Research Topics
Species | Stephen J QualmanSummaryAffiliation: The Ohio State University Country: USA Publications
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Publications
Protocol for the examination of specimens from patients with Wilms tumor (nephroblastoma) or other renal tumors of childhoodStephen J Qualman
Department of Laboratory Medicine, Children's Hospital, Columbus, Ohio 43205, USA
Arch Pathol Lab Med 127:1280-9. 2003- Risk assignment in pediatric soft-tissue sarcomas: an evolving molecular classificationStephen J Qualman
Division of Anatomic Pathology, Department of Laboratory Medicine, Childrens Hospital, 700 Childrens Drive, Columbus, OH 43205, USA
Curr Oncol Rep 4:123-30. 2002..Large clinical cooperative trials involving biologic studies of pediatric soft-tissue sarcomas could facilitate advancement of knowledge in this area of pediatric oncology... - Protocol for the examination of specimens from patients with neuroblastoma and related neuroblastic tumorsStephen J Qualman
Department of Laboratory Medicine, Children's Hospital, Columbus, Ohio, USA
Arch Pathol Lab Med 129:874-83. 2005 - Molecular basis of the brain tumor-polyposis (Turcot) syndromeStephen J Qualman
Department of Laboratory Medicine, Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA
Pediatr Dev Pathol 6:574-6. 2003 - Protocol for the examination of specimens from patients (children and young adults) with rhabdomyosarcomaStephen J Qualman
Department of Laboratory Medicine, Children's Hospital, Columbus, Ohio 43205, USA
Arch Pathol Lab Med 127:1290-7. 2003 - Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cellsChun Liang Chen
Center for Childhood Cancer, Columbus Children s Research Institute and Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
BMC Cancer 7:111. 2007..However, whether constitutive Stat3 signaling plays a role in the survival and growth of osteosarcomas, rhabdomyosarcomas, and soft-tissue sarcomas is still unclear... - NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcomaHuating Wang
Department of Molecular Virology, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
Cancer Cell 14:369-81. 2008..Together, these results identify a NF-kappaB-YY1-miR-29 regulatory circuit whose disruption may contribute to RMS... - Juvenile myelomonocytic leukemia: report of seven cases and review of literatureLatha Urs
Department of Laboratory Medicine, Nationwide Children s Hospital, Columbus, OH 43205, USA
Pediatr Dev Pathol 12:136-42. 2009..Two other cases had extramedullary involvement with symptoms referable to the organs of involvement at presentation. Clinical and pathologic findings are summarized with a review of relevant literature... - The coinheritance of beta- and alpha- thalassemia: a review of one patient and her familyKelley J Mast
Department of Pathology and Laboratory Medicine, Nationwide Children s Hospital, Columbus, Ohio 43205, USA
Lab Hematol 15:30-3. 2009..It also highlights the importance of family studies and close follow-up in diagnosing complex hemoglobinopathies... - Autoimmune lymphoproliferative syndrome (ALPS): a case with congenital onsetSamir B Kahwash
Department of Laboratory Medicine, Columbus Children s Hospital, Columbus, OH 43205, USA
Pediatr Dev Pathol 10:315-9. 2007..The patient underwent bone marrow transplant and is alive and well 20 months after diagnosis... - Phosphorylation profiles of protein kinases in alveolar and embryonal rhabdomyosarcomaLing Cen
Department of Pediatrics, Center for Childhood Cancer, Columbus Children s Research Institute, The Ohio State University, Columbus, OH 43205, USA
Mod Pathol 20:936-46. 2007..These protein kinases may play roles in the development or tumor progression of rhabdomyosarcomas and thus may serve as novel targets for therapeutic intervention... - Suppression of tumorigenicity in neuroblastoma cells by upregulation of human vasoactive intestinal peptide receptor type 1Douglas A Balster
Department of Pathology, The Ohio State University, Columbus, OH 43205, USA
Regul Pept 109:155-65. 2002..Taken together, these data support the hypothesis that VIP modulation of neural crest differentiation is mediated via VPAC1 and that high expression of VPAC1 induces differentiation in and decreases tumorigenicity of neuroblastoma cells... - Protocol for the examination of specimens from patients with soft tissue tumors of intermediate malignant potential, malignant soft tissue tumors, and benign/locally aggressive and malignant bone tumorsBrian P Rubin
Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
