Research Topics
| J PiSummaryAffiliation: The Hamner Institutes for Health Sciences Country: USA Publications
Research Grants
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Detail Information
Publications
Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndromePeng Xue
Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
Diabetes 62:845-54. 2013..Our findings support a novel role for Nrf2 in regulating adipose development and function, by which Nrf2 controls the capacity of WAT expansion and insulin sensitivity and maintains glucose and lipid homeostasis...- The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panelQian Liu
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
BMC Med Genomics 3:37. 2010..A comprehensive study examining the mechanisms and potential signaling pathways contributing to the anti-tumor properties of arsenic trioxide has not been carried out... - ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell functionJingbo Pi
Division of Translational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 244:77-83. 2010..In addition, we summarized our recent findings that persistent oxidative stress due to absence of uncoupling protein 2 activates cellular adaptive response which is associated with impaired pancreatic beta-cell function... - Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell functionJingbo Pi
Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
Endocrinology 150:3040-8. 2009..These data show that the chronic absence of UCP2 causes oxidative stress, including in islets, and is accompanied by impaired glucose-stimulated insulin secretion... - Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2Jingbo Pi
Laboratory of Comparative Carcinogenesis, NCI at NIEHS, NIH, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 45:651-8. 2008.... - Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesityJingbo Pi
Department of Laboratory Medicine and Pathology, University of California, Irvine, California 92697, USA
J Biol Chem 285:9292-300. 2010.... 
Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acidJingbo Pi
Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 226:236-43. 2008..Taken together, we provide direct evidence that HOCl activates Nrf2-mediated antioxidant response, which protects cells from oxidative damage...- Reactive oxygen species as a signal in glucose-stimulated insulin secretionJingbo Pi
Endocrine Biology Program, The Hamner Institutes for Health Sciences, 6 Davis Dr, Research Triangle Park, NC 27709, USA
Diabetes 56:1783-91. 2007..Taken together, these findings suggest that H2O2 derived from glucose metabolism is one of the metabolic signals for insulin secretion, whereas oxidative stress may disturb its signaling function... 
Reactive oxygen species and uncoupling protein 2 in pancreatic β-cell functionJ Pi
Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
Diabetes Obes Metab 12:141-8. 2010..This review will focus on the paradoxical roles of ROS in pancreatic β-cell function and the regulatory role of UCP2 in ROS signalling and GSIS...- Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient miceFatiha Moukdar
The Endocrine Biology Program, Division of Translational Biology, The Hamner Institutes for Health Sciences, NC 27709, USA
J Lipid Res 50:59-70. 2009..These data establish that in the vasculature UCP2 functions as an adaptive antioxidant defense to protect against the development of atherosclerosis in response to a fat and cholesterol diet... - Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxideJingbo Pi
Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
Exp Cell Res 290:234-45. 2003..Taken together, these data clearly show that arsenic increases Nrf2 expression and activity at multiple levels and that H(2)O(2) is one of the mediators of this process... - A systems biology perspective on Nrf2-mediated antioxidant responseQiang Zhang
Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 244:84-97. 2010..Our analysis highlights some possible adverse effects of these widely consumed antioxidants... - Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophagesCourtney G Woods
Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 238:27-36. 2009..These findings confirm an Nrf2-centric mechanism of action of HOCl in mouse macrophages and provide evidence of interactions between Nrf2, inflammatory, and other stress pathways... - Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responsesQiang Zhang
Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
Toxicol Appl Pharmacol 237:345-56. 2009..Feedforward control, often operating in combination with negative feedback regulation in a homeostatic system, may be a general control theme responsible for steady-state hormesis... - Identification of Nrf2-dependent airway epithelial adaptive response to proinflammatory oxidant-hypochlorous acid challenge by transcription profilingLingxiang Zhu
Division of Translational Biology, The Hamner Institutes for Health Sciences, 6 Davis Dr, Research Triangle Park, NC 27709, USA
