N Quan

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Induction of IkappaBalpha mRNA expression in the brain by glucocorticoids: a negative feedback mechanism for immune-to-brain signaling
    N Quan
    Department of Oral Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 20:6473-7. 2000
  2. ncbi request reprint Molecular mechanisms of glucocorticoid resistance in splenocytes of socially stressed male mice
    Ning Quan
    Section of Oral Biology, The Ohio State University Health Science Center, Institute for Behavioral Medicine Research and Neuroscience Graduate Studies Program, The Ohio State University, Columbus, OH 43210, USA
    J Neuroimmunol 137:51-8. 2003
  3. ncbi request reprint Endothelial activation is an intermediate step for peripheral lipopolysaccharide induced activation of paraventricular nucleus
    Ning Quan
    Department of Oral Biology, Health Science Center, Ohio State University, Columbus, OH 43210, USA
    Brain Res Bull 59:447-52. 2003
  4. pmc Immune-to-brain signaling: how important are the blood-brain barrier-independent pathways?
    Ning Quan
    Institute of Behavior Medicine, Ohio State University, 4179 Postle Hall, 305 W 12th Ave, Columbus, OH 43210 1094, USA
    Mol Neurobiol 37:142-52. 2008
  5. ncbi request reprint Connecting cytokines and brain: a review of current issues
    N Quan
    Department of Oral Biology, Ohio State University, Columbus 43210, USA
    Histol Histopathol 17:273-88. 2002
  6. ncbi request reprint Intraventricular infusion of antagonists of IL-1 and TNF alpha attenuates neurodegeneration induced by the infection of Trypanosoma brucei
    Ning Quan
    Section of Oral Biology, Ohio State University Health Science Center, Columbus, OH, USA
    J Neuroimmunol 138:92-8. 2003
  7. ncbi request reprint Photoperiod alters hypothalamic cytokine gene expression and sickness responses following immune challenge in female Siberian hamsters (Phodopus sungorus)
    L M Pyter
    Department of Neuroscience, Institute of Behavioral Medicine Research, 48A Townshend Hall, Ohio State University, Columbus, OH 43210, USA
    Neuroscience 131:779-84. 2005
  8. pmc Localized inflammation in peripheral tissue signals the CNS for sickness response in the absence of interleukin-1 and cyclooxygenase-2 in the blood and brain
    H Zhang
    Institute of Behavior Medicine, 3132 Postle Hall, 305 West 12th Avenue, Ohio State University, Columbus, OH 43210 1094, USA
    Neuroscience 157:895-907. 2008
  9. ncbi request reprint Social stress increases the susceptibility to endotoxic shock
    N Quan
    Section of Oral Biology, The Ohio State University Health Science Center, Columbus, OH 43210, USA
    J Neuroimmunol 115:36-45. 2001
  10. ncbi request reprint IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system
    San Ching
    Department of Oral Biology, Ohio State University, Columbus, OH 43210 1094, USA
    Brain Behav Immun 19:127-37. 2005

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Induction of IkappaBalpha mRNA expression in the brain by glucocorticoids: a negative feedback mechanism for immune-to-brain signaling
    N Quan
    Department of Oral Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 20:6473-7. 2000
    ..Such an inhibitory control mechanism may be important for preventing prolonged expression of proinflammatory cytokines in the brain after peripheral immune challenge...
  2. ncbi request reprint Molecular mechanisms of glucocorticoid resistance in splenocytes of socially stressed male mice
    Ning Quan
    Section of Oral Biology, The Ohio State University Health Science Center, Institute for Behavioral Medicine Research and Neuroscience Graduate Studies Program, The Ohio State University, Columbus, OH 43210, USA
    J Neuroimmunol 137:51-8. 2003
    ..Thus, impaired nuclear translocation of GR and the lack of transcriptional suppression of NF-kappa B by GC were identified as the molecular mechanisms responsible for the observed GC resistance in spleens of socially stressed mice...
  3. ncbi request reprint Endothelial activation is an intermediate step for peripheral lipopolysaccharide induced activation of paraventricular nucleus
    Ning Quan
    Department of Oral Biology, Health Science Center, Ohio State University, Columbus, OH 43210, USA
    Brain Res Bull 59:447-52. 2003
    ..These results show that IL-1 acting on the endothelial cells of the brain, particularly in the PVN, may be an intermediate step relating peripheral immune signals to the brain...
  4. pmc Immune-to-brain signaling: how important are the blood-brain barrier-independent pathways?
