Kenneth Pollard

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Proteolytic cleavage of a self-antigen following xenobiotic-induced cell death produces a fragment with novel immunogenic properties
    K M Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 165:2263-70. 2000
  2. ncbi request reprint Interferon-γ and systemic autoimmunity
    Kenneth M Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Discov Med 16:123-31. 2013
  3. pmc Requirements for innate immune pathways in environmentally induced autoimmunity
    KENNETH MICHAEL POLLARD
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    BMC Med 11:100. 2013
  4. pmc Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity
    K Michael Pollard
    Department of Molecular and Experimental Medicine, MEM125, Scripps Research Institute, La Jolla, CA 92037, USA
    J Autoimmun 39:323-31. 2012
  5. pmc Gender differences in autoimmunity associated with exposure to environmental factors
    K Michael Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, United States
    J Autoimmun 38:J177-86. 2012
  6. pmc β2-microglobulin is required for the full expression of xenobiotic-induced systemic autoimmunity
    Kenneth M Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunotoxicol 8:228-37. 2011
  7. pmc Lupus-prone mice as models to study xenobiotic-induced acceleration of systemic autoimmunity
    K M Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Environ Health Perspect 107:729-35. 1999
  8. ncbi request reprint Immunology and genetics of induced systemic autoimmunity
    K Michael Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM131, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Autoimmun Rev 4:282-8. 2005
  9. ncbi request reprint Costimulation requirements of induced murine systemic autoimmune disease
    K Michael Pollard
    Department of Molecular and Experimental Medicine, The Scripps Institute, La Jolla, CA 92037, USA
    J Immunol 173:5880-7. 2004
  10. ncbi request reprint Using single-gene deletions to identify checkpoints in the progression of systemic autoimmunity
    K Michael Pollard
    Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Ann N Y Acad Sci 987:236-9. 2003

Research Grants

  1. Role of Daf in Systemic Autoimmunity
    KENNETH MICHAEL POLLARD; Fiscal Year: 2010
  2. IMMUNOTOXICOLOGY OF A HEAVY METAL
    Kenneth Pollard; Fiscal Year: 2002
  3. XENOBIOTIC ACCELERATION OF AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2003
  4. IMMUNOTOXICOLOGY OF A HEAVY METAL
    Kenneth Pollard; Fiscal Year: 2003
  5. IMMUNOTOXICOLOGY OF A HEAVY METAL
    Kenneth Pollard; Fiscal Year: 2004
  6. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2004
  7. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2005
  8. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2006
  9. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2007
  10. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2007

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Proteolytic cleavage of a self-antigen following xenobiotic-induced cell death produces a fragment with novel immunogenic properties
    K M Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 165:2263-70. 2000
    ..We propose that cell death following exposure to an autoimmunity-inducing xenobiotic can lead to the generation of novel protein fragments that may serve as sources of antigenic determinants for self-reactive T lymphocytes...
  2. ncbi request reprint Interferon-γ and systemic autoimmunity
    Kenneth M Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Discov Med 16:123-31. 2013
    ..The multifaceted nature of IFN-γ in adaptive immunity identifies numerous possible therapeutic targets that, because of the essential contribution of IFN-γ to systemic autoimmunity, have the potential for producing benefits. ..
  3. pmc Requirements for innate immune pathways in environmentally induced autoimmunity
    KENNETH MICHAEL POLLARD
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    BMC Med 11:100. 2013
    ..Greater understanding of the innate mechanisms responsible for idiopathic and environmentally induced autoimmunity should yield new information into the processes that instigate and drive systemic autoimmunity...
  4. pmc Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity
    K Michael Pollard
    Department of Molecular and Experimental Medicine, MEM125, Scripps Research Institute, La Jolla, CA 92037, USA
    J Autoimmun 39:323-31. 2012
    ..These findings have implications for the therapeutic targeting of IFN-γ pathways in systemic autoimmunity...
  5. pmc Gender differences in autoimmunity associated with exposure to environmental factors
    K Michael Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, United States
    J Autoimmun 38:J177-86. 2012
    ..Understanding how the environment influences the relationship between sex chromosome complement and innate and adaptive immune responses will be essential in determining the role of gender in environmentally-induced autoimmunity...
  6. pmc β2-microglobulin is required for the full expression of xenobiotic-induced systemic autoimmunity
    Kenneth M Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunotoxicol 8:228-37. 2011
    ..These findings demonstrate how a single genetic alteration can partially but significantly modify the clinical manifestations of systemic autoimmunity induced by exposure to xenobiotics...
  7. pmc Lupus-prone mice as models to study xenobiotic-induced acceleration of systemic autoimmunity
    K M Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Environ Health Perspect 107:729-35. 1999
    ....
  8. ncbi request reprint Immunology and genetics of induced systemic autoimmunity
    K Michael Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM131, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Autoimmun Rev 4:282-8. 2005
    ....
  9. ncbi request reprint Costimulation requirements of induced murine systemic autoimmune disease
    K Michael Pollard
    Department of Molecular and Experimental Medicine, The Scripps Institute, La Jolla, CA 92037, USA
    J Immunol 173:5880-7. 2004
    ..These findings indicate that breaking of self-tolerance in mHgIA requires signaling via both the CD28/B7 and CD40/CD40L pathways...
  10. ncbi request reprint Using single-gene deletions to identify checkpoints in the progression of systemic autoimmunity
    K Michael Pollard
    Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Ann N Y Acad Sci 987:236-9. 2003
    ..Thus, these genes may be part of the downstream events following IFN-gamma/IFN-gamma receptor interaction that promote the development of autoimmunity...
  11. pmc Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone bxsb mice
    K M Pollard
    W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92337, USA
    Environ Health Perspect 109:27-33. 2001
    ....
  12. ncbi request reprint The in vitro proliferation of murine lymphocytes to mercuric chloride is restricted to mature T cells and is interleukin 1 dependent
    K M Pollard
    W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Int Immunopharmacol 1:581-93. 2001
    ..The requirement for mature T cells, adherent cells, and co-stimulatory molecules argues that HgCl2-induced T cell proliferation possesses the properties of an antigen-induced response...
  13. pmc Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
    Dwight H Kono
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:12061-6. 2009
    ..Importantly, this helps provide an explanation for the high frequency of anti-nucleic acid Abs in lupus-like systemic autoimmunity...
  14. ncbi request reprint Reduced expression of decay-accelerating factor 1 on CD4+ T cells in murine systemic autoimmune disease
    David M Cauvi
    W M Keck Autoimmune Disease Center, The Scripps Research Institute, La Jolla, California, USA
    Arthritis Rheum 56:1934-44. 2007
    ..The aim of this study was to determine whether Daf1 expression on T cells is modulated during development of autoimmunity in mice...
  15. pmc Constitutive expression of murine decay-accelerating factor 1 is controlled by the transcription factor Sp1
    David M Cauvi
    Department of Molecular and Experimental Medicine, W M Keck Autoimmune Disease Center, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 177:3837-47. 2006
    ..These findings provide new information on the regulation of the mouse Daf1 promoter and will facilitate further studies on the expression of Daf1 during immune responses...
  16. pmc Toxicology of autoimmune diseases
    K Michael Pollard
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, 92037, USA
    Chem Res Toxicol 23:455-66. 2010
    ..Although a number of different pathways have been delineated for drug/chemical-induced autoimmunity, some similarities do exist, and a working model is proposed...
  17. ncbi request reprint Human scleroderma sera contain autoantibodies to protein components specific to the U3 small nucleolar RNP complex
    Jian Ming Yang
    The Scripps Research Institute, La Jolla, California 92037, USA
    Arthritis Rheum 48:210-7. 2003
    ..To determine whether antifibrillarin autoantibodies in scleroderma patients are associated with autoantibodies to protein components specific for U3 small nucleolar RNP (U3 snoRNP)...

