Luanne L Peters

Summary

Affiliation: The Jackson Laboratory
Country: USA

Publications

  1. ncbi request reprint Downeast anemia (dea), a new mouse model of severe nonspherocytic hemolytic anemia caused by hexokinase (HK(1)) deficiency
    L L Peters
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Blood Cells Mol Dis 27:850-60. 2001
  2. ncbi request reprint Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency
    Luanne L Peters
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 103:3233-40. 2004
  3. ncbi request reprint Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1)
    Steven L Ciciotte
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 101:4402-7. 2003
  4. ncbi request reprint Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume
    Luanne L Peters
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 16:749-63. 2005
  5. pmc Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 112:4298-307. 2008
  6. ncbi request reprint Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex
    Babette Gwynn
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Blood 104:3181-9. 2004
  7. pmc Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in alpha-spectrin-deficient red cells
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 115:1804-14. 2010
  8. ncbi request reprint Quantitative trait loci for baseline erythroid traits
    Luanne L Peters
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 17:298-309. 2006
  9. ncbi request reprint Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations
    Karen L Svenson
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    J Appl Physiol (1985) 102:2369-78. 2007
  10. pmc Sequence variation at multiple loci influences red cell hemoglobin concentration
    Luanne L Peters
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 116:e139-49. 2010

Detail Information

Publications45

  1. ncbi request reprint Downeast anemia (dea), a new mouse model of severe nonspherocytic hemolytic anemia caused by hexokinase (HK(1)) deficiency
    L L Peters
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Blood Cells Mol Dis 27:850-60. 2001
    ..We conclude that the primary gene defect in the dea mutation is in Hk1 and that dea is a model of generalized hexokinase deficiency, the first such model identified to date...
  2. ncbi request reprint Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency
    Luanne L Peters
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 103:3233-40. 2004
    ..The peak LOD score was obtained with a marker for Spnb1 encoding erythroid beta-spectrin, an obvious candidate gene...
  3. ncbi request reprint Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1)
    Steven L Ciciotte
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 101:4402-7. 2003
    ....
  4. ncbi request reprint Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume
    Luanne L Peters
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 16:749-63. 2005
    ..These analyses underscore the genetic complexity underlying these traits in normal populations and provide the basis for future studies to identify novel genes involved in the regulation of mammalian hematopoiesis...
  5. pmc Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 112:4298-307. 2008
    ..These data indicate that adducin plays a role in RBC membrane stability and in cerebrospinal fluid homeostasis...
  6. ncbi request reprint Reduced pigmentation (rp), a mouse model of Hermansky-Pudlak syndrome, encodes a novel component of the BLOC-1 complex
    Babette Gwynn
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Blood 104:3181-9. 2004
    ..Defects in all the 5 known components of BLOC-1, including RP, cause severe HPS in mice, suggesting that the subunits are nonredundant and that BLOC-1 plays a key role in organelle biogenesis...
  7. pmc Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in alpha-spectrin-deficient red cells
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 115:1804-14. 2010
    ..The data reinforce the notion that a membrane bridge in addition to the classic protein 4.1-p55-glycophorin C linkage exists at the RBC junctional complex that involves interactions between spectrin, adducin, and band 3...
  8. ncbi request reprint Quantitative trait loci for baseline erythroid traits
    Luanne L Peters
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 17:298-309. 2006
    ..These analyses emphasize the genetic complexity underlying the regulation of erythroid peripheral blood traits in normal populations and suggest that genes not previously recognized as significantly impacting normal erythropoiesis exist...
  9. ncbi request reprint Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations
    Karen L Svenson
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    J Appl Physiol (1985) 102:2369-78. 2007
    ..Data generated by this effort builds on the value of inbred mouse strains as a powerful tool for biomedical research...
  10. pmc Sequence variation at multiple loci influences red cell hemoglobin concentration
    Luanne L Peters
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 116:e139-49. 2010
    ..85 versus 7.13. Thus, as shown in human erythrocytes, positively charged Hbs are associated with cell dehydration and increased CHCM in mouse erythrocytes...
  11. pmc Targeted deletion of the gamma-adducin gene (Add3) in mice reveals differences in alpha-adducin interactions in erythroid and nonerythroid cells
    Kenneth E Sahr
    The Jackson Laboratory, Bar Harbor, Maine 04606, USA
    Am J Hematol 84:354-61. 2009
    ..These results suggest that the structural properties of adducin differ significantly between erythroid and various nonerythroid cell types...
  12. ncbi request reprint A mouse TRAPP-related protein is involved in pigmentation
    Babette Gwynn
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Genomics 88:196-203. 2006
    ..The data implicate mammalian TRAPPC6A in vesicle trafficking during melanosome biogenesis...
  13. pmc A new mouse mutant for the LDL receptor identified using ENU mutagenesis
    Karen L Svenson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Lipid Res 49:2452-62. 2008
    ..Further investigation of genomic differences between the ENU mutant and KO strains may reveal previously unappreciated sequence functionality...
  14. ncbi request reprint The mouse as a model for human biology: a resource guide for complex trait analysis
    Luanne L Peters
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Genet 8:58-69. 2007
    ..This review summarizes those resources and provides practical guidelines for their use, particularly in the analysis of quantitative traits...
  15. pmc Effects of housing density in five inbred strains of mice
    Judith L Morgan
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 9:e90012. 2014
    ..Percent fat increased slightly in strains 129S1/SvImJ, A/J, and DBA/2J, but did not increase in strains BALB/cByJ, and C57BL/6J. These results indicate that mice can be housed at higher densities than those currently recommended. ..
  16. doi request reprint Relationships of dietary fat, body composition, and bone mineral density in inbred mouse strain panels
    Renhua Li
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 33:26-32. 2008
    ..Sex has no net effect on areal BMD, but after accounting for body mass difference females have higher areal BMD. Leptin is affected by relative fat mass and has no net effect on areal BMD. IGF-I has a direct effect on areal BMD...
  17. ncbi request reprint Invited review: Identifying new mouse models of cardiovascular disease: a review of high-throughput screens of mutagenized and inbred strains
    Karen L Svenson
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Appl Physiol (1985) 94:1650-9; discussion 1673. 2003
    ..Here, we review our cardiovascular screens and present some hypertensive, obese, and cardiovascular models identified with this approach...
  18. pmc Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice
    Annerose Berndt
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Physiol Genomics 43:1-11. 2011
    ..e., genome-wide association studies or quantitative trait locus studies) measures something fundamentally different than airway resistance and lung elastance...
  19. pmc Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels
    Rong Yuan
    The Jackson Aging Center at The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Aging Cell 8:277-87. 2009
    ..53, P < 0.01). These results support the hypothesis that the IGF1 pathway plays a key role in regulating longevity in mice and indicates that common genetic mechanisms may exist for regulating IGF1 levels and lifespan...
  20. pmc Mice as a mammalian model for research on the genetics of aging
    Rong Yuan
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    ILAR J 52:4-15. 2011
    ....
  21. pmc Strain-specific hyperkyphosis and megaesophagus in Add1 null mice
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genesis 50:882-91. 2012
    ..These unforeseen phenotypes, described here, reveal new functions for adducin and provide new models of mammalian disease. genesis 50:882-891, 2012. © 2012 Wiley Periodicals, Inc...
  22. pmc Mouse models of USH1C and DFNB18: phenotypic and molecular analyses of two new spontaneous mutations of the Ush1c gene