Arch Pathol Lab Med 130:1616-29. 2006 - PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology groupPoul H B Sorensen
Department of Pathology, Children s and Women s Hospital of British Columbia, Vancouver, British Columbia, Canada
J Clin Oncol 20:2672-9. 2002..We wished to confirm the diagnostic specificity of gene fusion detection in a large cohort of RMS patients and to evaluate whether these alterations influence clinical outcome in ARMS... - Sclerosing rhabdomyosarcomas in children and adolescents: a clinicopathologic review of 13 cases from the Intergroup Rhabdomyosarcoma Study Group and Children's Oncology GroupMelissa C Chiles
Department of Pathology, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Slot 820, 800 Marshall Street, Little Rock, AR 72202, USA
Pediatr Dev Pathol 7:583-94. 2004..Sclerosing RMS may arise in children, have mixed ERMS-ARMS histology, originate from the head and neck, and lack strong myogenin staining... - Cyclophosphamide dose intensification during induction therapy for intermediate-risk pediatric rhabdomyosarcoma is feasible but does not improve outcome: a report from the soft tissue sarcoma committee of the children's oncology groupSheri L Spunt
St Jude Children s Research Hospital and University of Tennessee College of Medicine, Memphis, Tennessee 38105 2794, USA
Clin Cancer Res 10:6072-9. 2004..More than half of pediatric rhabdomyosarcoma cases have intermediate-risk features and suboptimal outcome (3-year failure-free survival estimates, 55 to 76%). Dose intensification of known active agents may improve outcome... - Results of treatment of fifty-six patients with localized retroperitoneal and pelvic rhabdomyosarcoma: a report from The Intergroup Rhabdomyosarcoma Study-IV, 1991-1997R Beverly Raney
Department of Clinical Pediatrics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Pediatr Blood Cancer 42:618-25. 2004..We reviewed 56 IRS-IV patients with localized rhabdomyosarcoma [RMS] of the retroperitoneum/pelvis to assess outcome and prognostic factors, including the value of initially excising >or=50% of the tumor (debulking) before chemotherapy... - The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescenceCorinne M Linardic
Department of Pediatrics, Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
Cancer Res 67:6691-9. 2007..We surmise that the generation of the PAX3-FKHR fusion protein may require loss of p16(INK4A) to promote malignant proliferation of skeletal muscle cells as an early step in ARMS tumorigenesis... - Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's Oncology GroupDavid M Parham
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Am J Surg Pathol 31:895-901. 2007..No features seemed to predict the presence of a particular fusion type. Our results suggest that histologic assessment of ARMS has limited correlation with PAX/FKHR fusion status... - Protocol for the examination of specimens from pediatric patients with hepatoblastomaMilton J Finegold
Department of Pathology, Texas Children's Cancer Center at Baylor College, Houston, USA
Arch Pathol Lab Med 131:520-9. 2007 - Assessment of response to induction therapy and its influence on 5-year failure-free survival in group III rhabdomyosarcoma: the Intergroup Rhabdomyosarcoma Study-IV experience--a report from the Soft Tissue Sarcoma Committee of the Children's Oncology GrMegan Burke
Children s Hospital Cleveland Clinic, Cleveland, USA
J Clin Oncol 25:4909-13. 2007..For Intergroup Rhabdomyosarcoma Study (IRS) IV patients with group III rhabdomyosarcoma, we assessed whether reported response assessed by anatomic imaging at week 8 predicted FFS... - Embryonal rhabdomyosarcoma with a der(16)t(1;16) translocationKayla M Kapels
Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
Cancer Genet Cytogenet 174:68-73. 2007..These results suggest that the unbalanced t(1;16) translocation may be seen in RMSs lacking a primary genetic rearrangement... - An immunohistochemical algorithm to facilitate diagnosis and subtyping of rhabdomyosarcoma: the Children's Oncology Group experienceRaffaella A Morotti
Department of Pathology, Mount Sinai School of Medicine, New York, USA
Am J Surg Pathol 30:962-8. 2006..Their differential expression in reactive myogenic lesions, variability in ARMS versus ERMS, and absence in undifferentiated sarcomas suggest new biologic questions to be explored in future studies... - Examination of gene fusion status in archival samples of alveolar rhabdomyosarcoma entered on the Intergroup Rhabdomyosarcoma Study-III trial: a report from the Children's Oncology GroupFrederic G Barr
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6100, USA