Am J Physiol Lung Cell Mol Physiol 294:L469-77. 2008..By both methods, we conclude that Nrf2 directly protects airway epithelial cells from HOCl-induced toxicity... - Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stressJingqi Fu
Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 118:864-70. 2010..Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a central transcription factor regulating cellular adaptive response to oxidative stress... - Prolonged exposure to insulin suppresses mitochondrial production in primary hepatocytesHui Yu Liu
Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 284:14087-95. 2009..Together, our results show prolonged exposure of isolated hepatocytes to insulin suppresses mitochondrial production and function through the classical Akt-dependent insulin signaling pathway... - Cadmium-induced malignant transformation in rat liver cells: role of aberrant oncogene expression and minimal role of oxidative stressWei Qu
Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Int J Cancer 114:346-55. 2005.... - Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5'-AMP-activated protein kinaseQu Fan Collins
Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 282:30143-9. 2007..Together, our results demonstrate an inhibitory role for EGCG in hepatic gluconeogenesis and shed new light on the mechanism by which EGCG suppresses gluconeogenesis... - Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistanceY Y He
Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Oncogene 25:3680-8. 2006..Further comparisons between the transformed ULTH and control cells should lead to a better understanding of the mechanism of UVA carcinogenesis and may help identify biomarkers for UVA-induced skin malignancies... - Acute stimulation of white adipocyte respiration by PKA-induced lipolysisEinav Yehuda-Shnaidman
Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
Diabetes 59:2474-83. 2010..We examined the effect of β-adrenergic receptor (βAR) activation and cAMP-elevating agents on respiration and mitochondrial uncoupling in human adipocytes and probed the underlying molecular mechanisms... - Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential role in skin co-carcinogenesisJingbo Pi
Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
Int J Cancer 116:20-6. 2005..The observation that As-TL cells show no lessening of UV-induced genotoxicity supports this possibility... - Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesisYang Sun
Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Reasearch Triangle Park, NC 27709, USA
Toxicology 262:162-70. 2009.... - Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2Jingbo Pi
Laboratory of Comparative Carcinogenesis, NCI at NIEHS, NIH, Research Triangle Park, NC 27709, USA
Free Radic Biol Med 42:1797-806. 2007..In contrast, Nrf2-118 is more susceptible to degradation. These results provide evidence for phosphorylation by CK2 as a critical controlling factor in Nrf2-mediated cellular antioxidant response... - Urinary arsenic speciation and its correlation with 8-OHdG in Chinese residents exposed to arsenic through coal burningXin Li
Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110001, China
Bull Environ Contam Toxicol 81:406-11. 2008.... - Molecular basis for arsenic-induced alteration in nitric oxide production and oxidative stress: implication of endothelial dysfunctionYoshito Kumagai
Department of Environmental Medicine, Institute of Community Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
Toxicol Appl Pharmacol 198:450-7. 2004.... - Decreased enzyme activity of hepatic thioredoxin reductase and glutathione reductase in rabbits by prolonged exposure to inorganic arsenateMasatoshi Nikaido
Master's Program in Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan
Environ Toxicol 18:306-11. 2003.... - A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbitsJingbo Pi
Graduate School Doctoral Program in Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
Free Radic Biol Med 35:102-13. 2003..produced from endothelial NOS, such that enhanced free radicals are produced at the expense of NO... - Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking waterJingbo Pi
Graduate School Doctoral Program in Medical Sciences, University of Tsukuba, Ibaraki, Japan
Environ Health Perspect 110:331-6. 2002..Some possible mechanisms for the arsenic-induced oxidative stress are discussed...
Research Grants
- Paradoxical roles of Nrf2 activation in arsenic-induced beta-cell dysfunctionJingbo Pi; Fiscal Year: 2009..The results may enable new therapeutic managements and preventive strategies for arsenic or other environmental oxidative stress-associated diabetes. ..
- Paradoxical roles of Nrf2 activation in arsenic-induced beta-cell dysfunctionJingbo Pi; Fiscal Year: 2010..The results may enable new therapeutic managements and preventive strategies for arsenic or other environmental oxidative stress-associated diabetes. ..