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| I RaadSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Chelator-based catheter lock solutions in eradicating organisms in biofilmI Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Antimicrob Agents Chemother 57:586-8. 2013..M-EDTA-25% ETOH was able to fully eradicate all biofilms within 2 h. MB-CIT was only effective against immature biofilms but was unable to fully eradicate most of the mature biofilms tested...
Diagnosis of catheter-related bloodstream infections: is it necessary to culture the subcutaneous catheter segment?I I Raad
The University of Texas M D Anderson Cancer Center, Department of Infectious Diseases, Infection Control and Employee Health, Houston 77030, USA
Eur J Clin Microbiol Infect Dis 20:566-8. 2001....
Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infectionsIssam I Raad
The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Clin Infect Dis 42:1726-34. 2006..Antifungal therapy is often required for long periods. Safety data from the clinical development program of the triazole antifungal agent, posaconazole, were analyzed...
Polymerase chain reaction on blood for the diagnosis of invasive pulmonary aspergillosis in cancer patientsIssam Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 94:1032-6. 2002..Two prospective studies confirmed this finding but included a small number of IPA cases...
Diagnosis of invasive pulmonary aspergillosis using polymerase chain reaction-based detection of aspergillus in BALIssam Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Chest 121:1171-6. 2002..To assess the value of Aspergillus polymerase chain reaction (PCR) test performed on the BAL in diagnosing invasive pulmonary aspergillosis (IPA)...
Intravascular catheter-related infections: new horizons and recent advancesIssam I Raad
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Arch Intern Med 162:871-8. 2002....
Posaconazole as salvage treatment for invasive fusariosis in patients with underlying hematologic malignancy and other conditionsIssam I Raad
The M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
Clin Infect Dis 42:1398-403. 2006..Posaconazole is a broad-spectrum antifungal agent with in vitro and in vivo activity against Fusarium species...
Vancomycin-resistant Enterococcus faecium: catheter colonization, esp gene, and decreased susceptibility to antibiotics in biofilmIssam I Raad
Department of Infectious Diseases, Infection Control and Employee Health Unit 402, The University of Texas M D Anderson Cancer Center, P O Box 301402, Houston, Texas 77230 1402, USA
Antimicrob Agents Chemother 49:5046-50. 2005..In biofilm, daptomycin and minocycline were the most active antibiotics against VREF, and linezolid was the least active...
Catheter-related vancomycin-resistant Enterococcus faecium bacteremia: clinical and molecular epidemiologyIssam I Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Infect Control Hosp Epidemiol 26:658-61. 2005..To study the clinical and molecular epidemiology of vancomycin-resistant Enterococcus faecium organisms causing catheter-related bacteremia in patients with cancer...
Clinical-use-associated decrease in susceptibility of vancomycin-resistant Enterococcus faecium to linezolid: a comparison with quinupristin-dalfopristinIssam I Raad
Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Antimicrob Agents Chemother 48:3583-5. 2004..More than 6 months after their clinical use, a decrease in susceptibility was noted for only linezolid at 83%. This was related in part to a single G2576U gene mutation in domain V of the 23S rRNA gene...
Relationship between myalgias/arthralgias occurring in patients receiving quinupristin/dalfopristin and biliary dysfunctionIssam Raad
M D Anderson Cancer Center, Department of Infectious Diseases, 1515 Holcombe Blvd, Unit 402, Houston, TX 77030, USA
J Antimicrob Chemother 53:1105-8. 2004..To determine whether myalgias/arthralgias occurring in cancer patients who receive quinupristin/dalfopristin are associated with biliary tract dysfunction...
Management of central venous catheters in patients with cancer and candidemiaIssam Raad
Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Infect Dis 38:1119-27. 2004..03). CVC removal < or =72 h after onset should be considered in patients with suspected catheter-related candidemia who have no evidence of dissemination, recent corticosteroid therapy, or chemotherapy...
Prospective, randomized study comparing quinupristin-dalfopristin with linezolid in the treatment of vancomycin-resistant Enterococcus faecium infectionsIssam Raad
Departments of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Texas 77030, USA
J Antimicrob Chemother 53:646-9. 2004..The objective of this study was to compare the safety and efficacy of the two drugs in the treatment of VREF infections in cancer patients...
