Dennis Dm O'Leary

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi Patterning centers, regulatory genes and extrinsic mechanisms controlling arealization of the neocortex
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 96037, USA
    Curr Opin Neurobiol 12:14-25. 2002
  2. ncbi Genetic regulation of arealization of the neocortex
    Dennis Dm O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Curr Opin Neurobiol 18:90-100. 2008
  3. ncbi Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations
    Hao Li
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Neural Dev 7:10. 2012
  4. ncbi Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning
    Setsuko Sahara
    Molecular Neurobiology Laboratory, The Salk Institute, N Torrey Pines Road, La Jolla, CA 92037, USA
    Neural Dev 2:10. 2007
  5. ncbi A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype
    Noelle D Dwyer
    Howard Hughes Medical Institute, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neural Dev 6:3. 2011
  6. ncbi Mechanisms of retinotopic map development: Ephs, ephrins, and spontaneous correlated retinal activity
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Prog Brain Res 147:43-65. 2005
  7. ncbi Cortical ventricular zone progenitors and their progeny maintain spatial relationships and radial patterning during preplate development indicating an early protomap
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cereb Cortex 16:i46-56. 2006
  8. ncbi Area patterning of the mammalian cortex
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 56:252-69. 2007
  9. ncbi Regulation of laminar and area patterning of mammalian neocortex and behavioural implications
    Shen Ju Chou
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 96037, USA
    Novartis Found Symp 288:141-59; discussion 159-64, 276-81. 2007

Research Grants

  1. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2004
  2. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 2003
  3. LIM-HD Transcription Factors in Forebrain Patterning
    DENNIS O LEARY; Fiscal Year: 2007
  4. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2007
  5. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 2007
  6. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2009
  7. Transcriptional Factors in Forebrain Patterning
    DENNIS D O apos LEARY; Fiscal Year: 2010
  8. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS D O apos LEARY; Fiscal Year: 2010
  9. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 1999
  10. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 1993

Collaborators

  • Todd McLaughlin
  • Setsuko Sahara
  • Yasushi Nakagawa
  • DENNIS O LEARY
  • DENNIS D O apos LEARY
  • Shen Ju Chou
  • Hao Li
  • Noelle D Dwyer
  • Tadashi Hamasaki
  • Carlos G Perez-Garcia
  • Danielle K Manning
  • Michael S Fleming
  • Vita M Vock
  • Carlita B Favero
  • Christopher A Walsh
  • Jennifer L Moran
  • David R Beier
  • Raksha Mudbhary
  • Axel Leingartner
  • Akihide Takeuchi
  • Sandrine Thuret
  • Shen-Ju Chou

Detail Information

Publications9

  1. ncbi Patterning centers, regulatory genes and extrinsic mechanisms controlling arealization of the neocortex
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 96037, USA
    Curr Opin Neurobiol 12:14-25. 2002
    ....
  2. ncbi Genetic regulation of arealization of the neocortex
    Dennis Dm O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Curr Opin Neurobiol 18:90-100. 2008
    ....
  3. ncbi Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations
    Hao Li
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Neural Dev 7:10. 2012
    ..Because most, if not all, migrating MGE-derived INs express the neuregulin (NRG) receptor, ErbB4, we investigated influences of Nrg1 isoforms and Nrg3 on IN migration through ventral telencephalon (vTel) and within cortex...
  4. ncbi Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning
    Setsuko Sahara
    Molecular Neurobiology Laboratory, The Salk Institute, N Torrey Pines Road, La Jolla, CA 92037, USA
    Neural Dev 2:10. 2007
    ..In summary, Sp8 and Fgf8 robustly induce one another, and may act to balance the anterior-posterior area patterning of the cortex...
  5. ncbi A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype
    Noelle D Dwyer
    Howard Hughes Medical Institute, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neural Dev 6:3. 2011
    ..The axons grow along a complex multistep pathway, making sharp turns, crossing expression boundaries, and encountering intermediate targets. However, the cellular and molecular components mediating these steps remain poorly understood...
  6. ncbi Mechanisms of retinotopic map development: Ephs, ephrins, and spontaneous correlated retinal activity
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Prog Brain Res 147:43-65. 2005
    ..In summary, multiple graded guidance molecules, retinal waves and correlated spontaneous RGC activity cooperate to generate retinotopic maps...
  7. ncbi Cortical ventricular zone progenitors and their progeny maintain spatial relationships and radial patterning during preplate development indicating an early protomap
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cereb Cortex 16:i46-56. 2006
    ..However, our findings show that at the early stage of cortical development, when PP/SP neurons are generated, the VZ is, at a cellular level, a "protomap" of the PP/SP...
  8. ncbi Area patterning of the mammalian cortex
    Dennis D M O'Leary
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 56:252-69. 2007
    ..They also interact to modify their expression, as well as expression of Fgf8. We review these mechanisms of arealization and discuss models and concepts of cortical area patterning...
  9. ncbi Regulation of laminar and area patterning of mammalian neocortex and behavioural implications
    Shen Ju Chou
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 96037, USA
    Novartis Found Symp 288:141-59; discussion 159-64, 276-81. 2007
    ..Finally, we will describe studies showing that area size dictates performance at modality-specific behaviours...

Research Grants35

  1. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2004
    ..Aim 4. To determine the molecular control of retinal axon patterning in the diencephalon. Hypothesis: Slit proteins influence the patterning of retinal projections in the diencephalon through a Robo mediated repellent action. ..
  2. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 2003
    ..Due to the conserved structural and functional homology of genes between rodents and humans, the mechanisms identified in the rodent model are anticipated to be similarly involved in human development. ..
  3. LIM-HD Transcription Factors in Forebrain Patterning
    DENNIS O LEARY; Fiscal Year: 2007
    ..abstract_text> ..
  4. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2007
    ..Therefore, the proposed studies complement one another and make efficient use of many lines of genetically altered mice. ..
  5. EARLY EVENTS IN CORTICAL DEVELOPMENT
    DENNIS O LEARY; Fiscal Year: 2007
    ..We expect findings that support our hypotheses, but the experiments are designed such that results that disprove our hypotheses will be equally informative. ..
  6. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 2009
    ..Therefore, the proposed studies complement one another and make efficient use of many lines of genetically altered mice. ..
  7. Transcriptional Factors in Forebrain Patterning
    DENNIS D O apos LEARY; Fiscal Year: 2010
    ..The findings from the proposed aims will form a basis of understanding of cognitive dysfunction and neurological disorders. ..
  8. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS D O apos LEARY; Fiscal Year: 2010
    ..This proposal addresses the molecular mechanisms that control retinotopic map development by the axons of retinal ganglion cells within the brain. ..
  9. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 1999
    ....
  10. MECHANISMS GOVERNING DEVELOPMENT OF VISUAL CONNECTIONS
    DENNIS O LEARY; Fiscal Year: 1993
    ....
  11. Transcriptional Factors in Forebrain Patterning
    DENNIS D O apos LEARY; Fiscal Year: 2011
    ..The findings from the proposed aims will form a basis of understanding of cognitive dysfunction and neurological disorders. ..