Research Topics
| Michael A PereiraSummaryAffiliation: The Ohio State University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-alpha gene in rat colon tumorsMichael A Pereira
Department of Pathology, Medical College of Ohio, Toledo, OH 43614, USA
Carcinogenesis 25:1917-23. 2004..Celecoxib and DFMO reversed DNA hypomethylation and the hypermethylation of the ER-alpha gene in colon tumors supporting the hypothesis that modulation of methylation is a biomarker of chemoprevention...- Effect of budesonide on the methylation and mRNA expression of the insulin-like growth factor 2 and c-myc genes in mouse lung tumorsLianhui Tao
Department of Pathology, Medical College of Ohio, Toledo, Ohio 43614, USA
Mol Carcinog 35:93-102. 2002..The results support the possibility of using decreased mRNA expression and remethylation of the Igf-II and c-myc genes as biomarkers for the efficacy of budesonide... - Effect of dibromoacetic acid on DNA methylation, glycogen accumulation, and peroxisome proliferation in mouse and rat liverLianhui Tao
Department of Pathology, Medical College of Ohio, Toledo, OH 43614 5806, USA
Toxicol Sci 82:62-9. 2004..Again like DCA, DBA also induced glycogen accumulation. These results indicate that DBA shares biochemical and molecular activities in common with DCA and/or TCA, suggesting that it might also be a liver carcinogen... - Chemoprevention: mouse colon and lung tumor bioassay and modulation of DNA methylation as a biomarkerMichael A Pereira
Department of Pathology, Medical College of Ohio, Toledo, Ohio, USA
Exp Lung Res 31:145-63. 2005..These results indicate that reversal of the hypomethylation of DNA and of specific genes in lung tumors may be applicable as a surrogate end-point biomarker for chemoprevention... - Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (Zarnestra MT)Fadel S Alyaqoub
Medical University of Ohio, Toledo, OH 43614, USA
Carcinogenesis 28:124-9. 2007..These results support the combined use of budesonide and R115777 in prevention of lung tumors and suggest that reversal of DNA hypomethylation in lung tumors would be useful as a surrogate end-point biomarker for prevention... - Hypomethylation of DNA and the insulin-like growth factor-II gene in dichloroacetic and trichloroacetic acid-promoted mouse liver tumorsLianhui Tao
Department of Pathology, Medical College of Ohio, 3055 Arlington Avenue, Toledo, OH 43614 5806, USA
Toxicology 196:127-36. 2004..The results support the hypothesis that DNA hypomethylation is involved in the mechanism for the tumorigenicity of DCA and TCA... - Modulation by budesonide of a CpG endonuclease in mouse lung tumorsLong Li
Department of Biochemistry and Cancer Biology, Medical University of Ohio, 3055 Arlington Avenue, Toledo, OH 43614 5806, USA
Carcinogenesis 28:1499-503. 2007..The increased CpG endonuclease activity in mouse lung tumors and its inhibition by budesonide would suggest this endonuclease as a potential molecular target for chemoprevention... - Modulation of DNA hypomethylation as a surrogate endpoint biomarker for chemoprevention of colon cancerLianhui Tao
Department of Pathology, Medical College of Ohio, Toledo, Ohio, USA
Mol Carcinog 39:79-84. 2004..The results suggest that the ability to reverse the DNA hypomethylation in colon tumors could be useful as a surrogate end-point biomarker for chemoprevention of colon cancer... - Modulation by bexarotene of mRNA expression of genes in mouse lung tumorsFadel S Alyaqoub
Department of Biochemistry and Cancer Biology, Medical University of Ohio, Toledo, Ohio, USA
Mol Carcinog 47:165-71. 2008.... - DNA hypomethylation induced by non-genotoxic carcinogens in mouse and rat colonMichael A Pereira
Department of Pathology, Medical College of Ohio, 3055 Arlington Avenue, Toledo 43614 5806, USA
Cancer Lett 212:145-51. 2004..In summary, the ability of non-genotoxic colon carcinogens to cause DNA hypomethylation correlated with their carcinogenic activity in the colon... - Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agentsLianhui Tao
Department of Pathology, HEB, Rm 202, Medical College of Ohio, 3055 Arlington Ave, Toledo, OH 43614 5806, USA