In vitro and ex vivo activities of minocycline and EDTA against microorganisms embedded in biofilm on catheter surfacesIssam Raad
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Antimicrob Agents Chemother 47:3580-5. 2003..01). We concluded that M-EDTA is highly active in eradicating microorganisms embedded in fresh and mature biofilm adhering to catheter surfaces...
Sources and outcome of bloodstream infections in cancer patients: the role of central venous cathetersI Raad
Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77230 1402, USA
Eur J Clin Microbiol Infect Dis 26:549-56. 2007..In addition to critical illness and persistent neutropenia, quantitative blood cultures might be useful in predicting outcomes for neutropenic patients with catheter-related bloodstream infections...
Efficacy of minocycline and EDTA lock solution in preventing catheter-related bacteremia, septic phlebitis, and endocarditis in rabbitsIssam Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Antimicrob Agents Chemother 46:327-32. 2002..06). In conclusion, the M-EDTA catheter flush solution was highly efficacious in preventing catheter-related colonization, bacteremia, septic phlebitis, and endocarditis in rabbits...
Intravascular catheters impregnated with antimicrobial agents: a milestone in the prevention of bloodstream infectionsI Raad
The University of Texas, M D Anderson Cancer Center, Section of Infection Control, 1515 Holcombe Blvd, Houston, TX 77030, USA
Support Care Cancer 7:386-90. 1999..In conclusion, antimicrobial catheters have been shown to be highly cost effective in decreasing the risk of catheter-related bloodstream infection...
Improved antibiotic-impregnated catheters with extended-spectrum activity against resistant bacteria and fungiIssam Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Antimicrob Agents Chemother 56:935-41. 2012..Our study shows that novel CHX-M/R-coated catheters have unique properties in completely inhibiting biofilm colonization of MRSA, VRE, P. aeruginosa, and fungi in a manner superior to that of M/R- and chlorhexidine-treated catheters...
The prevention of biofilm colonization by multidrug-resistant pathogens that cause ventilator-associated pneumonia with antimicrobial-coated endotracheal tubesIssam I Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, United States
Biomaterials 32:2689-94. 2011..Future animal and clinical studies are warranted to determine whether the gardine- and gendine-coated ETTs can significantly reduce the risk of VAP...
Management of the catheter in documented catheter-related coagulase-negative staphylococcal bacteremia: remove or retain?Issam Raad
The University of Texas MD Anderson Cancer Center, Houston and 2Kadlec Medical Center, Richland, Washington, USA
Clin Infect Dis 49:1187-94. 2009..In this study, we used strict definitions of coagulase-negative staphylococcal bacteremia to determine the impact of CVC retention on response to and recurrence of infection...
Treatment of nosocomial postoperative pneumonia in cancer patients: a prospective randomized studyI Raad
Department of Internal Medicine Specialties, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
Ann Surg Oncol 8:179-86. 2001..Nosocomial pneumonia continues to be associated with high morbidity and mortality in cancer patients...
Role of ethylene diamine tetra-acetic acid (EDTA) in catheter lock solutions: EDTA enhances the antifungal activity of amphotericin B lipid complex against Candida embedded in biofilmIssam I Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Int J Antimicrob Agents 32:515-8. 2008..04). In patients with catheter-related candidaemia when catheter removal is not feasible, the combination of ABLC+EDTA may be considered for antifungal catheter lock solution as part of a catheter salvage therapy...
Treatment of febrile neutropenic patients with cancer who require hospitalization: a prospective randomized study comparing imipenem and cefepimeIssam I Raad
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer 98:1039-47. 2003....
Commentary: zero tolerance for catheter-related bloodstream infections: the unnegotiable objectiveIssam I Raad
University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Infect Control Hosp Epidemiol 29:951-3. 2008
Anti-adherence activity and antimicrobial durability of anti-infective-coated catheters against multidrug-resistant bacteriaI Raad
The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
J Antimicrob Chemother 62:746-50. 2008....
The role of chelators in preventing biofilm formation and catheter-related bloodstream infectionsIssam I Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Curr Opin Infect Dis 21:385-92. 2008..This review focuses on recent advances in the role of chelators in biofilm disruption and prevention of catheter-related bloodstream infections...
Intravascular catheter-related infections: advances in diagnosis, prevention, and managementIssam Raad
Department of Infectious Diseases, Infection Control and Employee Health, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Lancet Infect Dis 7:645-57. 2007....
