Research Topics
Species | Maryka QuikSummaryAffiliation: The Parkinson's Institute Country: USA Publications
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Detail Information
Publications
Chronic oral nicotine normalizes dopaminergic function and synaptic plasticity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned primatesMaryka Quik
The Parkinson s Institute, Sunnyvale, California 94089, USA
J Neurosci 26:4681-9. 2006..These cellular alterations may underlie the ability of nicotine to maintain/restore normal function with nigrostriatal damage...- L-DOPA treatment modulates nicotinic receptors in monkey striatumMaryka Quik
The Parkinson s Institute, 1170 Morse Ave, Sunnyvale, CA 94089 1605, USA
Mol Pharmacol 64:619-28. 2003..These declines in nAChRs with l-DOPA may be relevant to both the therapeutic and side effect profiles of l-DOPA therapy in Parkinson's disease... - Loss of alpha-conotoxinMII- and A85380-sensitive nicotinic receptors in Parkinson's disease striatumM Quik
The Parkinson s Institute, Sunnyvale, California 94089, USA
J Neurochem 88:668-79. 2004..In summary, these results show that alpha-conotoxinMII-sensitive sites are present in human striatum and that there are high- and low-affinity subtypes which are both decreased in Parkinson's disease... - Smoking, nicotine and Parkinson's diseaseMaryka Quik
The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
Trends Neurosci 27:561-8. 2004..An understanding of the molecular basis for the reduced occurrence of PD in tobacco users is crucial for the development of intervention strategies to reduce or halt disease progression... - Nicotine partially protects against paraquat-induced nigrostriatal damage in mice; link to alpha6beta2* nAChRsMirium Khwaja
The Parkinson s Institute, Sunnyvale, CA 94089, USA
J Neurochem 100:180-90. 2007..Moreover, these data support epidemiological findings that environmental influences can elicit opposing effects on nigrostriatal dopaminergic integrity... 
Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeysLuping Z Huang
Basic Research Department, The Parkinson s Institute, Sunnyvale, California 94085, USA
J Neurochem 109:826-37. 2009..The observations suggest that protection against nigrostriatal damage may be linked to striatal alpha6alpha4beta2* nAChRs...- Chronic nicotine treatment increases nAChRs and microglial expression in monkey substantia nigra after nigrostriatal damageMaryka Quik
The Parkinson s Institute, Sunnyvale, CA 94085, USA
J Mol Neurosci 40:105-13. 2010..These observations may have therapeutic implications for Parkinson's disease... - Chronic oral nicotine treatment protects against striatal degeneration in MPTP-treated primatesMaryka Quik
The Parkinson s Institute, Sunnyvale, California, USA
J Neurochem 98:1866-75. 2006..These data further support the possibility that nicotine contributes to the lower incidence of Parkinson's disease in smokers... - Decrease in alpha3*/alpha6* nicotinic receptors but not nicotine-evoked dopamine release in monkey brain after nigrostriatal damageSarah E McCallum
The Parkinson's Institute, 1170 Morse Ave, Sunnyvale, CA 94089-1605, USA
Mol Pharmacol 68:737-46. 2005..Maintenance of function in putamen, a region with a selective loss of dopaminergic terminals, may be important in PD... - Partial recovery of striatal nicotinic receptors in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned monkeys with chronic oral nicotineTanuja Bordia
The Parkinson's Institute, 1170 Morse Ave, Sunnyvale, CA 94089-1605, USA
J Pharmacol Exp Ther 319:285-92. 2006..Such findings suggest that nicotine or nicotinic agonists may be of therapeutic value in Parkinson's disease... - Multiple roles for nicotine in Parkinson's diseaseMaryka Quik
The Parkinson s Institute, Sunnyvale, CA 94085, United States
Biochem Pharmacol 78:677-85. 2009..Treatment with nAChR ligands directed to these subtypes may thus yield optimal therapeutic benefit for Parkinson's disease, with a minimum of adverse side effects... - Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson's disease striatumTanuja Bordia
The Parkinson s Institute, 1170 Morse Ave, Sunnyvale, CA 94089 1605, USA
Mol Pharmacol 72:52-61. 2007..This latter nAChR subtype, identified with alpha-CtxMII E11A, may therefore provide a unique marker for dopaminergic terminals particularly sensitive to nigrostriatal degeneration in Parkinson's disease... - Cotinine selectively activates a subpopulation of alpha3/alpha6beta2 nicotinic receptors in monkey striatumKathryn O'Leary
The Parkinson s Institute, 675 Almanor Ave, Sunnyvale, CA 94085 2934, USA
