Stephen J Qualman

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Establishing a tumour bank: banking, informatics and ethics
    S J Qualman
    Columbus Children s Hospital, 700 Children s Drive, Columbus, OH 43205, USA
    Br J Cancer 90:1115-9. 2004
  2. ncbi request reprint Protocol for the examination of specimens from patients with Wilms tumor (nephroblastoma) or other renal tumors of childhood
    Stephen J Qualman
    Department of Laboratory Medicine, Children s Hospital, Columbus, Ohio 43205, USA
    Arch Pathol Lab Med 127:1280-9. 2003
  3. ncbi request reprint Molecular basis of the brain tumor-polyposis (Turcot) syndrome
    Stephen J Qualman
    Department of Laboratory Medicine, Children s Hospital, 700 Children s Drive, Columbus, OH 43205, USA
    Pediatr Dev Pathol 6:574-6. 2003
  4. ncbi request reprint Protocol for the examination of specimens from patients (children and young adults) with rhabdomyosarcoma
    Stephen J Qualman
    Department of Laboratory Medicine, Children s Hospital, Columbus, Ohio 43205, USA
    Arch Pathol Lab Med 127:1290-7. 2003
  5. ncbi request reprint Protocol for the examination of specimens from patients with neuroblastoma and related neuroblastic tumors
    Stephen J Qualman
    Department of Laboratory Medicine, Children s Hospital, Columbus, Ohio, USA
    Arch Pathol Lab Med 129:874-83. 2005
  6. ncbi request reprint Risk assignment in pediatric soft-tissue sarcomas: an evolving molecular classification
    Stephen J Qualman
    Division of Anatomic Pathology, Department of Laboratory Medicine, Children s Hospital, 700 Children s Drive, Columbus, OH 43205, USA
    Curr Oncol Rep 4:123-30. 2002
  7. pmc Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells
    Chun Liang Chen
    Center for Childhood Cancer, Columbus Children s Research Institute and Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    BMC Cancer 7:111. 2007
  8. doi request reprint Juvenile myelomonocytic leukemia: report of seven cases and review of literature
    Latha Urs
    Department of Laboratory Medicine, Nationwide Children s Hospital, Columbus, OH 43205, USA
    Pediatr Dev Pathol 12:136-42. 2009
  9. pmc NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma
    Huating Wang
    Department of Molecular Virology, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 14:369-81. 2008
  10. doi request reprint The coinheritance of beta- and alpha- thalassemia: a review of one patient and her family
    Kelley J Mast
    Department of Pathology and Laboratory Medicine, Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Lab Hematol 15:30-3. 2009

