Research Topics
Species | Andrew J PhippsSummaryAffiliation: The Ohio State University Country: USA Publications
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Detail Information
Publications
Rabbit and nonhuman primate models of toxin-targeting human anthrax vaccinesAndrew J Phipps
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210 1093, USA
Microbiol Mol Biol Rev 68:617-29. 2004..The ongoing evaluation of human anthrax vaccines will be dependent on animal efficacy data in the absence of human efficacy data for licensure by the U.S. Food and Drug Administration...- Human T-lymphotropic virus type 1 mitochondrion-localizing protein p13(II) is required for viral infectivity in vivoHajime Hiraragi
Center for Retrovirus Research and Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
J Virol 80:3469-76. 2006..Our data are the first to indicate that the HTLV-1 mitochondrion-localizing protein p13(II) has an essential biological role during the early phase of virus infection in vivo... - Early spatial and temporal events of human T-lymphotropic virus type 1 spread following blood-borne transmission in a rabbit model of infectionRashade A H Haynes
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
J Virol 84:5124-30. 2010..Our data support emerging evidence that HTLV-1 promotes lymphocyte proliferation preceding early viral spread in lymphoid compartments to establish and maintain persistent infection... - Cyclosporine-induced immune suppression alters establishment of HTLV-1 infection in a rabbit modelRashade A H Haynes
Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus, USA
Blood 115:815-23. 2010..Collectively, these data indicate immunologic control is a key determinant of early HTLV-1 spread and have important implications for therapeutic intervention during HTLV-1-associated diseases... - Development of a cytotoxic T-cell assay in rabbits to evaluate early immune response to human T-lymphotropic virus type 1 infectionRashade A H Haynes
Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210 1093, USA
Viral Immunol 22:397-405. 2009..Our data suggest that during the early weeks following infection, HTLV-1-specific CTL responses are primarily targeted against Env-SU... - In vivo analysis of replication and immunogenicity of proviral clones of human T-lymphotropic virus type 1 with selective envelope surface-unit mutationsLee R Silverman
Center for Retrovirus Research and Department of Veterinary Biosciences, the Center for Biostatistics, The Ohio State University, Columbus, 43210, USA
Blood 106:3602-8. 2005..Our data are the first to demonstrate that mutations in critical determinants of HTLV-1 Env SU altered antibody responses and proviral loads, but do not prevent viral replication in vivo... 
Examination of Bacillus anthracis spores by multiparameter flow cytometryWilliam C Schumacher
The Department of Chemistry, Ohio State University, Columbus, OH, USA
Methods Mol Biol 739:37-48. 2011..In this chapter, we describe a two-color flow cytometric assay capable of simultaneously identifying B. anthracis spores and the presence of spore-associated protective antigen, a virulence marker for strains harboring the pXO1 plasmid...- Complement protein C3 binding to Bacillus anthracis spores enhances phagocytosis by human macrophagesChristopher Premanandan
Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210 1093, USA
Microb Pathog 46:306-14. 2009..However, surface-bound IgG does initiate the classical pathway of complement activation, which is active in the lung, resulting in deposition of the opsonin C3b on the spore surface... 
Human T-lymphotropic virus type-1 p30 alters cell cycle G2 regulation of T lymphocytes to enhance cell survivalAntara Datta
Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA
Retrovirology 4:49. 2007....
Quantitative measurement of anthrax toxin receptor messenger RNA in primary mononuclear phagocytesChristopher Premanandan
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210-1093, USA
Microb Pathog 41:193-8. 2006..Our results indicate that CMG2 transcripts are preferentially expressed over TEM8 transcripts in primary human and mouse macrophages as compared to immortalized cell lines...- Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1Joshua Arnold
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA
Blood 107:3976-82. 2006..This study demonstrates that retroviruses use negative-strand-encoded proteins in the establishment of chronic viral infections... - Identification and characterization of Bacillus anthracis spores by multiparameter flow cytometryWilliam C Schumacher
Department of Chemistry, Ohio State University, Columbus, Ohio 43210, USA
Appl Environ Microbiol 74:5220-3. 2008..anthracis spores and the presence of spore-associated protective antigen, a virulence marker for strains harboring the pXO1 plasmid... - Human T-cell lymphotropic virus type 1 open reading frame II-encoded p30II is required for in vivo replication: evidence of in vivo reversionLee R Silverman
Center for Retrovirus Research and Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
J Virol 78:3837-45. 2004..Our data provide evidence that HTLV-1 must maintain its key accessory genes to survive in vivo and that in vivo pressures select for maintenance of wild-type ORF II gene products during the early course of infection...