Leslie E Orgel

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi The origin of life--a review of facts and speculations
    L E Orgel
    Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Trends Biochem Sci 23:491-5. 1998
  2. ncbi Prebiotic adenine revisited: eutectics and photochemistry
    Leslie E Orgel
    The Salk Institute for Biological Studies, San Diego, CA, USA
    Orig Life Evol Biosph 34:361-9. 2004
  3. ncbi Geothermal synthesis and metabolism
    Leslie E Orgel
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Astrobiology 6:297-8. 2006
  4. ncbi Molecular biology. Retrospective: Francis Crick (1916-2004)
    Leslie E Orgel
    Salk Institute, La Jolla, CA 92037, USA
    Science 305:1118. 2004
  5. ncbi Prebiotic chemistry and the origin of the RNA world
    Leslie E Orgel
    The Salk Institute, La Jolla, California 92097, USA
    Crit Rev Biochem Mol Biol 39:99-123. 2004
  6. ncbi Is cyanoacetylene prebiotic?
    Leslie E Orgel
    The Salk Institute for Biological Studies, La Jolla, CA, USA
    Orig Life Evol Biosph 32:279-81. 2002
  7. ncbi Origin of life. A simpler nucleic acid
    L Orgel
    Salk Institute for Biomedical Study, La Jolla, CA 92037, USA
    Science 290:1306-7. 2000
  8. pmc Self-organizing biochemical cycles
    L E Orgel
    Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 1099, USA
    Proc Natl Acad Sci U S A 97:12503-7. 2000
  9. doi Self-assembling sequence-adaptive peptide nucleic acids
    Yasuyuki Ura
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 325:73-7. 2009
  10. ncbi Synthesis of adenine from HCN tetramer and ammonium formate
    Aubrey Hill
    Salk Institute for Biological Studies, 10010 N Torrey Pines Road, San Diego, CA 92037 1099, USA
    Orig Life Evol Biosph 32:99-102. 2002

Collaborators

Detail Information

Publications14

  1. ncbi The origin of life--a review of facts and speculations
    L E Orgel
    Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Trends Biochem Sci 23:491-5. 1998
    ..It is not possible to decide which is correct. It is also unclear whether the RNA world was the first biological world or whether some simpler world preceded it...
  2. ncbi Prebiotic adenine revisited: eutectics and photochemistry
    Leslie E Orgel
    The Salk Institute for Biological Studies, San Diego, CA, USA
    Orig Life Evol Biosph 34:361-9. 2004
    ..It is further suggested that the reaction of cyanoacetylene with cyanate in eutectic solution to give cytosine might have proceeded in parallel with adenine synthesis...
  3. ncbi Geothermal synthesis and metabolism
    Leslie E Orgel
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Astrobiology 6:297-8. 2006
  4. ncbi Molecular biology. Retrospective: Francis Crick (1916-2004)
    Leslie E Orgel
    Salk Institute, La Jolla, CA 92037, USA
    Science 305:1118. 2004
  5. ncbi Prebiotic chemistry and the origin of the RNA world
    Leslie E Orgel
    The Salk Institute, La Jolla, California 92097, USA
    Crit Rev Biochem Mol Biol 39:99-123. 2004
    ..This in turn leads to a discussion of genetic systems simpler than RNA that might have "invented" RNA. Finally, we review studies of prebiotic membrane formation...
  6. ncbi Is cyanoacetylene prebiotic?
    Leslie E Orgel
    The Salk Institute for Biological Studies, La Jolla, CA, USA
    Orig Life Evol Biosph 32:279-81. 2002
    ..There is no scientific basis for the claim that cyanoacetaldehyde is more plausibly prebiotic than cyanoacetylene in this context...
  7. ncbi Origin of life. A simpler nucleic acid
    L Orgel
    Salk Institute for Biomedical Study, La Jolla, CA 92037, USA
    Science 290:1306-7. 2000
    ..These molecules have threose rather than ribose in their sugar-phosphate backbones and yet retain many of the properties of RNA including the ability to pair up in double helices...
  8. pmc Self-organizing biochemical cycles
    L E Orgel
    Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 1099, USA
    Proc Natl Acad Sci U S A 97:12503-7. 2000
    ....
  9. doi Self-assembling sequence-adaptive peptide nucleic acids
    Yasuyuki Ura
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 325:73-7. 2009
    ..These characteristics might prove advantageous for the design or selection of catalytic constructs or biomaterials that are capable of dynamic sequence repair and adaptation...
  10. ncbi Synthesis of adenine from HCN tetramer and ammonium formate
    Aubrey Hill
    Salk Institute for Biological Studies, 10010 N Torrey Pines Road, San Diego, CA 92037 1099, USA
    Orig Life Evol Biosph 32:99-102. 2002
    ..Adenine is formed in about 18% yield when HCN tetramer is heated with ammonium formate at 110 degrees C. The prebiotic significance of this reaction is discussed...
  11. ncbi Some consequences of the RNA world hypothesis
    Leslie E Orgel
    The Salk Institute for Biological Studies, San Diego, CA, USA
    Orig Life Evol Biosph 33:211-8. 2003
    ..This suggests that the construction of replicating polymers from simple, not necessarily standard, aminoacids should be explored...
  12. ncbi Amino acid dependent formation of phosphate anhydrides in water mediated by carbonyl sulfide
    Luke J Leman
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 128:20-1. 2006
    ..The amino acid dependent activations of phosphate reported here, which occur in parallel with the production of peptides, suggest that these two reactions may have shared a common intermediate on the prebiotic Earth...
  13. ncbi Protein disulfide oxidoreductases and the evolution of thermophily: was the last common ancestor a heat-loving microbe?
    Arturo Becerra
    Facultad de Ciencias, UNAM, Apdo Postal 70 407, Cd Universitaria, 04510, Mexico, DF, Mexico
    J Mol Evol 65:296-303. 2007
    ..These results imply that the last common ancestor (LCA) of all extant living beings lacked a PDO and argue, albeit weakly, against a thermophilic LCA...
  14. pmc The implausibility of metabolic cycles on the prebiotic Earth
    Leslie E Orgel
    The Salk Institute for BiologicalStudies, San Diego, California, United States ofAmerica
    PLoS Biol 6:e18. 2008