P A Offit

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi Vaccines and autism: a tale of shifting hypotheses
    Jeffrey S Gerber
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    Clin Infect Dis 48:456-61. 2009
  2. ncbi The future of rotavirus vaccines
    Paul A Offit
    Section of Infectious Diseases, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
    Semin Pediatr Infect Dis 13:190-5. 2002
  3. ncbi Addressing parents' concerns: do vaccines cause allergic or autoimmune diseases?
    Paul A Offit
    Division of Infectious Diseases, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, and the Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, USA
    Pediatrics 111:653-9. 2003
  4. ncbi Communicating science to the public: MMR vaccine and autism
    Paul A Offit
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Vaccine 22:1-6. 2003
  5. ncbi Addressing parents' concerns: do vaccines contain harmful preservatives, adjuvants, additives, or residuals?
    Paul A Offit
    Division of Infectious Diseases, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, and Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 112:1394-7. 2003
  6. ncbi Meningococcal conjugate vaccine in the UK: an update
    Paul A Offit
    Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Lancet 364:309-10. 2004
  7. ncbi Why are pharmaceutical companies gradually abandoning vaccines?
    Paul A Offit
    Children s Hospital, Philadelphia, PA, USA
    Health Aff (Millwood) 24:622-30. 2005
  8. ncbi RotaTeq: a pentavalent bovine--human reassortant rotavirus vaccine
    Paul A Offit
    Division of Infectious Diseases, The Children's Hospital of Philadelphia, PA, USA
    Pediatr Ann 35:29-34. 2006
  9. ncbi Rotavirus vaccines: round two
    Paul A Offit
    Division of Infectious Diseases, The Children's Hospital of Philadelphia, PA 19104, USA
    Hum Vaccin 2:84-5. 2006
  10. ncbi New book about vaccine safety
    Paul A Offit
    Division of Infectious Diseases, Vaccine Education Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatrics 122:871-2. 2008

Research Grants

  1. PROTECTION FROM VIRAL GASTROENTERITIS BY INTESTINAL CTLS
    Paul Offit; Fiscal Year: 1993
  2. ENHANCEMENT OF IMMUNOGENICITY BY MICROENCAPSULATION
    Paul Offit; Fiscal Year: 1999
  3. ENHANCING MUCOSAL IMMUNE RESPONSES BY MICROENCAPSULATION
    Paul Offit; Fiscal Year: 2005

