S Ogawa

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Roles of estrogen receptor-alpha gene expression in reproduction-related behaviors in female mice
    S Ogawa
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, New York 10021, USA
    Endocrinology 139:5070-81. 1998
  2. ncbi request reprint Current status of antisense DNA methods in behavioral studies
    S Ogawa
    Laboratory of Neurobiology and Behavior, Rockefeller University, New York, NY 10021, USA
    Chem Senses 23:249-55. 1998
  3. ncbi request reprint Modifications of testosterone-dependent behaviors by estrogen receptor-alpha gene disruption in male mice
    S Ogawa
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, New York 10021, USA
    Endocrinology 139:5058-69. 1998
  4. pmc Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice
    S Ogawa
    Laboratory of Neurobiology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:12887-92. 1999
  5. pmc Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO)
    S Ogawa
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:14737-41. 2000
  6. ncbi request reprint Differential distribution of estrogen receptor (ER)-alpha and ER-beta in the midbrain raphe nuclei and periaqueductal gray in male mouse: Predominant role of ER-beta in midbrain serotonergic systems
    M Nomura
    Laboratory of Neurobiology and Behavior, The Rockefeller University, Box 275, 1230 York Avenue, New York, NY 10021, USA
    Neuroscience 130:445-56. 2005
  7. pmc Estradiol acts via estrogen receptors alpha and beta on pathways important for synaptic plasticity in the mouse hippocampal formation
    J L Spencer-Segal
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA
    Neuroscience 202:131-46. 2012
  8. pmc Female preproenkephalin-knockout mice display altered emotional responses
    A Ragnauth
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:1958-63. 2001
  9. ncbi request reprint Hormones, genes and the structure of sexual arousal
    J Frohlich
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA
    Behav Brain Res 105:5-27. 1999
  10. pmc A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors
    C J Krebs
    Laboratory of Neurobiology and Behavior and Laboratory of Animal Behavior, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:12816-21. 2000

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Roles of estrogen receptor-alpha gene expression in reproduction-related behaviors in female mice
    S Ogawa
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, New York 10021, USA
    Endocrinology 139:5070-81. 1998
    ..In addition, persistence of genotype differences in parental and aggressive behavior after gonadectomy indicates that ER alpha activation during neural developmental processes may also be involved in the regulation of these behaviors...
  2. ncbi request reprint Current status of antisense DNA methods in behavioral studies
    S Ogawa
    Laboratory of Neurobiology and Behavior, Rockefeller University, New York, NY 10021, USA
    Chem Senses 23:249-55. 1998
    ....
  3. ncbi request reprint Modifications of testosterone-dependent behaviors by estrogen receptor-alpha gene disruption in male mice
    S Ogawa
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, New York 10021, USA
    Endocrinology 139:5058-69. 1998
    ..With respect to three major testosterone-dependent behavioral systems reflecting masculinization, these findings demonstrate three different types of effects due to ER alpha gene disruption...
  4. pmc Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice
    S Ogawa
    Laboratory of Neurobiology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:12887-92. 1999
    ....
  5. pmc Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO)
    S Ogawa
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:14737-41. 2000
    ..Offensive attacks, on the other hand, depend specifically on the ER-alpha gene. Different patterns of natural behaviors require different patterns of functions by ER genes...
  6. ncbi request reprint Differential distribution of estrogen receptor (ER)-alpha and ER-beta in the midbrain raphe nuclei and periaqueductal gray in male mouse: Predominant role of ER-beta in midbrain serotonergic systems
    M Nomura
    Laboratory of Neurobiology and Behavior, The Rockefeller University, Box 275, 1230 York Avenue, New York, NY 10021, USA
    Neuroscience 130:445-56. 2005
    ..These findings support a hypothesis that ER-beta activation may contribute to the estrogenic regulation of neuroendocrine and behavioral functions, in part, by acting directly on 5-HT neurons in the raphe nuclei in male mice...
  7. pmc Estradiol acts via estrogen receptors alpha and beta on pathways important for synaptic plasticity in the mouse hippocampal formation
    J L Spencer-Segal
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA
    Neuroscience 202:131-46. 2012
    ..By further delineating these mechanisms, we will better understand and predict the effects of endogenous and exogenous ovarian steroids on mood, cognition, and other hippocampal-dependent behaviors...
  8. pmc Female preproenkephalin-knockout mice display altered emotional responses
    A Ragnauth
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:1958-63. 2001
    ..These transgenic data strongly suggest that opioids, and particularly enkephalin gene products, are acting naturally to inhibit fear and anxiety...
