M Perego

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc The bicarbonate transporter is essential for Bacillus anthracis lethality
    Adam C Wilson
    Department of Molecular and Experimental Medicine, Division of Cellular Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS Pathog 4:e1000210. 2008
  2. pmc Forty years in the making: understanding the molecular mechanism of peptide regulation in bacterial development
    Marta Perego
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS Biol 11:e1001516. 2013
  3. pmc Bacillus subtilis RapA phosphatase domain interaction with its substrate, phosphorylated Spo0F, and its inhibitor, the PhrA peptide
    Alejandra R Diaz
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, California, USA
    J Bacteriol 194:1378-88. 2012
  4. ncbi request reprint Commingling regulatory systems following acquisition of virulence plasmids by Bacillus anthracis
    Marta Perego
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Microbiol 16:215-21. 2008
  5. pmc Rap phosphatase of virulence plasmid pXO1 inhibits Bacillus anthracis sporulation
    Cristina Bongiorni
    Division of Cellular Biology, Mail Code MEM 116, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037
    J Bacteriol 188:487-98. 2006
  6. ncbi request reprint Protein aspartate phosphatases control the output of two-component signal transduction systems
    M Perego
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Genet 12:97-101. 1996
  7. pmc Functional genomics of gram-positive microorganisms
    Marta Perego
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Bacteriol 186:903-9. 2004
  8. ncbi request reprint A new family of aspartyl phosphate phosphatases targeting the sporulation transcription factor Spo0A of Bacillus subtilis
    M Perego
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Microbiol 42:133-43. 2001
  9. ncbi request reprint Kinase-phosphatase competition regulates Bacillus subtilis development
    M Perego
    Dept of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Microbiol 6:366-70. 1998
  10. ncbi request reprint Pentapeptide regulation of aspartyl-phosphate phosphatases
    M Perego
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, MEM 116, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Peptides 22:1541-7. 2001

Research Grants

  1. Protein Aspartate Phosphatases in Development
    Marta Perego; Fiscal Year: 2006
  2. Signal Transduction in Enterococci
    Marta Perego; Fiscal Year: 2005
  3. Protein Aspartate Phosphatases in Development
    Marta Perego; Fiscal Year: 2003
  4. Signal Transduction in Enterococci
    Marta Perego; Fiscal Year: 2007
  5. Signal Transduction in Enterococci
    Marta Perego; Fiscal Year: 2006
  6. Signal Transduction in Enterococci
    Marta Perego; Fiscal Year: 2004
  7. PROTEIN ASPARATE PHOSPHATASES IN DEVELOPMENT
    Marta Perego; Fiscal Year: 2002
  8. PROTEIN ASPARATE PHOSPHATASES IN DEVELOPMENT
    Marta Perego; Fiscal Year: 2001
  9. PROTEIN ASPARATE PHOSPHATASES IN DEVELOPMENT
    Marta Perego; Fiscal Year: 2000
  10. PROTEIN ASPARATE PHOSPHATASES IN DEVELOPMENT
    Marta Perego; Fiscal Year: 1999

Collaborators

  • JAMES ALFRED HOCH
  • Adam C Wilson
  • Hendrik Szurmant
  • S P Cole
  • V Dartois
  • Takao Yagi
  • Leendert W Hamoen
  • Jeff Errington
  • R A Edwards
  • Cristina Bongiorni
  • Christina Chiang
  • Alejandra R Diaz
  • Maria Florencia Del Papa
  • Sophie Stephenson
  • Tatsuya Fukushima
  • Lynn E Hancock
  • Kris Ann Baker
  • Shu Ishikawa
  • Leighton Core
  • Francesca Scaramozzino
  • L Wang
  • Min Jiang
  • Wiep Klaas Smits
  • Billyana Tsvetanova
  • Anthony J Wilkinson
  • Ricarda Stoessel
  • Rosa Grenha
  • Andrea K White
  • Lucia Musumeci
  • Andrei Osterman
  • Ryan L Brunsing
  • Lieh Yoon Low
  • Mou Chieh Kao
  • Jörg Sievers
  • Kyoko Kanamaru
  • Sophie J Stephenson
  • L J Core
