box 1030, One Gustave Levy Place, New York, NY 10029, USA
    Hum Gene Ther 15:619-24. 2004
    ....
  27. doi request reprint Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways
    Zubair Shah
    Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, USA
    Vascul Pharmacol 55:2-9. 2011
    ..DPP-4 inhibition by alogliptin mediates rapid vascular relaxation via GLP-1 independent, Src-Akt-eNOS mediated NO release and the activation of vascular potassium channels...
  28. pmc Ambient particulates alter vascular function through induction of reactive oxygen and nitrogen species
    Zhekang Ying
    Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio 43210, USA
    Toxicol Sci 111:80-8. 2009
    ..CAPs exposure in Manhattan alters vasomotor tone and enhances atherosclerosis through NADPH oxidase dependent pathways...
  29. pmc Aliskiren effect on plaque progression in established atherosclerosis using high resolution 3D MRI (ALPINE): a double-blind placebo-controlled trial
    Georgeta Mihai
    Dorothy M Davis Heart and Lung Research Institute and the Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Am Heart Assoc 2:e004879. 2013
    ....
  30. pmc Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse
    Steve Oghumu
    Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, USA
    J Immunol 190:2229-40. 2013
    ..These newly generated CIBER mice provide a novel tool for studying the role of CXCR3 and CXCR3-expressing cells in vivo...
  31. pmc A potential role for dendritic cell/macrophage-expressing DPP4 in obesity-induced visceral inflammation
    Jixin Zhong
    Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio, USA
    Diabetes 62:149-57. 2013
    ..The nonenzymatic function of DPP4 on DC may play a role in potentiation of inflammation in obesity by interacting with ADA. These findings suggest a novel role for the paracrine regulation of inflammation in adipose tissue by DPP4...
  32. doi request reprint No effect of acute exposure to coarse particulate matter air pollution in a rural location on high-density lipoprotein function
    Andrei Maiseyeu
    Davis Heart Lung Research Institute, College of Medicine, Ohio State University, Columbus, OH, USA
    Inhal Toxicol 26:23-9. 2014
    ..Whether coarse PM derived from urban sites, fine particles or longer term PM exposures can promote HDL dysfunction warrant future investigations. ..
  33. pmc Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK
    Qinghua Sun
    Division of Environmental Health Sciences, Davis Heart Lung Research Institute, Colleges of Medicine and Public Health, The Ohio State University, Columbus, OH 43210 1252, USA
    Arterioscler Thromb Vasc Biol 28:1760-6. 2008
    ..Fine particulate matter <2.5 microm (PM(2.5)) has been implicated in vasoconstriction and potentiation of hypertension in humans. We investigated the effects of short-term exposure to PM(2.5) in the angiotensin II (AII) infusion model...
  34. pmc The prolonged survival of fibroblasts with forced lipid catabolism in visceral fat following encapsulation in alginate-poly-L-lysine
    Fangping Yang
    Department of Human Nutrition, The Ohio State University, Columbus, OH 43210, USA
    Biomaterials 33:5638-49. 2012
    ..The non-treated subcutaneous fat was not altered. Our data suggest that the AP(L) polymer supports long-term catabolic functions of genetically-modified fibroblasts, which can be potentially used for depot-specific obesity treatment...
  35. doi request reprint Simultaneous right and left heart real-time, free-breathing CMR flow quantification identifies constrictive physiology
    Paaladinesh Thavendiranathan
    The Ohio State University, Columbus, Ohio 43210, USA
    JACC Cardiovasc Imaging 5:15-24. 2012
    ....
  36. doi request reprint Assessment of carotid stenosis using three-dimensional T2-weighted dark blood imaging: Initial experience
    Georgeta Mihai
    Department of Internal Medicine, Division of Cardiovascular Medicine, Ohio State University, Columbus, Ohio, USA
    J Magn Reson Imaging 35:449-55. 2012
    ..To evaluate the use of a T2-weighted SPACE sequence (T2w-SPACE) to assess carotid stenosis via several methods and compare its performance with contrast-enhanced magnetic resonance angiography (ceMRA)...