  9. ncbi request reprint Hormones, genes and the structure of sexual arousal
    J Frohlich
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA
    Behav Brain Res 105:5-27. 1999
    ..Is 'general arousal' a monolithic, undifferentiated process? In no way can a review at this time settle such issues, but the reasons behind six new experimental approaches to these questions are described...
  10. pmc A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors
    C J Krebs
    Laboratory of Neurobiology and Behavior and Laboratory of Animal Behavior, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:12816-21. 2000
    ..These findings suggest a mechanism in which the activation of nuclear P receptor represses expression of a membrane P receptor, 25-Dx, during lordosis facilitation...
  11. ncbi request reprint Estrogens, brain and behavior: studies in fundamental neurobiology and observations related to women's health
    D W Pfaff
    Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230 York Avenue, NY 10021, New York, USA
    J Steroid Biochem Mol Biol 74:365-73. 2000
    ..The hypothesis is raised that the synaptic effects of estrogens are secondary to the trophic actions of this type of hormone in the nucleus and nerve cell body...
  12. pmc Behavioral effects of estrogen receptor gene disruption in male mice
    S Ogawa
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:1476-81. 1997
    ..Together, these findings indicate that ER gene expression during development plays a major role in the organization of male-typical aggressive and emotional behaviors in addition to simple sexual behaviors...
  13. ncbi request reprint Statistical analysis of measures of arousal in ovariectomized female mice
    J Frohlich
    Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230 York Avenue, New York, New York 10021, U SA
    Horm Behav 39:39-47. 2001
    ..Besides providing a baseline for ongoing estrogen/thyroid and related genetic experiments, this statistical approach should be useful for a variety of hormonal studies of complex behaviors in mice...
  14. ncbi request reprint Estrogen-regulated progestin receptors are found in the midbrain raphe but not hippocampus of estrogen receptor alpha (ER alpha) gene-disrupted mice
    S E Alves
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    J Comp Neurol 427:185-95. 2000
    ..Collectively, these findings suggest that estrogen can regulate the expression of one gene (the PR) via multiple mechanisms, based upon brain region...
  15. pmc Reproduction-related behaviors of Swiss-Webster female mice living in a cold environment
    J Chan
    Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:700-4. 2001
    ..We suggest that cold temperatures accompanied by reduced photoperiod and reduced metabolic fuel can reduce overall activity in female mice, thus indirectly blocking untimely reproductive behaviors...
  16. pmc Hippocampal cells encode places by forming small anatomical clusters
    N H Nakamura
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Neuroscience 166:994-1007. 2010
    ..We propose that spatial encoding recruits specific cell ensembles in the hippocampus and that with repeated exposure to the same place the ensembles become better organized to more accurately represent the "spatial map."..
  17. pmc Genetic contributions to generalized arousal of brain and behavior
    J Garey
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:11019-22. 2003
    ..A combination of mathematical and genetic approaches to arousal in an experimentally tractable mammal opens up analysis of a CNS function of considerable theoretical and practical significance...
  18. pmc Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior
    J A Gogos
    The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:9991-6. 1998
    ....
  19. ncbi request reprint Enhanced up-regulation of corticotropin-releasing hormone gene expression in response to restraint stress in the hypothalamic paraventricular nucleus of oxytocin gene-deficient male mice
    M Nomura
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA
    J Neuroendocrinol 15:1054-61. 2003
    ..Furthermore, neuronal activity in the BNST and the medial amygdala may be involved in this neuroendocrine regulatory system...
  20. ncbi request reprint Role of adrenal steroid mineralocorticoid and glucocorticoid receptors in long-term potentiation in the CA1 field of hippocampal slices
    C Pavlides
    Rockefeller University, New York, NY 10021, USA
    Brain Res 738:229-35. 1996
    ..The present results are in agreement with previous studies showing that elevations in corticosterone or an acute episode of experimentally induced stress in vivo causes a suppression in LTP in the hippocampal CA1 field, in vitro...
  21. ncbi request reprint Potentiation of the excitatory action of NMDA in ventrolateral periaqueductal gray by the mu-opioid receptor agonist, DAMGO
    L M Kow
    The Rockefeller University, Laboratory of Neurobiology and Behavior, 1230 York Avenue, Box 336, New York, NY 10021 6399, USA
    Brain Res 935:87-102. 2002
    ..These observations may help understanding behaviorally important mechanisms linked to acute and chronic opioid functions in the vlPAG...
  22. ncbi request reprint Amyloid beta -peptide-binding alcohol dehydrogenase is a component of the cellular response to nutritional stress
    S Du Yan
    Departments of Pathology, Surgery, Physiology and Cellular Biophysics, Neurosurgery and Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Biol Chem 275:27100-9. 2000
    ..These data suggest that ABAD contributes to the protective response to metabolic stress, especially in the setting of ischemia...