  • Christina H Chiang
  • Michela Morelli
  • Leighton J Core
  • Andrea White
  • M Cecilia Mansilla
  • Vladimir M Levdikov
  • A Koide
  • Eun Ja Kim
  • J Michael Green
  • Jan Willem Veening
  • Oscar P Kuipers
  • Mark J Fogg
  • Keith S Wilson
  • Eiso Ab
  • Gert E Folkers
  • Dorinda Shoemaker
  • Adam Godzik
  • Neil J Rzechorzek
  • Robert Kaptein
  • James A Brannigan
  • Marcin Grynberg
  • Rob N de Jong
  • Tammo Diercks
  • Joanne C Ladds
  • Vincent Truffault
  • Chandra La Clair
  • Naotake Ogasawara
  • Chen Yang
  • Lutz Tautz
  • Nunzio Bottini
  • Sharon Tang
  • Tomas Mustelin
  • Robert C Liddington
  • Eiko Nakamaru-Ogiso
  • Salvatore Di Bernardo
  • Akemi Matsuno-Yagi
  • Christian Mueller
  • Brian Raether
  • C Fabret
  • K Kanamaru
  • S Ishikawa
  • K Stephenson
  • R Grau
  • M A Strauch
  • W C Johnson
  • G B Spiegelman
  • D Burbulys

Detail Information

Publications50

  1. pmc The bicarbonate transporter is essential for Bacillus anthracis lethality
    Adam C Wilson
    Department of Molecular and Experimental Medicine, Division of Cellular Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS Pathog 4:e1000210. 2008
    ....
  2. pmc Forty years in the making: understanding the molecular mechanism of peptide regulation in bacterial development
    Marta Perego
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS Biol 11:e1001516. 2013
    ..The results invite speculation regarding the potential exploitation of this module as a molecular tool for applications in therapeutic design and biotechnology...
  3. pmc Bacillus subtilis RapA phosphatase domain interaction with its substrate, phosphorylated Spo0F, and its inhibitor, the PhrA peptide
    Alejandra R Diaz
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, California, USA
    J Bacteriol 194:1378-88. 2012
    ....
  4. ncbi request reprint Commingling regulatory systems following acquisition of virulence plasmids by Bacillus anthracis
    Marta Perego
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Microbiol 16:215-21. 2008
    ..An example of such a conversion is seen in Bacillus anthracis, and how acquired plasmid regulatory functions affect the activity of the regulatory processes of the bacterium, and vice versa, is now being revealed...
  5. pmc Rap phosphatase of virulence plasmid pXO1 inhibits Bacillus anthracis sporulation
    Cristina Bongiorni
    Division of Cellular Biology, Mail Code MEM 116, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037
    J Bacteriol 188:487-98. 2006
    ..anthracis, one of which, BA3790-3791, also affected sporulation initiation. The results suggest that the plasmid-borne Rap-Phr system may provide a selective advantage to the virulence of B. anthracis...
  6. ncbi request reprint Protein aspartate phosphatases control the output of two-component signal transduction systems
    M Perego
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Genet 12:97-101. 1996
    ..Such phosphatases are prevalent in signal transduction systems controlling complex processes, such as the initiation of development in microorganisms...
  7. pmc Functional genomics of gram-positive microorganisms
    Marta Perego
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Bacteriol 186:903-9. 2004
  8. ncbi request reprint A new family of aspartyl phosphate phosphatases targeting the sporulation transcription factor Spo0A of Bacillus subtilis
    M Perego
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Microbiol 42:133-43. 2001
    ..Negative signals interpreted by aspartyl phosphate phosphatases appear to be a common mechanism in Gram-positive spore-forming microorganisms...
  9. ncbi request reprint Kinase-phosphatase competition regulates Bacillus subtilis development
    M Perego
    Dept of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Trends Microbiol 6:366-70. 1998
    ....