  37. doi request reprint Direct T2 quantification of myocardial edema in acute ischemic injury
    David Verhaert
    The Ohio State University, Columbus, Ohio 43210, USA
    JACC Cardiovasc Imaging 4:269-78. 2011
    ..To evaluate the utility of rapid, quantitative T2 mapping compared with conventional T2-weighted imaging in patients presenting with various forms of acute myocardial infarction...
  38. doi request reprint Evidence that α-lipoic acid inhibits NF-κB activation independent of its antioxidant function
    Zhekang Ying
    Davis Heart and Lung Research Institute, Colleges of Medicine and Public Health, The Ohio State University, Room 110, 473W 12th Avenue, Columbus, OH 43210 1252, USA
    Inflamm Res 60:219-25. 2011
    ..It is postulated that the anti-inflammatory function of LA results from its antioxidant function. In this study we tested whether inhibition of NF-κB by LA is dependent on its antioxidant function...
  39. doi request reprint Quantification of chronic functional mitral regurgitation by automated 3-dimensional peak and integrated proximal isovelocity surface area and stroke volume techniques using real-time 3-dimensional volume color Doppler echocardiography: in vitro and clini
    Paaladinesh Thavendiranathan
    Ohio State University, Columbus, OH, USA
    Circ Cardiovasc Imaging 6:125-33. 2013
    ....
  40. doi request reprint Effect of niacin ER/lovastatin on claudication symptoms in patients with peripheral artery disease
    William R Hiatt
    Section of Vascular Medicine, Division of Geriatrics, University of Colorado Denver School of Medicine, Denver, CO 80203, USA
    Vasc Med 15:171-9. 2010
    ..6% on low niacin-statin (p = 0.096). Flushing as the most common event leading to discontinuation and treatment was associated with increases in liver enzymes, fasting blood glucose concentration and a decrease in platelet count...
  41. doi request reprint T1-weighted-SPACE dark blood whole body magnetic resonance angiography (DB-WBMRA): initial experience
    Georgeta Mihai
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA
    J Magn Reson Imaging 31:502-9. 2010
    ....
  42. doi request reprint An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: potential implications in cardiovascular disease
    Jixin Zhong
    Davis Heart and Lung Research Institute and Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA
    Atherosclerosis 226:305-14. 2013
    ..Several prospective randomized controlled clinical trials in humans with established atherosclerosis are testing the effects of DPP4 inhibition on hard cardiovascular events...
  43. pmc Autocrine function of aldehyde dehydrogenase 1 as a determinant of diet- and sex-specific differences in visceral adiposity
    Rumana Yasmeen
    Department of Human Nutrition, The Ohio State University, Columbus, Ohio, USA
    Diabetes 62:124-36. 2013
    ..Our data suggest that Aldh1 is a potential target for sex-specific antiobesity therapy...
  44. ncbi request reprint Development of a multicenter peripheral arterial interventional database: the PVD-QI2
    Debabrata Mukherjee
    Gill Heart Institute, Division of Cardiovascular Medicine, Lexington, KY 40436 0200, USA
    Am Heart J 149:1003-8. 2005
    ..The registry aims to elucidate which comorbid conditions and procedure-related variables are associated with beneficial or adverse outcomes after vascular interventions...
  45. ncbi request reprint Sustained vascular endothelial growth factor delivery enhances angiogenesis and perfusion in ischemic hind limb
    Qinghua Sun
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Hospitals and Health System, Ann Arbor, Michigan 48109 0311, USA
    Pharm Res 22:1110-6. 2005
    ..We hypothesized that sustained delivery of vascular endothelial growth factor (VEGF) using a polymer [85:15 poly(lactide-co-glycolide) (PLG)] would enhance angiogenesis and improve perfusion of ischemic tissue...
  46. ncbi request reprint Regional Angiogenesis with Vascular Endothelial Growth Factor (VEGF) in peripheral arterial disease: Design of the RAVE trial
    Sanjay Rajagopalan
    Department of Internal Medicine, Section of Vascular Medicine, Division of Cardiology, University of Michigan Health System, Ann Arbor 48109 0273, USA
    Am Heart J 145:1114-8. 2003
    ..10)) to patients with severe IC caused by infrainguinal disease...