Treatment of vancomycin-resistant enterococcal infections in the immunocompromised host: quinupristin-dalfopristin in combination with minocyclineI Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4095, USA
Antimicrob Agents Chemother 45:3202-4. 2001..The response rate was 68%, and the most frequent adverse event was arthralgia or myalgia (36%). Q-D-MIN is effective for VRE infection in cancer patients but is associated with a substantial frequency of arthralgia or myalgia...
Novel antifungal agents as salvage therapy for invasive aspergillosis in patients with hematologic malignancies: posaconazole compared with high-dose lipid formulations of amphotericin B alone or in combination with caspofunginI I Raad
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Leukemia 22:496-503. 2008..03). In conclusion, posaconazole salvage therapy demonstrated greater efficacy and safety than HD-LPD/AMB alone or in combination with caspofungin in the salvage therapy of invasive aspergillosis in hematologic malignancy...
In vitro study of the potential role of quinupristin/dalfopristin in the treatment of catheter-related staphylococcal infectionsR Garcia
University of Texas M D Anderson Cancer Center, Department of Medical Specialties, Houston 77030, USA
Eur J Clin Microbiol Infect Dis 15:933-6. 1996..Its activity was similar to that of vancomycin but superior to that of teicoplanin. Quinupristin/dalfopristin may prove to be an important addition to our armamentarium against catheter-related staphylococcal infections...
Cytomegalovirus pneumonia in adult autologous blood and marrow transplant recipientsS Konoplev
Department of Blood and Marrow Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Bone Marrow Transplant 27:877-81. 2001....
Outcomes for and risk factors associated with vancomycin-resistant Enterococcus faecalis and vancomycin-resistant Enterococcus faecium bacteremia in cancer patientsG Ghanem
Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Infect Control Hosp Epidemiol 28:1054-9. 2007....
Mycobacterium kansasii infections in patients with cancerK L Jacobson
Section of Infectious Diseases, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Infect Dis 30:965-9. 2000..The infections responded well to rifampin-based antimycobacterial regimens. M. kansasii is an infrequent but serious cause of pulmonary and, occasionally, disseminated disease in patients with cancer...
Comparison of amphotericin B lipid complex (ABLC) vs. ambisome in the treatment of suspected or documented fungal infections in patients with leukemiaR V Fleming
Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
Leuk Lymphoma 40:511-20. 2001..AmBisome was better tolerated than ABLC but was associated with mild abnormalities in liver function tests at the end of therapy...
Antibacterial activity of linezolid and vancomycin in an in vitro pharmacodynamic model of gram-positive catheter-related bacteraemiaNathan P Wiederhold
The University of Houston College of Pharmacy, Houston, TX 77030, USA
J Antimicrob Chemother 55:792-5. 2005..CONCLUSIONS: Lack of activity against biofilm-embedded organisms appeared to be the primary reason for microbiological failure of both drugs in the model...
The epidemiology of Candida glabrata and Candida albicans fungemia in immunocompromised patients with cancerGerald P Bodey
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Am J Med 112:380-5. 2002..glabrata than against C. albicans (20/38 [53%] vs. 57/74 [77%], P = 0.008). CONCLUSION: C. glabrata has emerged as an important cause of candidemia, especially among neutropenic patients who receive fluconazole prophylaxis...
Streptococcus pneumoniae infections in 47 hematopoietic stem cell transplantation recipients: clinical characteristics of infections and vaccine-breakthrough infections, 1989-2005Souad Youssef
Department of Infectious Diseases, M D Anderson Cancer Center, Houston, Texas 77030, USA
Medicine (Baltimore) 86:69-77. 2007..It is noteworthy that there were no cases of extrapulmonary organ infection in HSCT recipients who presented with S. pneumoniae infection at our institution...
Aspergillosis caused by non-fumigatus Aspergillus species: risk factors and in vitro susceptibility compared with Aspergillus fumigatusHarrys A Torres
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
Diagn Microbiol Infect Dis 46:25-8. 2003..group than in the A. fumigatus one. The Aspergillus species distribution in IA cases in our institution shows a predominance of the more antifungal-resistant or -tolerant non-fumigatus Aspergillus spp...
The role of molecular methods in the prevention of nosocomial methicillin-resistant Staphylococcus aureus clusters in cancer patientsGhazi Ghanem
University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Am J Infect Control 36:656-60. 2008....