Detail Information

Publications37

  1. ncbi Vaccines and autism: a tale of shifting hypotheses
    Jeffrey S Gerber
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    Clin Infect Dis 48:456-61. 2009
    ..We will discuss the genesis of each of these theories and review the relevant epidemiological evidence...
  2. ncbi The future of rotavirus vaccines
    Paul A Offit
    Section of Infectious Diseases, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
    Semin Pediatr Infect Dis 13:190-5. 2002
    ..The continuing interest of pharmaceutical companies in developing a safe and effective vaccine is encouraging, especially given the enormous burden of rotavirus disease in developing countries...
  3. ncbi Addressing parents' concerns: do vaccines cause allergic or autoimmune diseases?
    Paul A Offit
    Division of Infectious Diseases, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, and the Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, USA
    Pediatrics 111:653-9. 2003
    ..Flaws in proposed biological mechanisms that explain how vaccines might cause chronic diseases are consistent with the findings of many well-controlled large epidemiologic studies that fail to show a causal relationship...
  4. ncbi Communicating science to the public: MMR vaccine and autism
    Paul A Offit
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Vaccine 22:1-6. 2003
    ....
  5. ncbi Addressing parents' concerns: do vaccines contain harmful preservatives, adjuvants, additives, or residuals?
    Paul A Offit
    Division of Infectious Diseases, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, and Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 112:1394-7. 2003
    ..However, quantities of mercury, aluminum, formaldehyde, human serum albumin, antibiotics, and yeast proteins in vaccines have not been found to be harmful in humans or experimental animals...
  6. ncbi Meningococcal conjugate vaccine in the UK: an update
    Paul A Offit
    Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Lancet 364:309-10. 2004
  7. ncbi Why are pharmaceutical companies gradually abandoning vaccines?
    Paul A Offit
    Children s Hospital, Philadelphia, PA, USA
    Health Aff (Millwood) 24:622-30. 2005
    ..Congressional action could assure both a steady supply of existing vaccines and the promise of vaccines for the future...
  8. ncbi RotaTeq: a pentavalent bovine--human reassortant rotavirus vaccine
    Paul A Offit
    Division of Infectious Diseases, The Children's Hospital of Philadelphia, PA, USA
    Pediatr Ann 35:29-34. 2006
  9. ncbi Rotavirus vaccines: round two
    Paul A Offit
    Division of Infectious Diseases, The Children's Hospital of Philadelphia, PA 19104, USA
    Hum Vaccin 2:84-5. 2006
  10. ncbi New book about vaccine safety
    Paul A Offit
    Division of Infectious Diseases, Vaccine Education Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatrics 122:871-2. 2008
  11. ncbi The problem with Dr Bob's alternative vaccine schedule
    Paul A Offit
    Vaccine Education Center, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatrics 123:e164-9. 2009
    ....
  12. ncbi Addressing parents' concerns: do multiple vaccines overwhelm or weaken the infant's immune system?
    Paul A Offit
    Section of Infectious Diseases, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, and Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA
    Pediatrics 109:124-9. 2002
    ....
  13. ncbi The rotavirus vaccine
    P A Offit
    Section of Infectious Diseases, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA
    J Clin Virol 11:155-9. 1998
    ..Rotavirus gastroenteritis is an important cause of morbidity and mortality worldwide...
  14. ncbi Immunologic correlates of protection against rotavirus challenge after intramuscular immunization of mice
    S E Coffin
    Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, 19104, USA
    J Virol 71:7851-6. 1997
    ..The mechanisms by which i.m. inoculation induces virus-specific humoral immune responses in the small intestinal LP were examined...
  15. ncbi Relative importance of rotavirus-specific effector and memory B cells in protection against challenge
    C A Moser
    Section of Infectious Diseases, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    J Virol 72:1108-14. 1998
    ....
  16. ncbi Induction of mucosal B-cell memory by intramuscular inoculation of mice with rotavirus
    S E Coffin
    Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, 19104, USA
    J Virol 72:3479-83. 1998
    ..We found that prior i.m. immunization enhanced the magnitude of mucosal virus-specific immunoglobulin A (IgA) production but did not alter the site and timing of induction of virus-specific IgA responses after challenge...
  17. ncbi Migration of antigen-presenting B cells from peripheral to mucosal lymphoid tissues may induce intestinal antigen-specific IgA following parenteral immunization
    S E Coffin
    Division of Immunologic and Infectious Diseases, Children s Hospital of Philadelphia, PA 19104, USA
    J Immunol 163:3064-70. 1999
    ..Strategies that promote Ag uptake and presentation by B cells may enhance mucosal IgA production following parenteral immunization...
  18. ncbi Effect of water-based microencapsulation on protection against EDIM rotavirus challenge in mice
    C A Moser
    Section of Infectious Diseases, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    J Virol 72:3859-62. 1998
    ..Possible mechanisms by which microcapsules enhance protection against rotavirus challenge are discussed...
  19. ncbi Hypertrophy, hyperplasia, and infectious virus in gut-associated lymphoid tissue of mice after oral inoculation with simian-human or bovine-human reassortant rotaviruses
    C A Moser
    Section of Infectious Diseases, Children s Hospital of Philadelphia, Abramson Research Building, Philadelphia, PA 19104, USA
    J Infect Dis 183:1108-11. 2001
    ..However, infectious virus was detected in PP and mesenteric lymph nodes after oral inoculation with simian, but not bovine, reassortant rotaviruses. Implications of these findings on the pathogenesis of intussusception are discussed...
  20. ncbi Circulating rotavirus-specific antibody-secreting cells (ASCs) predict the presence of rotavirus-specific ASCs in the human small intestinal lamina propria
    K A Brown
    Division of Gastroenterology and Nutrition, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Infect Dis 182:1039-43. 2000