  47. pmc Gadolinium-containing phosphatidylserine liposomes for molecular imaging of atherosclerosis
    Andrei Maiseyeu
    Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, USA
    J Lipid Res 50:2157-63. 2009
    ..Gd-PS-enriched liposomes enhance atherosclerotic plaque and colocalize with macrophages in experimental atherosclerosis...
  48. doi request reprint Epidemiological and experimental links between air pollution and type 2 diabetes
    Cuiqing Liu
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    Toxicol Pathol 41:361-73. 2013
    ....
  49. pmc Steady-state first-pass perfusion (SSFPP): A new approach to 3D first-pass myocardial perfusion imaging
    Shivraman Giri
    Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA Dorothy M Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA Siemens Healthcare, Chicago, Illinois, USA
    Magn Reson Med 71:133-44. 2014
    ..To describe and characterize a new approach to first-pass myocardial perfusion utilizing balanced steady-state free precession acquisition without the use of saturation recovery or other magnetization preparation...
  50. doi request reprint "Environmental hypertensionology" the effects of environmental factors on blood pressure in clinical practice and research
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48188, USA
    J Clin Hypertens (Greenwich) 13:836-42. 2011
    ..The authors propose using the term environmental hypertensionology to refer to the study of the effects of environmental factors on BP in clinical and research settings...
  51. pmc T2 quantification for improved detection of myocardial edema
    Shivraman Giri
    Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA
    J Cardiovasc Magn Reson 11:56. 2009
    ..In this work we demonstrate the advantages of a quantitative T2 mapping technique to accurately and reliably detect regions of edematous myocardial tissue without the limitations of qualitative T2W imaging...
  52. ncbi request reprint Peripheral arterial disease in patients with end-stage renal disease: observations from the Dialysis Outcomes and Practice Patterns Study (DOPPS)
    Sanjay Rajagopalan
    Division of Cardiovascular Medicine, 473 W 12th Ave, Ohio State University, Columbus, OH 43202, USA
    Circulation 114:1914-22. 2006
    ..The aims of the present study were to describe the prevalence of peripheral arterial disease (PAD) and its effects on prognosis and health-related quality of life (HRQOL) in an international cohort of patients on hemodialysis...
  53. doi request reprint Exercise-mediated changes in high-density lipoprotein: impact on form and function
    Alisa Blazek
    Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH
    Am Heart J 166:392-400. 2013
    ..Exercise as an intervention for patients at risk for cardiovascular events can lead to small improvements in HDL-C and potential changes in HDL function. There is an important modifier effect of genetics in determining these changes. ..
  54. doi request reprint Particulate matter air pollution and atherosclerosis
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Dr, PO Box 322, Ann Arbor, MI 48106, USA
    Curr Atheroscler Rep 12:291-300. 2010
    ..Due to the billions of people continually exposed to PM(2.5), the long-term pro-atherosclerotic effects of this ubiquitous air pollutant are likely to be of enormous and growing global public health importance...
  55. doi request reprint Perspectives on optimizing trial design and endpoints in peripheral arterial disease: a case for imaging-based surrogates as endpoints of functional efficacy
    Sanjay Rajagopalan
    Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, 473 West 12 Avenue, Columbus, OH 43210, USA
    Cardiol Clin 29:419-31. 2011
    ..This review focuses on aspects relating to the current state of surrogate endpoints in PAD and reviews emerging endpoints using imaging approaches that may have the potential of improving study design in PAD...
  56. ncbi request reprint Effect of short-term weight loss on the metabolic syndrome and conduit vascular endothelial function in overweight adults
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Am J Cardiol 93:1012-6. 2004
    ..18 +/- 5.89 vs 18.87 +/- 7.11%, p = 0.13) of the brachial artery. A moderate degree of weight reduction over 3 months improved the metabolic syndrome profile but not the vascular dysfunction associated with uncomplicated obesity...
