D D O'Leary

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi Molecular development of sensory maps: representing sights and smells in the brain
    P A Yates
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Cell 96:255-69. 1999
  2. ncbi Eph receptors and ephrins in neural development
    D D O'Leary
    Molecular Neurobiology Laboratory The Salk Institute 10010 North Torrey Pines Road La Jolla California 92037 USA
    Curr Opin Neurobiol 9:65-73. 1999
  3. ncbi A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system
    L Erkman
    Howard Hughes Medical Institute and, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 28:779-92. 2000
  4. ncbi Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling
    A Brown
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Cell 102:77-88. 2000
  5. ncbi Combinatorial expression patterns of LIM-homeodomain and other regulatory genes parcellate developing thalamus
    Y Nakagawa
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 21:2711-25. 2001
  6. ncbi Fate of midbrain dopaminergic neurons controlled by the engrailed genes
    H H Simon
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 21:3126-34. 2001
  7. ncbi Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection
    J E Braisted
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    J Neurosci 20:5792-801. 2000
  8. ncbi Regulation of area identity in the mammalian neocortex by Emx2 and Pax6
    K M Bishop
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 288:344-9. 2000
  9. ncbi Slit inhibition of retinal axon growth and its role in retinal axon pathfinding and innervation patterns in the diencephalon
    T Ringstedt
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 20:4983-91. 2000
  10. ncbi The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain
    S Bertuzzi
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 13:3092-105. 1999

Collaborators

  • W Wurst
  • A Brown
  • S M Catalano
  • T Ringstedt
  • M A Kirby
  • T E Kennedy
  • S Bertuzzi
  • D G Wilkinson
  • P A Yates
  • Y Nakagawa
  • H H Simon
  • J E Braisted
  • L Erkman
  • Q Xu
  • K M Bishop
  • T McLaughlin
  • N W Gale
  • A Smith
  • A M Flenniken
  • G D Yancopoulos
  • H Saueressig
  • M D Goulding
  • A I Krones
  • T Whisenhunt
  • S M O'Connell
  • M Tessier-Lavigne
  • M G Rosenfeld
  • C J Shatz
  • D H Rapaport
  • R J McEvilly
  • G Goudreau
  • G Mellitzer
  • J R Bermingham
  • R Stimac
  • V Robinson
  • K Patel
  • K Strebhardt
  • H Hirai
  • L Pan
  • S J Holland
  • T E Ryan
  • S Davis
  • D M Valenzuela
  • A Flenniken
  • M Henkemeyer
  • T Pawson

Detail Information

Publications16

  1. ncbi Molecular development of sensory maps: representing sights and smells in the brain
    P A Yates
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Cell 96:255-69. 1999
  2. ncbi Eph receptors and ephrins in neural development
    D D O'Leary
    Molecular Neurobiology Laboratory The Salk Institute 10010 North Torrey Pines Road La Jolla California 92037 USA
    Curr Opin Neurobiol 9:65-73. 1999
    ..Recent findings are beginning to characterize the function and signaling of ephrins, as well as major roles for them in other tissues...
  3. ncbi A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system
    L Erkman
    Howard Hughes Medical Institute and, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 28:779-92. 2000
    ..elegans homolog, UNC-115. Our findings provide insights into a Brn-3.2-directed hierarchical program linking signaling events to cytoskeletal changes required for axon pathfinding...
  4. ncbi Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling
    A Brown
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Cell 102:77-88. 2000
    ..We find that these two populations form separate maps in the colliculus, which can be predicted as a function of the net EphA receptor level that a given ganglion cell expresses relative to its neighbors...
  5. ncbi Combinatorial expression patterns of LIM-homeodomain and other regulatory genes parcellate developing thalamus
    Y Nakagawa
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 21:2711-25. 2001
    ..These genes may also influence the pathfinding and targeting of thalamocortical axons through both cell-autonomous and non-autonomous mechanisms...
  6. ncbi Fate of midbrain dopaminergic neurons controlled by the engrailed genes
    H H Simon
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 21:3126-34. 2001
    ..However, the engrailed genes control the survival of midbrain dopaminergic neurons in a gene dose-dependent manner. Our findings also suggest a link between engrailed and Parkinson's disease...
  7. ncbi Netrin-1 promotes thalamic axon growth and is required for proper development of the thalamocortical projection
    J E Braisted
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    J Neurosci 20:5792-801. 2000
    ..These findings demonstrate that netrin-1 promotes the growth of TCAs through the ventral telencephalon and cooperates with other guidance cues to control their pathfinding from dorsal thalamus to cortex...
  8. ncbi Regulation of area identity in the mammalian neocortex by Emx2 and Pax6
    K M Bishop
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 288:344-9. 2000
    ..These findings suggest that Emx2 and Pax6 cooperate to regulate arealization of the neocortex and to confer area identity to cortical cells...
  9. ncbi Slit inhibition of retinal axon growth and its role in retinal axon pathfinding and innervation patterns in the diencephalon
    T Ringstedt
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 20:4983-91. 2000
    ....
  10. ncbi The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain
    S Bertuzzi
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 13:3092-105. 1999
    ..Vax1 therefore regulates the guidance properties of a set of anterior midline cells that orchestrate axon trajectories in the developing mammalian forebrain...
  11. ncbi Distinct and overlapping expression patterns of ligands for Eph-related receptor tyrosine kinases during mouse embryogenesis
    A M Flenniken
    Division of Developmental Neurobiology, National Institute for Medical Research, London, United Kingdom
    Dev Biol 179:382-401. 1996
    ....
  12. ncbi The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells
    A Smith
    Division of Developmental Neurobiology, National Institute for Medical Research, London, UK
    Curr Biol 7:561-70. 1997
    ..Here, we investigated the role of Eph receptors and ephrins-mediators of cell-contact-dependent interactions that have been implicated in neuronal pathfinding-in this targeted migration...
  13. ncbi Roles of Eph receptors and ephrins in segmental patterning
    Q Xu
    Division of Developmental Neurobiology, National Institute for Medical Research, London, UK
    Philos Trans R Soc Lond B Biol Sci 355:993-1002. 2000
    ..Eph receptors and ephrins have thus emerged as key regulators that, in parallel with cell adhesion molecules, underlie the establishment and maintenance of patterns of cellular organization...
  14. ncbi Multiple roles of EPH receptors and ephrins in neural development
    D G Wilkinson
    Division of Developmental Neurobiology, National Institute for Medical Research, Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Rev Neurosci 2:155-64. 2001
    ..Eph receptor tyrosine kinases and their ephrin ligands are key players in controlling these cell movements in many tissues and at multiple stages of patterning...
  15. ncbi Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis
    N W Gale
    Regeneron Pharmaceuticals, Incorporated, Tarrytown, New York, 10591 6707, USA
    Neuron 17:9-19. 1996
    ..This reciprocal compartmentalization implicates the Eph family in the formation of spatial boundaries that may help to organize the developing body plan...
  16. ncbi Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development
    D G Wilkinson
    Laboratory of Developmental Biochemistry, National Institute for Medical Research, London, UK
    Development 105:131-6. 1989
    ..In addition, int-2 RNA is detected in the mesenchyme of the developing teeth and in sensory regions of the inner ear. This complex and dynamic pattern suggests multiple roles of this proto-oncogene during fetal development of the mouse...