Elena Pasquale

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. pmc The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways
    Caroline Bourgin
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    J Cell Biol 178:1295-307. 2007
  2. ncbi request reprint Neurobiology. Turning attraction into repulsion
    E Pasquale
    Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 289:1308-10. 2000
  3. pmc Eph receptors and ephrins in cancer: bidirectional signalling and beyond
    Elena B Pasquale
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Nat Rev Cancer 10:165-80. 2010
  4. doi request reprint Eph-ephrin bidirectional signaling in physiology and disease
    Elena B Pasquale
    Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 133:38-52. 2008
  5. ncbi request reprint Eph receptor signalling casts a wide net on cell behaviour
    Elena B Pasquale
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Mol Cell Biol 6:462-75. 2005
  6. ncbi request reprint EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity
    Mitchell Koolpe
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 280:17301-11. 2005
  7. pmc Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor
    Nicole K Noren
    The Burnham Institute for Medical Research, La Jolla, CA 92037, U S A
    Biochem J 422:433-42. 2009
  8. pmc EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1
    Fumitoshi Irie
    Developmental Neurobiology Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Cell Biol 7:501-9. 2005
  9. ncbi request reprint Eph receptors in the adult brain
    Yu Yamaguchi
    Developmental Neurobiology Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Opin Neurobiol 14:288-96. 2004
  10. ncbi request reprint Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion
    Monique Dail
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Sci 119:1244-54. 2006

Research Grants

Collaborators

Detail Information

Publications50

  1. pmc The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways
    Caroline Bourgin
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    J Cell Biol 178:1295-307. 2007
    ..Our results support a model in which EphA4 interferes with integrin signaling pathways that stabilize dendritic spines, thus modulating synaptic interactions with the extracellular environment...
  2. ncbi request reprint Neurobiology. Turning attraction into repulsion
    E Pasquale
    Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 289:1308-10. 2000
    ..and Galko and Tessier-Lavigne)...
  3. pmc Eph receptors and ephrins in cancer: bidirectional signalling and beyond
    Elena B Pasquale
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Nat Rev Cancer 10:165-80. 2010
    ..However, Eph signalling activities in cancer seem to be complex, and are characterized by puzzling dichotomies. Nevertheless, the Eph receptors are promising new therapeutic targets in cancer...
  4. doi request reprint Eph-ephrin bidirectional signaling in physiology and disease
    Elena B Pasquale
    Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 133:38-52. 2008
    ....
  5. ncbi request reprint Eph receptor signalling casts a wide net on cell behaviour
    Elena B Pasquale
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Mol Cell Biol 6:462-75. 2005
    ....
  6. ncbi request reprint EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity
    Mitchell Koolpe
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 280:17301-11. 2005
    ..These peptides should be useful as selective inhibitors of the pathological activities of EphB receptors and as targeting agents for imaging probes and therapeutic drugs...
  7. pmc Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor
    Nicole K Noren
    The Burnham Institute for Medical Research, La Jolla, CA 92037, U S A
    Biochem J 422:433-42. 2009
    ..These findings demonstrate that EphB4 can affect cancer cell behaviour in an ephrin-independent manner...
  8. pmc EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1
    Fumitoshi Irie
    Developmental Neurobiology Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Cell Biol 7:501-9. 2005
    ..Our results indicate that ephrinB-EphB signalling regulates clathrin-mediated endocytosis in various cellular contexts by influencing protein interactions and phosphoinositide turnover through tyrosine phosphorylation of synaptojanin 1...
  9. ncbi request reprint Eph receptors in the adult brain
    Yu Yamaguchi
    Developmental Neurobiology Program, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Opin Neurobiol 14:288-96. 2004
    ....
  10. ncbi request reprint Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion
    Monique Dail
    The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Sci 119:1244-54. 2006
    ..Therefore, Eph receptors can regulate R-Ras in two different ways to achieve cell repulsion...
  11. ncbi request reprint Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
    Keith K Murai
    The Burnham Institute, Neurobiology Program, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 6:153-60. 2003
    ..Thus, our data support a model in which transient interactions between the ephrin-A3 ligand and the EphA4 receptor regulate the structure of excitatory synaptic connections through neuroglial cross-talk...
