J Pi

Summary

Affiliation: The Hamner Institutes for Health Sciences
Country: USA

Publications

  1. pmc Association between arsenic suppression of adipogenesis and induction of CHOP10 via the endoplasmic reticulum stress response
    Yongyong Hou
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 121:237-43. 2013
  2. pmc Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes
    Rui Zhao
    School of Forensic Medicine, China Medical University, Shenyang, China
    Environ Health Perspect 120:583-9. 2012
  3. pmc Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes
    Rui Zhao
    School of Forensic Medicine, China Medical University, Shenyang, China
    Environ Health Perspect 119:56-62. 2011
  4. pmc Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome
    Peng Xue
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Diabetes 62:845-54. 2013
  5. pmc The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel
    Qian Liu
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    BMC Med Genomics 3:37. 2010
  6. doi request reprint Reactive oxygen species and uncoupling protein 2 in pancreatic β-cell function
    J Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Diabetes Obes Metab 12:141-8. 2010
  7. pmc Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity
    Jingbo Pi
    Department of Laboratory Medicine and Pathology, University of California, Irvine, California 92697, USA
    J Biol Chem 285:9292-300. 2010
  8. pmc ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function
    Jingbo Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 244:77-83. 2010
  9. pmc Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function
    Jingbo Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 150:3040-8. 2009
  10. pmc Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2
    Jingbo Pi
    Laboratory of Comparative Carcinogenesis, NCI at NIEHS, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 45:651-8. 2008

