M R Parthun

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc The tale beyond the tail: histone core domain modifications and the regulation of chromatin structure
    Erica L Mersfelder
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 34:2653-62. 2006
  2. pmc Expanded binding specificity of the human histone chaperone NASP
    Huanyu Wang
    Department of Molecular and Cellular Biochemistry, The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 36:5763-72. 2008
  3. pmc Increasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis
    Rajbir Singh
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA, Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 41:9284-95. 2013
  4. pmc H1 histones: current perspectives and challenges
    Sean W Harshman
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, USA, College of Medicine and Arthur G James Comprehensive Cancer Center, Columbus, Ohio, USA, National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, USA and Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio, USA
    Nucleic Acids Res 41:9593-609. 2013
  5. pmc Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4
    Prabakaran Nagarajan
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USA
    PLoS Genet 9:e1003518. 2013
  6. pmc The human histone chaperone sNASP interacts with linker and core histones through distinct mechanisms
    Huanyu Wang
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 40:660-9. 2012
  7. ncbi request reprint Histone acetyltransferase 1: more than just an enzyme?
    Mark R Parthun
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Biochim Biophys Acta 1819:256-63. 2013
  8. pmc Characterization of yeast histone H3-specific type B histone acetyltransferases identifies an ADA2-independent Gcn5p activity
    Amy R Sklenar
    Department of Molecular and Cellular Biochemistry, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    BMC Biochem 5:11. 2004
  9. ncbi request reprint Hat1: the emerging cellular roles of a type B histone acetyltransferase
    M R Parthun
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USA
    Oncogene 26:5319-28. 2007
  10. ncbi request reprint The nuclear Hat1p/Hat2p complex: a molecular link between type B histone acetyltransferases and chromatin assembly
    Xi Ai
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell 14:195-205. 2004

Collaborators

  • Guido Marcucci
  • John Byrd
  • Amy R Sklenar
  • Michael Grever
  • David M Lucas
  • J C Reed
  • T J Kelly
  • Richard Fishel
  • Kalpana Ghoshal
  • C Plass
  • Samson Jacob
  • Anthony T Annunziato
  • CHARLES HOFFMAN
  • T Tsukiyama
  • Christine M Smith
  • Michael A Freitas
  • Liwen Zhang
  • Xiaodan Su
  • Amy R Knapp
  • Huanyu Wang
  • Prabakaran Nagarajan
  • Erica L Mersfelder
  • Melanie E Davis
  • Chen Ren
  • Song Qin
  • Sean W Harshman
  • Rajbir Singh
  • Zhongqi Ge
  • Xi Ai
  • Joseph Wickham
  • Scott T R Walsh
  • Laura J Benson
  • Kimberly C Lindstrom
  • Jianxin Ye
  • Ericka E Eugeni
  • Marko I Klisovic
  • Dino D Klisovic
  • Jennifer L Aron
  • M I Klisovic
  • Paula A Agudelo Garcia
  • Lukas Kenner
  • Steven K Clinton
  • Jennifer M Thomas-Ahner
  • David Cortez
  • Kelly H Telu
  • Amir Mortazavi
  • Michaela Schlederer
  • Bianca Sirbu
  • Nicolas L Young
  • Cheryl Doughty
  • Hua Xu
  • Donn C Young
  • Philip R O Payne
  • Vlad Zabrouskov
  • Naduparambil K Jacob
  • Ravindra Amunugama
  • Shujun Liu
  • Kari B Green-Church
  • Jane A Phillips
  • Yongli Gu
  • Jay C Vary
  • Jeffrey Delrow
  • Mary A Jelinek
  • Laura Rocco Carpenter
  • J Anon
  • Andrew P Mone
  • Martin Guimond
  • T Murphy
  • K J Archer
  • M Guimond
  • Timothy Murphy
  • E A Maghraby
  • Steven E Katz
  • K K Chan
  • David Effron
  • Shinichi Kitada
  • S P Whitman
  • L J Rush
  • Tiansheng Shen
  • Chris Kanakry