Cytomegalovirus infection in patients with lymphoma: an important cause of morbidity and mortalityHarrys A Torres
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-4009, USA
Clin Lymphoma Myeloma 6:393-8. 2006..01). CONCLUSION: In an era of intense and pleiotropic immunosuppressive therapy in patients with lymphoma, CMV-A and CMV-D are significant infections. Preventive strategies might be warranted for patients at risk...
Utility of galactomannan enzyme immunoassay and (1,3) beta-D-glucan in diagnosis of invasive fungal infections: low sensitivity for Aspergillus fumigatus infection in hematologic malignancy patientsR Y Hachem
Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
J Clin Microbiol 47:129-33. 2009..The diagnostic marker BG was shown to have a higher sensitivity than that of GM in detecting IA and other mold infections in hematologic malignancy patients...
Adenovirus infections in adult recipients of blood and marrow transplantsA M La Rosa
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Clin Infect Dis 32:871-6. 2001..The need for an effective, nontoxic antiviral therapy is apparent...
Effects of liposomal amphotericin B versus an amphotericin B lipid complex on liver histopathology in patients with hematologic malignancies and invasive fungal infections: a retrospective, nonrandomized autopsy studyGeorgios Chamilos
Department of Infectious Diseases and Infection Control, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Ther 29:1980-6. 2007..Because LFT abnormalities are multifactorial in severely immunocompromised patients, uncertainty remains regarding the clinical significance of these laboratory findings...
Breakthrough candidemia in patients with cancer differs from de novo candidemia in host factors and Candida species but not intensityDimitrios P Kontoyiannis
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD. Anderson Cancer Center, Houston 77030, USA
Infect Control Hosp Epidemiol 23:542-5. 2002..CONCLUSIONS: In breakthrough candidemia, the same risk factors seen in de novo candidemia were encountered, although more frequently. C. glabrata and C. krusei are the leading causes of breakthrough candidemia in patients with cancer...
Escherichia coli Pyomyositis: an emerging infectious disease among patients with hematologic malignanciesKaren J Vigil
The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1460, Houston, TX 77030, USA
Clin Infect Dis 50:374-80. 2010..Pyomyositis is typically caused by gram-positive bacteria, especially Staphylococcus aureus. Few cases of Escherichia coli pyomyositis have been reported, including only 1 involving a patient with a hematologic malignancy...
Optimal frequency of changing intravenous administration sets: is it safe to prolong use beyond 72 hours?I Raad
University of Texas M D Anderson Cancer Center, Houston 77030, USA
Infect Control Hosp Epidemiol 22:136-9. 2001..To determine the safety and cost-effectiveness of replacing the intravenous (IV) tubing sets in hospitalized patients at 4- to 7-day intervals instead of every 72 hours...
Management of an outbreak of vancomycin-resistant enterococci in the medical intensive care unit of a cancer centerH Hanna
Department of Internal Medicine Specialties, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
Infect Control Hosp Epidemiol 22:217-9. 2001..Multifaceted infection control measures, including decontamination of the environment and of nondisposable equipment, halted the nosocomial transmission of VRE in the MICU...
Increased frequency of non-fumigatus Aspergillus species in amphotericin B- or triazole-pre-exposed cancer patients with positive cultures for aspergilliMichail S Lionakis
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Diagn Microbiol Infect Dis 52:15-20. 2005..These Aspergillus isolates were found to be AMB-resistant by the more sensitive E-test method...
Multiple-species candidemia in patients with cancerMaha R Boktour
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 101:1860-5. 2004....
Phaeohyphomycosis in a tertiary care cancer centerRonen Ben-Ami
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Infect Dis 48:1033-41. 2009..To assess the range of clinical presentations and outcomes of phaeohyphomycosis in patients with cancer, we reviewed cases diagnosed at the M. D. Anderson Cancer Center (Houston, TX)...
Candidemia in a tertiary care cancer center: in vitro susceptibility and its association with outcome of initial antifungal therapyAnastasia Antoniadou
Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Medicine (Baltimore) 82:309-21. 2003..04, but not in univariate analysis), indicating the complexity of the variables that influence the response to antifungal treatment in cancer patients with candidemia...