  10. ncbi request reprint Pentapeptide regulation of aspartyl-phosphate phosphatases
    M Perego
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, MEM 116, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Peptides 22:1541-7. 2001
    ..The identification of tetratricopeptide repeats in the Rap proteins may explain the mechanism by which Phr peptides bind to and inhibit the activity of Rap phosphatases...
  11. pmc A novel histidine kinase inhibitor regulating development in Bacillus subtilis
    L Wang
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Genes Dev 11:2569-79. 1997
    ....
  12. pmc ScoC regulates peptide transport and sporulation initiation in Bacillus subtilis
    A Koide
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Bacteriol 181:4114-7. 1999
    ..Since peptide transport is essential for inactivation of the negative regulation of sporulation by Rap phosphatases, the control of ScoC transcription repression activity plays a crucial role in the initiation of sporulation...
  13. ncbi request reprint Structure of the gene for the transition state regulator, abrB: regulator synthesis is controlled by the spo0A sporulation gene in Bacillus subtilis
    M Perego
    Division of Cellular Biology, Research Institute of Scripps Clinic, La Jolla, California 92037
    Mol Microbiol 2:689-99. 1988
    ..The level of this regulator is, in turn, controlled by the spo0A gene. The pleiotropic phenotypes of spo0A mutants result from uncontrolled overexpression of the abrB regulator...
  14. pmc Characterization of the gene for a protein kinase which phosphorylates the sporulation-regulatory proteins Spo0A and Spo0F of Bacillus subtilis
    M Perego
    Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, La Jolla, California 92037
    J Bacteriol 171:6187-96. 1989
    ..The results suggest that multiple kinases exist for the Spo0A protein...
  15. pmc Dissection of the functional and structural domains of phosphorelay histidine kinase A of Bacillus subtilis
    L Wang
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Bacteriol 183:2795-802. 2001
    ..The N-terminal region appears to be essential both for signal sensing and for maintaining the correct conformation of the autokinase component domains...
  16. ncbi request reprint Isolation and sequence of the spo0E gene: its role in initiation of sporulation in Bacillus subtilis
    M Perego
    Division of Cellular Biology, Research Insititute of Scripps Clinic, La Jolla, CA 92037
    Mol Microbiol 1:125-32. 1987
    ..Studies of the regulation of this gene have allowed the generation of a hypothesis to explain the interactions of those five stage 0 genes involved in the activation of sporulation-specific transcription...
  17. pmc A peptide export-import control circuit modulating bacterial development regulates protein phosphatases of the phosphorelay
    M Perego
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 94:8612-7. 1997
    ..Chromosome sequencing has revealed several other phosphatase-prepeptide gene pairs in B. subtilis, suggesting that the use of this mechanism may be widespread in signal transduction...
  18. pmc The transition state transcription regulator abrB of Bacillus subtilis is a DNA binding protein
    M A Strauch
    Department of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, CA 92037
    EMBO J 8:1615-21. 1989
    ..The results suggested that stationary phase functions and sporulation are repressed during active growth by AbrB and other transition state regulators by binding to the affected promoters in a concentration-dependent manner...
  19. pmc Sensor domains encoded in Bacillus anthracis virulence plasmids prevent sporulation by hijacking a sporulation sensor histidine kinase
    Andrea K White
    Division of Cellular Biology, Mail Code MEM 116, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 188:6354-60. 2006
    ..anthracis sporulation in the bloodstream of its infected host, a salient characteristic in the virulence of this organism, and provides an additional role for the virulence plasmids in anthrax pathogenesis...
  20. pmc Sequence analysis and regulation of the hpr locus, a regulatory gene for protease production and sporulation in Bacillus subtilis
    M Perego
    Department of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, California 92037
    J Bacteriol 170:2560-7. 1988
    ..The results are consistent with the view that the spoOA gene may control sporulation and transcription by modulating the level and activity of several regulatory proteins...
  21. ncbi request reprint A free terminal carboxylate group is required for PhrA pentapeptide inhibition of RapA phosphatase
    L J Core
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, MEM-116, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Peptides 22:1549-53. 2001
    ..Therefore, coordination of the terminal carboxylate group appears to be critical for peptide binding to RapA...