Collaborators

Detail Information

Publications32

  1. pmc Association between arsenic suppression of adipogenesis and induction of CHOP10 via the endoplasmic reticulum stress response
    Yongyong Hou
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 121:237-43. 2013
    ..However, the mechanisms for the diabetogenic effect of iAs are still largely unknown. White adipose tissue (WAT) actively stores and releases energy and maintains lipid and glucose homeostasis...
  2. pmc Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes
    Rui Zhao
    School of Forensic Medicine, China Medical University, Shenyang, China
    Environ Health Perspect 120:583-9. 2012
    ..Human exposure to inorganic arsenic, a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer...
  3. pmc Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes
    Rui Zhao
    School of Forensic Medicine, China Medical University, Shenyang, China
    Environ Health Perspect 119:56-62. 2011
    ..Nuclear factor-erythroid 2-related factor 1 (NRF1, also called NFE2L1) plays a critical role in regulating the expression of many antioxidant response element (ARE)-dependent genes...
  4. pmc Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome
    Peng Xue
    Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Diabetes 62:845-54. 2013
    ..Our findings support a novel role for Nrf2 in regulating adipose development and function, by which Nrf2 controls the capacity of WAT expansion and insulin sensitivity and maintains glucose and lipid homeostasis...
  5. pmc The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel
    Qian Liu
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    BMC Med Genomics 3:37. 2010
    ..A comprehensive study examining the mechanisms and potential signaling pathways contributing to the anti-tumor properties of arsenic trioxide has not been carried out...
  6. doi request reprint Reactive oxygen species and uncoupling protein 2 in pancreatic β-cell function
    J Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Diabetes Obes Metab 12:141-8. 2010
    ..This review will focus on the paradoxical roles of ROS in pancreatic β-cell function and the regulatory role of UCP2 in ROS signalling and GSIS...
  7. pmc Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity
    Jingbo Pi
    Department of Laboratory Medicine and Pathology, University of California, Irvine, California 92697, USA
    J Biol Chem 285:9292-300. 2010
    ....
  8. pmc ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function
    Jingbo Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 244:77-83. 2010
    ..In addition, we summarized our recent findings that persistent oxidative stress due to absence of uncoupling protein 2 activates cellular adaptive response which is associated with impaired pancreatic beta-cell function...
  9. pmc Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function
    Jingbo Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 150:3040-8. 2009
    ..These data show that the chronic absence of UCP2 causes oxidative stress, including in islets, and is accompanied by impaired glucose-stimulated insulin secretion...
  10. pmc Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2
    Jingbo Pi
    Laboratory of Comparative Carcinogenesis, NCI at NIEHS, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 45:651-8. 2008
    ....
  11. ncbi request reprint Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid
    Jingbo Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 226:236-43. 2008
    ..Taken together, we provide direct evidence that HOCl activates Nrf2-mediated antioxidant response, which protects cells from oxidative damage...
  12. ncbi request reprint Reactive oxygen species as a signal in glucose-stimulated insulin secretion
    Jingbo Pi
    Endocrine Biology Program, The Hamner Institutes for Health Sciences, 6 Davis Dr, Research Triangle Park, NC 27709, USA
    Diabetes 56:1783-91. 2007
    ..Taken together, these findings suggest that H2O2 derived from glucose metabolism is one of the metabolic signals for insulin secretion, whereas oxidative stress may disturb its signaling function...
  13. doi request reprint Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice
    Fatiha Moukdar
    The Endocrine Biology Program, Division of Translational Biology, The Hamner Institutes for Health Sciences, NC 27709, USA
    J Lipid Res 50:59-70. 2009
    ..These data establish that in the vasculature UCP2 functions as an adaptive antioxidant defense to protect against the development of atherosclerosis in response to a fat and cholesterol diet...
  14. ncbi request reprint Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide
    Jingbo Pi
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Exp Cell Res 290:234-45. 2003
    ..Taken together, these data clearly show that arsenic increases Nrf2 expression and activity at multiple levels and that H(2)O(2) is one of the mediators of this process...
  15. ncbi request reprint Identification of Nrf2-dependent airway epithelial adaptive response to proinflammatory oxidant-hypochlorous acid challenge by transcription profiling
    Lingxiang Zhu
    Division of Translational Biology, The Hamner Institutes for Health Sciences, 6 Davis Dr, Research Triangle Park, NC 27709, USA
    Am J Physiol Lung Cell Mol Physiol 294:L469-77. 2008
    ..By both methods, we conclude that Nrf2 directly protects airway epithelial cells from HOCl-induced toxicity...
  16. pmc A systems biology perspective on Nrf2-mediated antioxidant response
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 244:84-97. 2010
    ..Our analysis highlights some possible adverse effects of these widely consumed antioxidants...
  17. pmc Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages
    Courtney G Woods
    Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 238:27-36. 2009
    ..These findings confirm an Nrf2-centric mechanism of action of HOCl in mouse macrophages and provide evidence of interactions between Nrf2, inflammatory, and other stress pathways...
  18. pmc Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses
    Qiang Zhang
    Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 237:345-56. 2009
    ..Feedforward control, often operating in combination with negative feedback regulation in a homeostatic system, may be a general control theme responsible for steady-state hormesis...
  19. pmc Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5'-AMP-activated protein kinase
    Qu Fan Collins
    Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 282:30143-9. 2007
    ..Together, our results demonstrate an inhibitory role for EGCG in hepatic gluconeogenesis and shed new light on the mechanism by which EGCG suppresses gluconeogenesis...
  20. pmc Prolonged exposure to insulin suppresses mitochondrial production in primary hepatocytes
    Hui Yu Liu
    Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 284:14087-95. 2009
    ..Together, our results show prolonged exposure of isolated hepatocytes to insulin suppresses mitochondrial production and function through the classical Akt-dependent insulin signaling pathway...
  21. ncbi request reprint Cadmium-induced malignant transformation in rat liver cells: role of aberrant oncogene expression and minimal role of oxidative stress
    Wei Qu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Int J Cancer 114:346-55. 2005
    ....
  22. pmc Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress
    Jingqi Fu
    Division of Translational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 118:864-70. 2010
    ..Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a central transcription factor regulating cellular adaptive response to oxidative stress...
  23. ncbi request reprint Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance
    Y Y He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Oncogene 25:3680-8. 2006
    ..Further comparisons between the transformed ULTH and control cells should lead to a better understanding of the mechanism of UVA carcinogenesis and may help identify biomarkers for UVA-induced skin malignancies...
  24. pmc Acute stimulation of white adipocyte respiration by PKA-induced lipolysis
    Einav Yehuda-Shnaidman
    Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA
    Diabetes 59:2474-83. 2010
    ..We examined the effect of β-adrenergic receptor (βAR) activation and cAMP-elevating agents on respiration and mitochondrial uncoupling in human adipocytes and probed the underlying molecular mechanisms...
  25. ncbi request reprint Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential role in skin co-carcinogenesis
    Jingbo Pi
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Int J Cancer 116:20-6. 2005
    ..The observation that As-TL cells show no lessening of UV-induced genotoxicity supports this possibility...
  26. pmc Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis
    Yang Sun
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Reasearch Triangle Park, NC 27709, USA
    Toxicology 262:162-70. 2009
    ....
  27. pmc Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2
    Jingbo Pi
    Laboratory of Comparative Carcinogenesis, NCI at NIEHS, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 42:1797-806. 2007
    ..In contrast, Nrf2-118 is more susceptible to degradation. These results provide evidence for phosphorylation by CK2 as a critical controlling factor in Nrf2-mediated cellular antioxidant response...
  28. doi request reprint Urinary arsenic speciation and its correlation with 8-OHdG in Chinese residents exposed to arsenic through coal burning
    Xin Li
    Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110001, China
    Bull Environ Contam Toxicol 81:406-11. 2008
    ....
  29. ncbi request reprint Molecular basis for arsenic-induced alteration in nitric oxide production and oxidative stress: implication of endothelial dysfunction
    Yoshito Kumagai
    Department of Environmental Medicine, Institute of Community Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Toxicol Appl Pharmacol 198:450-7. 2004
    ....
  30. ncbi request reprint Decreased enzyme activity of hepatic thioredoxin reductase and glutathione reductase in rabbits by prolonged exposure to inorganic arsenate
    Masatoshi Nikaido
    Master s Program in Environmental Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Environ Toxicol 18:306-11. 2003
    ....
  31. ncbi request reprint A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits
    Jingbo Pi
    Graduate School Doctoral Program in Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Free Radic Biol Med 35:102-13. 2003
    ..produced from endothelial NOS, such that enhanced free radicals are produced at the expense of NO...
  32. pmc Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water
    Jingbo Pi
    Graduate School Doctoral Program in Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Environ Health Perspect 110:331-6. 2002
    ..Some possible mechanisms for the arsenic-induced oxidative stress are discussed...

Research Grants4

  1. Paradoxical roles of Nrf2 activation in arsenic-induced beta-cell dysfunction
    Jingbo Pi; Fiscal Year: 2009
    ..The results may enable new therapeutic managements and preventive strategies for arsenic or other environmental oxidative stress-associated diabetes. ..
  2. Paradoxical roles of Nrf2 activation in arsenic-induced beta-cell dysfunction
    Jingbo Pi; Fiscal Year: 2010
    ..The results may enable new therapeutic managements and preventive strategies for arsenic or other environmental oxidative stress-associated diabetes. ..