Predictors of catheter-related gram-negative bacilli bacteraemia among cancer patientsJ Cairo
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Centre, Houston, TX 77030, USA
Clin Microbiol Infect 17:1711-6. 2011....
blaVIM-2 and blaVIM-7 carbapenemase-producing Pseudomonas aeruginosa isolates detected in a tertiary care medical center in the United States: report from the MYSTIC programH Aboufaycal
The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Clin Microbiol 45:614-5. 2007..The isolates had distinct ribotype and pulsed-field gel electorphoresis patterns and appeared independently, remote in time and location, at the same cancer center...
The role of vitamin B6 in the prevention of haematological toxic effects of linezolid in patients with cancerS Youssef
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
J Antimicrob Chemother 61:421-4. 2008..Previous authors have reported that administration of vitamin B6 with linezolid reversed pancytopenia in two patients...
Comparing clinical and microbiological methods for the diagnosis of true bacteraemia among patients with multiple blood cultures positive for coagulase-negative staphylococciI Al Wohoush
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Clin Microbiol Infect 17:569-71. 2011..The CDC clinical criteria had low accuracy, which can be improved by speciation, particularly if the patient had more than two positive blood cultures...
Catheter-related Corynebacterium bacteremia: should the catheter be removed and vancomycin administered?S Ghide
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1460, Houston, TX 77030, USA
Eur J Clin Microbiol Infect Dis 29:153-6. 2010..Treatment with a systemic active antibiotic over a 7-day period appears to be adequate for resolution of the infection...
Gastrointestinal cytomegalovirus disease in patients with cancer: a two decade experience in a tertiary care cancer centerHarrys A Torres
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, Unit 402, M.D. Anderson Cancer Center, Houston, TX 77030-4009, USA
Eur J Cancer 41:2268-79. 2005..01). The presentation of GI-CMVd varies according to the type of cancer, and AIDS. GI-CMVd is associated with a high mortality among cancer patients, particularly those with disseminated CMV disease or AIDS...
Monotherapy with caspofungin for candidaemia in adult patients with cancer: a retrospective, single institution studyNikolaos V Sipsas
Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Int J Antimicrob Agents 34:95-8. 2009....
Antifungal activity of amphotericin B, fluconazole, and voriconazole in an in vitro model of Candida catheter-related bloodstream infectionRussell E Lewis
University of Houston College of Pharmacy, Houston, Texas 77030, USA
Antimicrob Agents Chemother 46:3499-505. 2002..Lack of in vitro antifungal activity against biofilm-encased organisms appeared to be the primary reason for mycological failure of antifungal regimens in the model...
Blood products: a significant risk factor for long-term catheter-related bloodstream infections in cancer patientsH A Hanna
University of Texas M.D. Anderson Cancer Center, Section of Infection Control, Houston 77030, USA
Infect Control Hosp Epidemiol 22:165-6. 2001..through central venous catheters was a risk factor for CR BSI, whereas thrombocytopenia during catheterization may have provided protection against CR BSI, as did central venous catheter insertion under maximal sterile barrier precautions..
Infections in 100 cord blood transplantations: spectrum of early and late posttransplant infections in adult and pediatric patients 1996-2005Amar Safdar
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Medicine (Baltimore) 86:324-33. 2007..47; p < 0.007) were less likely to die from infection. More effective measures for surveillance and prevention of late cytomegalovirus and varicella zoster virus infections in children with CBT and chronic GVHD are needed...
Pentamidine is active in a neutropenic murine model of acute invasive pulmonary fusariosisMichail S Lionakis
Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
Antimicrob Agents Chemother 50:294-7. 2006..PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no difference in fungal burden versus untreated mice...
Efficacy of antimicrobial-impregnated silicone sections from penile implants in preventing device colonization in an animal modelRabih O Darouiche
Center for Prostheses Infection and Infectious Disease Section, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
Urology 59:303-7. 2002..aureus and protect against staphylococcal colonization of devices implanted for 2 days in animals...
Respiratory syncytial virus infections in autologous blood and marrow transplant recipients with breast cancer: combination therapy with aerosolized ribavirin and parenteral immunoglobulinsS Ghosh
Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Bone Marrow Transplant 28:271-5. 2001....