Research Grants26

  1. Role of Daf in Systemic Autoimmunity
    KENNETH MICHAEL POLLARD; Fiscal Year: 2010
    ..This project will use gene therapy to determine if increasing the level of expression of Daf1 in autoimmune prone mice offers a defense against autoimmunity. ..
  2. IMMUNOTOXICOLOGY OF A HEAVY METAL
    Kenneth Pollard; Fiscal Year: 2002
    ..Analysis of the interaction between fibrillarin, mercury and cells of the lymphoid system may lead to insights into how an imunotoxin renders self-antigen immunogenic. ..
  3. XENOBIOTIC ACCELERATION OF AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2003
    ..abstract_text> ..
  4. IMMUNOTOXICOLOGY OF A HEAVY METAL
    Kenneth Pollard; Fiscal Year: 2003
    ..Analysis of the interaction between fibrillarin, mercury and cells of the lymphoid system may lead to insights into how an imunotoxin renders self-antigen immunogenic. ..
  5. IMMUNOTOXICOLOGY OF A HEAVY METAL
    Kenneth Pollard; Fiscal Year: 2004
    ..Analysis of the interaction between fibrillarin, mercury and cells of the lymphoid system may lead to insights into how an imunotoxin renders self-antigen immunogenic. ..
  6. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2004
    ..Identification of the role that IFN-gamma plays in the development of induced murine systemic autoimmunity should prove applicable to murine models of idiopathic systemic autoimmunity and to human lupus. ..
  7. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2005
    ..Identification of the role that IFN-gamma plays in the development of induced murine systemic autoimmunity should prove applicable to murine models of idiopathic systemic autoimmunity and to human lupus. ..
  8. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2006
    ..Identification of the role that IFN-gamma plays in the development of induced murine systemic autoimmunity should prove applicable to murine models of idiopathic systemic autoimmunity and to human lupus. ..
  9. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2007
    ..Identification of the role that IFN-gamma plays in the development of induced murine systemic autoimmunity should prove applicable to murine models of idiopathic systemic autoimmunity and to human lupus. ..
  10. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2007
    ..Identification of the role that IFN-gamma plays in the development of induced murine systemic autoimmunity should prove applicable to murine models of idiopathic systemic autoimmunity and to human lupus. ..
  11. Role of Daf in Systemic Autoimmunity
    Kenneth Pollard; Fiscal Year: 2009
    ..This project will use gene therapy to determine if increasing the level of expression of Daf1 in autoimmune prone mice offers a defense against autoimmunity. ..
  12. XENOBIOTIC ACCELERATION OF AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2002
    ..abstract_text> ..
  13. XENOBIOTIC ACCELERATION OF AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2001
    ..abstract_text> ..
  14. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 1999
    ....
  15. XENOBIOTIC ACCELERATION OF AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2000
    ..abstract_text> ..
  16. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2000
    ....
  17. BECTON DICKINSON FACS CALIBUR 4 COLOR WITH SORT UNIT
    Kenneth Pollard; Fiscal Year: 2001
    ..Flow cytometry will be used to select and sort cell populations prior to and after transplantation studies. ..
  18. MERCURY INDUCED AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2001
    ....
  19. IMMUNOTOXICOLOGY OF A HEAVY METAL
    Kenneth Pollard; Fiscal Year: 2001
    ..Analysis of the interaction between fibrillarin, mercury and cells of the lymphoid system may lead to insights into how an imunotoxin renders self-antigen immunogenic. ..
  20. XENOBIOTIC ACCELERATION OF AUTOIMMUNITY
    Kenneth Pollard; Fiscal Year: 2000
    ..abstract_text> ..