I T Paulsen

Summary

Affiliation: The Institute for Genomic Research
Country: USA

Publications

  1. pmc Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic
    Daniel H Haft
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville MD 20850, USA
    BMC Biol 4:29. 2006
  2. ncbi request reprint Microbial genome analyses: comparative transport capabilities in eighteen prokaryotes
    I T Paulsen
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    J Mol Biol 301:75-100. 2000
  3. ncbi request reprint Multidrug efflux pumps and resistance: regulation and evolution
    Ian T Paulsen
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Curr Opin Microbiol 6:446-51. 2003
  4. ncbi request reprint Comparative genomics of microbial drug efflux systems
    I T Paulsen
    The Institute for Genomic Research, Rockville, MD 20850, USA
    J Mol Microbiol Biotechnol 3:145-50. 2001
  5. ncbi request reprint Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis
    I T Paulsen
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 299:2071-4. 2003
  6. pmc The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts
    Ian T Paulsen
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 99:13148-53. 2002
  7. ncbi request reprint Complete genome sequence of a virulent isolate of Streptococcus pneumoniae
    H Tettelin
    The Institute for Genomic Research (TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 293:498-506. 2001
  8. ncbi request reprint Genome of Geobacter sulfurreducens: metal reduction in subsurface environments
    B A Methé
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 302:1967-9. 2003
  9. pmc Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae
    T D Read
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Nucleic Acids Res 31:2134-47. 2003
  10. pmc Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements
    Martin Wu
    The Institute for Genomic Research, Rockville, Maryland, USA
    PLoS Biol 2:E69. 2004

