Research Topics
| Zhizhong PanSummaryAffiliation: The University of Texas Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
cAMP-mediated mechanisms for pain sensitization during opioid withdrawalBihua Bie
Department of Anesthesiology, The University of Texas-M.D. Anderson Cancer Center, Houston, Texas 77030, USA
J Neurosci 25:3824-32. 2005..These results illustrate neurobiological mechanisms for the cAMP-mediated withdrawal pain and provide potential therapeutic targets for the treatment of opioid dependence and withdrawal-related problems...
Trafficking of central opioid receptors and descending pain inhibitionBihua Bie
Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mol Pain 3:37. 2007..This article reviews current understanding of the mechanisms underlying GPCRs and DOR membrane trafficking, and the analgesic function of emerged DOR through membrane trafficking under certain pathophysiological circumstances...- Presynaptic mechanism for anti-analgesic and anti-hyperalgesic actions of kappa-opioid receptorsBihua Bie
Department of Symptom Research, The University of Texas-MD Anderson Cancer Center, Houston, Texas 77030, USA
J Neurosci 23:7262-8. 2003.... 
Increased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant ratsBihua Bie
Department of Anesthesiology, Unit 110, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Mol Pain 1:7. 2005..This glutamate-mediated activation of these NRM neurons that are thought to facilitate spinal pain transmission may contribute to the reduced opioid analgesia during opioid tolerance...- Transcriptional control of Gad2Zhizhong Z Pan
Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Transcription 3:68-72. 2012.... - Signaling cascades for δ-opioid receptor-mediated inhibition of GABA synaptic transmission and behavioral antinociceptionZhi Zhang
Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Mol Pharmacol 81:375-83. 2012.... - Epigenetic suppression of GAD65 expression mediates persistent painZhi Zhang
Department of Anesthesiology and Pain Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Nat Med 17:1448-55. 2011..These findings suggest GAD65 and HDACs as potential therapeutic targets in an epigenetic approach to the treatment of chronic pain... - Kappa-opioid receptor-mediated enhancement of the hyperpolarization-activated current (I(h)) through mobilization of intracellular calcium in rat nucleus raphe magnusZhizhong Z Pan
Department of Symptom Research, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
J Physiol 548:765-75. 2003..This provides a physiological function for kappa-receptor-stimulated calcium release and may suggest another Ih-regulating mechanism by intracellular calcium in central neurons... - Contribution of brainstem GABA(A) synaptic transmission to morphine analgesic toleranceJunyi Ma
Department of Anesthesiology and Pain Medicine, The University of Texas-MD Anderson Cancer Center, Houston, TX, USA
Pain 122:163-73. 2006.... - Opioid tolerance in adult and neonatal ratsZhizhong Z Pan
Departments of Symptom Research and Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Methods Mol Med 84:223-32. 2003 - Rewarding morphine-induced synaptic function of delta-opioid receptors on central glutamate synapsesBihua Bie
Department of Anesthesiology and Pain Medicine, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Pharmacol Exp Ther 329:290-6. 2009..These findings provide functional evidence for an adaptive modulation by presynaptic DOR of a key synaptic activity altered by morphine, thus implying likely important involvement of DOR in opioid reward and addiction... - Myoblast-derived neuronal cells form glutamatergic neurons in the mouse cerebellumVidya Gopalakrishnan
Department of Pediatrics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Stem Cells 28:1839-47. 2010..Our findings suggest that although activation of REST-target genes can reprogram myoblasts to assume a general neuronal phenotype, the subtype specificity may then be directed by the brain microenvironment... - Synaptic mechanism for functional synergism between delta- and mu-opioid receptorsZhi Zhang
Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
J Neurosci 30:4735-45. 2010.... - Nerve growth factor-regulated emergence of functional delta-opioid receptorsBihua Bie
Department of Anesthesiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
J Neurosci 30:5617-28. 2010..Thus, NGF may function as a key molecular switch that redirects the sorting of intracellularly targeted DOPr to plasma membrane, resulting in new functional DOPr on central synapses under chronic opioid conditions... - Involvement of non-NMDA glutamate receptors in central amygdala in synaptic actions of ethanol and ethanol-induced reward behaviorWei Zhu
Department of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
J Neurosci 27:289-98. 2007.... - Conversion of myoblasts to physiologically active neuronal phenotypeYumi Watanabe
Department of Molecular Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
Genes Dev 18:889-900. 2004.... - Emergence of functional delta-opioid receptors induced by long-term treatment with morphineJunyi Ma
Department of Anesthesiology and Pain Medicine, Unit 110, University of Texas-MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mol Pharmacol 69:1137-45. 2006..They also suggest that opioid drugs with preference for delta-opioid receptors may have better therapeutic effect in a mu-opioid-tolerant state...
Research Grants
- Delta-Opioid Receptor Trafficking and Pain InhibitionZhizhong Z Pan; Fiscal Year: 2010..These studies may provide neuropharmacological evidence for using these opioid compounds as more effective analgesics under an opioid-tolerant and dependent state. ..
- Synaptic mechanisms for interactions of chronic pain and opioid addictionZhizhong Pan; Fiscal Year: 2009..The goal of this project is to identify pharmacological targets to reduce the abuse potential of opioids taken for pain control while maintaining their analgesic effects. ..
- Opioid Receptors in the Mechanisms of Opioid ToleranceZhizhong Pan; Fiscal Year: 2005..This research will significantly expand our knowledge of the neural mechanisms for opioid tolerance and contribute to our efforts to improve the treatment for chronic pain and other chronic opioid-related problems. ..
- Synaptic mechanisms for interactions of chronic pain and opioid addictionZhizhong Z Pan; Fiscal Year: 2010..The goal of this project is to identify pharmacological targets to reduce the abuse potential of opioids taken for pain control while maintaining their analgesic effects. ..