    ..In contrast, serum rotavirus-specific IgA correlated less well with the presence of virus-specific ASCs in the small intestine...
  21. ncbi Specific attachment of aqueous-based microcapsules to macrophages, B cells, and dendritic cells in vitro
    J O Brubaker
    Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, 19104, USA
    J Microencapsul 19:213-23. 2002
    ..The availability of APC-specific microcapsules should allow for the uptake of antigens by specific APC, and further one's understanding of the relative capacities of different APC to induce antigen-specific immune responses...
  22. ncbi Rotavirus isolate WI61 representing a presumptive new human serotype
    H F Clark
    Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104
    J Clin Microbiol 25:1757-62. 1987
    ..WI61 rotavirus caused diarrhea in newborn mice with a 50% diarrhea-inducing dose of 10(7.0) PFU...
  23. ncbi Distribution of rotavirus-specific memory B cells in gut-associated lymphoid tissue after primary immunization
    C A Moser
    Section of Infectious Diseases, The Children s Hospital of Philadelphia, Abramson Research Building, Room 1205A, 3516 Civic Center Blvd, Philadelphia, PA 19104, USA
    J Gen Virol 82:2271-4. 2001
    ..We found that protection against rotavirus challenge was determined by the frequency of rotavirus-specific memory B cells in GALT LP...
  24. ncbi The new pentavalent rotavirus vaccine composed of bovine (strain WC3) -human rotavirus reassortants
    H Fred Clark
    Division of Infectious Diseases, ARC 1202, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Pediatr Infect Dis J 25:577-83. 2006
    ..In developing countries, it is associated with a high mortality. A licensed vaccine against rotavirus was withdrawn because of a causal association with intussusception. A new vaccine has been developed and is a candidate for licensure...
  25. ncbi Infant immune response to human rotavirus serotype G1 vaccine candidate reassortant WI79-9: different dose response patterns to virus surface proteins VP7 and VP4
    H Fred Clark
    Division of Immunologic and Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 23:206-11. 2004
    ..It is a key component of a pentavalent (G1, G2, G3, G4 and P1) WC3 reassortant vaccine candidate, RotaTeq, now being tested in Phase III clinical trials...
  26. ncbi Primary murine small intestinal epithelial cells, maintained in long-term culture, are susceptible to rotavirus infection
    K K Macartney
    Section of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Virol 74:5597-603. 2000
    ....
  27. ncbi Thimerosal and vaccines--a cautionary tale
    Paul A Offit
    Division of Infectious Diseases at the Children's Hospital of Philadelphia, Philadelphia, USA
    N Engl J Med 357:1278-9. 2007
  28. ncbi Correlates of protection against rotavirus infection and disease
    P A Offit
    Children's Hospital of Philadelphia, 34th St. and Civic Center Blvd, USA
    Novartis Found Symp 238:106-13; discussion 114-24. 2001
    ..This paradigm will be used to explore the immunological effector functions associated with protection against rotavirus challenge...
  29. ncbi Vaccines for rotavirus gastroenteritis universally needed for infants
    H Fred Clark
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Ann 33:536-43. 2004
    ..It is essential that there be vigorous pursuit of new technologies to manufacture these products at drastically reduced cost if their true lifesaving potential is to be achieved...
  30. ncbi The Cutter incident, 50 years later
    Paul A Offit
    Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, USA
    N Engl J Med 352:1411-2. 2005
  31. ncbi Vaccines and autism revisited--the Hannah Poling case
    Paul A Offit
    Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, USA
    N Engl J Med 358:2089-91. 2008
  32. ncbi The meningococcal vaccine--public policy and individual choices
    Paul A Offit
    Division of Infectious Diseases, Children's Hospital of Philadelphia, and the Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, USA
    N Engl J Med 349:2353-6. 2003
  33. ncbi Effects of the potency and composition of the multivalent human-bovine (WC3) reassortant rotavirus vaccine on efficacy, safety and immunogenicity in healthy infants
    Timo Vesikari
    University of Tampere Medical School, Tampere, Finland
    Vaccine 24:4821-9. 2006
    ....
  34. ncbi Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine
    Timo Vesikari
    University of Tampere Medical School, Tampere, Finland
    N Engl J Med 354:23-33. 2006
    ..The risk of intussusception was similar in vaccine and placebo recipients. (ClinicalTrials.gov number, NCT00090233.)..
  35. ncbi The power of 'box a'
    Paul A Offit
    Expert Rev Vaccines 2:1-3. 2003
  36. ncbi Rotavirus immunoglobulin a responses stimulated by each of 3 doses of a quadrivalent human/bovine reassortant rotavirus vaccine
    Richard L Ward
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Infect Dis 189:2290-3. 2004
    ..In total, 16, 19, and 15 vaccine recipients had increases after 1, 2, and 3 doses, respectively, indicating that a 3-dose regimen increased the immune response elicited by this vaccine...
  37. ncbi Yellow fever vaccine. Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2002
    Martin S Cetron
    Division of Global Migration and Quarantine, National Center for Infectious Diseases, CDC, USA
    MMWR Recomm Rep 51:1-11; quiz CE1-4. 2002
    ..cdc.gov/travel/index.htm, and through the website for the Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, CDC, at http://www.cdc.gov/ncidod/ dvbid/yellowfever/index.htm...

Research Grants15

  1. PROTECTION FROM VIRAL GASTROENTERITIS BY INTESTINAL CTLS
    Paul Offit; Fiscal Year: 1993
    ..Adaptation of murine rotaviruses to growth in tissue culture allows for an accurate determination of the virus dose used for in vitro and in vivo studies...
  2. ENHANCEMENT OF IMMUNOGENICITY BY MICROENCAPSULATION
    Paul Offit; Fiscal Year: 1999
    ..alter the fine antigenic specificities of virus-specific neutralizing antibodies or CTLs? 4) Does oral inoculation of mice with microencapsulated virus or viral proteins enhance the capacity of immunization to protect against challenge? ..
  3. ENHANCING MUCOSAL IMMUNE RESPONSES BY MICROENCAPSULATION
    Paul Offit; Fiscal Year: 2005
    ..The availability of microencapsulated virus provides a unique opportunity to understand the relationship between APC and protective mucosal immune responses. ..