    Ning Quan
    Institute of Behavior Medicine, Ohio State University, 4179 Postle Hall, 305 W 12th Ave, Columbus, OH 43210 1094, USA
    Mol Neurobiol 37:142-52. 2008
    ..In addition, I will provide a critical analysis of the literature to point to areas where our knowledge of the immunological afferent signaling to the central nervous system is still sorely lacking...
  5. ncbi request reprint Connecting cytokines and brain: a review of current issues
    N Quan
    Department of Oral Biology, Ohio State University, Columbus 43210, USA
    Histol Histopathol 17:273-88. 2002
    ..These issues will be reviewed not only in isolation, as most of the original reports focused on only one of the questions, but also in parallel such that inter-issue insights may be gained...
  6. ncbi request reprint Intraventricular infusion of antagonists of IL-1 and TNF alpha attenuates neurodegeneration induced by the infection of Trypanosoma brucei
    Ning Quan
    Section of Oral Biology, Ohio State University Health Science Center, Columbus, OH, USA
    J Neuroimmunol 138:92-8. 2003
    ..These results suggest that TNFalpha is a major mediator for trypanosome-induced neurodegeneration although its neurotoxic effects can be augmented by IL-1...
  7. ncbi request reprint Photoperiod alters hypothalamic cytokine gene expression and sickness responses following immune challenge in female Siberian hamsters (Phodopus sungorus)
    L M Pyter
    Department of Neuroscience, Institute of Behavioral Medicine Research, 48A Townshend Hall, Ohio State University, Columbus, OH 43210, USA
    Neuroscience 131:779-84. 2005
    ..These data suggest that differences in cytokine production in the hypothalamus may underlie the photoperiod-induced differences in sickness responses, and that these changes are not mediated by estradiol...
  8. pmc Localized inflammation in peripheral tissue signals the CNS for sickness response in the absence of interleukin-1 and cyclooxygenase-2 in the blood and brain
    H Zhang
    Institute of Behavior Medicine, 3132 Postle Hall, 305 West 12th Avenue, Ohio State University, Columbus, OH 43210 1094, USA
    Neuroscience 157:895-907. 2008
    ..These findings suggest that local inflammation can activate the CNS via pathways distinguishable from those mediating systemic inflammation-induced CNS activation...
  9. ncbi request reprint Social stress increases the susceptibility to endotoxic shock
    N Quan
    Section of Oral Biology, The Ohio State University Health Science Center, Columbus, OH 43210, USA
    J Neuroimmunol 115:36-45. 2001
    ....
  10. ncbi request reprint IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system
    San Ching
    Department of Oral Biology, Ohio State University, Columbus, OH 43210 1094, USA
    Brain Behav Immun 19:127-37. 2005
    ..This did not occur in IL-1R1-knockout mice. Thus, IL-1R1 appears to be important for the recruitment of leukocytes across the blood-brain barrier...
  11. ncbi request reprint Peripheral injection of lipopolysaccharide prevents brain recruitment of leukocytes induced by central injection of interleukin-1
    S Ching
    Department of Oral Biology, Ohio State University, 4161 Postle Hall, 305 West 12th Avenue, Columbus, 43210 1094, USA
    Neuroscience 137:717-26. 2006
    ..These results suggest that systemic inflammation actively inhibits recruitment of leukocytes by CNS. Inhibition of the expression of p- and e-selectins is a mechanism by which peripheral inflammation regulate CNS leukocyte recruitment...
  12. pmc Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen
    Harald Engler
    Section of Oral Biology, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA
    Psychoneuroendocrinology 33:108-17. 2008
    ..These findings suggest that IL-1 plays a critical role in the development of the social stress-associated GC resistance in the murine spleen...
  13. ncbi request reprint Differential expression of extracellular matrix and adhesion molecule genes in the brain of juvenile versus adult mice in responses to intracerebroventricular administration of IL-1
    San Ching
    Department of Oral Biology, Ohio State University, Columbus, Ohio, USA
    Neuroimmunomodulation 14:46-56. 2007
    ..This study compares the differential gene expression patterns of extracellular matrix and adhesion molecules in the brain of juvenile and adult mice...
  14. doi request reprint Masticatory (;superfast') myosin heavy chain and embryonic/atrial myosin light chain 1 in rodent jaw-closing muscles
    Peter J Reiser
    Department of Oral Biology, The Ohio State University, Columbus, OH 43210, USA
    J Exp Biol 212:2511-9. 2009
    ..We conclude that rodent speciation did not completely eliminate masticatory myosin and that its persistent expression in some rodent species might be related to not only diet but also to feeding style...
