BRENDA PORTER

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint Disorders of cortical development and epilepsy
    Brenda E Porter
    Division of Child Neurology, Children s Hospital of Philadelphia, Wood Bldg 6th Floor, Philadelphia, PA 19104, USA
    Arch Neurol 59:361-5. 2002
  2. ncbi request reprint Dysplasia: a common finding in intractable pediatric temporal lobe epilepsy
    B E Porter
    Pediatric Regional Epilepsy Program, Children s Hospital of Philadelphia, and Department of Pediatrics and Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neurology 61:365-8. 2003
  3. ncbi request reprint Fate of newborn dentate granule cells after early life status epilepticus
    Brenda E Porter
    Division of Pediatric Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 45:13-9. 2004
  4. ncbi request reprint Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients
    Brenda E Porter
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Neurobiol Dis 18:484-91. 2005
  5. pmc Neurogenesis and epilepsy in the developing brain
    Brenda E Porter
    The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 49:50-4. 2008
  6. pmc The role of transcription factors cyclic-AMP responsive element modulator (CREM) and inducible cyclic-AMP early repressor (ICER) in epileptogenesis
    B E Porter
    Department of Pediatrics, The Children Hospital of Philadelphia at the University of Pennsylvania, 502C Abramson, 3516 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Neuroscience 152:829-36. 2008
  7. ncbi request reprint Increased GABA(A)-receptor alpha1-subunit expression in hippocampal dentate gyrus after early-life status epilepticus
    YogendraSinh H Raol
    Division of Neurology, Pediatric Regional Epilepsy Program, Children s Hospital of Philadelphia, Philapelphia, Pennsylvania, USA
    Epilepsia 47:1665-73. 2006
  8. pmc Seizures increase cell proliferation in the dentate gyrus by shortening progenitor cell-cycle length
    Florence P Varodayan
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Epilepsia 50:2638-47. 2009
  9. pmc Interictal EEG spikes identify the region of electrographic seizure onset in some, but not all, pediatric epilepsy patients
    Eric D Marsh
    Division of Child Neurology, Department of Neurology and Pediatrics, Children s Hospital of Philadelphia, The University of Pennsylvania, Philadelphia, PA 19104, USA
    Epilepsia 51:592-601. 2010
  10. pmc Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure
    Paulette A McRae
    Division of Neurology, Department of Pediatrics at the Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Neurobiol Dis 39:439-48. 2010

Research Grants

  1. CRE Mediated Transcription in Epileptogenesis
    Brenda E Porter; Fiscal Year: 2010
  2. Neurogenesis in Pediatric Temporal Lobe Epilepsy
    BRENDA PORTER; Fiscal Year: 2007

