Hay Oak Park

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity
    H O Park
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 0448, USA
    Proc Natl Acad Sci U S A 94:4463-8. 1997
  2. pmc Localization of Bud2p, a GTPase-activating protein necessary for programming cell polarity in yeast to the presumptive bud site
    H O Park
    Department of Molecular Genetics, Ohio State University, Columbus, Ohio 43210 1292, USA
    Genes Dev 13:1912-7. 1999
  3. ncbi request reprint Localization of the Rsr1/Bud1 GTPase involved in selection of a proper growth site in yeast
    Hay Oak Park
    Graduate Program in Molecular, Cellular, and Developmental Biology, Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210 1292, USA
    J Biol Chem 277:26721-4. 2002
  4. pmc Central roles of small GTPases in the development of cell polarity in yeast and beyond
    Hay Oak Park
    Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210 1292, USA
    Microbiol Mol Biol Rev 71:48-96. 2007
  5. ncbi request reprint Specific residues of the GDP/GTP exchange factor Bud5p are involved in establishment of the cell type-specific budding pattern in yeast
    Pil Jung Kang
    Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210 1292, USA
    J Biol Chem 279:27980-5. 2004
  6. pmc Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast
    Pil Jung Kang
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210 1292, USA
    Mol Biol Cell 15:5145-57. 2004
  7. pmc Bud4 mediates the cell-type-specific assembly of the axial landmark in budding yeast
    Pil Jung Kang
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Sci 125:3840-9. 2012
  8. pmc The Rsr1/Bud1 GTPase interacts with itself and the Cdc42 GTPase during bud-site selection and polarity establishment in budding yeast
    Pil Jung Kang
    Department of Molecular Genetics and The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 21:3007-16. 2010
  9. pmc The Rho1 GTPase acts together with a vacuolar glutathione S-conjugate transporter to protect yeast cells from oxidative stress
    Mid Eum Lee
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210 1292, USA
    Genetics 188:859-70. 2011
  10. pmc Coupling of septins to the axial landmark by Bud4 in budding yeast
    Pil Jung Kang
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Sci 126:1218-26. 2013