Research Grants

  1. Genome Sequencing of Toxoplasma gondii
    Ian Paulsen; Fiscal Year: 2002

Detail Information

Publications57

  1. pmc Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic
    Daniel H Haft
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville MD 20850, USA
    BMC Biol 4:29. 2006
    ..Detection in some genomes, but not others, may reveal sorting system components by comparison of the phylogenetic profile of the class of sorting signal to that of various protein families...
  2. ncbi request reprint Microbial genome analyses: comparative transport capabilities in eighteen prokaryotes
    I T Paulsen
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    J Mol Biol 301:75-100. 2000
    ..Archaea and spirochetes exhibit fewer proteins with multiple transmembrane segments and fewer net transporters than most bacteria. These results provide insight into the relevance of transport to the overall physiology of prokaryotes...
  3. ncbi request reprint Multidrug efflux pumps and resistance: regulation and evolution
    Ian T Paulsen
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Curr Opin Microbiol 6:446-51. 2003
    ..This structural data provides the context for understanding other questions about the evolution of multidrug transporters and their natural physiological roles...
  4. ncbi request reprint Comparative genomics of microbial drug efflux systems
    I T Paulsen
    The Institute for Genomic Research, Rockville, MD 20850, USA
    J Mol Microbiol Biotechnol 3:145-50. 2001
    ..Microarray and gene knockout studies to date have suggested that predicted drug efflux genes often appear to be a) non-essential and b) expressed at detectable levels under standard laboratory growth conditions...
  5. ncbi request reprint Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis
    I T Paulsen
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 299:2071-4. 2003
    ..The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci...
  6. pmc The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts
    Ian T Paulsen
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 99:13148-53. 2002
    ..A limited repertoire of genes homologous to known bacterial virulence factors were identified...
  7. ncbi request reprint Complete genome sequence of a virulent isolate of Streptococcus pneumoniae
    H Tettelin
    The Institute for Genomic Research (TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 293:498-506. 2001
    ..Comparative genome hybridization with DNA arrays revealed strain differences in S. pneumoniae that could contribute to differences in virulence and antigenicity...
  8. ncbi request reprint Genome of Geobacter sulfurreducens: metal reduction in subsurface environments
    B A Methé
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 302:1967-9. 2003
    ..As well as playing roles in the global cycling of metals and carbon, this organism clearly has the potential for use in bioremediation of radioactive metals and in the generation of electricity...
  9. pmc Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae
    T D Read
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Nucleic Acids Res 31:2134-47. 2003
    ..pneumoniae. This crucial addition to the set of completed Chlamydiaceae genome sequences is enabling dissection of the roles played by niche-specific genes in these important bacterial pathogens...
  10. pmc Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements
    Martin Wu
    The Institute for Genomic Research, Rockville, Maryland, USA
    PLoS Biol 2:E69. 2004
    ..With the availability of the complete genomes of both species and excellent genetic tools for the host, the wMel-D. melanogaster symbiosis is now an ideal system for studying the biology and evolution of Wolbachia infections...
  11. ncbi request reprint Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis
    John F Heidelberg
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Nat Biotechnol 20:1118-23. 2002
    ....
  12. ncbi request reprint Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440
    K E Nelson
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Environ Microbiol 4:799-808. 2002
    ..Analysis of the genome gives insight into the non-pathogenic nature of P. putida and points to potential new applications in agriculture, biocatalysis, bioremediation and bioplastic production...
  13. pmc Complete genome sequence of Caulobacter crescentus
    W C Nierman
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 98:4136-41. 2001
    ....
  14. pmc Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae
    Herve Tettelin
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 99:12391-6. 2002
    ..agalactiae strains from several serotypes using whole-genome microarrays, revealed the genetic heterogeneity among S. agalactiae strains, even of the same serotype, and provided insights into the evolution of virulence mechanisms...
  15. ncbi request reprint Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5
    Ian T Paulsen
    The Institute for Genomic Research, Rockville, Maryland, USA
    Nat Biotechnol 23:873-8. 2005
    ..In addition to six known secondary metabolites produced by P. fluorescens Pf-5, three novel secondary metabolite biosynthesis gene clusters were also identified that may contribute to the biocontrol properties of P. fluorescens Pf-5...
  16. pmc Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain
    Steven R Gill
    Microbial Genomics, The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
    J Bacteriol 187:2426-38. 2005
    ..Overall differences in pathogenicity can be attributed to genome islands in S. aureus which encode enterotoxins, exotoxins, leukocidins, and leukotoxins not found in S. epidermidis...
  17. pmc Comparative genomic evidence for a close relationship between the dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter crescentus
    Jonathan H Badger
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    J Bacteriol 188:6841-50. 2006
    ..neptunium genome will provide an important resource for the study of other interesting biological processes including chromosome segregation, polar growth, and cell aging...
  18. pmc Genome sequence of Aedes aegypti, a major arbovirus vector
    Vishvanath Nene
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 316:1718-23. 2007
    ..An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species...
  19. pmc Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes
    Rekha Seshadri
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:5646-51. 2004
    ....
  20. ncbi request reprint The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough
    John F Heidelberg
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nat Biotechnol 22:554-9. 2004
    ....
  21. pmc Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne pathogen Listeria monocytogenes reveal new insights into the core genome components of this species