J Mol Diagn 8:202-8. 2006.... - Treatment of children and adolescents with localized parameningeal sarcoma: experience of the Intergroup Rhabdomyosarcoma Study Group protocols IRS-II through -IV, 1978-1997Richard Beverly Raney
Department of Clinical Pediatrics, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Med Pediatr Oncol 38:22-32. 2002..We reviewed 611 patients with parameningeal sarcoma entered on Intergroup Rhabdomyosarcoma Study Group (IRSG) Protocols-II through IV (1978-1997), to delineate treatment results and evaluate prognostic factors... - Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusionsFrederic G Barr
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Res 62:4704-10. 2002.... - Children from ethnic minorities have benefited equally as other children from contemporary therapy for rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study GroupK Scott Baker
University of Minnesota, Minneapolis, MN, USA
J Clin Oncol 20:4428-33. 2002..To define the clinical characteristics of rhabdomyosarcoma (RMS) occurring in children from ethnic minorities and determine whether these children have benefited equally from advances in therapy... - Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma--a report from the Intergroup Rhabdomyosarcoma Study IVJohn C Breneman
Children s Hospital Medical Center, Division of Radiation Oncology, Cincinnati, OH 45219 0757, USA
J Clin Oncol 21:78-84. 2003..To identify risk factors associated with outcomes in children with metastatic rhabdomyosarcoma (RMS) treated on the fourth Intergroup Rhabdomyosarcoma Study (IRS-IV)... - Treatment of localized nonorbital, nonparameningeal head and neck rhabdomyosarcoma: lessons learned from intergroup rhabdomyosarcoma studies III and IVAlberto S Pappo
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
J Clin Oncol 21:638-45. 2003..The characteristics and clinical outcomes of children and adolescents with localized nonorbital, nonparameningeal head and neck rhabdomyosarcoma (RMS) treated on national protocols from the Intergroup Rhabdomyosarcoma Group are reported... - Recognition of Crohn disease on incidental gastric biopsy in childhoodJudy Mae Pascasio
Department of Pathology and Laboratory Medicine, St. Christopher's Hospital for Children, Front Street at Erie Avenue, Philadelphia, PA 19134, USA
Pediatr Dev Pathol 6:209-14. 2003..Gastric biopsy can be used to identify or support the diagnosis of CD in children in the appropriate clinicopathologic setting... - Efficacy of topotecan and cyclophosphamide given in a phase II window trial in children with newly diagnosed metastatic rhabdomyosarcoma: a Children's Oncology Group studyDavid O Walterhouse
Hematology Oncology, Children s Memorial Medical Center, 2300 Children s Plaza, Box 30, Chicago, IL 60614, USA
J Clin Oncol 22:1398-403. 2004.... - Sclerosing rhabdomyosarcomas in children and adolescents: a clinicopathologic review of 13 cases from the Intergroup Rhabdomyosarcoma Study Group and Children's Oncology GroupMelissa C Chiles
Department of Pathology and Pediatrics, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Slot 820, 800 Marshall Street, Little Rock, AR 72202, USA
Pediatr Dev Pathol 8:141. 2005 - Protocol for the examination of specimens from pediatric and adult patients with osseous and extraosseous ewing sarcoma family of tumors, including peripheral primitive neuroectodermal tumor and ewing sarcomaDavid F Carpentieri
Department of Pathology, Phoenix Children's Hospital, Phoenix, Ariz, USA
Arch Pathol Lab Med 129:866-73. 2005 - Rhabdomyosarcomas utilize developmental, myogenic growth factors for disease advantage: a report from the Children's Oncology GroupMary C Blandford
Department of Pediatrics, Division of Pediatric Hematology-Oncology, University of Utah, Salt Lake City, USA
Pediatr Blood Cancer 46:329-38. 2006..Dual blockade of these growth-factor-signaling pathways may be a valuable strategy in preclinical therapeutic studies... - Use of a novel FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of alveolar rhabdomyosarcomaJun Nishio
Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, 68198-3135, USA
Lab Invest 86:547-56. 2006..The findings also suggest that FISH may be a more sensitive assay than RT-PCR in some settings, capable of revealing variant translocations... - Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypesJulia A Bridge
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
Genes Chromosomes Cancer 33:310-21. 2002....
Research Grants
- PEDIATRIC CHTN--AIDS CANCER RESEARCHStephen Qualman; Fiscal Year: 2007..fs20\par \par } ..