  12. pmc Heparan sulfate regulates ephrin-A3/EphA receptor signaling
    Fumitoshi Irie
    Sanford Children s Health Research Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:12307-12. 2008
    ..These results show that heparan sulfate modulates ephrin/Eph signaling and suggest a physiological role for heparan sulfate proteoglycans in the regulation of ephrin-A3-dependent biological processes...
  13. ncbi request reprint Molecular determinants for interaction of SHEP1 with Cas localize to a highly solvent-protected region in the complex
    Celine Derunes
    Cancer Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    FEBS Lett 580:175-8. 2006
    ..This region is predominately hydrophilic, yet remains protected from solvent in the complex...
  14. ncbi request reprint SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases
    Monique Dail
    The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 279:41892-902. 2004
    ..Furthermore, the SHEP1-Cas complex may have different roles downstream of EphB2 and the EGF receptor...
  15. ncbi request reprint An ephrin mimetic peptide that selectively targets the EphA2 receptor
    Mitchell Koolpe
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 277:46974-9. 2002
    ..Bioactive ephrin mimetic peptides could be used to selectively deliver agents to Eph receptor-expressing tissues and modify Eph signaling in therapies for cancer, pathological angiogenesis, and nerve regeneration...
  16. ncbi request reprint Proliferation and tumor suppression: not mutually exclusive for Eph receptors
    Roberta Noberini
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Cancer Cell 16:452-4. 2009
    ..These separate pathways simultaneously promote proliferation but suppress invasive growth of intestinal adenomas...
  17. ncbi request reprint Targeting the EphA4 receptor in the nervous system with biologically active peptides
    Keith K Murai
    The Burnham Institute, Neurobiology Program, La Jolla, CA 92037, USA
    Mol Cell Neurosci 24:1000-11. 2003
    ..This panel of peptides may lead to the development of pharmaceuticals that differentially target Eph receptors to modulate neuronal function in specific regions of the nervous system...
  18. ncbi request reprint Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins
    Nicole K Noren
    Neurobiology Program, Neurobiology Cancer Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Signal 16:655-66. 2004
    ..Understanding the signaling networks involved is an important step to understand the molecular basis for normal and defective cell-cell communication through Eph receptors and ephrins...
  19. ncbi request reprint The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway
    Nicole K Noren
    Burnham Institute for Medical Research, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Nat Cell Biol 8:815-25. 2006
    ..These findings identify a novel Eph receptor signalling pathway with tumour-suppressor activity and predict that therapeutic intervention to activate EphB4 signalling will inhibit tumour progression...
  20. ncbi request reprint Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition
    Jill E Chrencik
    Department of Cellular Biology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 282:36505-13. 2007
    ..The structure of EphB2 in complex with the SNEW peptide reveals novel binding determinants that could serve as starting points in the development of compounds that modulate Eph receptor/ephrin interactions and biological activities...
  21. pmc The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain
    Lei Wang
    Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Neurosci 30:13201-10. 2010
    ....
  22. pmc Structure-activity relationship analysis of peptides targeting the EphA2 receptor
    Sayantan Mitra
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 49:6687-95. 2010
    ..The two peptides and derivatives are quite stable in conditioned cell culture medium and show promise for delivering drugs and imaging agents to EphA2-expressing tumors...
  23. pmc The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas
    Séverine Roselli
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Cell Signal 22:1745-52. 2010
    ..These data demonstrate that Shep1 plays a critical role in the in vivo regulation of Src activity and Cas downstream signaling through Crk, and suggest that the SH2 domain of Shep1 is critical for these effects...
  24. pmc Pericyte deficiencies lead to aberrant tumor vascularizaton in the brain of the NG2 null mouse
    Feng Ju Huang
    Sanford Burnham Medical Research Institute, Cancer Center, La Jolla, CA 92037, USA
    Dev Biol 344:1035-46. 2010
    ..These findings demonstrate the importance of NG2-dependent pericyte/endothelial cell interaction in the development and maturation of tumor blood vessels, identifying NG2 as a potential target for anti-angiogenic cancer therapy...