  57. ncbi request reprint Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery disease
    Michael A Schmidt
    Section of Vascular Medicine, Division of Cardiology, University of Michigan School of Medicine, Ann Arbor, MI 48109 0273, USA
    Vasc Med 8:177-83. 2003
    ....
  58. ncbi request reprint Management of chronic critical limb ischemia
    Sanjay Rajagopalan
    Section of Vascular Medicine, Division of Cardiology, L3119, Women s Hospital 1500, East Medical Center Dr, Ann Arbor, MI 48109 0273, USA
    Cardiol Clin 20:535-45. 2002
    ..Fig. 4 details the approach at the University of Michigan's comprehensive vascular medicine program...
  59. pmc Concerted action of aldehyde dehydrogenases influences depot-specific fat formation
    Barbara Reichert
    Department of Human Nutrition, Ohio State University, Columbus, Ohio, 43210, USA
    Mol Endocrinol 25:799-809. 2011
    ..Our data suggest a paradigm for regulation of fat depots through the concerted action of Aldh1 enzymes that establish RA-dependent tandem regulation of transcription factors ZFP423 and PPARγ in a depot-specific manner...
  60. ncbi request reprint Effect of carotid atherosclerosis screening on risk stratification during primary cardiovascular disease prevention
    Robert L Bard
    Division of Cardiovascular Medicine, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Am J Cardiol 93:1030-2. 2004
    ..These tests adjust the risk strata of >/=63% of patients deemed as having intermediate risk by Framingham scores...
  61. ncbi request reprint Effects of valsartan alone versus valsartan/simvastatin combination on ambulatory blood pressure, C-reactive protein, lipoproteins, and monocyte chemoattractant protein-1 in patients with hyperlipidemia and hypertension
    Sanjay Rajagopalan
    Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA
    Am J Cardiol 100:222-6. 2007
    ..In conclusion, addition of simvastatin to valsartan did not incrementally lower BP. However, V/S80 was superior to V and V/S20 in reducing high-sensitivity C-reactive protein...
  62. ncbi request reprint Magnetic resonance angiographic techniques for the diagnosis of arterial disease
    Sanjay Rajagopalan
    Division of Cardiology, Section of Vascular Medicine, University of Michigan, 1311 Women s Hospital, 1500 E Medical Center Drive, Ann Arbor, MI 48107, USA
    Cardiol Clin 20:501-12, v. 2002
    ..Additionally, recognition of artifacts and learning to avoid them is important...
  63. doi request reprint The effect of acute exposure to coarse particulate matter air pollution in a rural location on circulating endothelial progenitor cells: results from a randomized controlled study
    Robert D Brook
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48106, USA
    Inhal Toxicol 25:587-92. 2013
    ..However, the impact of coarse PM on EPCs is unknown...
  64. ncbi request reprint Calf flow reserve with H(2)(15)O PET as a quantifiable index of lower extremity flow
    Michael A Schmidt
    Section of Vascular Medicine, Division of Cardiology, University of Michigan, Ann Arbor, Michigan, USA
    J Nucl Med 44:915-9. 2003
    ..Objective measures of recruitable blood flow are of importance in angiogenesis trials. We validated a new PET-derived flow reserve (FR) measurement in healthy subjects and subjects with peripheral artery disease (PAD)...
  65. ncbi request reprint Particulate matter, air pollution, and blood pressure
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Am Soc Hypertens 3:332-50. 2009
    ..Due to the ubiquitous, continuous and often involuntary nature of exposure, PM(2.5) may be an important and under-appreciated worldwide environmental risk factor for increased arterial BP...
  66. ncbi request reprint Ambient air particulate matter exposure and tissue factor expression in atherosclerosis
    Qinghua Sun
    Division of Environmental Health Sciences, The Ohio State University, Columbus, Ohio, USA
    Inhal Toxicol 20:127-37. 2008
    ..TF mRNA expression increased rapidly (within 1 h) in response to SRM PM. We conclude that in vivo and in vitro exposure to ambient air PM(2.5) induces TF expression...