  22. ncbi request reprint The oligopeptide transport system of Bacillus subtilis plays a role in the initiation of sporulation
    M Perego
    Department of Molecular and Experimental Medicine, Research Institute of Scripps Clinic, La Jolla, California 92037
    Mol Microbiol 5:173-85. 1991
    ..We postulate that the accumulation of such peptides may play a signalling role in the initiation of sporulation, and that the sporulation defect in opp mutants results from an inability to transport these peptides...
  23. pmc Overexpression of the PepF oligopeptidase inhibits sporulation initiation in Bacillus subtilis
    Kyoko Kanamaru
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Bacteriol 184:43-50. 2002
    ..The function of PepF in B. subtilis remains unknown. Limited experiments with a yjbG paralogue called yusX indicated that a frameshift is present, making the corresponding gene product inactive...
  24. pmc Negative regulation of Bacillus anthracis sporulation by the Spo0E family of phosphatases
    Cristina Bongiorni
    Division of Cellular Biology, Mail Code MEM 116, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 189:2637-45. 2007
    ..J. Biol. Chem. 281:37993-38003, 2006). We propose that these proteins may contribute to maintain B. anthracis in the transition phase of growth during an active infection and therefore contribute to the virulence of this organism...
  25. ncbi request reprint Opposing effects of histidine phosphorylation regulate the AtxA virulence transcription factor in Bacillus anthracis
    Billyana Tsvetanova
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, Division of Cellular Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Microbiol 63:644-55. 2007
    ..Our results link virulence factor production in B. anthracis to carbohydrate metabolism and, for the first time, provide a mechanistic explanation for AtxA transcriptional activity...
  26. pmc Dual promoters control expression of the Bacillus anthracis virulence factor AtxA
    Cristina Bongiorni
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 190:6483-92. 2008
    ..The dual promoter activity and the extended untranslated mRNA suggest that as-yet-unknown regulatory mechanisms may act on this region to influence the level of AtxA in the cell...
  27. pmc Two small c-type cytochromes affect virulence gene expression in Bacillus anthracis
    Adam C Wilson
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, Division of Cellular Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Microbiol 72:109-23. 2009
    ..These findings are significant not only to virulence regulation in B. anthracis, but also to analysis of virulence regulation in many pathogenic bacteria and to the study of cytochrome c activity in Gram-positive bacteria...
  28. pmc Synergistic regulation of competence development in Bacillus subtilis by two Rap-Phr systems
    Cristina Bongiorni
    Division of Cellular Biology, Mail Code MEM 116, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 187:4353-61. 2005
    ..Since the transcription of the RapC- and RapF-encoding genes is positively regulated by their own target ComA, an autoregulatory circuit must exist for the competence transcription factor in order to modulate its activity...
  29. pmc Molecular analysis of Phr peptide processing in Bacillus subtilis
    Sophie Stephenson
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Bacteriol 185:4861-71. 2003
    ..subtilis (SipS, SipT, SipU, SipV, and SipW) are indispensable for Phr processing. However, we show that SipV and SipT have a previously undescribed role in sporulation, competence, and cell growth...
  30. pmc A unique GTP-dependent sporulation sensor histidine kinase in Bacillus anthracis
    Francesca Scaramozzino
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 191:687-92. 2009
    ....
  31. pmc YycH regulates the activity of the essential YycFG two-component system in Bacillus subtilis
    Hendrik Szurmant
    Division of Cellular Biology, Mail Code MEM 116, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 187:5419-26. 2005
    ....
  32. pmc The Enterococcus faecalis fsr two-component system controls biofilm development through production of gelatinase
    Lynn E Hancock
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Bacteriol 186:5629-39. 2004
    ....
  33. pmc Virulence gene expression is independent of ResDE-regulated respiration control in Bacillus anthracis
    Adam C Wilson
    Department of Molecular and Experimental Medicine, Division of Cellular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Bacteriol 190:5522-5. 2008
    ..The results indicate that the loss of ResDE-controlled respiratory capacity does not affect the synthesis of anthrax toxin...