A comparison of galactomannan-ELISA and a newly developed galactomannan-LATEX test in the serologic diagnosis of invasive aspergillosis in patients with hematologic malignanciesX Keutgen
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Eur J Clin Microbiol Infect Dis 26:655-8. 2007..Both tests demonstrated a specificity of 99%. The GM-LATEX test demonstrated a superior sensitivity in terms of detecting galactomannan and thus may be useful in the diagnosis of IA in patients with HM...
Amphotericin B lipid complex versus liposomal amphotericin B monotherapy for invasive aspergillosis in patients with hematologic malignancyRay Y Hachem
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
Cancer 112:1282-7. 2008..There are limited data comparing the efficacy and safety of these 2 agents in the treatment of IA in patients with cancer...
Tigecycline use in cancer patients with serious infections: a report on 110 cases from a single institutionRoy F Chemaly
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas77030 4009, USA
Medicine (Baltimore) 88:211-20. 2009..Patients with refractory pneumonia had a relatively low clinical response rate in our study...
Drug-induced nephrotoxicity caused by amphotericin B lipid complex and liposomal amphotericin B: a review and meta-analysisAmar Safdar
Immunology Research Program, Department of Infectious Diseases, Infection Control and Employee Health, The Anderson Cancer Center, Houston, Texas 77030, USA
Medicine (Baltimore) 89:236-44. 2010..09; n = 839); the 7 remaining studies were more homogenous by Breslow-Day test (p = 0.054). Our results suggest that nephrotoxicity is generally similar for ABLC and L-AmB in patients receiving antifungal therapy and prophylaxis...
Characteristics and outcomes of methicillin-resistant Staphylococcus aureus surgical-site infections in patients with cancer: a case-control studyRoy F Chemaly
Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Ann Surg Oncol 17:1499-506. 2010..We experienced an increased incidence of MRSA surgical-site infections (MRSA SSIs) at our institution. However, to our knowledge, no studies have evaluated the risk factors and outcomes of MRSA SSIs in cancer patients...
Trichosporonosis in a tertiary care cancer center: risk factors, changing spectrum and determinants of outcomeDimitrios P Kontoyiannis
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Scand J Infect Dis 36:564-9. 2004..01). TS is associated with a high mortality rate in cancer patients. The spectrum of infection at our institution has shifted from a predominance of disseminated infection to CVC-related fungemias without evidence of tissue invasion...
Does combination of lipid formulation of amphotericin B and echinocandins improve outcome of invasive aspergillosis in hematological malignancy patients?Coralia N Mihu
Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Cancer 116:5290-6. 2010..Furthermore, clinical studies suggested that this combination may improve response of invasive aspergillosis (IA)...
Candidemia in patients with hematologic malignancies in the era of new antifungal agents (2001-2007): stable incidence but changing epidemiology of a still frequently lethal infectionNikolaos V Sipsas
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 115:4745-52. 2009....
Streptococcus pneumoniae bacteremia in patients with cancer: disease characteristics and outcomes in the era of escalating drug resistance (1998-2002)Padmavati Kumashi
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Medicine (Baltimore) 84:303-12. 2005..pneumoniae, and other conventional predictors of unfavorable outcome were not associated with increased mortality rates in these high-risk patients with cancer...
The role of interventional molecular epidemiology in controlling clonal clusters of multidrug resistant Pseudomonas aeruginosa in critically ill cancer patientsJavier A Adachi
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Am J Infect Control 37:442-6. 2009..The objective was to evaluate the impact of molecular identification of clonal multidrug-resistant (MDR) P aeruginosa strains and the implementation of infection control measures...
Risk of bioaerosol contamination with Aspergillus species before and after cleaning in rooms filtered with high-efficiency particulate air filters that house patients with hematologic malignancyLinda D Lee
Department of Environmental Health and Safety, The University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
Infect Control Hosp Epidemiol 28:1066-70. 2007....
Increased bone marrow iron stores is an independent risk factor for invasive aspergillosis in patients with high-risk hematologic malignancies and recipients of allogeneic hematopoietic stem cell transplantationDimitrios P Kontoyiannis
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 110:1303-6. 2007..Laboratory studies have demonstrated that iron is essential for Aspergillus growth and virulence...
Efficacy and toxicity of caspofungin in combination with liposomal amphotericin B as primary or salvage treatment of invasive aspergillosis in patients with hematologic malignanciesDimitrios P Kontoyiannis
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 98:292-9. 2003..Therefore, the authors retrospectively evaluated the efficacy and toxicity of CAS plus liposomal amphotericin B (LipoAMB) in patients with documented (definite or probable) or possible IA...
