Emmett O'Flaherty

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi TOX: an HMG box protein implicated in the regulation of thymocyte selection
    Beverley Wilkinson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Immunol 3:272-80. 2002
  2. pmc TOX defines a conserved subfamily of HMG-box proteins
    Emmett O'Flaherty
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA92037, USA
    BMC Genomics 4:13. 2003
  3. pmc TOX provides a link between calcineurin activation and CD8 lineage commitment
    Parinaz Aliahmad
    Department of Immunology IMM 8, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Exp Med 199:1089-99. 2004
  4. pmc Development of all CD4 T lineages requires nuclear factor TOX
    Parinaz Aliahmad
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 205:245-56. 2008
  5. ncbi An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection
    Peggy Han
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 172:5931-9. 2004

Collaborators

  • J D Molkentin
  • Parinaz Aliahmad
  • Jonathan Kaye
  • Peggy Han
  • Beverley Wilkinson
  • Olivia D Goularte
  • Kevin Rufner
  • Masanobu Satake
  • Kevin M Rufner
  • Jeff Y F Chen

Detail Information

Publications5

  1. ncbi TOX: an HMG box protein implicated in the regulation of thymocyte selection
    Beverley Wilkinson
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Immunol 3:272-80. 2002
    ..This molecular marker of thymic selection events may therefore play a role in establishing the activation threshold of developing T cells and patterning changes in gene expression...
  2. pmc TOX defines a conserved subfamily of HMG-box proteins
    Emmett O'Flaherty
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA92037, USA
    BMC Genomics 4:13. 2003
    ..We recently identified an HMG-box protein involved in T cell development, designated TOX, which is highly conserved in humans and mice...
  3. pmc TOX provides a link between calcineurin activation and CD8 lineage commitment
    Parinaz Aliahmad
    Department of Immunology IMM 8, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Exp Med 199:1089-99. 2004
    ..We further demonstrate that up-regulation of TOX in double positive thymocytes is calcineurin dependent, linking this critical signaling pathway to nuclear changes during positive selection...
  4. pmc Development of all CD4 T lineages requires nuclear factor TOX
    Parinaz Aliahmad
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 205:245-56. 2008
    ..Our data suggest that TOX-dependent transition to the CD4(+)CD8(lo) stage is required for continued development of class II major histocompatibility complex-specific T cells, regardless of ultimate lineage fate...
  5. ncbi An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection
    Peggy Han
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 172:5931-9. 2004
    ..Conversely, anti-BTLA Ab can inhibit T cell activation. These results implicate BTLA as a negative regulator of the activation and/or function of various hemopoietic cell types...