Detail Information

Publications32

  1. pmc The tale beyond the tail: histone core domain modifications and the regulation of chromatin structure
    Erica L Mersfelder
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 34:2653-62. 2006
    ..This article reviews the recent developments in regards to these novel histone modifications and discusses their important role in the regulation of chromatin structure...
  2. pmc Expanded binding specificity of the human histone chaperone NASP
    Huanyu Wang
    Department of Molecular and Cellular Biochemistry, The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 36:5763-72. 2008
    ..The interaction between NASP and histones H3 and H4 is functional as NASP is active in in vitro chromatin assembly assays using histone substrates depleted of H1...
  3. pmc Increasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis
    Rajbir Singh
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA, Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 41:9284-95. 2013
    ..Taken together, these results indicate that replication-dependent histone isoforms can possess distinct cellular functions and that regulation of these isoforms may play a role in carcinogenesis. ..
  4. pmc H1 histones: current perspectives and challenges
    Sean W Harshman
    Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, USA, College of Medicine and Arthur G James Comprehensive Cancer Center, Columbus, Ohio, USA, National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, USA and Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio, USA
    Nucleic Acids Res 41:9593-609. 2013
    ..We also discuss various experimental challenges to the study of H1 and related proteins, including limitations of immunological reagents and practical difficulties in the analysis of posttranslational modifications by mass spectrometry. ..
  5. pmc Histone acetyl transferase 1 is essential for mammalian development, genome stability, and the processing of newly synthesized histones H3 and H4
    Prabakaran Nagarajan
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USA
    PLoS Genet 9:e1003518. 2013
    ....
  6. pmc The human histone chaperone sNASP interacts with linker and core histones through distinct mechanisms
    Huanyu Wang
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Nucleic Acids Res 40:660-9. 2012
    ..Finally, analysis of cellular proteins demonstrated that sNASP existed in distinct complexes that contained either linker or core histones...
  7. ncbi request reprint Histone acetyltransferase 1: more than just an enzyme?
    Mark R Parthun
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Biochim Biophys Acta 1819:256-63. 2013
    ..These results are incorporated into a model for the function of HAT1 in histone deposition and chromatin assembly. This article is part of a Special issue entitled: Histone chaperones and Chromatin assembly...
  8. pmc Characterization of yeast histone H3-specific type B histone acetyltransferases identifies an ADA2-independent Gcn5p activity
    Amy R Sklenar
    Department of Molecular and Cellular Biochemistry, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    BMC Biochem 5:11. 2004
    ..To date, the only type B histone acetyltransferase activities identified are specific for histone H4...
  9. ncbi request reprint Hat1: the emerging cellular roles of a type B histone acetyltransferase
    M R Parthun
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USA
    Oncogene 26:5319-28. 2007
    ..This review will discuss recent results that have begun to shed light on the roles of Hat1 and also address several outstanding questions relating to the cellular function of this enzyme...
  10. ncbi request reprint The nuclear Hat1p/Hat2p complex: a molecular link between type B histone acetyltransferases and chromatin assembly
    Xi Ai
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Mol Cell 14:195-205. 2004
    ..The association of Hif1p with acetylated H4 requires Hat1p and Hat2p providing a link between type B histone acetyltransferases and chromatin assembly...
  11. pmc Type B histone acetyltransferase Hat1p participates in telomeric silencing
    T J Kelly
    The Department of Molecular and Cellular Biochemistry, Cellular and Developmental Biology Program, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Cell Biol 20:7051-8. 2000
    ..Thus, in contrast to other histone acetyltransferases, Hat1p activity was required for transcriptional repression rather than gene activation...
  12. pmc Recruitment of the type B histone acetyltransferase Hat1p to chromatin is linked to DNA double-strand breaks
    Song Qin
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Cell Biol 26:3649-58. 2006
    ..These results indicate that Hat1p plays a direct role in DNA damage repair and is responsible for specific changes in histone modification that occur during the course of recombinational DNA repair...
  13. pmc Involvement of Hat1p (Kat1p) catalytic activity and subcellular localization in telomeric silencing
    Erica L Mersfelder
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 283:29060-8. 2008
    ..Hence both enzymatic activity and nuclear localization are necessary characteristics of Hat1p function in telomeric silencing...
  14. ncbi request reprint A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia
    John C Byrd
    Department of Internal Medicine, Division of Hematology Oncology, Starling Loving Hall, Rm 302, The Ohio State University, Columbus, OH 43210, USA
    Blood 105:959-67. 2005
    ..Future studies with depsipeptide should examine alternative administration schedules...
  15. ncbi request reprint Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells
    M I Klisovic
    Division of Hematology Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Leukemia 17:350-8. 2003
    ....
  16. pmc Histone H4 lysine 91 acetylation a core domain modification associated with chromatin assembly
    Jianxin Ye
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Cell 18:123-30. 2005
    ..These results indicate an important role for histone modifications outside the NH2-tail domains in the processes of chromatin assembly, DNA repair, and transcriptional silencing...
  17. pmc Histone H3 and the histone acetyltransferase Hat1p contribute to DNA double-strand break repair
    Song Qin
