M B A Oldstone

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes
    Michael B A Oldstone
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS Pathog 8:e1003044. 2012
  2. ncbi Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection
    Michael B A Oldstone
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 435:92-101. 2013
  3. ncbi Frank J. Dixon 1920-2008
    Michael B A Oldstone
    Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 9:333. 2008
  4. ncbi A suspenseful game of 'hide and seek' between virus and host
    Michael B A Oldstone
    Molecular and Integrative Neurosciences Department and Department of Infectology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 8:325-7. 2007
  5. ncbi Viral persistence: parameters, mechanisms and future predictions
    Michael B A Oldstone
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 344:111-8. 2006
  6. ncbi Future trends in neurovirology: neuronal survival during virus infection and analysis of virus-specific T cells in central nervous system tissues
    Michael B A Oldstone
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Neurovirol 10:207-15. 2004
  7. ncbi Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry
    M B A Oldstone
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 296:65-87. 2005
  8. ncbi Modeling subacute sclerosing panencephalitis in a transgenic mouse system: uncoding pathogenesis of disease and illuminating components of immune control
    M B A Oldstone
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla CA, USA
    Curr Top Microbiol Immunol 330:31-54. 2009
  9. ncbi Travels along the viral-immunobiology highway
    Michael B A Oldstone
    Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 185:54-68. 2002
  10. ncbi Decoding arenavirus pathogenesis: essential roles for alpha-dystroglycan-virus interactions and the immune response
    Michael B A Oldstone
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 411:170-9. 2011

Research Grants

  1. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
  2. PATHOGENESIS OF PERSISTENT VIRAL INFECTION
    Michael Oldstone; Fiscal Year: 2007
  3. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
  4. PATHOGENESIS OF PERSISTENT VIRAL INFECTION
    Michael Oldstone; Fiscal Year: 2006
  5. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2006
  6. Viruses and Diabetes
    Michael Oldstone; Fiscal Year: 2005
  7. ARENAVIRUS RECEPTOR--STRUCTURE/FUNCTION STUDIES
    Michael Oldstone; Fiscal Year: 2007
  8. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael Oldstone; Fiscal Year: 2007
  9. In Vivo Analysis of T lymphocytes in the Persistently Infected CNS
    Michael B Oldstone; Fiscal Year: 2010
  10. PATHOGENESIS OF PERSISTENT VIRAL INFECTION
    Michael B Oldstone; Fiscal Year: 2010

Collaborators

Detail Information

Publications82

  1. ncbi Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes
    Michael B A Oldstone
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS Pathog 8:e1003044. 2012
    ..Silencing both immunodominant epitopes (GP33, GP276-286) in the infecting virus led to a four-fold reduction in viral specific CD8 CTL responses, negligible lymphocyte infiltration into islets and absence of diabetes...
  2. ncbi Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection
    Michael B A Oldstone
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 435:92-101. 2013
    ..The functional mechanism of S1P receptor agonist(s) action and the predominant role played by pulmonary endothelial cells as amplifiers of cytokine storm during influenza infection are described...
  3. ncbi Frank J. Dixon 1920-2008
    Michael B A Oldstone
    Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 9:333. 2008
  4. ncbi A suspenseful game of 'hide and seek' between virus and host
    Michael B A Oldstone
    Molecular and Integrative Neurosciences Department and Department of Infectology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 8:325-7. 2007
    ..As part of the most important contributions to the understanding of viral immunity, Michael Oldstone recounts his pioneering work on lymphocytic choriomeningitis virus...
  5. ncbi Viral persistence: parameters, mechanisms and future predictions
    Michael B A Oldstone
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 344:111-8. 2006
    ..We also consider how the compromised antiviral immune response can be revigorated or replaced with a potent response that purges the virus and thereby terminates persistent infection...
  6. ncbi Future trends in neurovirology: neuronal survival during virus infection and analysis of virus-specific T cells in central nervous system tissues
    Michael B A Oldstone
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Neurovirol 10:207-15. 2004
    ....
  7. ncbi Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry
    M B A Oldstone
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 296:65-87. 2005
    ..Knowledge of the cells, their numbers, and the molecules required to cause diabetes allows the design of successful strategies to treat and prevent the autoimmune disease...