  25. ncbi request reprint The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies
    Marilisa Leone
    Cancer Center and Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, CA, USA
    Biopolymers 89:86-92. 2008
    ..Therefore, our studies suggest that capture of lipids by the PTB domain of tensin1 may play a role for the protein function at focal adhesions...
  26. pmc Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors
    Roberta Noberini
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 283:29461-72. 2008
    ..Furthermore, the newly identified inhibitors represent possible leads for the development of therapies to treat pathologies in which EphA4 and EphA2 are involved, including nerve injuries and cancer...
  27. pmc SHEP1 partners with CasL to promote marginal zone B-cell maturation
    Cecille D Browne
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:18944-9. 2010
    ..Thus, SHEP1 orchestrates marginal zone B-cell movement and retention as a key downstream effector of the BCR and S1P receptors...
  28. ncbi request reprint Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity
    Jill E Chrencik
    Department of Cellular Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Structure 14:321-30. 2006
    ..These studies reveal structural features that will aid drug discovery initiatives to develop EphB4 antagonists for therapeutic applications...
  29. ncbi request reprint 'Eph'ective signaling: forward, reverse and crosstalk
    Keith K Murai
    The Burnham Institute, Neurobiology Program, La Jolla, CA 92037, USA
    J Cell Sci 116:2823-32. 2003
    ..Deciphering the bi-directional pathways emanating from an Eph receptor-ephrin complex will not only help us to understand basic biological processes, but may also provide important insight into disease...
  30. pmc Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth
    Nicole K Noren
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:5583-8. 2004
    ..These results support a model in which EphB4 promotes tumor growth by stimulating angiogenesis through ephrin-B2...
  31. pmc Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport
    Maria A Carmona
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:12524-9. 2009
    ..Our results suggest that the interaction between neuronal EphA4 and glial ephrin-A3 bidirectionally controls synapse morphology and glial glutamate transport, ultimately regulating hippocampal function...
  32. ncbi request reprint The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases
    Melanie Richter
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Neurosci 27:14205-15. 2007
    ..Together, our data implicate SPAR as an important signaling intermediate that links the EphA4 receptor with Rap GTPase function in the regulation of neuronal morphology...
  33. ncbi request reprint Can Eph receptors stimulate the mind?
    Keith K Murai
    The Burnham Institute, Neurobiology Program, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 33:159-62. 2002
    ..Three new articles show that the Eph receptors continue to be important in modifying the strength of existing neuronal connections (synapses). They do so in close association with at least one family of ion channels, the NMDA receptors...
  34. pmc Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling
    Virginie S Vervoort
    The Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Gene 391:161-70. 2007
    ..These expression patterns suggest differential roles for the three genes during breast cancer progression in either the vasculature or the tumor cells...
  35. ncbi request reprint Eph receptors, ephrins, and synaptic function
    Keith K Murai
    Centre for Research in Neuroscience, McGill University Health Centre, Montreal General Hospital, Montreal, Canada
    Neuroscientist 10:304-14. 2004
    ..In this review, we discuss how Eph receptors and ephrins are integrated into the molecular machinery that supports synaptic function...
  36. ncbi request reprint Engineered fibrin matrices for functional display of cell membrane-bound growth factor-like activities: study of angiogenic signaling by ephrin-B2
    Andreas H Zisch
    Department of Materials Science, Institute for Biomedical Engineering, ETH Zurich, University of Zurich, Moussonstr 18, 8044 Zurich, Switzerland
    Biomaterials 25:3245-57. 2004
    ....
  37. ncbi request reprint Eph/ephrins and N-cadherin coordinate to control the pattern of sympathetic ganglia
    Jennifer C Kasemeier-Kulesa
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Development 133:4839-47. 2006
    ....
  38. ncbi request reprint EphA receptors and ephrin-A ligands exhibit highly regulated spatial and temporal expression patterns in the developing olfactory system
    James A St John
    Department of Anatomy and Developmental Biology, School of Biomedical Sciences, The University of Queensland, 4072, Brisbane, Australia
    Brain Res Dev Brain Res 138:1-14. 2002
    ..While EphA4, EphA5 and EphA7 are not mosaically expressed by bulbar neurons, other Eph receptors may have expression patterns complementary to the ephrin-A5-positive subpopulation of glomeruli...