  15. doi request reprint The myosin light chain 1 isoform associated with masticatory myosin heavy chain in mammals and reptiles is embryonic/atrial MLC1
    Peter J Reiser
    Department of Oral Biology, The Ohio State University, Postle Hall, Box 192, 305 West 12th Avenue, Columbus, OH 43210, USA
    J Exp Biol 213:1633-42. 2010
    ..We conclude that MLC1E/A is the exclusive or predominant MLC1 isoform that is expressed in jaw-closing muscles of vertebrates that express MHC-M, and that a unique masticatory isoform of MLC1 probably does not exist...
  16. pmc Altered expression of circadian rhythm genes among individuals with a history of depression
    Jean Philippe Gouin
    Department of Psychology, The Ohio State University, USA
    J Affect Disord 126:161-6. 2010
    ..The interaction of several circadian clock genes generates these daily circadian rhythms...
  17. pmc Short day lengths attenuate the symptoms of infection in Siberian hamsters
    Staci D Bilbo
    Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218 2686, USA
    Proc Biol Sci 269:447-54. 2002
    ..Taken together, short day lengths attenuated the symptoms of infection, presumably to optimize energy expenditure and survival outcome...
  18. ncbi request reprint Photoperiod alters the time course of brain cyclooxygenase-2 expression in Siberian hamsters
    S D Bilbo
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    J Neuroendocrinol 15:958-64. 2003
    ..We conclude that short photoperiods significantly altered the time course of central COX-2 protein expression in hamsters in a manner consistent with reduced fever duration...
  19. ncbi request reprint Supplementation of N-acetylcysteine normalizes lipopolysaccharide-induced nuclear factor kappaB activation and proinflammatory cytokine production during early rehabilitation of protein malnourished mice
    Jun Li
    Department of Human Nutrition, School of Dentistry, Ohio State University, Columbus, OH 43210, USA
    J Nutr 132:3286-92. 2002
    ....
  20. ncbi request reprint Brain's firewall: blood-brain barrier actively regulates neuroimmune information flow
    Ning Quan
    The Ohio State University, USA
    Brain Behav Immun 20:447-8. 2006
  21. ncbi request reprint Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice
    E Ho
    Department of Human Nutrition, The Ohio State University, Columbus 43210, USA
    Exp Biol Med (Maywood) 226:103-11. 2001
    ..Inhibition of the NFkappaB pathway may prove to be an important criterion for choosing nutritional strategies for Type I diabetes prevention...
  22. pmc Induction of muscle weakness by local inflammation: an experimental animal model
    S Bicer
    Department of Oral Biology, Ohio State University, Columbus, OH 43210 1247, USA
    Inflamm Res 58:175-83. 2009
    ..The objective of this study was to characterize the response of skeletal muscle to a localized inflammation induced by the inflammatory agent casein...
  23. ncbi request reprint Brain-immune communication pathways
    Ning Quan
    Institute of Behavioral Medicine, Ohio State University, USA
    Brain Behav Immun 21:727-35. 2007
    ..These and other pathways have established the existence of a neuroimmune axis, but raise new questions on how they act and interact with one another...
  24. ncbi request reprint Endothelial-specific knockdown of interleukin-1 (IL-1) type 1 receptor differentially alters CNS responses to IL-1 depending on its route of administration
    San Ching
    Department of Oral Biology, Ohio State University, Columbus, Ohio 43210 1094, USA
    J Neurosci 27:10476-86. 2007
    ..These results show that the effects of intravenous and intracerebroventricular IL-1 are mediated by endothelial IL-1R1, whereas the effects of intraperitoneal IL-1 are partially dependent on endothelial IL-1R1...
  25. doi request reprint Living history: Clark M. Blatteis
    Ning Quan
    Department of Oral Biology, Ohio State University, Columbus, OH, USA
    Adv Physiol Educ 33:1-6. 2009
    ..During 2007, the APS Section of Environmental and Exercise Physiology selected Clark M. Blatteis to be profiled in Advances in Physiology Education...
  26. pmc Three Promoters Regulate Tissue- and Cell Type-specific Expression of Murine Interleukin-1 Receptor Type I
    Qun Chen
    Department of Oral Biology, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 284:8703-13. 2009
    ..Further, glucocorticoids differentially regulate these promoters in a cell type-specific manner. Together, these results suggest that the different IL-1R1 promoters contribute to the discrete and diverse actions of IL-1...