  8. ncbi Modeling subacute sclerosing panencephalitis in a transgenic mouse system: uncoding pathogenesis of disease and illuminating components of immune control
    M B A Oldstone
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla CA, USA
    Curr Top Microbiol Immunol 330:31-54. 2009
    ..Further, an active role in prolonging MV replication while inhibiting its spread in the CNS can be mapped to a direct affect of the biased hypermutations (A to G changes) of the MV M gene in vivo...
  9. ncbi Travels along the viral-immunobiology highway
    Michael B A Oldstone
    Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 185:54-68. 2002
    ....
  10. ncbi Decoding arenavirus pathogenesis: essential roles for alpha-dystroglycan-virus interactions and the immune response
    Michael B A Oldstone
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 411:170-9. 2011
    ..A major component for understanding the pathogenesis of these arenaviruses revolves around study of the interaction of virus with its receptor, alpha-dystroglycan (α-DG)...
  11. ncbi Molecular mimicry, microbial infection, and autoimmune disease: evolution of the concept
    M B A Oldstone
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 296:1-17. 2005
    ..The formation of this concept initially via study of monoclonal antibody or clone T cell cross-recognition in vitro through its evolution to in vivo animal models and to selected human diseases is explored in this mini-review...
  12. ncbi Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion
    Michael B A Oldstone
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:4357-63. 2002
    ....
  13. ncbi A role for dual viral hits in causation of subacute sclerosing panencephalitis
    Michael B A Oldstone
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 202:1185-90. 2005
    ..These sera contained high titers of antibodies to MV. Thus, a small animal model is now available to both molecularly probe the pathogenesis of SSPE and to test a variety of therapies to treat the disease...
  14. ncbi Common antiviral cytotoxic t-lymphocyte epitope for diverse arenaviruses
    M B Oldstone
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 75:6273-8. 2001
    ..Use of site-specific amino acid exchanges in the NP CTL epitope among these arenaviruses identified amino acids involved in major histocompatibility complex binding and CTL recognition...
  15. ncbi Measles virus infection in a transgenic model: virus-induced immunosuppression and central nervous system disease
    M B Oldstone
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell 98:629-40. 1999
    ..Infectious virus was recovered from the CNS, replicated primarily in neurons, and spread to distal sites presumably by fast axonal transport. Thus, a small animal model is available for analysis of MV pathogenesis...
  16. ncbi Viral persistence: mechanisms and consequences
    M B Oldstone
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Microbiol 1:436-41. 1998
    ....
  17. ncbi Molecular mimicry and immune-mediated diseases
    M B Oldstone
    Viral Immunobiology Laboratory, Division of Virology, The Scripps Research Institute, Department of Neuropharmacology, La Jolla, California 92037, USA
    FASEB J 12:1255-65. 1998
    ..In both scenarios, analysis of the T cells or antibodies specifically engaged in the autoimmune response and disease provides a fingerprint for uncovering the initiating infectious agent...
  18. ncbi Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule
    Bumsuk Hahm
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:3505-15. 2003
    ....
  19. ncbi Measles virus interacts with human SLAM receptor on dendritic cells to cause immunosuppression
    Bumsuk Hahm
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 323:292-302. 2004
    ..Individual expression of human SLAM, interferon alpha/beta receptor, tumor necrosis factor-alpha, and lymphotoxin-alpha or beta from T cells was not required for MV-infected DCs to inhibit the proliferation of T cells...
  20. ncbi Infection of dendritic cells by lymphocytic choriomeningitis virus
    N Sevilla
    The Scripps Research Institute, Division of Virology, Department of Neuropharmacology, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 276:125-44. 2003
    ..Because several other viruses known to cause immunosuppression (HIV, measles) interact with DCs, the observations noted here are likely a common selective mechanism by which viruses also are able to evade the host's immune system...
  21. ncbi c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity
    Nathalie Arbour
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 195:801-10. 2002
    ..JNK1 is involved in survival of activated T cells during immune responses, and JNK2 plays a role in control of CD8(+) T cell expansion in vivo...