  23. ncbi request reprint Abolition of sex-dependent effects of prenatal exposure to diethylstilbestrol on emotional behavior in estrogen receptor-alpha knockout mice
    Kazuya Tomihara
    Department of Psychology, Faculty of Law, Economics and Humanities, Kagoshima University, Kagoshima, Japan
    Neuroreport 17:1169-73. 2006
    ..These results suggest that the sex-dependent effects of diethylstilbestrol on emotionality are mainly produced by its action on estrogen receptor-alpha...
  24. pmc Estrogen receptors in the medial amygdala inhibit the expression of male prosocial behavior
    Bruce S Cushing
    Department of Biology, The University of Akron, Akron, Ohio 44325 3908, USA
    J Neurosci 28:10399-403. 2008
    ....
  25. ncbi request reprint Differential roles of estrogen receptor alpha and beta in the regulation of neuroendocrine functions and socio-sexual behaviors
    Sonoko Ogawa
    Laboratory of Neurobiology and Behavior, The Rockefeller University, USA
    J Nippon Med Sch 70:530. 2003
  26. ncbi request reprint Genetic influences on aggressive behaviors and arousability in animals
    Sonoko Ogawa
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, New York 10021, USA
    Ann N Y Acad Sci 1036:257-66. 2004
    ..Normal performance of this micronet is required for social recognition and thus for control over aggression. Underlying certain genetic influences on sociosexual behaviors and aggression may be alterations in generalized brain arousal...
  27. pmc Inadvertent social information and the avoidance of parasitized male mice: a role for oxytocin
    Martin Kavaliers
    Department of Psychology and Statistical and Actuarial Sciences, University of Western Ontario, London, ON, Canada N6A 5C2
    Proc Natl Acad Sci U S A 103:4293-8. 2006
    ..These findings suggest that OT genes are necessary for the processing of inadvertent social information and likely the integration of both direct and indirect social information...
  28. ncbi request reprint Estrogen receptor-beta gene disruption potentiates estrogen-inducible aggression but not sexual behaviour in male mice
    Masayoshi Nomura
    Laboratory of Neurobiology and Behaviour, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Eur J Neurosci 23:1860-8. 2006
    ..These findings support the notion that ER-beta activation may exert an attenuating action on male aggression induced by estrogen through ER-alpha-mediated brain mechanisms, whereas its effect on male sexual behaviour is relatively small...
  29. pmc RNAi-mediated silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors
    Sergei Musatov
    Neurologix, Inc, Fort Lee, NJ 07024, USA
    Proc Natl Acad Sci U S A 103:10456-60. 2006
    ..These results provide evidence that adeno-associated virus-mediated long-term knockdown of genes can be used to delineate their effects on complex behaviors in discrete brain regions...
  30. doi request reprint Estrogen receptors alpha and beta mediate different aspects of the facilitatory effects of female cues on male risk taking
    Martin Kavaliers
    Department Psychology, University of Western Ontario, London, Ontario, Canada N6A 5C2
    Psychoneuroendocrinology 33:634-42. 2008
    ....
  31. ncbi request reprint Anxiety and fear behaviors in adult male and female C57BL/6 mice are modulated by maternal separation
    Russell D Romeo
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Horm Behav 43:561-7. 2003
    ..These results indicate that the emotionality of adult male and female mice can be modulated by maternal separation. However, this effect is dependent on the sex of the offspring and the phase of the estrous cycle of the female...
  32. ncbi request reprint Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice
    Masayoshi Nomura
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, New York 10021, USA
    Horm Behav 41:288-96. 2002
    ..These results suggest that ER-beta mediated actions of gonadal steroids may more profoundly be involved in the inhibitory regulation of aggressive behavior in pubertal and young adult mice...
  33. ncbi request reprint Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes
    Karina Del Punta
    The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 419:70-4. 2002
    ..Electrophysiologically, the epithelium of the VNO of such mice does not respond detectably to specific pheromonal ligands. The behavioural impairment and chemosensory deficit support a role of V1r receptors as pheromone receptors...
  34. ncbi request reprint Temporal and spatial quantitation of nesting and mating behaviors among mice housed in a semi-natural environment
    Joan Garey
    Laboratory of Neurobiology and Behavior, The Rockerfeller University, New York, New York 10021, USA
    Horm Behav 42:294-306. 2002
    ..These behaviors have not been reported previously for mice and may provide additional endpoints for the exploration of hormonal and genetic influences on reproductive behaviors...