    Karen E Nelson
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Nucleic Acids Res 32:2386-95. 2004
    ..Whole genome comparative analyses revealed that the L.monocytogenes genomes are essentially syntenic, with the majority of genomic differences consisting of phage insertions, transposable elements and SNPs...
  22. pmc Genomic insights into methanotrophy: the complete genome sequence of Methylococcus capsulatus (Bath)
    Naomi Ward
    The Institute for Genomic Research, Rockville, Maryland, USA
    PLoS Biol 2:e303. 2004
    ..We have gained evidence for greater metabolic flexibility than was previously known, and for genetic components that may have biotechnological potential...
  23. ncbi request reprint Large-scale comparative genomic analyses of cytoplasmic membrane transport systems in prokaryotes
    Qinghu Ren
    The Institute for Genomic Research, Rockville, MD 20850, USA
    J Mol Microbiol Biotechnol 12:165-79. 2007
    ..These findings strongly suggest the correlation of transporter profiles to both evolutionary history and the overall physiology and lifestyles of the organisms...
  24. ncbi request reprint Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes
    Malcolm J Gardner
    Institute for Genomic Research TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 309:134-7. 2005
    ..Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated...
  25. ncbi request reprint Genome sequence of the human malaria parasite Plasmodium falciparum
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:498-511. 2002
    ..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria...
  26. pmc The value of complete microbial genome sequencing (you get what you pay for)
    Claire M Fraser
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    J Bacteriol 184:6403-5; discusion 6405. 2002
  27. pmc The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium
    Jonathan A Eisen
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 99:9509-14. 2002
    ..tepidum and many Archaeal species...
  28. ncbi request reprint The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria
    Timothy D Read
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 423:81-6. 2003
    ..The complete sequence of B. anthracis is a step towards a better understanding of anthrax pathogenesis...
  29. pmc Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83
    Karen E Nelson
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    J Bacteriol 185:5591-601. 2003
    ..gingivalis can metabolize a range of amino acids and generate a number of metabolic end products that are toxic to the human host or human gingival tissue and contribute to the development of periodontal disease...
  30. pmc The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000
    C Robin Buell
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 100:10181-6. 2003
    ..Comparative analyses confirmed a high degree of similarity with two sequenced pseudomonads, Pseudomonas putida and Pseudomonas aeruginosa, yet revealed 1,159 genes unique to DC3000, of which 811 lack a known function...
  31. pmc TransportDB: a relational database of cellular membrane transport systems
    Qinghu Ren
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Nucleic Acids Res 32:D284-8. 2004
    ..TransportDB will be regularly updated with data obtained from newly sequenced genomes...
  32. pmc TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels
    Qinghu Ren
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Nucleic Acids Res 35:D274-9. 2007
    ..TransportDB has now been in existence for over 10 years and continues to be regularly updated with new evidence and data from newly sequenced genomes, as well as having new features added periodically...
  33. pmc Comparative analyses of fundamental differences in membrane transport capabilities in prokaryotes and eukaryotes
    Qinghu Ren
    The Institute for Genomic Research, Rockville, Maryland, USA
    PLoS Comput Biol 1:e27. 2005
    ....
  34. ncbi request reprint Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus
    Garry S A Myers
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nat Biotechnol 25:569-75. 2007
    ..Screening of these proteins against ovine antisera identified eight immunogenic proteins that are candidate antigens for a cross-protective vaccine...
  35. pmc Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens
    Garry S A Myers
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Genome Res 16:1031-40. 2006
    ....
  36. pmc Complete genome sequence of the Q-fever pathogen Coxiella burnetii
    Rekha Seshadri
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 100:5455-60. 2003
    ..burnetii genome. These analyses suggest that the obligate intracellular lifestyle of C. burnetii may be a relatively recent innovation...
  37. ncbi request reprint Transport capabilities encoded within the Bacillus subtilis genome
    Milton H Saier
    Department of Biology University of California at San Diego La Jolla, 92093 0116, USA
    J Mol Microbiol Biotechnol 4:37-67. 2002
    ..The recognized transporters fall into 58 families including 4 channel types, 42 secondary carrier types, 3 primary carrier types, 4 PTS-types and 5 unknown types...
  38. pmc Genome sequence of Synechococcus CC9311: Insights into adaptation to a coastal environment
    Brian Palenik
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 103:13555-9. 2006
    ..In addition, the types of potentially horizontally transferred genes are markedly different between the coastal and open ocean genomes and suggest a more prominent role for phages in horizontal gene transfer in oligotrophic environments...
  39. ncbi request reprint Regulation of carbon utilization by sulfur availability in Escherichia coli and Salmonella typhimurium
    John A Quan
    Department of Biology, University of California at San Diego, La Jolla, CA 92093 0116, USA
    Microbiology 148:123-31. 2002
    ..These observations may have physiological significance allowing carbon and sulfur regulon coordination during the growth of enteric bacteria in response to nutrient availability...
  40. pmc The genome of deep-sea vent chemolithoautotroph Thiomicrospira crunogena XCL-2
    Kathleen M Scott
    Biology Department, University of South Florida, Tampa, Florida, United States of America
    PLoS Biol 4:e383. 2006
    ..The genome has characteristics consistent with an obligately chemolithoautotrophic lifestyle, including few transporters predicted to have organic allocrits, and Calvin-Benson-Bassham cycle CDSs scattered throughout the genome...
  41. pmc Genome of the epsilonproteobacterial chemolithoautotroph Sulfurimonas denitrificans
    Stefan M Sievert
    Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
    Appl Environ Microbiol 74:1145-56. 2008