  22. ncbi CD4 T cell control primary measles virus infection of the CNS: regulation is dependent on combined activity with either CD8 T cells or with B cells: CD4, CD8 or B cells alone are ineffective
    Antoinette Tishon
    Departments of Molecular and Integrative Neurosciences, and Infectology (IMM-6, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 347:234-45. 2006
    ..TNF-alpha combined with interferon-gamma is more effective in protection than interferon alone. Further, the lack of an interferon-gamma response leads to persistence of MV...
  23. ncbi Detection of low-avidity CD4+ T cells using recombinant artificial APC: following the antiovalbumin immune response
    Valérie I Mallet-Designe
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 170:123-31. 2003
    ..Artificial APC will allow T cell detection and the dissection of the molecular events of T cell activation and will help us understand the fundamental differences between CD4+ and CD8+ T cells...
  24. ncbi Visualizing the viral burden: phenotypic and functional alterations of T cells and APCs during persistent infection
    Dirk Homann
    Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 172:6239-50. 2004
    ....
  25. ncbi Viral targeting of hematopoietic progenitors and inhibition of DC maturation as a dual strategy for immune subversion
    Noemi Sevilla
    The Scripps Research Institute, Division of Virology, Department of Neuropharmacology, La Jolla, California, USA
    J Clin Invest 113:737-45. 2004
    ..Thus, a virus can evolve a strategy to boost its survival by preventing the maturation of DCs from infected progenitor cells and by reducing the expression of antigen-presenting and costimulatory molecules on developed DCs...
  26. ncbi Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection
    Henning Lauterbach
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 203:1963-75. 2006
    ....
  27. ncbi IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory
    Derek C Lenz
    Departments of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:9357-62. 2004
    ..We propose that homeostatic control of antiviral CD4(+) and CD8(+) T cell memory is fundamentally similar and characterized by quantitative, rather than qualitative, differences...
  28. ncbi Does Toll-like receptor 3 play a biological role in virus infections?
    Kurt H Edelmann
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 322:231-8. 2004
    ....
  29. ncbi Electron microscopy of an alpha-dystroglycan fragment containing receptor sites for lymphocytic choriomeningitis virus and laminin, and use of the receptoid body as a reagent to neutralize virus
    Stefan Kunz
    Viral-Immunobiology Laboratory, Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 91037, USA
    Virology 325:207-15. 2004
    ..However, the receptor body formed by either alpha-DG fragment alone or complexed to antibody to human Fc failed to efficiently neutralize virus...
  30. ncbi Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling
    Bumsuk Hahm
    Division of Virology, Department of Neuropharmacology, Department of Infectology, The Scripps Research Institute, La Jolla, California 92037, USA
    Immunity 22:247-57. 2005
    ..These observations have implications for understanding and developing therapies to treat diseases caused by immunosuppression and/or persistent infections...
  31. ncbi Prion-induced amyloid heart disease with high blood infectivity in transgenic mice
    Matthew J Trifilo
    Viral-Immunobiology Laboratory, Departments of Molecular and Integrative Neurosciences and Infectology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 313:94-7. 2006
    ..The titer of infectious scrapie in blood plasma exceeded 10(7) 50% infectious doses per milliliter. The hearts of these transgenic mice contained PrPres-positive amyloid deposits that led to myocardial stiffness and cardiac disease...
  32. ncbi Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza
    David Marsolais
    Departments of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Pharmacol 74:896-903. 2008
    ..Thus, our results suggest that locally delivered sphingosine analogs induce immunosuppression by modulating S1P receptors other than S1P(1) or S1P(2) on dendritic cells in the lungs after influenza virus infection...
  33. ncbi Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway
    Philippe Georgel
    Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Virology 362:304-13. 2007
    ....
  34. ncbi Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections
    Elina I Zuniga
    Department of Immunology and Microbial Sciences, Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Host Microbe 4:374-86. 2008
    ..These findings provide a mechanistic explanation for the occurrence of opportunistic infections following viral insults and have important implications for treating such medical complications...
  35. ncbi Extraneural manifestations of prion infection in GPI-anchorless transgenic mice
    Andrew M Lee
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Virology 411:1-8. 2011
    ..By high-resolution electron microscopy, we show PrP is located primarily in α cells and also β cells. Islets contain abundant insulin and there is no abnormality in glucose metabolism in infected GPI⁻/⁻ PrP tg mice...