  34. pmc New transposon delivery plasmids for insertional mutagenesis in Bacillus anthracis
    Adam C Wilson
    The Scripps Research Institute, Department of Molecular and Experimental, Medicine, Division of Cellular Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States
    J Microbiol Methods 71:332-5. 2007
    ..The utility of both systems was directly demonstrated through the mutagenesis of a widely used B. anthracis strain...
  35. ncbi request reprint Functional role for a conserved aspartate in the Spo0E signature motif involved in the dephosphorylation of the Bacillus subtilis sporulation regulator Spo0A
    Alejandra R Diaz
    Department of Molecular and Experimental Medicine, Division of Cellular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 283:2962-72. 2008
    ..S., and Dijkstra, B. W. (1999) Biochem. J. 339, 223-226 )...
  36. ncbi request reprint Interaction surface of the Spo0A response regulator with the Spo0E phosphatase
    Sophie J Stephenson
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, MEM 116, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Microbiol 44:1455-67. 2002
    ..The residues involved in Spo0E interaction are identical in all Spo0A orthologues from spore-forming Bacilli encoding Spo0E phosphatases...
  37. pmc Characterization of sporulation histidine kinases of Bacillus anthracis
    Ryan L Brunsing
    Division of Cellular Biology, Mail Code MEM 116, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 187:6972-81. 2005
    ..The sporulation of B. anthracis ex vivo appears to result from any one or a combination of the sporulation sensor histidine kinases remaining...
  38. ncbi request reprint TPR-mediated interaction of RapC with ComA inhibits response regulator-DNA binding for competence development in Bacillus subtilis
    Leighton Core
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, MEM 116, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Microbiol 49:1509-22. 2003
    ..The RapC mechanism of regulating ComA activity is a new example of how TPR motifs and their structural organization have been adapted for different specific functions within the B. subtilis Rap family...
  39. pmc A sensor histidine kinase co-ordinates cell wall architecture with cell division in Bacillus subtilis
    Tatsuya Fukushima
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Mol Microbiol 69:621-32. 2008
    ....
  40. ncbi request reprint Structure and lytic activity of a Bacillus anthracis prophage endolysin
    Lieh Yoon Low
    Infectious and Inflammatory Disease Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 280:35433-9. 2005
    ..These results may have broad implications for the design of endolysins as therapeutic agents...
  41. pmc Transcription antitermination by a phosphorylated response regulator and cobalamin-dependent termination at a B₁₂ riboswitch contribute to ethanolamine utilization in Enterococcus faecalis
    Kris Ann Baker
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, La Jolla, California 92037, USA
    J Bacteriol 193:2575-86. 2011
    ....
  42. pmc Glucose-dependent activation of Bacillus anthracis toxin gene expression and virulence requires the carbon catabolite protein CcpA
    Christina Chiang
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, MEM 116, La Jolla, California 92037, USA
    J Bacteriol 193:52-62. 2011
    ..The data demonstrated that glucose is an important host environment-derived signaling molecule and that CcpA is a molecular link between environmental sensing and B. anthracis pathogenesis...
  43. pmc Enterococcus faecalis virulence regulator FsrA binding to target promoters
    Maria Florencia Del Papa
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, Mail Code MEM 116, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 193:1527-32. 2011
    ..In this study, we demonstrated that FsrA also binds to two imperfect direct repeats separated by 13 bp, based on the consensus sequence of FsrA, T/AT/CAA/GGGAA/G, which is consistent with the binding characteristics of LytTR domains...
  44. ncbi request reprint Biochemical characterization of aspartyl phosphate phosphatase interaction with a phosphorylated response regulator and its inhibition by a pentapeptide
    Shu Ishikawa
    Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:20483-9. 2002
    ..The structural organization of Rap phosphatases in tetratricopeptide repeats provides insights on the mechanisms of RapA interaction with its substrate and its inhibitor...
  45. pmc Ethanolamine activates a sensor histidine kinase regulating its utilization in Enterococcus faecalis
    Maria Florencia Del Papa
    Division of Cellular Biology, Mail Code MEM 116, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Bacteriol 190:7147-56. 2008
    ..These results assign a role to the RR-HK17 TCS as coordinator of the enterococcal response to specific nutritional conditions existing at the site of bacterial invasion, the intestinal tract of an animal host...
