Fumitaka Osakada

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. doi request reprint In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction
    Fumitaka Osakada
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Chuo Ku, Kobe, Japan
    J Cell Sci 122:3169-79. 2009
  2. ncbi request reprint Neural induction and patterning in Mammalian pluripotent stem cells
    Fumitaka Osakada
    Systems Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey, Pines Road, La Jolla, California, 92037, USA
    CNS Neurol Disord Drug Targets 10:419-32. 2011
  3. ncbi request reprint Stem cell biology and cell transplantation therapy in the retina
    Fumitaka Osakada
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Chuo Ku, Kobe 650 0047, Japan
    Biotechnol Genet Eng Rev 26:297-334. 2010
  4. doi request reprint Stepwise differentiation of pluripotent stem cells into retinal cells
    Fumitaka Osakada
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Kobe, Japan
    Nat Protoc 4:811-24. 2009
  5. doi request reprint Generation of retinal cells from mouse and human induced pluripotent stem cells
    Yasuhiko Hirami
    Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Neurosci Lett 458:126-31. 2009
  6. doi request reprint Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells
    Fumitaka Osakada
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, 650 0047, Japan
    Nat Biotechnol 26:215-24. 2008
  7. pmc Neural conversion of ES cells by an inductive activity on human amniotic membrane matrix
    Morio Ueno
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 103:9554-9. 2006
  8. doi request reprint Detection of localized retinal malfunction in retinal degeneration model using a multielectrode array system
    Kohei Homma
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Chou ku, Kobe, Japan
    J Neurosci Res 87:2175-82. 2009
  9. pmc Targeted deletion of miR-182, an abundant retinal microRNA
    Zi Bing Jin
    Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan
    Mol Vis 15:523-33. 2009
  10. pmc Design and generation of recombinant rabies virus vectors
    Fumitaka Osakada
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California, USA
    Nat Protoc 8:1583-601. 2013

Collaborators

Detail Information

Publications15

  1. doi request reprint In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction
    Fumitaka Osakada
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Chuo Ku, Kobe, Japan
    J Cell Sci 122:3169-79. 2009
    ..This method provides a solution to the problem of cross-species antigenic contamination in cell-replacement therapy, and is also useful for in vitro modeling of development, disease and drug screening...
  2. ncbi request reprint Neural induction and patterning in Mammalian pluripotent stem cells
    Fumitaka Osakada
    Systems Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey, Pines Road, La Jolla, California, 92037, USA
    CNS Neurol Disord Drug Targets 10:419-32. 2011
    ..Retinal differentiation from ES cells and iPS cells is also outlined...
  3. ncbi request reprint Stem cell biology and cell transplantation therapy in the retina
    Fumitaka Osakada
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Chuo Ku, Kobe 650 0047, Japan
    Biotechnol Genet Eng Rev 26:297-334. 2010
    ..Here, we review the current progress in retinal regeneration, focusing on the therapeutic potential of pluripotent stem cells...
  4. doi request reprint Stepwise differentiation of pluripotent stem cells into retinal cells
    Fumitaka Osakada
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Kobe, Japan
    Nat Protoc 4:811-24. 2009
    ..It will also improve our understanding of the development of the central nervous system, especially the eye...
  5. doi request reprint Generation of retinal cells from mouse and human induced pluripotent stem cells
    Yasuhiko Hirami
    Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Neurosci Lett 458:126-31. 2009
    ..We propose that iPSCs can be induced to differentiate into retinal cells which have a possibility to be used as patient-specific donor cells for transplantation therapies...
  6. doi request reprint Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells
    Fumitaka Osakada
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, 650 0047, Japan
    Nat Biotechnol 26:215-24. 2008
    ..Subsequent treatment with retinoic acid and taurine induced photoreceptor differentiation. These findings may facilitate the development of human ES cell-based transplantation therapies for retinal diseases...
  7. pmc Neural conversion of ES cells by an inductive activity on human amniotic membrane matrix
    Morio Ueno
    Organogenesis and Neurogenesis Group, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 103:9554-9. 2006
    ....
  8. doi request reprint Detection of localized retinal malfunction in retinal degeneration model using a multielectrode array system
    Kohei Homma
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Chou ku, Kobe, Japan
    J Neurosci Res 87:2175-82. 2009
    ..This spatial information should be valuable in investigating local functional recovery in therapeutically treated areas, such as in gene transfer or cell transplantation...
  9. pmc Targeted deletion of miR-182, an abundant retinal microRNA
    Zi Bing Jin
    Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan
    Mol Vis 15:523-33. 2009
    ..MicroRNA-182 (miR-182) is expressed abundantly in the mammalian retina and is therefore thought to perform important roles for the retinal development and the function. To test this hypothesis, we generated miR-182 knockout mice...
  10. pmc Design and generation of recombinant rabies virus vectors
    Fumitaka Osakada
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California, USA
    Nat Protoc 8:1583-601. 2013
    ..The entire protocol takes 6-8 weeks. ..
  11. pmc Modeling retinal degeneration using patient-specific induced pluripotent stem cells
    Zi Bing Jin
    Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Kobe, Japan
    PLoS ONE 6:e17084. 2011
    ..Our results demonstrate that the use of patient-derived iPS cells will help to elucidate the pathogenic mechanisms caused by genetic mutations in RP...
  12. ncbi request reprint Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: targeting the Wnt pathway and transplantation therapy as strategies for retinal repair
    Fumitaka Osakada
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Japan
    J Pharmacol Sci 109:168-73. 2009
    ..To restore visual function, we need to understand the mechanisms underlying the integration of newly generated neurons or transplanted cells into the existing neural networks...
  13. pmc New rabies virus variants for monitoring and manipulating activity and gene expression in defined neural circuits
    Fumitaka Osakada
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 71:617-31. 2011
    ....
  14. pmc Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells
    Hanako Ikeda
    Organogenesis and Neurogenesis Group, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 102:11331-6. 2005
    ..Taken together, ES cells treated with SFEB/Dkk1/LeftyA/serum/activin generate neural retinal precursors, which have the competence of photoreceptor differentiation...
  15. ncbi request reprint Wnt signaling promotes regeneration in the retina of adult mammals
    Fumitaka Osakada
    Laboratory for Retinal Regeneration, Center for Developmental Biology, RIKEN, Kobe 650 0047, Japan
    J Neurosci 27:4210-9. 2007
    ..This Wnt3a-mediated regeneration of retinal cells also occurs in rd mice, a model of retinal degeneration. These results provide evidence that Wnt/beta-catenin signaling contributes to CNS regeneration in the adult mammal...