- Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific mannerDaniel L Popkin
Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Cell Host Microbe 9:212-22. 2011..These results support in vivo targeting of Mbtps1 in the treatment of arenavirus infections and demonstrate a critical role for dendritic cells in persistent viral infections...
- Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infectionAmanda L Blasius
Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
PLoS Pathog 8:e1002915. 2012..Ultimately, infection persisted in feeble mice. We conclude that pDCs are likely required for efficient T cell priming and subsequent viral clearance. Our data suggest that reduced pDC functionality may lead to chronic infection...
- Expanded potential for recombinant trisegmented lymphocytic choriomeningitis viruses: protein production, antibody production, and in vivo assessment of biological function of genes of interestDaniel L Popkin
The Scripps Research Institute, Department of Immunology and Microbial Sciences IMM 6, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
J Virol 85:7928-32. 2011..These findings demonstrate the utility of tripartite LCMV in vitro and in vivo to study genes in the context of a well-defined model system...