  36. ncbi Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway
    Matthew J Trifilo
    The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 82:9890-9. 2008
    ..Thus, the clinical defects of learning and memory loss in vivo in GPI(-/-) PrP tg mice infected with scrapie agent may likely involve the GABAergic pathway...
  37. ncbi IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection
    David G Brooks
    Viral Immunobiology Laboratory, Department of Molecular and Integrative Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 205:533-41. 2008
    ..Consequently, blocking key suppressive factors could render ineffective vaccines more efficient at improving T cell immunity, and thereby allow immune-mediated control of persistent viral infection...
  38. ncbi Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, The Scripps Research Institute, La Jolla, California, USA
    J Clin Invest 116:1675-85. 2006
    ..Thus, dysfunctional antiviral T cells can regain activity, providing a basis for future therapeutic strategies to treat persistent viral infections...
  39. ncbi Interleukin-10 determines viral clearance or persistence in vivo
    David G Brooks
    Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Med 12:1301-9. 2006
    ..Thus, we identify a single molecule that directly induces immunosuppression leading to viral persistence and demonstrate that a therapy to neutralize IL-10 results in T-cell recovery and the prevention of viral persistence...
  40. ncbi Measles virus-dendritic cell interaction via SLAM inhibits innate immunity: selective signaling through TLR4 but not other TLRs mediates suppression of IL-12 synthesis
    Bumsuk Hahm
    Viral Immunobiology Laboratory, Departments of Molecular and Integrative Neurosciences and Infectology, IMM6, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 358:251-7. 2007
    ..These results suggest that MV, by altering DC function, renders them unresponsive to secondary pathogens via TLR4...
  41. ncbi Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding
    Stefan Kunz
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 79:14282-96. 2005
    ..Hence, LARGE-dependent glycosylation of alpha-DG has important implications for the virus-host cell interaction and the pathogenesis of LFV in humans...
  42. ncbi Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection
    David G Brooks
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 79:10514-27. 2005
    ....
  43. ncbi Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo
    Dorian B McGavern
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Immunol 3:918-25. 2002
    ..In addition, we have established an in vivo approach for assessing the intricacies of antigen-specific T cell activation, migration, engagement, memory and other defining elements of adaptive immunity...
  44. ncbi T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies
    Hanna Lewicki
    Division of Virology, Department of Neuropharmacology (IMM-6, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:3799-808. 2003
    ..However, these CD4 and CD8 T cells are defective in such an effector function(s) as IFN-gamma and TNF-alpha expression or release or lytic activity...
  45. ncbi One, two, or three step: measles virus receptor dance
    Michael B A Oldstone
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey pinesRoad, IMM-6, La Jolla, CA 92037-1092, USA
    Virology 299:162-3. 2002
  46. ncbi Alpha-dystroglycan can mediate arenavirus infection in the absence of beta-dystroglycan
    Stefan Kunz
    The Scripps Research Institute, Department of Neuropharmacology, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 316:213-20. 2003
    ....
  47. ncbi Use of alternative receptors different than alpha-dystroglycan by selected isolates of lymphocytic choriomeningitis virus
    Stefan Kunz
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Virology 325:432-45. 2004
    ..Biochemical characterization of the alternative receptor(s) for LCMV indicated that they are either protein(s) or protein-bound entities...
  48. ncbi Decrease in measles virus-specific CD4 T cell memory in vaccinated subjects
    Denise Naniche
    Division of Virology, Department of Neuropharmacology, Scripps Research Institute, San Diego, California, USA
    J Infect Dis 190:1387-95. 2004
    ..These results show that MV-specific T cell immunity after vaccination is long lasting and reveal different dynamics between CD4 and CD8 cells after vaccination...
  49. ncbi Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons
    Jose R Criado
    Department of Neuropharmacology TPC 10, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurobiol Dis 19:255-65. 2005
    ....
  50. ncbi Characterization of the interaction of lassa fever virus with its cellular receptor alpha-dystroglycan
    Stefan Kunz
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Virol 79:5979-87. 2005
    ....
  51. ncbi Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection
    Elina I Zuniga
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nat Immunol 5:1227-34. 2004
    ..Our results establish a precursor-product developmental relationship between these two DC subsets and highlight unexpected plasticity of bone marrow pDCs...