    ..An elaborate arsenal of sensory and regulatory protein-encoding genes is in place, as are genes necessary to prevent and respond to oxidative stress...
  42. pmc Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa
    Kelly A Brayton
    Program in Genomics, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA
    PLoS Pathog 3:1401-13. 2007
    ..The genome sequence provides a greater understanding of B. bovis metabolism and potential avenues for drug therapies and vaccine development...
  43. pmc The Chlamydomonas genome reveals the evolution of key animal and plant functions
    Sabeeha S Merchant
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 318:245-50. 2007
    ....
  44. pmc The EcoCyc Database
    Peter D Karp
    Bioinformatics Research Group, SRI International, 333 Ravenswood Avenue EK207, Menlo Park, CA 94025, USA
    Nucleic Acids Res 30:56-8. 2002
    ..EcoCyc is queried using the Pathway Tools graphical user interface, which provides a wide variety of query operations and visualization tools. EcoCyc is available at http://ecocyc.org/...
  45. pmc Unraveling the genomic mosaic of a ubiquitous genus of marine cyanobacteria
    Alexis Dufresne
    Université Paris 6 and CNRS, UMR 7144, Station Biologique, 29682 Roscoff, France
    Genome Biol 9:R90. 2008
    ..Yet, the genetic basis of niche partitioning is still poorly understood in this ecologically important group...
  46. ncbi request reprint Microbial drug efflux proteins of the major facilitator superfamily
    Massoud Saidijam
    Astbury Centre for Structural Molecular Biology, School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK
    Curr Drug Targets 7:793-811. 2006
    ..This strategy is an important step towards reproducible production of transport proteins for the screening of drug binding and for optimisation of crystallisation conditions to enable subsequent structure determination...
  47. ncbi request reprint Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine environment
    Mary Ann Moran
    Department of Marine Sciences, University of Georgia, Athens, Georgia 30602, USA
    Nature 432:910-3. 2004
    ..This bacterium has a physiology distinct from that of marine oligotrophs, adding a new strategy to the recognized repertoire for coping with a nutrient-poor ocean...
  48. pmc EcoCyc: a comprehensive database resource for Escherichia coli
    Ingrid M Keseler
    SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA
    Nucleic Acids Res 33:D334-7. 2005
    ....
  49. pmc High-throughput phenotypic characterization of Pseudomonas aeruginosa membrane transport genes
    Daniel A Johnson
    J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000211. 2008
    ..Thus, rapid phenotype identification assays are an invaluable tool for confirming and extending bioinformatic predictions...
  50. pmc Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii
    Asis Khan
    Department of Molecular Microbiology, Center for Infectious Diseases, Washington University School of Medicine St Louis, MO 63110, USA
    Nucleic Acids Res 33:2980-92. 2005
    ..The resulting genome map provides a framework for analysis of complex traits such as virulence and transmission, and for comparative population genetic studies...
  51. pmc Computational inference and experimental validation of the nitrogen assimilation regulatory network in cyanobacterium Synechococcus sp. WH 8102
    Zhengchang Su
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Nucleic Acids Res 34:1050-65. 2006
    ..Moreover, for some of these genes, this coordination is probably mediated by NtcA through the canonical NtcA promoters in their regulatory regions...
  52. pmc Regulation of type IV fimbrial biogenesis in Dichelobacter nodosus
    Dane Parker
    Australian Research Council Centre of Excellence for Structrral and Functional Microbial Genomics and Victorian Bioinformatics Consortium, Department of Microbiology, Monash University, Victoria 3800, Australia
    J Bacteriol 188:4801-11. 2006
    ..nodosus to cause ovine footrot is regulated, as we have shown that the biogenesis of type IV fimbriae in D. nodosus is regulated by a sigma 54-dependent PilR/S system that also indirectly controls protease secretion...
  53. pmc ToxoDB: accessing the Toxoplasma gondii genome
    Jessica C Kissinger
    Department of Genetics Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA 30602 2606, USA
    Nucleic Acids Res 31:234-6. 2003
    ..the database will provide an integrated data analysis platform facilitating user-defined queries across the different data types...
  54. ncbi request reprint A high efficiency cloning and expression system for proteomic analysis
    Xuan Z Ding
    Department of Bacterial Diseases, Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Reseach, Silver Spring, MD 20910 7500, USA
    Proteomics 6:4038-46. 2006
    ..This method will allow selection of new reagents for diagnosis of brucellosis and development of vaccine against Brucella, an important zoonotic disease and biothreat agent...
  55. pmc Identification of a Dichelobacter nodosus ferric uptake regulator and determination of its regulatory targets
    Dane Parker
    ARC Centre for Structural and Functional Microbial Genomics and Victorian Bioinformatics Consortium, Department of Microbiology, Monash University, Victoria, Australia
    J Bacteriol 187:366-75. 2005
    ..Down-regulated proteins included a putative manganese superoxide dismutase and ornithine decarboxylase. Based on these data, it is suggested that in D. nodosus the Fur protein functions as a regulator of iron and oxidative metabolism...
  56. pmc Complete genome sequence of the broad-host-range vibriophage KVP40: comparative genomics of a T4-related bacteriophage
    Eric S Miller
    Department of Microbiology, North Carolina State University, Raleigh, NC 27695 7615, USA
    J Bacteriol 185:5220-33. 2003
    ..Features of the KVP40 genome that distinguish it from T4 are presented, as well as those, such as the replication and virion gene clusters, that are substantially conserved...
  57. ncbi request reprint Cloning, expression, and purification of Brucella suis outer membrane proteins
    Xuan Z Ding
    Division of CD and I, Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, DC, USA
    Protein Expr Purif 40:134-41. 2005
    ..The results suggested that recombinant B. suis OMPs were successfully cloned, expressed and purified. Some of the expressed OMPs showed high binding activity with immunized rabbit antiserum...

Research Grants1

  1. Genome Sequencing of Toxoplasma gondii
    Ian Paulsen; Fiscal Year: 2002
    ..gondii research community is solidly behind this effort, and the history of this group (in supporting and successfully exploiting the T. gondii EST project, for example) bodes well for successful utilization of the genomic sequence...