Research Grants

  1. PEDIATRIC CHTN--AIDS CANCER RESEARCH
    Stephen Qualman; Fiscal Year: 2007

Collaborators

Detail Information

Publications37

  1. pmc Establishing a tumour bank: banking, informatics and ethics
    S J Qualman
    Columbus Children s Hospital, 700 Children s Drive, Columbus, OH 43205, USA
    Br J Cancer 90:1115-9. 2004
    ..Increasing molecular genetics testing is also resulting in an increased demand for high-quality nucleic acids...
  2. ncbi request reprint Protocol for the examination of specimens from patients with Wilms tumor (nephroblastoma) or other renal tumors of childhood
    Stephen J Qualman
    Department of Laboratory Medicine, Children s Hospital, Columbus, Ohio 43205, USA
    Arch Pathol Lab Med 127:1280-9. 2003
  3. ncbi request reprint Molecular basis of the brain tumor-polyposis (Turcot) syndrome
    Stephen J Qualman
    Department of Laboratory Medicine, Children s Hospital, 700 Children s Drive, Columbus, OH 43205, USA
    Pediatr Dev Pathol 6:574-6. 2003
  4. ncbi request reprint Protocol for the examination of specimens from patients (children and young adults) with rhabdomyosarcoma
    Stephen J Qualman
    Department of Laboratory Medicine, Children s Hospital, Columbus, Ohio 43205, USA
    Arch Pathol Lab Med 127:1290-7. 2003
  5. ncbi request reprint Protocol for the examination of specimens from patients with neuroblastoma and related neuroblastic tumors
    Stephen J Qualman
    Department of Laboratory Medicine, Children s Hospital, Columbus, Ohio, USA
    Arch Pathol Lab Med 129:874-83. 2005
  6. ncbi request reprint Risk assignment in pediatric soft-tissue sarcomas: an evolving molecular classification
    Stephen J Qualman
    Division of Anatomic Pathology, Department of Laboratory Medicine, Children s Hospital, 700 Children s Drive, Columbus, OH 43205, USA
    Curr Oncol Rep 4:123-30. 2002
    ..Large clinical cooperative trials involving biologic studies of pediatric soft-tissue sarcomas could facilitate advancement of knowledge in this area of pediatric oncology...
  7. pmc Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells
    Chun Liang Chen
    Center for Childhood Cancer, Columbus Children s Research Institute and Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
    BMC Cancer 7:111. 2007
    ..However, whether constitutive Stat3 signaling plays a role in the survival and growth of osteosarcomas, rhabdomyosarcomas, and soft-tissue sarcomas is still unclear...
  8. doi request reprint Juvenile myelomonocytic leukemia: report of seven cases and review of literature
    Latha Urs
    Department of Laboratory Medicine, Nationwide Children s Hospital, Columbus, OH 43205, USA
    Pediatr Dev Pathol 12:136-42. 2009
    ..Two other cases had extramedullary involvement with symptoms referable to the organs of involvement at presentation. Clinical and pathologic findings are summarized with a review of relevant literature...
  9. pmc NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma
    Huating Wang
    Department of Molecular Virology, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA
    Cancer Cell 14:369-81. 2008
    ..Together, these results identify a NF-kappaB-YY1-miR-29 regulatory circuit whose disruption may contribute to RMS...
  10. doi request reprint The coinheritance of beta- and alpha- thalassemia: a review of one patient and her family
    Kelley J Mast
    Department of Pathology and Laboratory Medicine, Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Lab Hematol 15:30-3. 2009
    ..It also highlights the importance of family studies and close follow-up in diagnosing complex hemoglobinopathies...
  11. ncbi request reprint Phosphorylation profiles of protein kinases in alveolar and embryonal rhabdomyosarcoma
    Ling Cen
    Department of Pediatrics, Center for Childhood Cancer, Columbus Children s Research Institute, The Ohio State University, Columbus, OH 43205, USA
    Mod Pathol 20:936-46. 2007
    ..These protein kinases may play roles in the development or tumor progression of rhabdomyosarcomas and thus may serve as novel targets for therapeutic intervention...
  12. ncbi request reprint Autoimmune lymphoproliferative syndrome (ALPS): a case with congenital onset
    Samir B Kahwash
    Department of Laboratory Medicine, Columbus Children s Hospital, Columbus, OH 43205, USA
    Pediatr Dev Pathol 10:315-9. 2007
    ..The patient underwent bone marrow transplant and is alive and well 20 months after diagnosis...
  13. ncbi request reprint Suppression of tumorigenicity in neuroblastoma cells by upregulation of human vasoactive intestinal peptide receptor type 1
    Douglas A Balster
    Department of Pathology, The Ohio State University, Columbus, OH 43205, USA
    Regul Pept 109:155-65. 2002
    ..Taken together, these data support the hypothesis that VIP modulation of neural crest differentiation is mediated via VPAC1 and that high expression of VPAC1 induces differentiation in and decreases tumorigenicity of neuroblastoma cells...
  14. ncbi request reprint Protocol for the examination of specimens from patients with soft tissue tumors of intermediate malignant potential, malignant soft tissue tumors, and benign/locally aggressive and malignant bone tumors