    Molecular, Cellular and Developmental Biology Program Department of Molecular and Cellular Biochemistry, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Cell Biol 22:8353-65. 2002
    ..Epistasis analysis indicates that the histone H3 and HAT1 mutants may influence DNA double-strand break repair through Asf1p-dependent chromatin assembly...
  18. ncbi request reprint Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines
    Dino D Klisovic
    William H Havener Eye Center, The Ohio State University, Columbus, Ohio 43210, USA
    Invest Ophthalmol Vis Sci 44:2390-8. 2003
    ..Therefore, the ability of the histone deacetylase inhibitors (HDACIs), depsipeptide, sodium butyrate (NaB) and trichostatin A (TSA), to induce apoptosis and inhibit cell growth of UM cell lines in vitro was examined...
  19. ncbi request reprint Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein
    Jennifer L Aron
    Department of Internal Medicine, The Division of Hematology Oncology, The Ohio State University, Columbus, USA
    Blood 102:652-8. 2003
    ..These data suggest use of histone H3 and H4 acetylation, inhibition of histone deacetylase, and down-regulation of FLIP as pharmacodynamic end points for further evaluation of this drug in patients...
  20. pmc Peptide mass mapping of acetylated isoforms of histone H4 from mouse lymphosarcoma cells treated with histone deacetylase (HDACs) inhibitors
    Chen Ren
    Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA
    J Am Soc Mass Spectrom 16:1641-53. 2005
    ..An identical order of acetylation was found for cells treated with DDP...
  21. pmc Quantitative profiling of histone post-translational modifications by stable isotope labeling
    Amy R Knapp
    Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Methods 41:312-9. 2007
    ..These methods are applicable to a wide variety of model systems and examples of their use in both mammalian cells and Saccharomyces cerevisiae are presented...
  22. ncbi request reprint The histone deacetylase inhibitor MS-275 induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia cells
    D M Lucas
    Department of Internal Medicine, The Ohio State University, Columbus OH, USA
    Leukemia 18:1207-14. 2004
    ..Similar to many other therapeutic targets, MS-275-mediated apoptosis is reduced by overexpression of Bcl-2, justifying strategies to combine HDAC inhibitors with Bcl-2 antagonists...
  23. pmc Histone H4 acetylation dynamics determined by stable isotope labeling with amino acids in cell culture and mass spectrometry
    Xiaodan Su
    Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA
    Anal Biochem 363:22-34. 2007
    ....
  24. pmc Histone H4 N-terminal acetylation in Kasumi-1 cells treated with depsipeptide determined by acetic acid-urea polyacrylamide gel electrophoresis, amino acid coded mass tagging, and mass spectrometry
    Liwen Zhang
    Mass Spectrometry and Proteomics Facility, Campus Chemical Instrument Center, Department of Chemistry, Division of Hematology Oncology, The Ohio State University, Columbus, Ohio 43210, USA
    J Proteome Res 6:81-8. 2007
    ..The major pattern of acetylation was determined as follows: initial acetylation at K16, followed by acetylation at K12, and finally acetylation of either K8 and/or K5...
  25. ncbi request reprint Identification of novel histone post-translational modifications by peptide mass fingerprinting
    Liwen Zhang
    Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA
    Chromosoma 112:77-86. 2003
    ..Consistent with the role of histone H3 lysine 79 methylation in the formation of silent chromatin structure, histone H4 lysine 59 is essential for transcriptional silencing at the yeast silent mating loci and telomeres...
  26. pmc Application of mass spectrometry to the identification and quantification of histone post-translational modifications
    Michael A Freitas
    Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA
    J Cell Biochem 92:691-700. 2004
    ..Hence, the use of mass spectrometry promises to dramatically alter our view of histone post-translational modifications...
  27. ncbi request reprint Differential expression of histone post-translational modifications in acute myeloid and chronic lymphocytic leukemia determined by high-pressure liquid chromatography and mass spectrometry
    Liwen Zhang
    Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA
    J Am Soc Mass Spectrom 15:77-86. 2004
    ..An increase in the relative abundance of specific acetylated forms of histone H4 was readily observable in these patients at intervals of 4 and 24 h after treatment...
  28. pmc Validation of an LC-MS based approach for profiling histones in chronic lymphocytic leukemia
    Xiaodan Su
    Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    Proteomics 9:1197-206. 2009
    ..Protein identities were determined using high mass accuracy MS and shotgun proteomics...
  29. pmc Liquid chromatography mass spectrometry profiling of histones
    Xiaodan Su
    Department of Chemistry, Human Cancer Genetics, College of Medicine and Public Health, The Ohio State University Columbus, OH, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 850:440-54. 2007
    ..Protein identities were verified by the analysis of histone H2A species using RPLC fractionation, AU-PAGE separation and nano-LC-MS/MS...
  30. ncbi request reprint Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair
    Laura J Benson
    Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467, USA
    J Biol Chem 282:836-42. 2007
    ..Thus, although the role of Hat1 in DNA damage repair is evolutionarily conserved, the ability of H3 acetylation to compensate for Hat1 deletion appears to be more variable...
  31. pmc Heritable chromatin structure: mapping "memory" in histones H3 and H4
    Christine M Smith
    Division of Basic Sciences and Proteomics Facility, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 99:16454-61. 2002
    ....
  32. pmc Isw1 functions in parallel with the NuA4 and Swr1 complexes in stress-induced gene repression
    Kimberly C Lindstrom
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cell Biol 26:6117-29. 2006
    ..In contrast to a recruitment-based model, we find that the NuA4 and Swr1 complexes act throughout the genome while only a specific subset of the genome shows alterations in transcription...

