Zhizhong Z Pan
Affiliation: The University of Texas
Zhang Z, Tao W, Hou Y, Wang W, Kenny P, Pan Z. MeCP2 repression of G9a in regulation of pain and morphine reward. J Neurosci. 2014;34:9076-87 pubmed publisher
..These results suggest that MeCP2 directly represses G9a as a shared mechanism in central amygdala for regulation of emotional responses to pain and opioid reward, and for their behavioral interaction. ..
Cai Y, Wang W, Paulucci Holthauzen A, Pan Z. Brain Circuits Mediating Opposing Effects on Emotion and Pain. J Neurosci. 2018;38:6340-6349 pubmed publisher
..Thus, this study identifies a brain pathway that mediates pain-driven negative emotion and a brain pathway that counteracts these emotion behaviors in a top-down mechanism for brain control of negative emotion. ..
Pan Z. Kappa-opioid receptor-mediated enhancement of the hyperpolarization-activated current (I(h)) through mobilization of intracellular calcium in rat nucleus raphe magnus. J Physiol. 2003;548:765-75 pubmed
..This provides a physiological function for kappa-receptor-stimulated calcium release and may suggest another Ih-regulating mechanism by intracellular calcium in central neurons. ..
Cai Y, Wang W, Hou Y, Pan Z. Optogenetic activation of brainstem serotonergic neurons induces persistent pain sensitization. Mol Pain. 2014;10:70 pubmed publisher
..These results suggest that selective activation of RVM 5-HT neurons exerts a predominant effect of pain facilitation under control conditions. ..
Zhang Z, Cai Y, Zou F, Bie B, Pan Z. Epigenetic suppression of GAD65 expression mediates persistent pain. Nat Med. 2011;17:1448-55 pubmed publisher
..These findings suggest GAD65 and HDACs as potential therapeutic targets in an epigenetic approach to the treatment of chronic pain. ..
Hou Y, Cai Y, Pan Z. Persistent pain maintains morphine-seeking behavior after morphine withdrawal through reduced MeCP2 repression of GluA1 in rat central amygdala. J Neurosci. 2015;35:3689-700 pubmed publisher
..These results suggest direct MeCp2 repression of GluA1 function as a likely mechanism for morphine-seeking behavior maintained by long-lasting affective pain after morphine withdrawal. ..