    Brian P Rubin
    Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    Arch Pathol Lab Med 130:1616-29. 2006
  15. ncbi request reprint PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group
    Poul H B Sorensen
    Department of Pathology, Children s and Women s Hospital of British Columbia, Vancouver, British Columbia, Canada
    J Clin Oncol 20:2672-9. 2002
    ..We wished to confirm the diagnostic specificity of gene fusion detection in a large cohort of RMS patients and to evaluate whether these alterations influence clinical outcome in ARMS...
  16. ncbi request reprint Sclerosing rhabdomyosarcomas in children and adolescents: a clinicopathologic review of 13 cases from the Intergroup Rhabdomyosarcoma Study Group and Children's Oncology Group
    Melissa C Chiles
    Department of Pathology, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Slot 820, 800 Marshall Street, Little Rock, AR 72202, USA
    Pediatr Dev Pathol 7:583-94. 2004
    ..Sclerosing RMS may arise in children, have mixed ERMS-ARMS histology, originate from the head and neck, and lack strong myogenin staining...
  17. ncbi request reprint Cyclophosphamide dose intensification during induction therapy for intermediate-risk pediatric rhabdomyosarcoma is feasible but does not improve outcome: a report from the soft tissue sarcoma committee of the children's oncology group
    Sheri L Spunt
    St Jude Children s Research Hospital and University of Tennessee College of Medicine, Memphis, Tennessee 38105 2794, USA
    Clin Cancer Res 10:6072-9. 2004
    ..More than half of pediatric rhabdomyosarcoma cases have intermediate-risk features and suboptimal outcome (3-year failure-free survival estimates, 55 to 76%). Dose intensification of known active agents may improve outcome...
  18. ncbi request reprint Results of treatment of fifty-six patients with localized retroperitoneal and pelvic rhabdomyosarcoma: a report from The Intergroup Rhabdomyosarcoma Study-IV, 1991-1997
    R Beverly Raney
    Department of Clinical Pediatrics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Pediatr Blood Cancer 42:618-25. 2004
    ..We reviewed 56 IRS-IV patients with localized rhabdomyosarcoma [RMS] of the retroperitoneum/pelvis to assess outcome and prognostic factors, including the value of initially excising >or=50% of the tumor (debulking) before chemotherapy...
  19. ncbi request reprint The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence
    Corinne M Linardic
    Department of Pediatrics, Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Res 67:6691-9. 2007
    ..We surmise that the generation of the PAX3-FKHR fusion protein may require loss of p16(INK4A) to promote malignant proliferation of skeletal muscle cells as an early step in ARMS tumorigenesis...
  20. ncbi request reprint Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group
    David M Parham
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Am J Surg Pathol 31:895-901. 2007
    ..No features seemed to predict the presence of a particular fusion type. Our results suggest that histologic assessment of ARMS has limited correlation with PAX/FKHR fusion status...
  21. ncbi request reprint Protocol for the examination of specimens from pediatric patients with hepatoblastoma
    Milton J Finegold
    Department of Pathology, Texas Children s Cancer Center at Baylor College, Houston, USA
    Arch Pathol Lab Med 131:520-9. 2007
  22. ncbi request reprint Assessment of response to induction therapy and its influence on 5-year failure-free survival in group III rhabdomyosarcoma: the Intergroup Rhabdomyosarcoma Study-IV experience--a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Gr
    Megan Burke
    Children s Hospital Cleveland Clinic, Cleveland, USA
    J Clin Oncol 25:4909-13. 2007
    ..For Intergroup Rhabdomyosarcoma Study (IRS) IV patients with group III rhabdomyosarcoma, we assessed whether reported response assessed by anatomic imaging at week 8 predicted FFS...
  23. ncbi request reprint Embryonal rhabdomyosarcoma with a der(16)t(1;16) translocation
    Kayla M Kapels
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Cancer Genet Cytogenet 174:68-73. 2007
    ..These results suggest that the unbalanced t(1;16) translocation may be seen in RMSs lacking a primary genetic rearrangement...
  24. ncbi request reprint An immunohistochemical algorithm to facilitate diagnosis and subtyping of rhabdomyosarcoma: the Children's Oncology Group experience
    Raffaella A Morotti
    Department of Pathology, Mount Sinai School of Medicine, New York, USA
    Am J Surg Pathol 30:962-8. 2006
    ..Their differential expression in reactive myogenic lesions, variability in ARMS versus ERMS, and absence in undifferentiated sarcomas suggest new biologic questions to be explored in future studies...
  25. pmc Examination of gene fusion status in archival samples of alveolar rhabdomyosarcoma entered on the Intergroup Rhabdomyosarcoma Study-III trial: a report from the Children's Oncology Group
    Frederic G Barr
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6100, USA
    J Mol Diagn 8:202-8. 2006
    ....