  52. ncbi Type I interferon during viral infections: multiple triggers for a multifunctional mediator
    E I Zuniga
    Department of Molecular and Integrative Neuroscience, The Scripps Research Institute, La Jolla, CA, USA
    Curr Top Microbiol Immunol 316:337-57. 2007
    ....
  53. ncbi Receptor structure, binding, and cell entry of arenaviruses
    S Kunz
    Department of Neuropharmacology, Division of Virology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 262:111-37. 2002
  54. ncbi Biology and pathogenesis of lymphocytic choriomeningitis virus infection
    M B A Oldstone
    Division of Virology, Department of Neuropharmacology, Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 263:83-117. 2002
  55. ncbi Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection
    Kevin B Walsh
    Department of Immunology and Microbial Science, The Scripps Research Institute, IMM 6, TSRI, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 397:260-9. 2010
    ..Therefore, treatment with a sphingosine analog does not ameliorate persistent LCMV-Cl 13 infection...
  56. ncbi Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus
    Stefan Kunz
    Molecular and Integrative Neurosciences Department (MIND) IMM6, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 80:9082-92. 2006
    ..However, since IFNs have also been implicated in adverse effects on neuronal function, the chronic induction of some ISGs may also contribute to the observed cognitive impairment...
  57. ncbi Dendritic cell inhibition: memoirs from immunosuppressive viruses
    Matthew J Trifilo
    Department of Molecular and Integrative Neurosciences, Scripps Research Institute, La Jolla, CA, 92037, USA
    J Infect Dis 194:S3-10. 2006
  58. ncbi In vivo conversion of BM plasmacytoid DC into CD11b+ conventional DC during virus infection
    Li Ying Liou
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, IMM6, The Scripps Research Institute, La Jolla, CA, USA
    Eur J Immunol 38:3388-94. 2008
    ..Collectively, these data indicate that BM pDC actively contribute to the CD11b(+) cDC pool during in vivo viral infection and delineates molecular, functional, and phenotypic features of this novel developmental pathway...
  59. ncbi T cells in the central nervous system: the delicate balance between viral clearance and disease
    Dorian B McGavern
    Division of Virology, Department of Neuropharmacology, Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA
    J Infect Dis 186:S145-51. 2002
    ..Understanding the specific constraints imposed by the CNS on local T cell activity has important consequences for the design of therapeutic strategies aimed at preventing or curing CNS infection...
  60. ncbi Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses
    Andrew M Lee
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 283:18734-42. 2008
    ....
  61. ncbi A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection
    David Marsolais
    Department of Chemical Physiology and Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:1560-5. 2009
    ..These data indicate that sphingosine analogs display useful potential for controlling the immunopathology caused by influenza virus...
  62. ncbi TAM receptors are pleiotropic inhibitors of the innate immune response
    Carla V Rothlin
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cell 131:1124-36. 2007
    ....
  63. ncbi Old World arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell
    Jillian M Rojek
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 18:4493-507. 2007
    ..We provide evidence that virus-induced down-modulation of functional alpha-DG perturbs DG-mediated assembly of laminin at the cell surface, affecting normal cell-matrix interactions...
  64. ncbi A new approach for evaluating antigen-specific T cell responses to myelin antigens during the course of multiple sclerosis
    Nathalie Arbour
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute IMM 6, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Neuroimmunol 137:197-209. 2003
    ..A positive correlation occurred between antigen-specific T cell proliferation and interferon-gamma production with clinical relapses and MRI lesion activity that was absent when the same patients were in remission...
  65. ncbi Chronic wasting disease of deer and elk in transgenic mice: oral transmission and pathobiology
    Matthew J Trifilo
    Viral Immunobiology Laboratory, Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 365:136-43. 2007
    ..After 350 days when mice become clinically ill the cerebellum, cerebral cortex and hippocampus became positive for PrPres and displayed massive spongiosis, neuronal drop out, gliosis and florid plaques...
  66. ncbi Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity
    Thomas Stratmann
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Clin Invest 112:902-14. 2003
    ..Thus, a susceptible haplotype at the MHC seems to be the only element required for the selection and emergence of autoreactive T cells, without requiring other diabetogenic loci from the NOD genome...