    Kenneth R Johnson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Hum Mol Genet 12:3075-86. 2003
    ..The Ush1c mutant mice described here provide a means to directly investigate these interactions in vivo and to evaluate gene structure-function relationships that affect inner ear and eye phenotypes...
  23. ncbi request reprint Large-scale, high-throughput screening for coagulation and hematologic phenotypes in mice
    Luanne L Peters
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Physiol Genomics 11:185-93. 2002
    ..These data, freely available on the World Wide Web, allow investigators to knowledgeably select the most appropriate strain(s) to meet their individual study designs and goals...
  24. ncbi request reprint Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1)
    Paul A Stehberger
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    J Am Soc Nephrol 18:1408-18. 2007
    ....
  25. pmc Reduced DIDS-sensitive chloride conductance in Ae1-/- mouse erythrocytes
    Seth L Alper
    Molecular and Vascular Medicine Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Blood Cells Mol Dis 41:22-34. 2008
    ..Thus, loss of one or more distinct, DIDS-sensitive anion channel polypeptide(s) from the Ae1(-/-) red cell membrane cannot be ruled out as an explanation for the reduced DIDS-sensitive anion conductance...
  26. ncbi request reprint Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. II. Activation, cytokines, erythrocytes, and platelets
    Daila S Gridley
    Department of Radiation Medicine, Division of Microbiology and Molecular Genetics, Loma Linda University and Medical Center, Loma Linda, California 92354, USA
    J Appl Physiol 94:2095-103. 2003
    ..05) and were consistent with dehydration. These data indicate that relatively short exposure to the spaceflight environment can induce profound changes that may become significant during long-term space missions...
  27. pmc Characterization of glycolytic enzyme interactions with murine erythrocyte membranes in wild-type and membrane protein knockout mice
    M Estela Campanella
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA
    Blood 112:3900-6. 2008
    ..These data suggest that oxygenation-dependent assembly of GEs on the membrane could be a general phenomenon of mammalian erythrocytes and that stability of these interactions depends primarily on band 3...
  28. ncbi request reprint Evidence that the red cell skeleton protein 4.2 interacts with the Rh membrane complex member CD47
    Isabelle Mouro-Chanteloup
    Institut National de la Santé et de la Recherche Médicale INSERM U76, Institut National de la Transfusion Sanguine, Paris, France
    Blood 101:338-44. 2003
    ..2(-) and Rh(null) red cells...
  29. ncbi request reprint Novel secreted isoform of adhesion molecule ICAM-4: potential regulator of membrane-associated ICAM-4 interactions
    Gloria Lee
    Life Sciences Division, University of California, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Blood 101:1790-7. 2003
    ..We postulate that secretion of this newly described isoform, ICAM-4S, may modulate binding of membrane-associated ICAM-4 and could thus play a critical regulatory role in erythroblast molecular attachments...
  30. ncbi request reprint A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane
    Lesley J Bruce
    Department of Biochemistry, University of Bristol, United Kingom
    Blood 101:4180-8. 2003
    ..We speculate that this macrocomplex may function as an integrated CO(2)/O(2) gas exchange unit (metabolon) in the erythrocyte...
  31. ncbi request reprint Melanosome morphologies in murine models of hermansky-pudlak syndrome reflect blocks in organelle development
    Thuyen Nguyen
    Department of Dermatology, Veterans Affairs Medical Center, University of California, San Francisco 94121, USA
    J Invest Dermatol 119:1156-64. 2002
    ..In contrast, the hypopigmentation seen in the gunmetal strain is due to the retention of melanosomes in melanocytes, and inefficient transfer into keratinocytes...
  32. ncbi request reprint Combined deletion of mouse dematin-headpiece and beta-adducin exerts a novel effect on the spectrin-actin junctions leading to erythrocyte fragility and hemolytic anemia
    Huiqing Chen
    Department of Pharmacology Cancer Center, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 282:4124-35. 2007
    ....
  33. ncbi request reprint N-myristoyltransferase 1 is essential in early mouse development
    Shao H Yang
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 280:18990-5. 2005
    ..We conclude that Nmt1 is not essential for the viability of mammalian cells but is required for development, likely because it is the principal N-myristoyltransferase in early embryogenesis...