Carcinogenesis 23:1447-54. 2002..Hence, agents that prevented colon cancer decreased the mitotic index and altered the expression of c-myc, p16 and p27 suggesting that modulation in the expression of these genes are potential biomarkers for chemopreventive activity... - Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777William T Gunning
Department of Pathology, Medical College of Ohio, Toledo 43614, USA
Clin Cancer Res 9:1927-30. 2003..The efficacy of R115777 [Zarnestra; (B)-6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)-methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone] to prevent the development of lung tumors in mice was determined... - Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in miceWilliam T Gunning
Department of Pathology, Medical College of Ohio, Toledo, Ohio 43614, USA
Cancer Res 62:4199-201. 2002..These results demonstrate that leukotriene inhibitors prevent lung tumors and slow the growth and progression of adenomas to carcinoma; leukotriene inhibitors warrant further consideration for potential use in humans... - Prevention by methionine of dichloroacetic acid-induced liver cancer and DNA hypomethylation in miceMichael A Pereira
Department of Pathology, Medical College of Ohio, Toledo, Ohio 43614, USA
Toxicol Sci 77:243-8. 2004..028 (i.e., by 87 and 98%, respectively). Thus, the prevention of liver tumors by methionine was associated with its prevention of DNA hypomethylation, indicating that DNA hypomethylation was critical for the carcinogenic activity of DCA... - Prevention of mouse lung tumors by budesonide and its modulation of biomarkersMichael A Pereira
Department of Pathology, Medical College of Ohio, HEB, Room 200F, 3055 Arlington Avenue, Toledo, OH 43614 5806, USA
Carcinogenesis 23:1185-92. 2002..Thus, short-term treatment with budesonide modulated biological and molecular end-points in lung tumors that might be developed further as biomarkers for its clinical chemopreventive efficacy in the lung... - DNA hypomethylation induced by drinking water disinfection by-products in mouse and rat kidneyLianhui Tao
Department of Internal Medicine, Division of Hematology and Oncology, College of Medicine and Public Health, The Ohio State University, Columbus, 43210, USA
Toxicol Sci 87:344-52. 2005..That methionine prevents DCA- and TCA-induced hypomethylation of the c-myc gene would suggest it could prevent their carcinogenic activity in the kidney... - Prevention of mouse lung tumors by targretinMichael A Pereira
Division of Hematology and Oncology, Ohio State University, College of Medicine, Columbus, OH 43210, USA
Int J Cancer 118:2359-62. 2006..75 and 4.60 +/- 0.70, respectively. Hence, targretin demonstrated both preventive and therapeutic activity with respect to mouse lung tumors supporting its further development as a preventive and therapeutic agent for lung cancer... - Effect of peroxisome proliferators on the methylation and protein level of the c-myc protooncogene in B6C3F1 mice liverRongrong Ge
Department of Pathology, Medical College of Ohio, Toledo, OH 43614-5806, USA
J Biochem Mol Toxicol 16:41-7. 2002.... - Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumorsMichael A Pereira
Division of Hematology and Oncology, Ohio State University, College of Medicine, Columbus, OH 43210, USA
Int J Cancer 120:1150-3. 2007..Hence, budesonide rapidly decreased the size of lung tumors, reversed DNA hypomethylation and modulated mRNA expression of genes; with the molecular alterations requiring continued treatment with the drug for maintenance... - Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra)Young Won Chin
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
J Agric Food Chem 55:4691-7. 2007..Furthermore, isoliquiritigenin (7) was demonstrated to prevent the incidence of 1,2-dimethylhydrazine-induced colon and lung tumors in mice when administered at a dose of 300 mg/kg... - Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT)Fadel S Alyaqoub
Medical University of Ohio, Toledo OH 43614, USA
Carcinogenesis 27:2442-7. 2006..These results support the combined use of budesonide and R115777 in prevention of lung tumors and suggest that reversal of DNA hypomethylation in lung tumors would be useful as a surrogate endpoint biomarker for prevention...