Research Topics
Species | M Judith RadinSummaryAffiliation: The Ohio State University Country: USA Publications
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Publications
Gender modulates activation of renin-angiotensin and endothelin systems in hypertension and heart failureM Judith Radin
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
J Appl Physiol 92:935-40. 2002..During cardiac decompensation, generalized activation of the RAS, endothelin, and ANP systems occurs and is similar in male and female SHHF rats...
Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horsesM Judith Radin
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Vet Clin Pathol 38:136-56. 2009..It also reviews the current information on the characterization of adipokines in some domestic species in which rates of obesity and obesity-related disorders are increasing, such as the dog, cat, and horse...
Leptin modulates the negative inotropic effect of interleukin-1beta in cardiac myocytesM Judith Radin
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
Mol Cell Biochem 315:179-84. 2008..These data suggest that leptin may modulate IL-1beta signaling through the sphingolipid signaling pathway in cardiomyocytes...
Crosstalk between leptin and interleukin-1β abrogates negative inotropic effects in a model of chronic hyperleptinemiaM Judith Radin
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
Exp Biol Med (Maywood) 236:1263-73. 2011..Crosstalk between leptin and IL-1β can influence cardiac function and cytokine signaling and these interactions are moderated by the presence of long-term hyperleptinemia...
Increased salt sensitivity secondary to leptin resistance in SHHF rats is mediated by endothelinM Judith Radin
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Mol Cell Biochem 242:57-63. 2003..Our studies indicate that obesity secondary to leptin resistance (cp/cp) results in increased salt sensitivity that is mediated by endothelin in the SHHF rat...
Salt-induced cardiac hypertrophy is independent of blood pressure and endothelin in obese, heart failure-prone SHHF ratsM Judith Radin
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
Clin Exp Hypertens 30:541-52. 2008..These studies suggest that cardiac hypertrophy is independent of the level of hypertension and may be mediated by altered production of NOS isoforms in salt-sensitive, obese SHHF...
Effect of male sex and obesity on platelet arachidonic acid in spontaneous hypertensive heart failure ratsSonhee C Park
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
Exp Biol Med (Maywood) 229:657-64. 2004..There was no relationship between n-3 PUFA and platelet aggregation. In SHHF rats, elevated AA and n-6 PUFA levels in platelets are associated with enhanced platelet aggregation. This relationship is potentiated by obesity and male sex...
Multicentric mast cell tumors in a horseLaurie M Millward
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Vet Clin Pathol 39:365-70. 2010..This case illustrates the utility of staining for CD117 expression in combination with traditional stains, such as toluidine blue and Luna, in differentiating MCTs from other eosinophilic lesions in horses...
Cytokines in heart failure: potential interactions with angiotensin II and leptinBethany J Holycross
Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA
Mol Interv 2:424-7. 2002
IgM paraprotein interference with hemoglobin measurement using the CELL-DYN 3500Stephanie C Corn
Department of Veterinary Biosciences, The Ohio State University, 125 Coffey Road, Columbus, OH 43210, USA
Vet Clin Pathol 37:61-5. 2008..Paraprotein interference should be considered in veterinary patients with monoclonal gammopathy and unexpectedly high HGB and MCHC values...
Ontogeny of enhanced decorin levels and distribution within myocardium of failing heartsDenis M Medeiros
Department of Human Nutrition, Kansas State University, 213 Justin Hall, Manhattan, KS 66506 1407, USA
Connect Tissue Res 43:32-43. 2002..The enhanced expression and greater distribution of decorin may be linked to extracellular matrix remodeling which occurs with the development of heart failure...
Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure ratsCraig A Emter
Dept. of Integrative Physiology, Univ. of Colorado at Boulder, Boulder, CO 80309-0354, USA
Am J Physiol Heart Circ Physiol 289:H2030-8. 2005..These data support the idea that exercise may be a useful and inexpensive intervention in the treatment of HF...
Mechanical alternans and restitution in failing SHHF rat left ventriclesCristian Dumitrescu
The Ohio State University Biophysics Program and Dorothy M. Davis Heart and Lung Research Institute, Columbus 43210, USA
Am J Physiol Heart Circ Physiol 282:H1320-6. 2002....