  34. pmc Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis
    Lucia De Franceschi
    Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Italy
    Blood 106:1454-9. 2005
    ....
  35. ncbi request reprint Effect of complete protein 4.1R deficiency on ion transport properties of murine erythrocytes
    Alicia Rivera
    Children s Hospital Boston, Dept of Laboratory Medicine, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Cell Physiol 291:C880-6. 2006
    ..1 plays a major role in volume regulation and physiologically downregulates Na/H exchange in mouse erythrocytes. Upregulation of the Na/H exchange is an important contributor to the elevated cell Na content of 4.1(-/-) erythrocytes...
  36. ncbi request reprint Absence of erythroblast macrophage protein (Emp) leads to failure of erythroblast nuclear extrusion
    Shivani Soni
    Department of Medicine, Center for Cell Biology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    J Biol Chem 281:20181-9. 2006
    ..The availability of an Emp null model provides a unique experimental system to study the enucleation process and to evaluate the function of macrophages in definitive erythropoiesis...
  37. ncbi request reprint Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency
    Barry H Paw
    Department of Medicine, Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts, USA
    Nat Genet 34:59-64. 2003
    ..1R-binding domains. Our report establishes an evolutionarily conserved role for band 3 in erythroid-specific cell division and illustrates the concept of cell-specific adaptation for mitosis...
  38. pmc Implementing large-scale ENU mutagenesis screens in North America
    Amander T Clark
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Genetica 122:51-64. 2004
    ..The purpose of this article is to highlight the new projects in North America that are focused on isolating mouse mutations after ENU mutagenesis and phenotype screening...
  39. ncbi request reprint Ribosomal protein S19 expression during erythroid differentiation
    Lydie Da Costa
    New York Blood Center, NY 10021, USA
    Blood 101:318-24. 2003
    ..We anticipate that these findings will contribute to further development of our understanding of the contribution of RPS19 to erythropoiesis...
  40. ncbi request reprint Mitoferrin is essential for erythroid iron assimilation
    George C Shaw
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 440:96-100. 2006
    ..Our data show that mfrn functions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate erythroblasts...
  41. ncbi request reprint Role of hepatocyte nuclear factor 4alpha in control of blood coagulation factor gene expression
    Yusuke Inoue
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Med (Berl) 84:334-44. 2006
    ..In conclusion, HNF4alpha has a critical role in blood coagulation homeostasis by directing transcription of the FXII and XIIIB genes...
  42. ncbi request reprint Transgenic Cre expression mice for generation of erythroid-specific gene alterations
    Kenneth R Peterson
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160 7421, USA
    Genesis 39:1-9. 2004
    ..We demonstrate that beta(S) expression was not detected in the blood of bigenics, but the gene was present in nonerythroid cells. Thus, excision of the loxP-flanked beta(S) gene was restricted to erythroid cell lineages...
  43. ncbi request reprint Novel method for high-throughput phenotyping of sleep in mice
    Allan I Pack
    Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Physiol Genomics 28:232-8. 2007
    ..0 and -3.0 min per 2-h interval, respectively). This method has applications in chemical mutagenesis and for studies of molecular changes in brain with sleep/wakefulness...
  44. ncbi request reprint Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. I. Immune population distributions
    Michael J Pecaut
    Department of Radiation Medicine, Radiobiology Program, Division of Microbiology and Molecular Genetics, Loma Linda University and Medical Center, Loma Linda, California 92354, USA
    J Appl Physiol (1985) 94:2085-94. 2003
    ..Many of the results are similar to those using other models. Clearly, spaceflight can influence immune parameters ranging from hematopoiesis to mature leukocyte mechanisms...
  45. pmc Impaired synaptic plasticity and learning in mice lacking beta-adducin, an actin-regulating protein
    Rebecca L Rabenstein
    Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 25:2138-45. 2005
    ..The current results indicate that beta-adducin may play an important role in the cellular mechanisms underlying activity-dependent synaptic plasticity associated with learning and memory...