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Disorders of cortical development and epilepsy
    Brenda E Porter
    Division of Child Neurology, Children s Hospital of Philadelphia, Wood Bldg 6th Floor, Philadelphia, PA 19104, USA
    Arch Neurol 59:361-5. 2002
    ..In the future, strategies for blocking formation of the aberrant networks may prevent the development of epilepsy...
  2. ncbi request reprint Dysplasia: a common finding in intractable pediatric temporal lobe epilepsy
    B E Porter
    Pediatric Regional Epilepsy Program, Children s Hospital of Philadelphia, and Department of Pediatrics and Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neurology 61:365-8. 2003
    ..Pre-existing cortical dysplasia (CD) may also predispose to refractory TLE, independent of other risk factors for epilepsy...
  3. ncbi request reprint Fate of newborn dentate granule cells after early life status epilepticus
    Brenda E Porter
    Division of Pediatric Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 45:13-9. 2004
    ..To determine the fate of newborn dentate granule cells (DGCs) after lithium-pilocarpine-induced status epilepticus (SE) in an immature rat...
  4. ncbi request reprint Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients
    Brenda E Porter
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Neurobiol Dis 18:484-91. 2005
    ..Patient-specific GABAAR expression might contribute to variability in anti-epileptic drug efficacy, side-effect profiles, and seizure susceptibility...
  5. pmc Neurogenesis and epilepsy in the developing brain
    Brenda E Porter
    The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 49:50-4. 2008
    ..Future studies need to focus on how these changes in neurogenesis influence dentate gyrus function and what they imply for epileptogenesis and learning and memory impairments, so commonly found in children with temporal lobe epilepsy...
  6. pmc The role of transcription factors cyclic-AMP responsive element modulator (CREM) and inducible cyclic-AMP early repressor (ICER) in epileptogenesis
    B E Porter
    Department of Pediatrics, The Children Hospital of Philadelphia at the University of Pennsylvania, 502C Abramson, 3516 Civic Center Boulevard, Philadelphia, PA 19104, USA
    Neuroscience 152:829-36. 2008
    ..Together these data suggest that the increase in ICER mRNA following SE may have a role in suppressing the severity of epilepsy...
  7. ncbi request reprint Increased GABA(A)-receptor alpha1-subunit expression in hippocampal dentate gyrus after early-life status epilepticus
    YogendraSinh H Raol
    Division of Neurology, Pediatric Regional Epilepsy Program, Children s Hospital of Philadelphia, Philapelphia, Pennsylvania, USA
    Epilepsia 47:1665-73. 2006
    ..In the present study, we examined GABRA1 expression after SE at postnatal day 20 (P20), an intermediate age when only a subset of SE-exposed animals develop epilepsy...
  8. pmc Seizures increase cell proliferation in the dentate gyrus by shortening progenitor cell-cycle length
    Florence P Varodayan
    Division of Neurology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Epilepsia 50:2638-47. 2009
    ..Molecular mechanisms that regulate normal and pathologic cell birth in the dentate gyrus are poorly understood...
  9. pmc Interictal EEG spikes identify the region of electrographic seizure onset in some, but not all, pediatric epilepsy patients
    Eric D Marsh
    Division of Child Neurology, Department of Neurology and Pediatrics, Children s Hospital of Philadelphia, The University of Pennsylvania, Philadelphia, PA 19104, USA
    Epilepsia 51:592-601. 2010
    ..Indeed, past studies suggest an inconsistent relationship between IED and seizure-onset location, although these studies were based upon relatively short EEG epochs...
  10. pmc Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure
    Paulette A McRae
    Division of Neurology, Department of Pediatrics at the Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Neurobiol Dis 39:439-48. 2010
    ..This study shows the dynamic nature of the PN component of the ECM and the role neuronal activity has in molding the extracellular milieu of inhibitory interneurons...
  11. ncbi request reprint Seizures and antiepileptic drugs: does exposure alter normal brain development?
    Eric D Marsh
    Division of Child Neurology and Pediatric Regional Epilepsy Program, Children s Hospital of Philadelphia, and Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 47:1999-2010. 2006
    ..More research, both clinical and experimental, is needed before changes in current clinical practice, based on the scientific data, can be recommended...
  12. ncbi request reprint Status epilepticus differentially alters AMPA and kainate receptor subunit expression in mature and immature dentate granule neurons
    Brenda E Porter
    The Children s Hospital of Philadelphia, PA, USA
    Eur J Neurosci 23:2857-63. 2006
    ....
  13. ncbi request reprint Comparison of novel computer detectors and human performance for spike detection in intracranial EEG
    Merritt W Brown
    Division of Child Neurology, Children s Hospital of Philadelphia, and Department of Neurology and Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Neurophysiol 118:1744-52. 2007
    ..Accurate automated spike detectors are necessary for understanding the role of spikes in epileptogenesis...
  14. pmc Topiramate and adrenocorticotropic hormone (ACTH) as initial treatment for infantile spasms
    Bradley Peltzer
    Division of Neurology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Child Neurol 24:400-5. 2009
    ..Of the 19 patients treated with topiramate, 4 patients eventually, though over a period of 0, 1, 8, or 69 months, had resolution of spasms and hypsarrhythmia...

Research Grants4

  1. CRE Mediated Transcription in Epileptogenesis
    Brenda E Porter; Fiscal Year: 2010
    ..We will determine if blocking the increase in the regulatory proteins protects the animals from the development of epilepsy. In addition we will determine which genes these proteins regulate in epilepsy. ..
  2. Neurogenesis in Pediatric Temporal Lobe Epilepsy
    BRENDA PORTER; Fiscal Year: 2007
    ..The studies proposed will take place in the laboratories of Drs. Douglas Coulter and Amy Brooks-Kayal, at The Children's Hospital of Philadelphia. This Award will facilitate my goal of a career in academic medicine. ..