J Pharmacol Exp Ther 325:646-54. 2008..These data demonstrate that cotinine functionally discriminates between two alpha3/alpha6beta2* nAChRs in monkey striatum, with the cotinine-insensitive alpha3/alpha6beta2* nAChR preferentially vulnerable to nigrostriatal damage... - Increases in alpha4* but not alpha3*/alpha6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatmentSarah E McCallum
The Parkinson's Institute, Sunnyvale, California 94089, USA
J Neurochem 96:1028-41. 2006..Such knowledge is important for understanding nicotine dependence and the consequences of nicotine administration for the treatment of neurological disorders... - Subunit composition of nicotinic receptors in monkey striatum: effect of treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPAMaryka Quik
The Parkinson s Institute, 1170 Morse Ave, Sunnyvale, CA 94089 1605, USA
Mol Pharmacol 67:32-41. 2005..Overall, these results suggest that drugs targeting non-alpha7 nicotinic receptors may be useful in the treatment of disorders characterized by nigrostriatal dopaminergic damage, such as Parkinson's disease... - 5-Iodo-A-85380 binds to alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors (nAChRs) as well as alpha4beta2* subtypesJennifer M Kulak
The Parkinson's Institute, Sunnyvale, California 94089-1605, USA
J Neurochem 81:403-6. 2002..These data are important for identifying alterations in nicotinic receptor subtypes in Parkinson's disease and other basal ganglia disorders both in in vitro and in in vivo imaging studies... - Declines in different beta2* nicotinic receptor populations in monkey striatum after nigrostriatal damageJennifer M Kulak
The Parkinson's Institute, 1170 Morse Avenue, Sunnyvale, CA 94089-1605, USA
J Pharmacol Exp Ther 303:633-9. 2002.... - Differential declines in striatal nicotinic receptor subtype function after nigrostriatal damage in miceMaryka Quik
The Parkinson s Institute, Sunnyvale, California 94089 1605, USA
Mol Pharmacol 63:1169-79. 2003..These data suggest that the declines in nAChR sites observed in Parkinson's disease brains may be of functional significance... - Cigarette smoke, nicotine and cotinine protect against 6-hydroxydopamine-induced toxicity in SH-SY5Y cellsKaren Riveles
The Parkinson s Institute, Sunnyvale, CA 94085, USA
Neurotoxicology 29:421-7. 2008..These data suggest that nicotine may be of potential therapeutic value for Parkinson's disease... - Nicotine reduces levodopa-induced dyskinesias in lesioned monkeysMaryka Quik
The Parkinson s Institute, Sunnyvale, CA 94089, USA
Ann Neurol 62:588-96. 2007..Our objective, therefore, was to determine whether nicotine treatment reduced levodopa-induced dyskinesias... - Long-term nicotine treatment decreases striatal alpha 6* nicotinic acetylcholine receptor sites and function in miceAlbert Lai
The Parkinson's Institute, Sunnyvale, California 94089-1605, USA
Mol Pharmacol 67:1639-47. 2005..The present data suggest that the alpha6* nAChR subtype represents a key factor in the control of dopamine release from striatum, which adapts to long-term nicotine treatment by down-regulation of alpha6* receptor sites and function... - The selective kappa-opioid receptor agonist U50,488 reduces L-dopa-induced dyskinesias but worsens parkinsonism in MPTP-treated primatesHeather Cox
The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
Exp Neurol 205:101-7. 2007..These data suggest that kappa-opioid agonists such as U50,488 may not be clinically useful antidyskinetic agents because they also reverse the anti-parkinsonian effect of l-dopa... - Paraquat exposure reduces nicotinic receptor-evoked dopamine release in monkey striatumKathryn T O'Leary
The Parkinson s Institute, 675 Almanor Ave, Sunnyvale, CA 94085 2934, USA
J Pharmacol Exp Ther 327:124-9. 2008..The finding that paraquat treatment has a negative impact on striatal nAChR-mediated dopaminergic activity in monkeys but not mice indicates the need for determining the effects of pesticides in higher species... - Long-term nicotine treatment differentially regulates striatal alpha6alpha4beta2* and alpha6(nonalpha4)beta2* nAChR expression and functionXiomara A Perez
The Parkinson s Institute, 675 Almanor Avenue, Sunnyvale, CA 94085, USA
Mol Pharmacol 74:844-53. 2008..Thus, alpha6beta2(*) nAChR subtypes may represent important targets for smoking cessation therapies and neurological disorders involving these receptors such as Parkinson's disease... - Prominent role of alpha3/alpha6beta2* nAChRs in regulating evoked dopamine release in primate putamen: effect of long-term nicotine treatmentXiomara A Perez
The Parkinson s Institute, Sunnyvale, CA 94085, USA
