Zhizhong Pan

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint cAMP-mediated mechanisms for pain sensitization during opioid withdrawal
    Bihua Bie
    Department of Anesthesiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurosci 25:3824-32. 2005
  2. pmc Trafficking of central opioid receptors and descending pain inhibition
    Bihua Bie
    Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Pain 3:37. 2007
  3. ncbi request reprint Presynaptic mechanism for anti-analgesic and anti-hyperalgesic actions of kappa-opioid receptors
    Bihua Bie
    Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurosci 23:7262-8. 2003
  4. pmc Increased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats
    Bihua Bie
    Department of Anesthesiology, Unit 110, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Mol Pain 1:7. 2005
  5. pmc Transcriptional control of Gad2
    Zhizhong Z Pan
    Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Transcription 3:68-72. 2012
  6. pmc Signaling cascades for δ-opioid receptor-mediated inhibition of GABA synaptic transmission and behavioral antinociception
    Zhi Zhang
    Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Pharmacol 81:375-83. 2012
  7. pmc Epigenetic suppression of GAD65 expression mediates persistent pain
    Zhi Zhang
    Department of Anesthesiology and Pain Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Med 17:1448-55. 2011
  8. pmc Kappa-opioid receptor-mediated enhancement of the hyperpolarization-activated current (I(h)) through mobilization of intracellular calcium in rat nucleus raphe magnus
    Zhizhong Z Pan
    Department of Symptom Research, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Physiol 548:765-75. 2003
  9. ncbi request reprint Contribution of brainstem GABA(A) synaptic transmission to morphine analgesic tolerance
    Junyi Ma
    Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Pain 122:163-73. 2006
  10. ncbi request reprint Opioid tolerance in adult and neonatal rats
    Zhizhong Z Pan
    Departments of Symptom Research and Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Methods Mol Med 84:223-32. 2003

