Dennis Dm O'Leary

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi request reprint Patterning centers, regulatory genes and extrinsic mechanisms controlling arealization of the neocortex
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 96037, USA
    Curr Opin Neurobiol 12:14-25. 2002
  2. pmc Genetic regulation of arealization of the neocortex
    Dennis Dm O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Curr Opin Neurobiol 18:90-100. 2008
  3. pmc Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex
    Shen Ju Chou
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California, USA
    Nat Neurosci 12:1381-9. 2009
  4. pmc Slits are chemorepellents endogenous to hypothalamus and steer thalamocortical axons into ventral telencephalon
    Janet E Braisted
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cereb Cortex 19:i144-51. 2009
  5. pmc Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations
    Hao Li
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Neural Dev 7:10. 2012
  6. pmc Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning
    Setsuko Sahara
    Molecular Neurobiology Laboratory, The Salk Institute, N Torrey Pines Road, La Jolla, CA 92037, USA
    Neural Dev 2:10. 2007
  7. pmc A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype
    Noelle D Dwyer
    Howard Hughes Medical Institute, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neural Dev 6:3. 2011
  8. ncbi request reprint Area patterning of the mammalian cortex
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 56:252-69. 2007
  9. ncbi request reprint Cortical ventricular zone progenitors and their progeny maintain spatial relationships and radial patterning during preplate development indicating an early protomap
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cereb Cortex 16:i46-56. 2006
  10. ncbi request reprint Mechanisms of retinotopic map development: Ephs, ephrins, and spontaneous correlated retinal activity
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Prog Brain Res 147:43-65. 2005

Research Grants

  1. Transcriptional Factors in Forebrain Patterning
    DENNIS D O apos LEARY; Fiscal Year: 2011
  2. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 2000
  3. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2001
  4. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 2001
  5. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2002
  6. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2003
  7. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 2007
  8. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 2003
  9. LIM-HD Transcription Factors in Forebrain Patterning
    DENNIS O LEARY; Fiscal Year: 2006
  10. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 1993

Collaborators

  • Todd McLaughlin
  • Shen Ju Chou
  • Setsuko Sahara
  • Yasushi Nakagawa
  • DENNIS O LEARY
  • DENNIS D O apos LEARY
  • Hao Li
  • Noelle D Dwyer
  • Janet E Braisted
  • Carlos G Perez-Garcia
  • Tadashi Hamasaki
  • Christopher A Walsh
  • Raksha Mudbhary
  • Vita M Vock
  • Michael S Fleming
  • Danielle K Manning
  • Jennifer L Moran
  • David R Beier
  • Carlita B Favero
  • Thomas Ringstedt

Detail Information

Publications11

  1. ncbi request reprint Patterning centers, regulatory genes and extrinsic mechanisms controlling arealization of the neocortex
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 96037, USA
    Curr Opin Neurobiol 12:14-25. 2002
    ....
  2. pmc Genetic regulation of arealization of the neocortex
    Dennis Dm O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Curr Opin Neurobiol 18:90-100. 2008
    ....
  3. pmc Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex
    Shen Ju Chou
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California, USA
    Nat Neurosci 12:1381-9. 2009
    ..These findings establish a genetic mechanism for determining regional-fate in the Emx1 lineage of telencephalic progenitors that generate cerebral cortex...
  4. pmc Slits are chemorepellents endogenous to hypothalamus and steer thalamocortical axons into ventral telencephalon
    Janet E Braisted
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cereb Cortex 19:i144-51. 2009
    ..Thus, Slits are chemorepellents for TCAs endogenous to hypothalamus and steer TCAs from diencephalon into ventral telencephalon, a critical pathfinding event defective in Slit and Robo2 mutant mice...
  5. pmc Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations
    Hao Li
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Neural Dev 7:10. 2012
    ..Because most, if not all, migrating MGE-derived INs express the neuregulin (NRG) receptor, ErbB4, we investigated influences of Nrg1 isoforms and Nrg3 on IN migration through ventral telencephalon (vTel) and within cortex...
  6. pmc Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning
    Setsuko Sahara
    Molecular Neurobiology Laboratory, The Salk Institute, N Torrey Pines Road, La Jolla, CA 92037, USA
    Neural Dev 2:10. 2007
    ..In summary, Sp8 and Fgf8 robustly induce one another, and may act to balance the anterior-posterior area patterning of the cortex...
  7. pmc A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype
    Noelle D Dwyer
    Howard Hughes Medical Institute, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neural Dev 6:3. 2011
    ..The axons grow along a complex multistep pathway, making sharp turns, crossing expression boundaries, and encountering intermediate targets. However, the cellular and molecular components mediating these steps remain poorly understood...
  8. ncbi request reprint Area patterning of the mammalian cortex
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 56:252-69. 2007
    ..They also interact to modify their expression, as well as expression of Fgf8. We review these mechanisms of arealization and discuss models and concepts of cortical area patterning...
  9. ncbi request reprint Cortical ventricular zone progenitors and their progeny maintain spatial relationships and radial patterning during preplate development indicating an early protomap
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cereb Cortex 16:i46-56. 2006
    ..However, our findings show that at the early stage of cortical development, when PP/SP neurons are generated, the VZ is, at a cellular level, a "protomap" of the PP/SP...
  10. ncbi request reprint Mechanisms of retinotopic map development: Ephs, ephrins, and spontaneous correlated retinal activity
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Prog Brain Res 147:43-65. 2005
    ..In summary, multiple graded guidance molecules, retinal waves and correlated spontaneous RGC activity cooperate to generate retinotopic maps...
  11. ncbi request reprint Regulation of laminar and area patterning of mammalian neocortex and behavioural implications
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 96037, USA
    Novartis Found Symp 288:141-59; discussion 159-64, 276-81. 2007
    ..Finally, we will describe studies showing that area size dictates performance at modality-specific behaviours...