Itraconazole added to a lipid formulation of amphotericin B does not improve outcome of primary treatment of invasive aspergillosisDimitrios P Kontoyiannis
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 103:2334-7. 2005..Itraconazole (ITC), a triazole with activity against Aspergillus, has been used in combination with AMB or lipid formulations of AMB (LipoAMB) in the treatment of IA, although the efficacy of this strategy is uncertain...
Zygomycosis in a tertiary-care cancer center in the era of Aspergillus-active antifungal therapy: a case-control observational study of 27 recent casesDimitrios P Kontoyiannis
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Infect Dis 191:1350-60. 2005..Anecdotal evidence suggests a rise in zygomycosis in association with voriconazole (VRC) use in immunosuppressed patients...
Nonfermentative gram-negative bacilli in cancer patients: increasing frequency of infection and antimicrobial susceptibility of clinical isolates to fluoroquinolonesKenneth V I Rolston
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
Diagn Microbiol Infect Dis 51:215-8. 2005..The newer quinolones (gatifloxacin, moxifloxacin, and garenoxacin) had better activity than ofloxacin, levofloxacin, and ciprofloxacin, against many other nonfermenters (Stenotrophomonas maltophilia, P. fluorescens, and P. putida)...
The safety of interferon-gamma-1b therapy for invasive fungal infections after hematopoietic stem cell transplantationAmar Safdar
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 103:731-9. 2005..The authors sought to evaluate the safety of adjuvant recombinant interferon-gamma-1b as an immune-modulatory therapy HSCT recipients...
Impact of high-dose granulocyte transfusions in patients with cancer with candidemia: retrospective case-control analysis of 491 episodes of Candida species bloodstream infectionsAmar Safdar
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 101:2859-65. 2004..The authors sought to determine the impact of high-dose (approximately 5.5 x 10(10) cells) GTX in patients with candidemia...
Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major cancer centerRoy F Chemaly
Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Medicine (Baltimore) 85:278-87. 2006..HSCT recipients and patients with hematologic malignancies who develop upper respiratory infection due to CRVs should be considered for antiviral therapy of proven efficacy to reduce the risk of pneumonia and death...
Aspergillus terreus: an emerging amphotericin B-resistant opportunistic mold in patients with hematologic malignanciesRay Y Hachem
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
Cancer 101:1594-600. 2004..fumigatus as the most common cause of IA. In the current study, the authors compared the risk factors and outcomes associated with IA caused by A. terreus and IA caused by A. fumigatus...
Endogenous endophthalmitis secondary to vancomycin-resistant enterococci infectionBita Esmaeli
Ophthalmology Section, Department of Infectious Disease, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas, USA
Retina 23:118-9. 2003
Evaluation of the silver iontophoretic catheter in an animal modelRay Y Hachem
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Biomaterials 24:3619-22. 2003..1 to 2.23 microg/l with a mean of 0.62 (+/-0.44 SD). In conclusion SIC were safe with normal serum silver levels and were not associated with any local or systemic toxicity...
Sequential exposure of Aspergillus fumigatus to itraconazole and caspofungin: evidence of enhanced in vitro activityDimitrios P Kontoyiannis
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M D Anderson Cancer Center, Houston, TX, USA
Diagn Microbiol Infect Dis 47:415-9. 2003..fumigatus to itraconazole resulted in dose-dependent enhanced effects of caspofungin and vice versa. Our finding suggests a preferential role for azole-caspofungin sequential combinations and merits further in vivo investigation...
Antibiotic-impregnated catheters associated with significant decrease in nosocomial and multidrug-resistant bacteremias in critically ill patientsHend A Hanna
Department of Infectious Diseases, Infection Control, and Employee Health Unit 402, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Chest 124:1030-8. 2003..To evaluate the impact of using central venous catheters (CVCs) impregnated with the combination of minocycline and rifampin on nosocomial bloodstream infections (BSIs), morbidity, and mortality in cancer patients in the ICU...
Cytomegalovirus pneumonia in patients with lymphomaRoy F Chemaly
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, 77230, USA
Cancer 104:1213-20. 2005..Even when treated with antiviral therapy, cytomegalovirus pneumonia (CMVp) is associated with high morbidity and mortality in immunocompromised patients. CMVp has been rarely reported in patients with lymphoma...