  39. ncbi request reprint Expression of EphB receptors and EphrinB ligands in the developing chick auditory brainstem
    Karina S Cramer
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology, Head and Neck Surgery, University of Washington, Seattle, Washington 98195, USA
    J Comp Neurol 452:51-64. 2002
    ..Moreover, ephrin-B2 in growing axons may interact with the asymmetrically expressed EphA4 during the establishment of binaural segregation...
  40. ncbi request reprint EphA4 is not required for Purkinje cell compartmentation
    Sana D Karam
    Department of Physiology and Biophysics, University of Washington, P O Box 357290, Seattle, WA 98195, USA
    Brain Res Dev Brain Res 135:29-38. 2002
    ....
  41. ncbi request reprint Ephrin-A5 exerts positive or inhibitory effects on distinct subsets of EphA4-positive motor neurons
    Johann Eberhart
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    J Neurosci 24:1070-8. 2004
    ..Furthermore, we show that Eph activation localizes to distinct subcellular compartments of LMC(l) and MMC(m) neurons, consistent with distinct EphA4 signaling cascades in these neuronal subpopulations...
  42. ncbi request reprint Eph-ephrin promiscuity is now crystal clear
    Elena B Pasquale
    Nat Neurosci 7:417-8. 2004
  43. ncbi request reprint Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain
    David Bouvier
    Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central GRSNC, Universite de Montreal, Montreal, Quebec, Canada
    J Neurochem 106:682-95. 2008
    ..The localization of EphA4 and EphB2 in multiple compartments of neurons and synaptic junctions suggests that they interact with several distinct scaffolding proteins and play diverse roles at synapses...
  44. ncbi request reprint Tonotopic gradients of Eph family proteins in the chick nucleus laminaris during synaptogenesis
    Abigail L Person
    University of Washington, Seattle, 98195, USA
    J Neurobiol 60:28-39. 2004
    ..These results of this study provide a basis for the functional examination of the role of Eph proteins in the formation of tonotopic maps in the brainstem...
  45. ncbi request reprint Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases
    Hui Miao
    Rammelkamp Center for Research, MetroHealth Campus, and Department of Pharmacology and Ireland Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109, USA
    J Biol Chem 280:923-32. 2005
    ....
  46. ncbi request reprint New exchanges in eph-dependent growth cone dynamics
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4
    Neuron 46:161-3. 2005
    ..Two articles in this issue of Neuron (Sahin et al. and Cowan et al.) shed light on how Eph receptors recruit guanine nucleotide exchange factors for Rho family GTPases to modulate growth cone dynamics...
  47. ncbi request reprint EphB2 and ephrin-B1 expressed in the adult kidney regulate the cytoarchitecture of medullary tubule cells through Rho family GTPases
    Kazushige Ogawa
    Department of Veterinary Anatomy, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
    J Cell Sci 119:559-70. 2006
    ....
  48. ncbi request reprint Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus
    Marie Eve Tremblay
    Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central, Universite de Montreal, Montreal, Quebec, Canada
    J Comp Neurol 501:691-702. 2007
    ..The dual preferential labeling of EphA4 on pre- or postsynaptic specializations of excitatory synapses in adult rat hippocampus is consistent with roles for this receptor in synaptic plasticity and LTP...
  49. ncbi request reprint The EphB4 receptor-tyrosine kinase promotes the migration of melanoma cells through Rho-mediated actin cytoskeleton reorganization
    Nai Ying Yang
    Division of Biomedical Sciences, University of California Riverside, Riverside, CA 92521, USA
    J Biol Chem 281:32574-86. 2006
    ..These data suggest that EphB4 forward signaling contributes to the high migratory ability of invasive melanoma cells by influencing RhoA-mediated actin cytoskeleton reorganization...
  50. doi request reprint Neuroscience. Axons seek neighborly advice
    Keith K Murai
    Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, McGill University Health Centre, Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC H3G 1A4, Canada
    Science 320:185-6. 2008

Research Grants21

  1. The EphB4 Receptor as a Novel Breast Cancer Target
    Elena B Pasquale; Fiscal Year: 2010
    ..The information obtained will advance our basic understanding of the complex but intriguing molecular mechanisms used by the Eph receptors to influence tumorigenesis and angiogenesis, and possibly lead to new Eph-based therapies. ..