  67. doi request reprint Advances in CT angiography for peripheral arterial disease
    Michael C Walls
    Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University, 473 West 12th Avenue, Columbus, OH 43210, USA
    Cardiol Clin 29:331-40. 2011
    ..The introduction of dual-source scanners has allowed the possibility of tissue characterization in CT scans. This article briefly discusses the basic principles of MDCT and provides an overview of its application in vascular diseases...
  68. ncbi request reprint Statin therapy is associated with improved cardiovascular outcomes and levels of inflammatory markers in patients with heart failure
    Srikanth Sola
    Emory University School of Medicine, Division of Cardiology, Atlanta, Georgia 30303, USA
    J Card Fail 11:607-12. 2005
    ..We wished to determine whether the addition of statins affect cardiovascular events and markers of inflammation in patients with heart failure...
  69. ncbi request reprint Phase I study of direct administration of a replication deficient adenovirus vector containing the vascular endothelial growth factor cDNA (CI-1023) to patients with claudication
    Sanjay Rajagopalan
    Division of Cardiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Cardiol 90:512-6. 2002
    ..Conclusions on efficacy could not be made due to the small number of patients. However, there were encouraging trends in ABI at rest and peak walking time at follow-up...
  70. ncbi request reprint The longitudinal chronic kidney disease study: a prospective cohort study of predialysis renal failure
    Rachel L Perlman
    Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Semin Dial 16:418-23. 2003
    ..This article describes the LCKD Study in the context of current knowledge of CKD...
  71. ncbi request reprint Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute-CKD study
    Rachel L Perlman
    Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Am J Kidney Dis 45:658-66. 2005
    ..Dialysis patients have decreased QOL relative to healthy controls. Little is known about QOL in patients with chronic kidney disease (CKD) before renal replacement therapy...
  72. ncbi request reprint Neutral effect on markers of heart failure, inflammation, endothelial activation and function, and vagal tone after high-dose HMG-CoA reductase inhibition in non-diabetic patients with non-ischemic cardiomyopathy and average low-density lipoprotein level
    Barry E Bleske
    University of Michigan, College of Pharmacy, Ann Arbor, Michigan 48109 1065, USA
    J Am Coll Cardiol 47:338-41. 2006
    ....
  73. ncbi request reprint Angiotensin receptor blockade improves vascular compliance in healthy normotensive elderly individuals: results from a randomized double-blind placebo-controlled trial
    Sanjay Rajagopalan
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai Medical Center, New York, NY, USA
    J Clin Hypertens (Greenwich) 8:783-90. 2006
    ..Mechanisms regulating compliance and endothelial function are complex and may not necessarily converge in aging...
  74. ncbi request reprint ACCF/AHA 2007 clinical competence statement on vascular imaging with computed tomography and magnetic resonance. A report of the American College of Cardiology Foundation/American Heart Association/American College of Physicians Task Force on Clinical Com
    Christopher M Kramer
    J Am Coll Cardiol 50:1097-114. 2007
  75. ncbi request reprint Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults
    Robert D Brook
    University of Michigan, Ann Arbor, USA
    Circulation 105:1534-6. 2002
    ..Fine particulate air pollution and ozone are associated with increased cardiovascular events. To help explain the mechanism behind these observations, we investigated the effect of air pollution exposure on vascular function...
  76. ncbi request reprint Prevalence and predictors of cardiovascular calcium in chronic kidney disease (from the Prospective Longitudinal RRI-CKD Study)
    Santo Dellegrottaglie
    Zena and Michael A Wiener Cardiovascular Institute and Marie Josee and Henry R Kravis Center for Cardiovascular Health, New York, New York, USA
    Am J Cardiol 98:571-6. 2006
    ..The extent of cardiovascular calcium in patients with predialysis CKD is related to some of the traditional risk factors for atherosclerosis but not to indexes of abnormal renal function or progression in renal dysfunction...