Culture-positive and culture-negative endocarditis in patients with cancer: a retrospective observational study, 1994-2004Syed Wamique Yusuf
Department of Cardiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Medicine (Baltimore) 85:86-94. 2006..The clinical spectrums of CPE and CNE differed in these patients with cancer. In patients with CNE, embolic cerebrovascular and fatal myocardial infarction were relatively common...
Dose-related safety and immunogenicity of baculovirus-expressed trivalent influenza vaccine: a double-blind, controlled trial in adult patients with non-Hodgkin B cell lymphomaAmar Safdar
Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Infect Dis 194:1394-7. 2006..For each vaccine, the highest frequencies of increases in neutralizing antibody levels and the highest mean titers occurred in those given the 135- microg vaccine...
Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989-2003)Georgios Chamilos
Department of Infectious Diseases, Infection Control and Employee Health, Unit 402, Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Haematologica 91:986-9. 2006..The complex and evolving epidemiology of IFI in severely immunocompromised patients is not well captured by current diagnostic methods...
Neuraminidase inhibitors improve outcome of patients with leukemia and influenza: an observational studyRoy F Chemaly
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
Clin Infect Dis 44:964-7. 2007..001). The use of neuraminidase inhibitor therapy seems to improve the outcome of influenza in patients with leukemia...
Recombinant interferon gamma1b immune enhancement in 20 patients with hematologic malignancies and systemic opportunistic infections treated with donor granulocyte transfusionsAmar Safdar
Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 106:2664-71. 2006..The authors evaluated the safety and efficacy of immune enhancement using recombinant interferon gamma1b (rIFN-gamma1b) in patients with cancer who received GTX for refractory, systemic, opportunistic infections...
The spectrum of Gram-positive bloodstream infections in patients with hematologic malignancies, and the in vitro activity of various quinolones against Gram-positive bacteria isolated from cancer patientsKenneth V I Rolston
Section of Infectious Diseases, Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 402, Houston, TX 77030, USA
Int J Infect Dis 10:223-30. 2006....
Open-label, randomized comparison of itraconazole versus caspofungin for prophylaxis in patients with hematologic malignanciesGloria N Mattiuzzi
Department of Leukemia, Unit 428, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
Antimicrob Agents Chemother 50:143-7. 2006..In conclusion, intravenous itraconazole and caspofungin provided similar protection against invasive fungal infection during induction chemotherapy, and both drugs were well tolerated...
Posaconazole: a broad-spectrum triazole antifungalHarrys A Torres
Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M D Anderson Cancer Center, Houston, Texas 77030-4009, USA
Lancet Infect Dis 5:775-85. 2005..Posaconazole has shown promising clinical efficacy against life-threatening fungal infections that are often refractory to the currently available antifungal therapies-eg, invasive aspergillosis, fusariosis, and the emerging zygomycosis...
Colistin is effective in treatment of infections caused by multidrug-resistant Pseudomonas aeruginosa in cancer patientsRay Y Hachem
Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, P O Box 301402, Houston, TX 77230 1402, USA
Antimicrob Agents Chemother 51:1905-11. 2007..aeruginosa and, hence, may be a useful or preferred alternative therapy for this infection in cancer patients...
Mycobacterium kansasii infections in patients with cancerK L Jacobson
Section of Infectious Diseases, Universtiy of Texas M D Anderson Cancer Center, Houston, USA
Clin Infect Dis 31:628-31. 2000..The infections responded well to rifampin-based antimycobacterial regimens. M. kansasii is an infrequent but serious cause of pulmonary and, occasionally, disseminated disease in patients with cancer...
Outcome analysis of invasive aspergillosis in hematologic malignancy and hematopoietic stem cell transplant patients: the role of novel antimold azolesElizabeth R Ramos
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Oncologist 16:1049-60. 2011..Invasive aspergillosis (IA) continues to be a leading cause of morbidity and mortality in hematologic malignancy (HM) patients. We evaluated the prognostic factors for IA in HM patients...
Infections in patients with aplastic anemia: experience at a tertiary care cancer centerHarrys A Torres
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 98:86-93. 2003..Bacterial infections, especially those caused by gram-positive cocci, constitute the main cause of IE. Invasive mold infections, however, are the major cause of death in this patient population...