  26. ncbi request reprint Treatment of children and adolescents with localized parameningeal sarcoma: experience of the Intergroup Rhabdomyosarcoma Study Group protocols IRS-II through -IV, 1978-1997
    Richard Beverly Raney
    Department of Clinical Pediatrics, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Med Pediatr Oncol 38:22-32. 2002
    ..We reviewed 611 patients with parameningeal sarcoma entered on Intergroup Rhabdomyosarcoma Study Group (IRSG) Protocols-II through IV (1978-1997), to delineate treatment results and evaluate prognostic factors...
  27. ncbi request reprint Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions
    Frederic G Barr
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 62:4704-10. 2002
    ....
  28. ncbi request reprint Children from ethnic minorities have benefited equally as other children from contemporary therapy for rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study Group
    K Scott Baker
    University of Minnesota, Minneapolis, MN, USA
    J Clin Oncol 20:4428-33. 2002
    ..To define the clinical characteristics of rhabdomyosarcoma (RMS) occurring in children from ethnic minorities and determine whether these children have benefited equally from advances in therapy...
  29. ncbi request reprint Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma--a report from the Intergroup Rhabdomyosarcoma Study IV
    John C Breneman
    Children s Hospital Medical Center, Division of Radiation Oncology, Cincinnati, OH 45219 0757, USA
    J Clin Oncol 21:78-84. 2003
    ..To identify risk factors associated with outcomes in children with metastatic rhabdomyosarcoma (RMS) treated on the fourth Intergroup Rhabdomyosarcoma Study (IRS-IV)...
  30. ncbi request reprint Treatment of localized nonorbital, nonparameningeal head and neck rhabdomyosarcoma: lessons learned from intergroup rhabdomyosarcoma studies III and IV
    Alberto S Pappo
    Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
    J Clin Oncol 21:638-45. 2003
    ..The characteristics and clinical outcomes of children and adolescents with localized nonorbital, nonparameningeal head and neck rhabdomyosarcoma (RMS) treated on national protocols from the Intergroup Rhabdomyosarcoma Group are reported...
  31. ncbi request reprint Recognition of Crohn disease on incidental gastric biopsy in childhood
    Judy Mae Pascasio
    Department of Pathology and Laboratory Medicine, St Christopher s Hospital For Children, Front Street at Erie Avenue, Philadelphia, PA 19134, USA
    Pediatr Dev Pathol 6:209-14. 2003
    ..Gastric biopsy can be used to identify or support the diagnosis of CD in children in the appropriate clinicopathologic setting...
  32. ncbi request reprint Efficacy of topotecan and cyclophosphamide given in a phase II window trial in children with newly diagnosed metastatic rhabdomyosarcoma: a Children's Oncology Group study
    David O Walterhouse
    Hematology Oncology, Children s Memorial Medical Center, 2300 Children s Plaza, Box 30, Chicago, IL 60614, USA
    J Clin Oncol 22:1398-403. 2004
    ....
  33. ncbi request reprint Sclerosing rhabdomyosarcomas in children and adolescents: a clinicopathologic review of 13 cases from the Intergroup Rhabdomyosarcoma Study Group and Children's Oncology Group
    Melissa C Chiles
    Department of Pathology and Pediatrics, Arkansas Children s Hospital and University of Arkansas for Medical Sciences, Slot 820, 800 Marshall Street, Little Rock, AR 72202, USA
    Pediatr Dev Pathol 8:141. 2005
  34. ncbi request reprint Protocol for the examination of specimens from pediatric and adult patients with osseous and extraosseous ewing sarcoma family of tumors, including peripheral primitive neuroectodermal tumor and ewing sarcoma
    David F Carpentieri
    Department of Pathology, Phoenix Children s Hospital, Phoenix, Ariz, USA
    Arch Pathol Lab Med 129:866-73. 2005
  35. ncbi request reprint Rhabdomyosarcomas utilize developmental, myogenic growth factors for disease advantage: a report from the Children's Oncology Group
    Mary C Blandford
    Department of Pediatrics, Division of Pediatric Hematology Oncology, University of Utah, Salt Lake City, USA
    Pediatr Blood Cancer 46:329-38. 2006
    ..Unresectable or metastatic disease represents the greatest obstacle to cure for children with rhabdomyosarcoma. In this study we sought to identify gene expression signatures of advanced stage and progressive disease...
  36. ncbi request reprint Use of a novel FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of alveolar rhabdomyosarcoma
    Jun Nishio
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 983135 Nebraska Medical Center, Omaha, 68198 3135, USA
    Lab Invest 86:547-56. 2006
    ..The findings also suggest that FISH may be a more sensitive assay than RT-PCR in some settings, capable of revealing variant translocations...
  37. ncbi request reprint Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes
    Julia A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Genes Chromosomes Cancer 33:310-21. 2002
    ....

Research Grants1

  1. PEDIATRIC CHTN--AIDS CANCER RESEARCH
    Stephen Qualman; Fiscal Year: 2007
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