Olivia Osborn

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Metabolic characterization of a mouse deficient in all known leptin receptor isoforms
    Olivia Osborn
    Molecular and Integrative Neurosciences Department, The Harold L Dorris Neurological Research Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Mol Neurobiol 30:23-33. 2010
  2. doi request reprint Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance
    Olivia Osborn
    The Harold L Dorris Neurological Research Institute, and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Swiss Med Wkly 138:665-73. 2008
  3. pmc Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue
    Olivia Osborn
    The Harold L Dorris Neurological Research Institute, Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cytokine 53:311-9. 2011
  4. pmc G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice
    Olivia Osborn
    Division of Endocrinology and Metabolism, Department of Medicine, UCSD, La Jolla, CA, USA
    J Clin Invest 122:2444-53. 2012
  5. pmc Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons
    Manuel Sanchez-Alavez
    The Harold L Dorris Neurological Research Institute, Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, California, USA
    Diabetes 59:43-50. 2010
  6. pmc Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors
    Manuel Sanchez-Alavez
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 286:14983-90. 2011
  7. doi request reprint The cellular and signaling networks linking the immune system and metabolism in disease
    Olivia Osborn
    Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, La Jolla, California, USA
    Nat Med 18:363-74. 2012
  8. pmc Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases
    Saswata Talukdar
    Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, La Jolla, CA 92093, USA
    Trends Pharmacol Sci 32:543-50. 2011
  9. pmc Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
    Simon Schenk
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0673, USA
    J Clin Invest 121:4281-8. 2011

Collaborators

Detail Information

Publications9

  1. pmc Metabolic characterization of a mouse deficient in all known leptin receptor isoforms
    Olivia Osborn
    Molecular and Integrative Neurosciences Department, The Harold L Dorris Neurological Research Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Mol Neurobiol 30:23-33. 2010
    ....
  2. doi request reprint Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance
    Olivia Osborn
    The Harold L Dorris Neurological Research Institute, and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Swiss Med Wkly 138:665-73. 2008
    ..This review highlights results of studies in mice which indicate important roles for these proinflammatory cytokines during the development of obesity and insulin resistance, and in the treatment of type 2 diabetes...
  3. pmc Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue
    Olivia Osborn
    The Harold L Dorris Neurological Research Institute, Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cytokine 53:311-9. 2011
    ..We describe a novel role to the ligand Ccl22 and its receptor Ccr4 in the anterior hypothalamus in temperature regulation that depends on the synthesis of the endogenous pyrogen, prostaglandin E2...
  4. pmc G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice
    Olivia Osborn
    Division of Endocrinology and Metabolism, Department of Medicine, UCSD, La Jolla, CA, USA
    J Clin Invest 122:2444-53. 2012
    ..Cumulatively, our data indicate that GPR21 has a critical function in coordinating macrophage proinflammatory activity in the context of obesity-induced insulin resistance...
  5. pmc Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons
    Manuel Sanchez-Alavez
    The Harold L Dorris Neurological Research Institute, Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, California, USA
    Diabetes 59:43-50. 2010
    ..The objective is to examine the role of the metabolic signal insulin in the control of core body temperature (CBT)...
  6. pmc Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors
    Manuel Sanchez-Alavez
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 286:14983-90. 2011
    ..These central effects of IGF-1 signaling may play a role in regulation of metabolic rate, aging, and the risk of developing type 2 diabetes...
  7. doi request reprint The cellular and signaling networks linking the immune system and metabolism in disease
    Olivia Osborn
    Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, La Jolla, California, USA
    Nat Med 18:363-74. 2012
    ..Here we discuss how these various networks underlie the etiology of the inflammatory component of insulin resistance, with a particular focus on the central roles of macrophages in adipose tissue and liver...
  8. pmc Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases
    Saswata Talukdar
    Department of Medicine, Division of Endocrinology and Metabolism, University of California San Diego, La Jolla, CA 92093, USA
    Trends Pharmacol Sci 32:543-50. 2011
    ..In this review paper, we discuss lipid-sensing GPCRs and highlight potential outcomes of targeting such receptors in ameliorating disease...
  9. pmc Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
    Simon Schenk
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0673, USA
    J Clin Invest 121:4281-8. 2011
    ..Thus, these data demonstrate that Sirt1 is an integral signaling node in skeletal muscle linking CR to improved insulin action, primarily via modulation of PI3K signaling...