  77. doi request reprint Investigations of statins in heart failure: inflammatory biomarkers and hormones
    Bobby V Khan
    Emory University School of Medicine, Atlanta, GA, USA
    Heart Fail Clin 4:171-6. 2008
    ..This article evaluates the potential mechanisms for these effects in the management of heart failure and postulates their clinical and beneficial use...
  78. ncbi request reprint Letter by Brook et al regarding article "Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis"
    Robert D Brook
    Circulation 113:e871; author reply e872. 2006
  79. ncbi request reprint Technology insight: Clinical role of magnetic resonance angiography in the diagnosis and management of renal artery stenosis
    Santo Dellegrottaglie
    Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai Medical Center, New York, NY 10029, USA
    Nat Clin Pract Cardiovasc Med 3:329-38. 2006
    ..An overview of the clinical role of MRA, in conjunction with the other diagnostic modalities, in the identification and management of patients with renal artery stenosis, is also presented...
  80. ncbi request reprint Air pollution and cardiovascular events
    Robert D Brook
    N Engl J Med 356:2104-5; author reply 2105-6. 2007
  81. ncbi request reprint Technology Insight: magnetic resonance angiography for the evaluation of patients with peripheral artery disease
    Santo Dellegrottaglie
    Zena and Michael A Wiener Cardiovascular Institute and The Marie Josée and Henry R Kravis Center for Cardiovascular Health, Mount Sinai Medical Center, New York, NY, USA
    Nat Clin Pract Cardiovasc Med 4:677-87. 2007
    ..Continued hardware and software improvements will enable further refinements in imaging protocol for peripheral MRA, consolidating its clinical role for the evaluation of patients with PAD...
  82. ncbi request reprint Effect of losartan in aging-related endothelial impairment
    Sanjay Rajagopalan
    Department of Internal Medicine, Divisions of Cardiology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 0273, USA
    Am J Cardiol 89:562-6. 2002
    ..47, p = 0.05). Thus, administration of losartan for a duration of 6 weeks has favorable effects on inflammatory markers in healthy older subjects, but does not alter peripheral conduit endothelial function...
  83. ncbi request reprint Hypertension and triglyceride catabolism: implications for the hemodynamic model of the metabolic syndrome
    Robert D Brook
    Division of Hypertension, University of Michigan, 3918 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48104, USA
    J Am Coll Nutr 22:290-5. 2003
    ..We sought to determine if hypertensive adults have a blunted triglyceride catabolic rate (TG K(2)) and if related hemodynamic and vascular alterations are determinants of TG K(2)...
  84. ncbi request reprint Effects of cilostazol in patients with Raynaud's syndrome
    Sanjay Rajagopalan
    Division of Cardiology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Am J Cardiol 92:1310-5. 2003
    ..018). Cilostazol increased conduit vessel diameter in patients with primary and secondary RS, with a favorable impact on conduit vessel responsiveness to cold in patients with primary RS without affecting microvascular flow or symptoms...
  85. pmc ACCF/AHA 2007 Clinical Competence Statement on vascular imaging with computed tomography and magnetic resonance
    Christopher M Kramer
    Society of Cardiovascular Computed Tomography Representative
    Vasc Med 12:359-78. 2007
  86. ncbi request reprint Air pollution: the "Heart" of the problem
    Robert D Brook
    University of Michigan, 3918 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Curr Hypertens Rep 5:32-9. 2003
    ..Many questions, however, remain unanswered and future studies will be required to clarify the relevant biologic mechanisms and to identify the specific constituents responsible for mediating the adverse health impacts...
  87. ncbi request reprint Usefulness of quinapril and irbesartan to improve the anti-inflammatory response of atorvastatin and aspirin in patients with coronary heart disease
    Wright B Lauten
    Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Am J Cardiol 91:1116-9. 2003
  88. ncbi request reprint Circadian blood pressure overswinging in a physically fit, normotensive African American woman
    Katarina T Borer
    Division of Kinesiology, University of Michigan, Ann Arbor 48109 2214, USA
    Am J Hypertens 15:827-30. 2002
    ..These results suggest beta1-adrenergic mediation of CHAT and its refractoriness to exercise training...