Stefan Pfuhler

Summary

Affiliation: The Procter and Gamble Company
Country: USA

Publications

  1. ncbi request reprint Effects of the formaldehyde releasing preservatives dimethylol urea and diazolidinyl urea in several short-term genotoxicity tests
    Stefan Pfuhler
    Abteilung Pharmakologie und Toxikologie der Universität Ulm, Albert Einstein Allee 11 N26 428, D 89069, Ulm, Germany
    Mutat Res 514:133-46. 2002
  2. ncbi request reprint The in vivo comet assay: use and status in genotoxicity testing
    Susanne Brendler-Schwaab
    Federal Institute for Drugs and Medical Devices, Bonn, Germany
    Mutagenesis 20:245-54. 2005
  3. ncbi request reprint Genotoxicty and mutagenicity
    Daniela Maurici
    ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, 21020 Ispra VA, Italy
    Altern Lab Anim 33:117-30. 2005
  4. ncbi request reprint How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop
    David Kirkland
    Covance Laboratories Ltd, Otley Road, Harrogate HG3 1PY, UK
    Mutat Res 628:31-55. 2007
  5. ncbi request reprint Genetic toxicity assessment: employing the best science for human safety evaluation part IV: Recommendation of a working group of the Gesellschaft fuer Umwelt-Mutationsforschung (GUM) for a simple and straightforward approach to genotoxicity testing
    Stefan Pfuhler
    P and G Prestige and Professional, Cosmital SA, Experimental Product Safety, Marly, Switzerland
    Toxicol Sci 97:237-40. 2007
  6. ncbi request reprint The Cosmetics Europe strategy for animal-free genotoxicity testing: project status up-date
    S Pfuhler
    Procter and Gamble Co, 1 Procter and Gamble Plz, Cincinnati, OH, USA Electronic address
    Toxicol In Vitro 28:18-23. 2014
  7. doi request reprint Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities-Report from an ECVAM workshop
    Stefan Pfuhler
    Procter and Gamble, Cosmital SA, CH 1723 Marly, Switzerland
    Mutat Res 680:31-42. 2009
  8. ncbi request reprint A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: genotoxicity. A COLIPA analysis
    Stefan Pfuhler
    Procter and Gamble, Miami Valley Laboratories, Cincinnati, OH 45253, USA
    Regul Toxicol Pharmacol 57:315-24. 2010
  9. ncbi request reprint N-acetylation of three aromatic amine hair dye precursor molecules eliminates their genotoxic potential
    Andreas Zeller
    The Procter and Gamble Co, Cosmital SA, Route de Chésalles 21, 1723 Marly, Switzerland
    Mutagenesis 29:37-48. 2014
  10. pmc ECVAM retrospective validation of in vitro micronucleus test (MNT)
    Raffaella Corvi
    European Centre for the Validation of Alternative Methods, Institute for Health and Consumer Protection IHCP, European Commission Joint Research Centre JRC, Ispra, VA, Italy
    Mutagenesis 23:271-83. 2008

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Effects of the formaldehyde releasing preservatives dimethylol urea and diazolidinyl urea in several short-term genotoxicity tests
    Stefan Pfuhler
    Abteilung Pharmakologie und Toxikologie der Universität Ulm, Albert Einstein Allee 11 N26 428, D 89069, Ulm, Germany
    Mutat Res 514:133-46. 2002
    ..On account of these data and because of the widespread use of these two compounds in various products used in daily life, a reevaluation of the risk associated with these compounds seems to be necessary...
  2. ncbi request reprint The in vivo comet assay: use and status in genotoxicity testing
    Susanne Brendler-Schwaab
    Federal Institute for Drugs and Medical Devices, Bonn, Germany
    Mutagenesis 20:245-54. 2005
    ..Such findings will have practical consequences in the risk assessment processes and further development of substances...
  3. ncbi request reprint Genotoxicty and mutagenicity
    Daniela Maurici
    ECVAM, Institute for Health and Consumer Protection, European Commission Joint Research Centre, 21020 Ispra VA, Italy
    Altern Lab Anim 33:117-30. 2005
  4. ncbi request reprint How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop
    David Kirkland
    Covance Laboratories Ltd, Otley Road, Harrogate HG3 1PY, UK
    Mutat Res 628:31-55. 2007
    ....
  5. ncbi request reprint Genetic toxicity assessment: employing the best science for human safety evaluation part IV: Recommendation of a working group of the Gesellschaft fuer Umwelt-Mutationsforschung (GUM) for a simple and straightforward approach to genotoxicity testing
    Stefan Pfuhler
    P and G Prestige and Professional, Cosmital SA, Experimental Product Safety, Marly, Switzerland
    Toxicol Sci 97:237-40. 2007
    ..In the absence of additional data, such compounds will have to be assumed to be potential genotoxic carcinogens and potential germ cell mutagens...
  6. ncbi request reprint The Cosmetics Europe strategy for animal-free genotoxicity testing: project status up-date
    S Pfuhler
    Procter and Gamble Co, 1 Procter and Gamble Plz, Cincinnati, OH, USA Electronic address
    Toxicol In Vitro 28:18-23. 2014
    ....
  7. doi request reprint Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities-Report from an ECVAM workshop
    Stefan Pfuhler
    Procter and Gamble, Cosmital SA, CH 1723 Marly, Switzerland
    Mutat Res 680:31-42. 2009
    ..Furthermore, experimental proof is needed and under way to demonstrate the credibility of additional options for reduction of the number of animals, such as the integration of the Comet assay into repeat-dose toxicity studies...
  8. ncbi request reprint A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: genotoxicity. A COLIPA analysis
    Stefan Pfuhler
    Procter and Gamble, Miami Valley Laboratories, Cincinnati, OH 45253, USA
    Regul Toxicol Pharmacol 57:315-24. 2010
    ..A weight of evidence approach was employed to set up a decision-tree for the integration of alternative methods into tiered testing strategies...
  9. ncbi request reprint N-acetylation of three aromatic amine hair dye precursor molecules eliminates their genotoxic potential
    Andreas Zeller
    The Procter and Gamble Co, Cosmital SA, Route de Chésalles 21, 1723 Marly, Switzerland
    Mutagenesis 29:37-48. 2014
    ..The findings also indicate that the use of liver S-9 preparations, which generally underestimate Phase II reactions, contributes to the generation of irrelevant positive results in standard genotoxicity tests for this chemical class. ..
  10. pmc ECVAM retrospective validation of in vitro micronucleus test (MNT)
    Raffaella Corvi
    European Centre for the Validation of Alternative Methods, Institute for Health and Consumer Protection IHCP, European Commission Joint Research Centre JRC, Ispra, VA, Italy
    Mutagenesis 23:271-83. 2008
    ..Following peer review, these conclusions were formally endorsed by the ECVAM Scientific Advisory Committee...