  27. pmc Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma
    Sarmila Majumder
    Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    J Biol Chem 277:16048-58. 2002
    ..These data demonstrate suppression of the MT-I gene and probably other genes in a solid tumor by promoter methylation and have provided potential molecular mechanisms for the altered methylation profile of the genes in this tumor...
  28. ncbi request reprint Restraint stress alters the expression of interleukin-1 and keratinocyte growth factor at the wound site: an in situ hybridization study
    Ana M Mercado
    Department of Oral Biology, The Ohio State University, Columbus, OH 43210, USA
    J Neuroimmunol 129:74-83. 2002
    ..Therefore, stress-induced alterations in cutaneous proinflammatory cytokine and growth factor expression are associated with significant histological changes in healing wounds...
  29. ncbi request reprint Impaired wound contraction and delayed myofibroblast differentiation in restraint-stressed mice
    Michael P Horan
    Department of Oral Biology, The Ohio State University, Columbus, OH 43218 2357, USA
    Brain Behav Immun 19:207-16. 2005
    ..Thus, these data indicate that stress delays wound contraction and myofibroblast differentiation, which are likely independent of expression of TGF-beta1, -beta2, and -beta3...
  30. ncbi request reprint Biomechanical signals inhibit IKK activity to attenuate NF-kappaB transcription activity in inflamed chondrocytes
    Anar Dossumbekova
    The Ohio State University, Columbus, OH 43210, USA
    Arthritis Rheum 56:3284-96. 2007
    ..This study was undertaken to examine the intracellular mechanisms by which biomechanical signals suppress proinflammatory gene induction by the interleukin-1-beta (IL-1beta)-induced NF-kappaB signaling cascade in articular chondrocytes...
  31. ncbi request reprint Induced neuronal expression of class I major histocompatibility complex mRNA in acute and chronic inflammation models
    Jane A Foster
    Section on Functional Neuroanatomy, National Institute of Mental Health, 36 Convent Drive, Building 36, Room 2D15, Bethesda, MD 20892 4070, USA
    J Neuroimmunol 131:83-91. 2002
    ..These results demonstrate that neurons can be a source of immune signaling molecules and establish class I MHC as part of the neuronal component of immune responses...
  32. pmc Reduced ingestion of sweetened milk induced by interleukin-1 and lipopolysaccharide is associated with induction of cyclooxygenase-2 in brain endothelia
    Adrian J Dunn
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Neuroimmunomodulation 13:96-104. 2006
    ..These effects of IL-1 and LPS have been shown to be sensitive to inhibitors of cyclooxygenase (COX)...
  33. ncbi request reprint Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation
    Annemarie Ledeboer
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Eur J Neurosci 22:1977-86. 2005
    ..Together, these results demonstrate that spinal cord NF-kappaB activation is involved, at least in part, in exaggerated pain states...

Research Grants12

  1. IL-1R1 promoter complex in the neuroendocrine, nervous, and immune systems
    Ning Quan; Fiscal Year: 2011
    ..The results will provide a foundation for the understanding of how dysregulation of the expression of type 1 interleukin-1 receptor may be involved in the pathogenesis of diseases in multiple systems. ..
  2. IL-1R1 promoter complex in the neuroendocrine, nervous, and immune systems
    Ning Quan; Fiscal Year: 2010
    ..The results will provide a foundation for the understanding of how dysregulation of the expression of type 1 interleukin-1 receptor may be involved in the pathogenesis of diseases in multiple systems. ..
  3. IL-1R1 promoter complex in the neuroendocrine, nervous, and immune systems
    Ning Quan; Fiscal Year: 2009
    ..The results will provide a foundation for the understanding of how dysregulation of the expression of type 1 interleukin-1 receptor may be involved in the pathogenesis of diseases in multiple systems. ..
  4. Neuroimmune Communication at the Blood Brain Barrier
    Ning Quan; Fiscal Year: 2009
    ..The results of this project should provide a definitive analysis to determine the role of endothelial IL-1r1 in several aspects of neuroimmune interaction. ..
  5. Pathophysiology of Neuroimmune Communication
    Ning Quan; Fiscal Year: 2003
    ..The results will also provide critical information regarding the use of anti-inflammatory drugs for the treatment of CNS diseases. ..