Mol Pharmacol 75:938-46. 2009..These findings have implications for the development of treatments for addiction and neurological disorders with nAChR dysfunction... - Striatal alpha6* nicotinic acetylcholine receptors: potential targets for Parkinson's disease therapyMaryka Quik
The Parkinson s Institute, Sunnyvale, CA 94089 1605, USA
J Pharmacol Exp Ther 316:481-9. 2006.... - Differential regulation of mesolimbic alpha 3/alpha 6 beta 2 and alpha 4 beta 2 nicotinic acetylcholine receptor sites and function after long-term oral nicotine to monkeysSarah E McCallum
The Parkinson's Institute, 1170 Morse Ave, Sunnyvale, CA 94089-1605, and Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Pharmacol Exp Ther 318:381-8. 2006.... - Nicotine neuroprotection against nigrostriatal damage: importance of the animal modelMaryka Quik
The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
Trends Pharmacol Sci 28:229-35. 2007..These findings highlight the need to use the appropriate animal model and treatment conditions when testing putative neuroprotective agents... - Nicotinic receptors as CNS targets for Parkinson's diseaseMaryka Quik
The Parkinson s Institute, Sunnyvale, CA 94089, USA
Biochem Pharmacol 74:1224-34. 2007..These observations suggest that development of nAChR agonists or antagonists targeted to alpha6beta2-containing nAChRs may represent a particularly relevant target for Parkinson's disease therapeutics... - Pre-synaptic dopaminergic compensation after moderate nigrostriatal damage in non-human primatesXiomara A Perez
The Parkinson s Institute, Sunnyvale, California 94085, USA
J Neurochem 105:1861-72. 2008..Such an interpretation is supported by the results of dopamine turnover studies. This enhanced pre-synaptic dopaminergic activity may be important in maintaining normal motor function during the initial stages of Parkinson's disease... - The Webcam system: a simple, automated, computer-based video system for quantitative measurement of movement in nonhuman primatesDaniel M Togasaki
The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
J Neurosci Methods 145:159-66. 2005..These results indicate that the Webcam system is reliable under both untreated and experimental conditions and is an excellent method for quantifying motor activity in animals... 
Continuous and intermittent nicotine treatment reduces L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias in a rat model of Parkinson's diseaseTanuja Bordia
The Parkinson s Institute, 675 Almanor Ave, Sunnyvale, CA 94085 2934, USA
J Pharmacol Exp Ther 327:239-47. 2008..These results suggest that either intermittent or constant nicotine treatment may be useful in the treatment of L-DOPA-induced dyskinesias in patients with Parkinson's disease...- Nicotine and nicotinic receptors; relevance to Parkinson's diseaseMaryka Quik
The Parkinson s Institute, Sunnyvale, CA 94089, USA
Neurotoxicology 23:581-94. 2002..These data suggest that nicotinic receptor ligands directed to alpha6* nicotinic receptors might be particularly relevant for Parkinson's disease therapeutics... - Dyskinesias in normal squirrel monkeys induced by nomifensine and levodopaDaniel M Togasaki
The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
Neuropharmacology 48:398-405. 2005..Thus, this study suggests that diminished buffering capacity for dopamine could play a role in the development of dyskinesias, and that an endogenous mechanism might exist that ameliorates dyskinesias... - Nicotine and Parkinson's disease: implications for therapyMaryka Quik
The Parkinson s Institute, Sunnyvale, California, USA
Mov Disord 23:1641-52. 2008.... - Loss of nicotinic receptors in monkey striatum after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment is due to a decline in alpha-conotoxin MII sitesJennifer M Kulak
The Parkinson's Institute, Sunnyvale, California 94089-1605, USA
Mol Pharmacol 61:230-8. 2002.... - Effect of the D3 dopamine receptor partial agonist BP897 [N-[4-(4-(2-methoxyphenyl)piperazinyl)butyl]-2-naphthamide] on L-3,4-dihydroxyphenylalanine-induced dyskinesias and parkinsonism in squirrel monkeysAlbert Hsu
The Parkinson's Institute, 1170 Morse Ave, Sunnyvale, CA 94089, USA
J Pharmacol Exp Ther 311:770-7. 2004..These results suggest that BP897 may be less effective than originally anticipated for treating LIDs in Parkinson's disease... - Guidelines on nicotine dose selection for in vivo researchShannon G Matta
Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Crowe 115, Memphis, TN 38163, USA
Psychopharmacology (Berl) 190:269-319. 2007..In many cases, such discrepancies could be attributed to the complex variables comprising species-specific in vivo responses to acute or chronic nicotine exposure...