Collaborators

Detail Information

Publications17

  1. ncbi request reprint cAMP-mediated mechanisms for pain sensitization during opioid withdrawal
    Bihua Bie
    Department of Anesthesiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurosci 25:3824-32. 2005
    ..These results illustrate neurobiological mechanisms for the cAMP-mediated withdrawal pain and provide potential therapeutic targets for the treatment of opioid dependence and withdrawal-related problems...
  2. pmc Trafficking of central opioid receptors and descending pain inhibition
    Bihua Bie
    Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Pain 3:37. 2007
    ..This article reviews current understanding of the mechanisms underlying GPCRs and DOR membrane trafficking, and the analgesic function of emerged DOR through membrane trafficking under certain pathophysiological circumstances...
  3. ncbi request reprint Presynaptic mechanism for anti-analgesic and anti-hyperalgesic actions of kappa-opioid receptors
    Bihua Bie
    Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurosci 23:7262-8. 2003
    ....
  4. pmc Increased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats
    Bihua Bie
    Department of Anesthesiology, Unit 110, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Mol Pain 1:7. 2005
    ..This glutamate-mediated activation of these NRM neurons that are thought to facilitate spinal pain transmission may contribute to the reduced opioid analgesia during opioid tolerance...
  5. pmc Transcriptional control of Gad2
    Zhizhong Z Pan
    Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Transcription 3:68-72. 2012
    ....
  6. pmc Signaling cascades for δ-opioid receptor-mediated inhibition of GABA synaptic transmission and behavioral antinociception
    Zhi Zhang
    Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Pharmacol 81:375-83. 2012
    ....
  7. pmc Epigenetic suppression of GAD65 expression mediates persistent pain
    Zhi Zhang
    Department of Anesthesiology and Pain Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Med 17:1448-55. 2011
    ..These findings suggest GAD65 and HDACs as potential therapeutic targets in an epigenetic approach to the treatment of chronic pain...
  8. pmc Kappa-opioid receptor-mediated enhancement of the hyperpolarization-activated current (I(h)) through mobilization of intracellular calcium in rat nucleus raphe magnus
    Zhizhong Z Pan
    Department of Symptom Research, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Physiol 548:765-75. 2003
    ..This provides a physiological function for kappa-receptor-stimulated calcium release and may suggest another Ih-regulating mechanism by intracellular calcium in central neurons...
  9. ncbi request reprint Contribution of brainstem GABA(A) synaptic transmission to morphine analgesic tolerance
    Junyi Ma
    Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Pain 122:163-73. 2006
    ....
  10. ncbi request reprint Opioid tolerance in adult and neonatal rats
    Zhizhong Z Pan
    Departments of Symptom Research and Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Methods Mol Med 84:223-32. 2003
  11. pmc Rewarding morphine-induced synaptic function of delta-opioid receptors on central glutamate synapses
    Bihua Bie
    Department of Anesthesiology and Pain Medicine, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Pharmacol Exp Ther 329:290-6. 2009
    ..These findings provide functional evidence for an adaptive modulation by presynaptic DOR of a key synaptic activity altered by morphine, thus implying likely important involvement of DOR in opioid reward and addiction...
  12. pmc Myoblast-derived neuronal cells form glutamatergic neurons in the mouse cerebellum
    Vidya Gopalakrishnan
    Department of Pediatrics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Stem Cells 28:1839-47. 2010
    ..Our findings suggest that although activation of REST-target genes can reprogram myoblasts to assume a general neuronal phenotype, the subtype specificity may then be directed by the brain microenvironment...
  13. pmc Synaptic mechanism for functional synergism between delta- and mu-opioid receptors
    Zhi Zhang
    Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurosci 30:4735-45. 2010
    ....
  14. pmc Nerve growth factor-regulated emergence of functional delta-opioid receptors
    Bihua Bie
    Department of Anesthesiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurosci 30:5617-28. 2010
    ..Thus, NGF may function as a key molecular switch that redirects the sorting of intracellularly targeted DOPr to plasma membrane, resulting in new functional DOPr on central synapses under chronic opioid conditions...
  15. ncbi request reprint Involvement of non-NMDA glutamate receptors in central amygdala in synaptic actions of ethanol and ethanol-induced reward behavior
    Wei Zhu
    Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurosci 27:289-98. 2007
    ....
  16. pmc Conversion of myoblasts to physiologically active neuronal phenotype
    Yumi Watanabe
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Dev 18:889-900. 2004
    ....
  17. ncbi request reprint Emergence of functional delta-opioid receptors induced by long-term treatment with morphine
    Junyi Ma
    Department of Anesthesiology and Pain Medicine, Unit 110, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Pharmacol 69:1137-45. 2006
    ..They also suggest that opioid drugs with preference for delta-opioid receptors may have better therapeutic effect in a mu-opioid-tolerant state...

Research Grants10

  1. Delta-Opioid Receptor Trafficking and Pain Inhibition
    Zhizhong Z Pan; Fiscal Year: 2010
    ..These studies may provide neuropharmacological evidence for using these opioid compounds as more effective analgesics under an opioid-tolerant and dependent state. ..
  2. Synaptic mechanisms for interactions of chronic pain and opioid addiction
    Zhizhong Pan; Fiscal Year: 2009
    ..The goal of this project is to identify pharmacological targets to reduce the abuse potential of opioids taken for pain control while maintaining their analgesic effects. ..
  3. Opioid Receptors in the Mechanisms of Opioid Tolerance
    Zhizhong Pan; Fiscal Year: 2005
    ..This research will significantly expand our knowledge of the neural mechanisms for opioid tolerance and contribute to our efforts to improve the treatment for chronic pain and other chronic opioid-related problems. ..
  4. Synaptic mechanisms for interactions of chronic pain and opioid addiction
    Zhizhong Z Pan; Fiscal Year: 2010
    ..The goal of this project is to identify pharmacological targets to reduce the abuse potential of opioids taken for pain control while maintaining their analgesic effects. ..