  2. EPH RECEPTORS AND EPHRINS IN VISUAL SYSTEM ORGANIZATION
    Elena Pasquale; Fiscal Year: 2002
    ..Studies include (a) alteration of activation using a constitutively active myc-EphA3 lacking most of extracellular domain inserted into RCAS and myc-ephrin A5 and (b) examination of axon trajectories using DiI. ..
  3. EPH RECEPTORS AND EPHRINS IN VISUAL SYSTEM ORGANIZATION
    Elena Pasquale; Fiscal Year: 2001
    ..Studies include (a) alteration of activation using a constitutively active myc-EphA3 lacking most of extracellular domain inserted into RCAS and myc-ephrin A5 and (b) examination of axon trajectories using DiI. ..
  4. EPH RECEPTORS AND EPHRINS IN VISUAL SYSTEM ORGANIZATION
    Elena Pasquale; Fiscal Year: 2000
    ..Studies include (a) alteration of activation using a constitutively active myc-EphA3 lacking most of extracellular domain inserted into RCAS and myc-ephrin A5 and (b) examination of axon trajectories using DiI. ..
  5. The EphB4 Receptor as a Novel Breast Cancer Target
    Elena Pasquale; Fiscal Year: 2009
    ..The information obtained will advance our basic understanding of the complex but intriguing molecular mechanisms used by the Eph receptors to influence tumorigenesis and angiogenesis, and possibly lead to new Eph-based therapies. ..
  6. Signaling Interactions in Cell Survival and Invasion
    Elena Pasquale; Fiscal Year: 2007
    ..These studies may allow future development of small molecules that can disrupt pathologic signals by targeting protein interfaces. ..
  7. The EphB4 Receptor as a Novel Breast Cancer Target
    Elena Pasquale; Fiscal Year: 2007
    ..The information obtained will advance our basic understanding of the complex but intriguing molecular mechanisms used by the Eph receptors to influence tumorigenesis and angiogenesis, and possibly lead to new Eph-based therapies. ..
  8. EphA4 Receptor Antagonists for CNS Regeneration(RMI)
    Elena Pasquale; Fiscal Year: 2006
    ..A particularly promising therapeutic application of EphA4 antagonists is in spinal cord injury, where these reagents could be applied locally to improve functional recovery. ..
  9. The EphB4 Receptor as a Novel Breast Cancer Target
    Elena Pasquale; Fiscal Year: 2006
    ..The information obtained will advance our basic understanding of the complex but intriguing molecular mechanisms used by the Eph receptors to influence tumorigenesis and angiogenesis, and possibly lead to new Eph-based therapies. ..
  10. Dendritic Repulsion by the EphA4 Receptor
    Elena Pasquale; Fiscal Year: 2006
    ..Furthermore, it may clarify the neurological aspects of diseases characterized by abnormal dendritic spine structure, such as mental retardation, William's syndrome, Down's syndrome, and autism. ..
  11. Dendritic Repulsion by the EphA4 Receptor
    Elena Pasquale; Fiscal Year: 2005
    ..Furthermore, it may clarify the neurological aspects of diseases characterized by abnormal dendritic spine structure, such as mental retardation, William's syndrome, Down's syndrome, and autism. ..
  12. Dendritic Repulsion by the EphA4 Receptor
    Elena Pasquale; Fiscal Year: 2004
    ..Furthermore, it may clarify the neurological aspects of diseases characterized by abnormal dendritic spine structure, such as mental retardation, William's syndrome, Down's syndrome, and autism. ..
  13. Dendritic Repulsion by the EphA4 Receptor
    Elena Pasquale; Fiscal Year: 2003
    ..Furthermore, it may clarify the neurological aspects of diseases characterized by abnormal dendritic spine structure, such as mental retardation, William's syndrome, Down's syndrome, and autism. ..
  14. EPH RECEPTORS AND EPHRINS IN VISUAL SYSTEM ORGANIZATION
    Elena Pasquale; Fiscal Year: 1999
    ..Studies include (a) alteration of activation using a constitutively active myc-EphA3 lacking most of extracellular domain inserted into RCAS and myc-ephrin A5 and (b) examination of axon trajectories using DiI. ..