Research Grants35

  1. Transcriptional Factors in Forebrain Patterning
    DENNIS D O apos LEARY; Fiscal Year: 2011
    ..The findings from the proposed aims will form a basis of understanding of cognitive dysfunction and neurological disorders. ..
  2. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 2000
    ..Due to the conserved structural and functional homology of genes between rodents and humans, the mechanisms identified in the rodent model are anticipated to be similarly involved in human development. ..
  3. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2001
    ..Aim 4. To determine the molecular control of retinal axon patterning in the diencephalon. Hypothesis: Slit proteins influence the patterning of retinal projections in the diencephalon through a Robo mediated repellent action. ..
  4. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 2001
    ..Due to the conserved structural and functional homology of genes between rodents and humans, the mechanisms identified in the rodent model are anticipated to be similarly involved in human development. ..
  5. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2002
    ..Aim 4. To determine the molecular control of retinal axon patterning in the diencephalon. Hypothesis: Slit proteins influence the patterning of retinal projections in the diencephalon through a Robo mediated repellent action. ..
  6. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2003
    ..Aim 4. To determine the molecular control of retinal axon patterning in the diencephalon. Hypothesis: Slit proteins influence the patterning of retinal projections in the diencephalon through a Robo mediated repellent action. ..
  7. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 2007
    ..We expect findings that support our hypotheses, but the experiments are designed such that results that disprove our hypotheses will be equally informative. ..
  8. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 2003
    ..Due to the conserved structural and functional homology of genes between rodents and humans, the mechanisms identified in the rodent model are anticipated to be similarly involved in human development. ..
  9. LIM-HD Transcription Factors in Forebrain Patterning
    DENNIS O LEARY; Fiscal Year: 2006
    ..abstract_text> ..
  10. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 1993
    ....
  11. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 1999
    ..Due to the conserved structural and functional homology of genes between rodents and humans, the mechanisms identified in the rodent model are anticipated to be similarly involved in human development. ..
  12. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS D O apos LEARY; Fiscal Year: 2010
    ..This proposal addresses the molecular mechanisms that control retinotopic map development by the axons of retinal ganglion cells within the brain. ..
  13. Transcriptional Factors in Forebrain Patterning
    DENNIS D O apos LEARY; Fiscal Year: 2010
    ..The findings from the proposed aims will form a basis of understanding of cognitive dysfunction and neurological disorders. ..
  14. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2005
    ..Therefore, the proposed studies complement one another and make efficient use of many lines of genetically altered mice. ..
  15. Transcriptional Factors in Forebrain Patterning
    DENNIS O LEARY; Fiscal Year: 2009
    ..The findings from the proposed aims will form a basis of understanding of cognitive dysfunction and neurological disorders. ..
  16. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 1999
    ....
  17. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2009
    ..Therefore, the proposed studies complement one another and make efficient use of many lines of genetically altered mice. ..
  18. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2007
    ..Therefore, the proposed studies complement one another and make efficient use of many lines of genetically altered mice. ..
  19. LIM-HD Transcription Factors in Forebrain Patterning
    DENNIS O LEARY; Fiscal Year: 2007
    ..abstract_text> ..
  20. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2006
    ..Therefore, the proposed studies complement one another and make efficient use of many lines of genetically altered mice. ..
  21. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 2000
    ..Due to the conserved structural and functional homology of genes between rodents and humans, the mechanisms identified in the rodent model are anticipated to be similarly involved in human development. ..
  22. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 2002
    ..Due to the conserved structural and functional homology of genes between rodents and humans, the mechanisms identified in the rodent model are anticipated to be similarly involved in human development. ..
  23. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2004
    ..Aim 4. To determine the molecular control of retinal axon patterning in the diencephalon. Hypothesis: Slit proteins influence the patterning of retinal projections in the diencephalon through a Robo mediated repellent action. ..