Collaborators

Detail Information

Publications14

  1. pmc Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity
    H O Park
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 0448, USA
    Proc Natl Acad Sci U S A 94:4463-8. 1997
    ..We propose that Bud1 can exist in two active states for association with different partners and that the switch from Bud1-GTP to Bud1-GDP provides a regulatory device for ordered assembly of a macromolecular complex at the bud site...
  2. pmc Localization of Bud2p, a GTPase-activating protein necessary for programming cell polarity in yeast to the presumptive bud site
    H O Park
    Department of Molecular Genetics, Ohio State University, Columbus, Ohio 43210 1292, USA
    Genes Dev 13:1912-7. 1999
    ..These observations indicate that Bud2p becomes positioned in G(1) cells by recognizing cell type-specific landmarks at the presumptive bud site...
  3. ncbi request reprint Localization of the Rsr1/Bud1 GTPase involved in selection of a proper growth site in yeast
    Hay Oak Park
    Graduate Program in Molecular, Cellular, and Developmental Biology, Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210 1292, USA
    J Biol Chem 277:26721-4. 2002
    ..This localization of Rsr1/Bud1 is essential for its function in proper bud site selection because both mutations resulted in random bud site selection...
  4. pmc Central roles of small GTPases in the development of cell polarity in yeast and beyond
    Hay Oak Park
    Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210 1292, USA
    Microbiol Mol Biol Rev 71:48-96. 2007
    ..In this review, we discuss the key signaling pathways that regulate cell polarization during the mitotic cell cycle and during mating...
  5. ncbi request reprint Specific residues of the GDP/GTP exchange factor Bud5p are involved in establishment of the cell type-specific budding pattern in yeast
    Pil Jung Kang
    Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210 1292, USA
    J Biol Chem 279:27980-5. 2004
    ..Bud5p with these additional N-terminal residues interacted with Bud8p, a potential bipolar landmark, suggesting that the N-terminal region is necessary for recognition of the spatial cues...
  6. pmc Interactions among Rax1p, Rax2p, Bud8p, and Bud9p in marking cortical sites for bipolar bud-site selection in yeast
    Pil Jung Kang
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210 1292, USA
    Mol Biol Cell 15:5145-57. 2004
    ..Taken together, the results indicate that Rax1p and Rax2p interact closely with each other and with Bud8p and Bud9p in the establishment and/or maintenance of the cortical landmarks for bipolar budding...
  7. pmc Bud4 mediates the cell-type-specific assembly of the axial landmark in budding yeast
    Pil Jung Kang
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Sci 125:3840-9. 2012
    ..Together, our findings suggest that Bud4 plays a critical role in the assembly of the axial landmark and its link to the Rsr1 GTPase module...
  8. pmc The Rsr1/Bud1 GTPase interacts with itself and the Cdc42 GTPase during bud-site selection and polarity establishment in budding yeast
    Pil Jung Kang
    Department of Molecular Genetics and The Ohio State Biochemistry Program, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 21:3007-16. 2010
    ..Our findings thus suggest that dimerization of GTPases may be an efficient mechanism to set up cellular asymmetry...
  9. pmc The Rho1 GTPase acts together with a vacuolar glutathione S-conjugate transporter to protect yeast cells from oxidative stress
    Mid Eum Lee
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210 1292, USA
    Genetics 188:859-70. 2011
    ..Since both Rho1 and Ycf1 belong to highly conserved families of proteins, similar mechanisms may exist in other eukaryotes...
  10. pmc Coupling of septins to the axial landmark by Bud4 in budding yeast
    Pil Jung Kang
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Sci 126:1218-26. 2013
    ..Taken together, these results indicate that Bud4 functions as a platform that links septins to the axial landmark...
  11. pmc Polarization of diploid daughter cells directed by spatial cues and GTP hydrolysis of Cdc42 budding yeast
    Wing Cheong Lo
    Mathematical Biosciences Institute, The Ohio State University, Columbus, Ohio, USA
    PLoS ONE 8:e56665. 2013
    ..Moreover, modeling predicts different dynamics of Cdc42-GTP polarization when the landmark level and the initial level of Cdc42-GTP at the division site are perturbed by noise added in the model...
  12. pmc The Rho5 GTPase is necessary for oxidant-induced cell death in budding yeast
    Komudi Singh
    Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 105:1522-7. 2008
    ..Taken together, these data suggest that Rho5 mediates H(2)O(2)-induced cell death by regulating the level of Trr1 or by excluding Trr1 from its cytoplasmic substrate...
  13. ncbi request reprint Bud3 activates Cdc42 to establish a proper growth site in budding yeast
    Pil Jung Kang
    Department of Molecular Genetics and Molecular Cellular Developmental Biology Program, The Ohio State University, Columbus, OH 43210
    J Cell Biol 206:19-28. 2014
    ..Biphasic activation of Cdc42 or Rac GTPases may be a general mechanism for spatial cue-directed cell polarization in eukaryotes. ..
  14. pmc Interaction between a Ras and a Rho GTPase couples selection of a growth site to the development of cell polarity in yeast
    Keith G Kozminski
    Departments of Biology and Cell Biology, University of Virginia, Charlottesville, Virginia 22904, USA
    Mol Biol Cell 14:4958-70. 2003
    ....

Research Grants10

  1. Regulation of polarized cell growth by GTPases
    Hay Oak Park; Fiscal Year: 2009
    ..abstract_text> ..
  2. SPATIAL CONTROL OF CELL POLARITY DURING YEAST BUDDING
    Hay Oak Park; Fiscal Year: 1999
    ..This work will also help us to understand the mechanism of genesis of human cancer since mutations in human homologs of these yeast proteins have been found in human tumor. ..
  3. Regulation of polarized cell growth by GTPases
    Hay Oak Park; Fiscal Year: 2009
    ..abstract_text> ..
  4. Regulation of polarized cell growth by GTPases
    Hay Oak Park; Fiscal Year: 2007
    ....
  5. Regulation of polarized cell growth by GTPases
    Hay Oak Park; Fiscal Year: 2006
    ....
  6. SPATIAL CONTROL OF CELL POLARITY DURING YEAST BUDDING
    Hay Oak Park; Fiscal Year: 2003
    ..This work will also help us to understand the mechanism of genesis of human cancer since mutations in human homologs of these yeast proteins have been found in human tumor. ..
  7. SPATIAL CONTROL OF CELL POLARITY DURING YEAST BUDDING
    Hay Oak Park; Fiscal Year: 2002
    ..This work will also help us to understand the mechanism of genesis of human cancer since mutations in human homologs of these yeast proteins have been found in human tumor. ..
  8. SPATIAL CONTROL OF CELL POLARITY DURING YEAST BUDDING
    Hay Oak Park; Fiscal Year: 2001
    ..This work will also help us to understand the mechanism of genesis of human cancer since mutations in human homologs of these yeast proteins have been found in human tumor. ..
  9. SPATIAL CONTROL OF CELL POLARITY DURING YEAST BUDDING
    Hay Oak Park; Fiscal Year: 2000
    ..This work will also help us to understand the mechanism of genesis of human cancer since mutations in human homologs of these yeast proteins have been found in human tumor. ..