Research Grants10

  1. Characterization of Type B Histone Acetyltransferases
    Mark Parthun; Fiscal Year: 2001
    ..The second is to characterize the involvement of Hat1p and chromatin structure the repair of DNA double strand breaks. Third, we will isolate and characterize novel type B histone acetyltransferases. ..
  2. Type B Histone Acetyltransferases and the Assembly of Chromatin Structure
    Mark Parthun; Fiscal Year: 2009
    ..2. Characterize the function of the histone chaperone Hiflp in histone deposition. 3. Characterize core domain modifications on histones H3 and H4 associated with chromatin assembly. ..
  3. Type B Histone Acetyltransferases and the Assembly of Chromatin Structure
    Mark Parthun; Fiscal Year: 2007
    ..2. Characterize the function of the histone chaperone Hiflp in histone deposition. 3. Characterize core domain modifications on histones H3 and H4 associated with chromatin assembly. ..
  4. Type B Histone Acetyltransferases and the Assembly of Chromatin Structure
    Mark Parthun; Fiscal Year: 2006
    ..2. Characterize the function of the histone chaperone Hiflp in histone deposition. 3. Characterize core domain modifications on histones H3 and H4 associated with chromatin assembly. ..
  5. Characterization of Type B Histone Acetyltransferases
    Mark Parthun; Fiscal Year: 2005
    ..The second is to characterize the involvement of Hat1p and chromatin structure the repair of DNA double strand breaks. Third, we will isolate and characterize novel type B histone acetyltransferases. ..
  6. Characterization of Type B Histone Acetyltransferases
    Mark Parthun; Fiscal Year: 2004
    ..The second is to characterize the involvement of Hat1p and chromatin structure the repair of DNA double strand breaks. Third, we will isolate and characterize novel type B histone acetyltransferases. ..
  7. Characterization of Type B Histone Acetyltransferases
    Mark Parthun; Fiscal Year: 2003
    ..The second is to characterize the involvement of Hat1p and chromatin structure the repair of DNA double strand breaks. Third, we will isolate and characterize novel type B histone acetyltransferases. ..
  8. Characterization of Type B Histone Acetyltransferases
    Mark Parthun; Fiscal Year: 2002
    ..The second is to characterize the involvement of Hat1p and chromatin structure the repair of DNA double strand breaks. Third, we will isolate and characterize novel type B histone acetyltransferases. ..
  9. Type B Histone Acetyltransferases and the Assembly of Chromatin Structure
    Mark Parthun; Fiscal Year: 2009
    ..2. Characterize the function of the histone chaperone Hiflp in histone deposition. 3. Characterize core domain modifications on histones H3 and H4 associated with chromatin assembly. ..