  46. ncbi request reprint Functional roles of four conserved charged residues in the membrane domain subunit NuoA of the proton-translocating NADH-quinone oxidoreductase from Escherichia coli
    Mou Chieh Kao
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 279:32360-6. 2004
    ..The possible functional roles of residues Asp-79 and Glu-81 were discussed...
  47. ncbi request reprint Structural characterization of Spo0E-like protein-aspartic acid phosphatases that regulate sporulation in bacilli
    Rosa Grenha
    Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 281:37993-8003. 2006
    ..The implications of the structures for interactions between the phosphatases and their substrate Spo0A approximately P are discussed...
  48. pmc Characterization of the parB-like yyaA gene of Bacillus subtilis
    Jörg Sievers
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Bacteriol 184:1102-11. 2002
    ..Overexpression of yyaA caused a sporulation defect characterized by the formation of multiple septa within the cell. This phenotype indicates that YyaA may have a regulatory role at the onset of sporulation...
  49. ncbi request reprint Temporal separation of distinct differentiation pathways by a dual specificity Rap-Phr system in Bacillus subtilis
    Wiep Klaas Smits
    Groningen Biomolecular Sciences and Biotechnology Institute, Department of Genetics, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    Mol Microbiol 65:103-20. 2007
    ..Together, these results indicate that RapH is an integral part of a multifactorial regulatory circuit affecting the cell's decision between distinct developmental pathways...
  50. pmc Low-molecular-weight protein tyrosine phosphatases of Bacillus subtilis
    Lucia Musumeci
    The Institute for Genetic Medicine, University of Southern California, Los Angeles, 90033, USA
    J Bacteriol 187:4945-56. 2005
    ..Our study suggests that YfkJ and YwlE play roles in B. subtilis stress resistance...

Research Grants14

  1. Protein Aspartate Phosphatases in Development
    Marta Perego; Fiscal Year: 2006
    ..The role of the Rap phosphatases not involved in sporulation will be investigated by microbiological and genetic approaches ..
  2. Signal Transduction in Enterococci
    Marta Perego; Fiscal Year: 2005
    ....
  3. Protein Aspartate Phosphatases in Development
    Marta Perego; Fiscal Year: 2003
    ..The role of the Rap phosphatases not involved in sporulation will be investigated by microbiological and genetic approaches ..
  4. Signal Transduction in Enterococci
    Marta Perego; Fiscal Year: 2007
    ....
  5. Signal Transduction in Enterococci
    Marta Perego; Fiscal Year: 2006
    ....
  6. Signal Transduction in Enterococci
    Marta Perego; Fiscal Year: 2004
    ....
  7. PROTEIN ASPARATE PHOSPHATASES IN DEVELOPMENT
    Marta Perego; Fiscal Year: 2002
    ..The mechanisms of interaction of RapA with SpoOF will be studied by the surface plasmon resonance method and with a genetic approach. Genetic and biochemical approaches will be used for the identification of the target of RapC. ..
  8. PROTEIN ASPARATE PHOSPHATASES IN DEVELOPMENT
    Marta Perego; Fiscal Year: 2001
    ..The mechanisms of interaction of RapA with SpoOF will be studied by the surface plasmon resonance method and with a genetic approach. Genetic and biochemical approaches will be used for the identification of the target of RapC. ..
  9. PROTEIN ASPARATE PHOSPHATASES IN DEVELOPMENT
    Marta Perego; Fiscal Year: 2000
    ..The mechanisms of interaction of RapA with SpoOF will be studied by the surface plasmon resonance method and with a genetic approach. Genetic and biochemical approaches will be used for the identification of the target of RapC. ..
  10. PROTEIN ASPARATE PHOSPHATASES IN DEVELOPMENT
    Marta Perego; Fiscal Year: 1999
    ..The mechanisms of interaction of RapA with SpoOF will be studied by the surface plasmon resonance method and with a genetic approach. Genetic and biochemical approaches will be used for the identification of the target of RapC. ..