  67. ncbi Characterization of lassa virus cell entry inhibitors: determination of the active enantiomer by asymmetric synthesis
    Landon R Whitby
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 19:3771-4. 2009
    ..A limited deletion scan of lassamycin-1 defined key structural features required of the prototypical inhibitors...
  68. ncbi Mechanisms for lymphocytic choriomeningitis virus glycoprotein cleavage, transport, and incorporation into virions
    Stefan Kunz
    The Scripps Research Institute, Division of Virology, Department of Neuropharmacology, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA
    Virology 314:168-78. 2003
    ..The effect of the truncation of the cytoplasmic tail on cleavage suggests a structural interdependence between the cytoplasmic domain and the ectodomains of LCMVGP...
  69. ncbi Expanded potential for recombinant trisegmented lymphocytic choriomeningitis viruses: protein production, antibody production, and in vivo assessment of biological function of genes of interest
    Daniel L Popkin
    The Scripps Research Institute, Department of Immunology and Microbial Sciences IMM 6, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 85:7928-32. 2011
    ..These findings demonstrate the utility of tripartite LCMV in vitro and in vivo to study genes in the context of a well-defined model system...
  70. ncbi Functional glycosylation of dystroglycan is crucial for thymocyte development in the mouse
    Li Ying Liou
    Viral Immunobiology Laboratory, Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 5:e9915. 2010
    ..During its biosynthesis, alpha-DG undergoes specific and unusual O-glycosylation crucial for its function as a high-affinity cellular receptor for ECM proteins...
  71. ncbi New World arenavirus clade C, but not clade A and B viruses, utilizes alpha-dystroglycan as its major receptor
    Christina F Spiropoulou
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 76:5140-6. 2002
    ..In addition, GP1 amino acid position 259 also appears to be important, since all arenaviruses showing high-affinity alpha-DG binding possess a bulky aromatic amino acid (tyrosine or phenylalanine) at this position...
  72. ncbi Preferential escape of subdominant CD8+ T cells during negative selection results in an altered antiviral T cell hierarchy
    Mark K Slifka
    Oregon Health and Science University Vaccine and Gene Therapy Institute, Beaverton, OR 97006, USA
    J Immunol 170:1231-9. 2003
    ..By allowing the escape of subdominant T cells, this process still preserves a relatively broad peripheral TCR repertoire that can actively participate in antiviral and/or autoreactive immune responses...
  73. ncbi A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes
    Urs Christen
    Immune Regulation Lab, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Clin Invest 114:1290-8. 2004
    ..Sequential heterologous viral infections might therefore act in concert to precipitate clinical autoimmune disease, even if single exposure to a viral mimic does not always cause sufficient tissue destruction...
  74. ncbi Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity
    Dirk Homann
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center Mail stop B140, P O Box 6511, Aurora, CO 80045, USA
    J Virol 80:270-80. 2006
    ..These findings have implications for the physiologic, pathological, and therapeutic regulation of costimulation...
  75. ncbi Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Clin Invest 113:74-84. 2004
    ..Thus, virally induced proinflammatory cytokines and chemokines can influence the ongoing autoaggressive process beneficially at the preclinical stage, if produced at the correct location, time, and levels...
  76. ncbi Molecular recognition by LARGE is essential for expression of functional dystroglycan
    Motoi Kanagawa
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    Cell 117:953-64. 2004
    ..Therefore, molecular recognition of dystroglycan by LARGE is a key determinant in the biosynthetic pathway to produce mature and functional dystroglycan...
  77. ncbi Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease
    Urs Christen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 171:6838-45. 2003
    ....
  78. ncbi Targeting Schwann cells by nonlytic arenaviral infection selectively inhibits myelination
    Anura Rambukkana
    Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NY10021, USA
    Proc Natl Acad Sci U S A 100:16071-6. 2003
    ....
  79. ncbi Mapping and restriction of a dominant viral CD4+ T cell core epitope by both MHC class I and MHC class II
    Dirk Homann
    Barbara Davis Center, University of Colorado at Denver and Health Sciences Center, 12801 East 17th Avenue, Aurora CO, USA
    Virology 363:113-23. 2007
    ..Surprisingly, this epitope is also recognized by LCMV-specific CD8(+) T cells and thus constitutes a unique viral determinant with dual MHC class I- and II-restriction...