  35. ncbi request reprint Statistical analysis of hormonal influences on arousal measures in ovariectomized female mice
    Jonathan Frohlich
    Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Horm Behav 42:414-23. 2002
    ..Hormone effects on arousal components are of interest because of their likely contributions to emotional states and cognitive performance...
  36. ncbi request reprint Estrogen increases locomotor activity in mice through estrogen receptor alpha: specificity for the type of activity
    Sonoko Ogawa
    Laboratory of Neurobiology and Behavior, Rockefeller University, New York, New York 10021, USA
    Endocrinology 144:230-9. 2003
    ..e. home cage running wheel activity and open field activity) measured...
  37. pmc Estradiol differentially regulates lipocalin-type prostaglandin D synthase transcript levels in the rodent brain: Evidence from high-density oligonucleotide arrays and in situ hybridization
    Jessica A Mong
    Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:318-23. 2003
    ....
  38. ncbi request reprint Estrogen receptor-beta regulates transcript levels for oxytocin and arginine vasopressin in the hypothalamic paraventricular nucleus of male mice
    Masayoshi Nomura
    Laboratory of Neurobiology and Behavior, The Rockefeller University, Box 275, 1230 York Avenue, New York, NY 10021, USA
    Brain Res Mol Brain Res 109:84-94. 2002
    ..These results suggest that ER-beta activation may play a critical role in estrogenic regulation of OT and AVP gene expression in the PVN...
  39. ncbi request reprint Estrogen receptor beta (ERbeta) protein levels in neurons depend on estrogen receptor alpha (ERalpha) gene expression and on its ligand in a brain region-specific manner
    Masayoshi Nomura
    Laboratory of Neurobiology and Behavior, The Rockefeller University, Box 275, 1230 York Avenue, New York, NY 10021, USA
    Brain Res Mol Brain Res 110:7-14. 2003
    ..These results suggest that gonadal steroid hormones may regulate ERbeta protein in male mice and ERalpha may be involved in the expression and regulation of ERbeta in a region-specific manner...
  40. pmc An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-alpha and -beta knockout mice
    Elena Choleris
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:6192-7. 2003
    ..The proper operation of a social recognition mechanism allows for the expression of appropriate social behaviors, aggressive or affiliative...
  41. ncbi request reprint Immunolocalization of estrogen receptor beta in the mouse brain: comparison with estrogen receptor alpha
    Sudha Warrier Mitra
    Department of Atherosclerosis and Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Endocrinology 144:2055-67. 2003
    ..These data provide an anatomical framework for understanding the mechanisms by which estrogen regulates specific neural systems in the mouse...
  42. ncbi request reprint Reversal of sex differences in morphine analgesia elicited from the ventrolateral periaqueductal gray in rats by neonatal hormone manipulations
    Eliza K Krzanowska
    Department of Psychology and Neuropsychology Doctoral Sub Program, Queens College and City University of New York, Flushing, NY 11367, USA
    Brain Res 929:1-9. 2002
    ....
  43. pmc Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome
    Sergei Musatov
    Neurologix, Inc, Fort Lee, NJ 07024, USA
    Proc Natl Acad Sci U S A 104:2501-6. 2007
    ..Together, these findings indicate that ERalpha in the ventromedial nucleus of the hypothalamus neurons plays an essential role in the control of energy balance and the maintenance of normal body weight...
  44. pmc From gene networks underlying sex determination and gonadal differentiation to the development of neural networks regulating sociosexual behavior
    David Crews
    Section of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA
    Brain Res 1126:109-21. 2006
    ....
  45. ncbi request reprint Estrogen and thyroid hormone receptor interactions: physiological flexibility by molecular specificity
    Nandini Vasudevan
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, New York 10021, USA
    Physiol Rev 82:923-44. 2002
    ..The various combinations of these molecular interactions provide multiple and flexible opportunities for relations between two major hormonal systems important for neuroendocrine feedbacks and reproductive behaviors...
  46. ncbi request reprint Postnatal environment affects behavior of adult transgenic mice
    David Crews
    Section of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA
    Exp Biol Med (Maywood) 229:935-9. 2004
    ..These data suggest that the postnatal environment such as litter composition may influence the development of sociosexual behaviors in ERKO mice...
  47. ncbi request reprint Genes for sex hormone receptors controlling mouse aggression
    Donald Pfaff
    Laboratory of Neurobiology and Behaviour, The Rockefeller University, 1230 York A venue, New York, NY 10021, USA
    Novartis Found Symp 268:78-89; discussion 89-95, 96-9. 2005
    ..7) Some genetic influences on aggression derive from their effects on fundamental, generalized arousal of the mammalian brain, which underlies the expression of any emotional behaviour...