  80. ncbi Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development
    Antje Rhode
    Immune Regulation Laboratory, Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:3516-24. 2005
    ..Our results indicate that CXCL10 expression accelerates the autoimmune process by enhancing the migration of Ag-specific lymphocytes to their target site...
  81. ncbi Measles virus infection results in suppression of both innate and adaptive immune responses to secondary bacterial infection
    Mark K Slifka
    Oregon Health and Science University Vaccine and Gene Therapy Institute, Beaverton, Oregon, USA
    J Clin Invest 111:805-10. 2003
    ..These results document that MV infection can suppress both innate and adaptive immune responses and lead to increased susceptibility to bacterial infection...
  82. ncbi Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic
    Rafi Ahmed
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Immunol 8:1188-93. 2007
    ....

Research Grants60

  1. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
    ..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
  2. PATHOGENESIS OF PERSISTENT VIRAL INFECTION
    Michael Oldstone; Fiscal Year: 2007
    ..Lessons learned from this aspect of the LCMV model should provide in_,iohts for several persistent human viral infections that _ause immunosuooression. ..
  3. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
    ..abstract_text> ..
  4. PATHOGENESIS OF PERSISTENT VIRAL INFECTION
    Michael Oldstone; Fiscal Year: 2006
    ..Lessons learned from this aspect of the LCMV model should provide insights for several persistent human viral infections that cause immunosuppression. ..
  5. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2006
    ..abstract_text> ..
  6. Viruses and Diabetes
    Michael Oldstone; Fiscal Year: 2005
    ....
  7. ARENAVIRUS RECEPTOR--STRUCTURE/FUNCTION STUDIES
    Michael Oldstone; Fiscal Year: 2007
    ..These findings have relevance for biodefense of several viruses including LFV. ..
  8. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael Oldstone; Fiscal Year: 2007
    ..abstract_text> ..
  9. In Vivo Analysis of T lymphocytes in the Persistently Infected CNS
    Michael B Oldstone; Fiscal Year: 2010
    ..The main objective of this research is mechanistically define the factors that give rise to successful CNS viral clearance so that we are better able to supplement a failing (or inadequate) endogenous response. ..
  10. PATHOGENESIS OF PERSISTENT VIRAL INFECTION
    Michael B Oldstone; Fiscal Year: 2010
    ....
  11. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
    ..These findings have relevance for biodefense of several viruses including LFV. ..
  12. PATHOGENESIS OF PERSISTENT VIRAL INFECTION
    Michael Oldstone; Fiscal Year: 2009
    ....
  13. Arenavirus Receptor-Structure/Function Studies
    Michael Oldstone; Fiscal Year: 2009
    ..These findings have relevance for biodefense of several viruses including LFV. ..
  14. Novel Chemical and Immunological Approaches to Influenza Therapy
    Michael Oldstone; Fiscal Year: 2007
    ..Kawaoka will test novel sphingosine analogs against H5N1 influenza virus. ..
  15. ARENAVIRUS RECEPTOR--STRUCTURE/FUNCTION STUDIES
    Michael Oldstone; Fiscal Year: 2004
    ..We will also analyze alpha-DG content on IDDC and F4/80+ cells and look for coreceptor(s). ..
  16. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
  17. PATHOGENESIS OF PERSISTENT VIRAL INFECTION
    Michael Oldstone; Fiscal Year: 2003
    ..Lessons learned from this aspect of the LCMV model should provide insights for several persistent human viral infections that cause immunosuppression. ..
  18. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2003
    ..abstract_text> ..
  19. PATHOGENESIS OF PERSISTENT VIRAL INFECTION
    Michael Oldstone; Fiscal Year: 2002
    ..The eventual goal is to understand and then manipulate, for the profit of the host, the early events of arenavirus entry into cells. ..
  20. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2002
    ..The other newly made tg mice express CD46 widely (genomic CD46, CD46 driven by CMV promoter). The P.I. anticipates that these mice will be of value for similar studies. ..
  21. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
  22. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..