Travis J O'Brien

Summary

Affiliation: The George Washington University
Country: USA

Publications

  1. pmc DNA polymerase zeta is essential for hexavalent chromium-induced mutagenesis
    Travis J O'Brien
    Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA
    Mutat Res 663:77-83. 2009
  2. doi request reprint Development of an undergraduate pharmacogenomics curriculum
    Travis J O'Brien
    The George Washington University Medical Center, Ross Hall Room 660A, 2300 Eye Street, NW, Washington, DC 20037, USA
    Pharmacogenomics 10:1979-86. 2009
  3. ncbi request reprint Effects of hexavalent chromium on the survival and cell cycle distribution of DNA repair-deficient S. cerevisiae
    Travis J O'Brien
    Molecular and Cellular Oncology Program, Department of Pharmacology, The George Washington University Medical Center, Washington, DC 20037, USA
    DNA Repair (Amst) 1:617-27. 2002
  4. ncbi request reprint Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells
    Travis J O'Brien
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC 20037, USA
    Mol Cell Biochem 279:85-95. 2005
  5. ncbi request reprint Incision of trivalent chromium [Cr(III)]-induced DNA damage by Bacillus caldotenax UvrABC endonuclease
    Travis J O'Brien
    Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, United States
    Mutat Res 610:85-92. 2006
  6. pmc Excision repair is required for genotoxin-induced mutagenesis in mammalian cells
    Bradford Brooks
    Department of Pharmacology and Physiology, The George Washington University Medical Center, 2300 Eye Street Northwest, Washington, DC 20037, USA
    Carcinogenesis 29:1064-9. 2008
  7. pmc Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass
    Gina Chun
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC 20037, USA
    Carcinogenesis 31:785-93. 2010
  8. pmc Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis
    Dongsoon Bae
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC, USA
    Mutat Res 660:40-6. 2009
  9. doi request reprint First report of warfarin dose requirements in patients possessing the CYP2C9*12 allele
    Travis J O'Brien
    The George Washington University, Department of Pharmacology and Physiology, Washington, DC, United States
    Clin Chim Acta 424:73-5. 2013
  10. doi request reprint Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water
    Travis J O'Brien
    George Washington University, Department of Pharmacology and Physiology, Washington, DC 20037, United States
    Mutat Res 754:15-21. 2013

Collaborators

  • Barbara L Parsons
  • Chad M Thompson
  • Deborah M Proctor
  • Gina Chun
  • Dongsoon Bae
  • Steven R Patierno
  • Susan Ceryak
  • Tracey J Nickola
  • Bradford Brooks
  • James S Green
  • Arthur F Harralson
  • Kristen Nickens
  • Madhu Lal
  • Kristen Wright
  • Tura C Camilli
  • John Pierce Wise
  • Edward DeFabo
  • Sandra S Wise

Detail Information

Publications11

  1. pmc DNA polymerase zeta is essential for hexavalent chromium-induced mutagenesis
    Travis J O'Brien
    Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA
    Mutat Res 663:77-83. 2009
    ..This work provides novel information regarding the molecular mechanisms of Cr(VI)-induced mutagenesis and is the first report demonstrating a role for TLS in the fixation of mutations induced by a carcinogenic metal...
  2. doi request reprint Development of an undergraduate pharmacogenomics curriculum
    Travis J O'Brien
    The George Washington University Medical Center, Ross Hall Room 660A, 2300 Eye Street, NW, Washington, DC 20037, USA
    Pharmacogenomics 10:1979-86. 2009
    ..This course offers the advantage of exposing students to the concepts of pharmacogenomics prior to their enrollment in PhD, PharmD or MD/DO graduate programs...
  3. ncbi request reprint Effects of hexavalent chromium on the survival and cell cycle distribution of DNA repair-deficient S. cerevisiae
    Travis J O'Brien
    Molecular and Cellular Oncology Program, Department of Pharmacology, The George Washington University Medical Center, Washington, DC 20037, USA
    DNA Repair (Amst) 1:617-27. 2002
    ..Furthermore, only the combined inactivation of multiple excision repair genes affects cell growth after Cr(VI) treatment...
  4. ncbi request reprint Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells
    Travis J O'Brien
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC 20037, USA
    Mol Cell Biochem 279:85-95. 2005
    ..Consequently, NER may represent an important mechanism for preventing Cr(VI)-induced mutagenesis and neoplastic transformation...
  5. ncbi request reprint Incision of trivalent chromium [Cr(III)]-induced DNA damage by Bacillus caldotenax UvrABC endonuclease
    Travis J O'Brien
    Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, United States
    Mutat Res 610:85-92. 2006
    ..Taken together, our data suggest that a sub-fraction of Cr(III)-DNA adducts is recognized and processed by the prokaryotic NER machinery and that ICLs are not necessarily the sole lesions generated by Cr(III) that are substrates for NER...
  6. pmc Excision repair is required for genotoxin-induced mutagenesis in mammalian cells
    Bradford Brooks
    Department of Pharmacology and Physiology, The George Washington University Medical Center, 2300 Eye Street Northwest, Washington, DC 20037, USA
    Carcinogenesis 29:1064-9. 2008
    ..We postulate that, in the absence of ER, DNA damage is channeled into an error-free system of DNA repair or damage tolerance...
  7. pmc Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass
    Gina Chun
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC 20037, USA
    Carcinogenesis 31:785-93. 2010
    ..Our studies highlight a role for Plk1 in the loss of checkpoint control, increased survival and mutagenesis after genotoxic exposure in normal cells, which in turn may lead to genomic instability and carcinogenesis...
  8. pmc Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis
    Dongsoon Bae
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC, USA
    Mutat Res 660:40-6. 2009
    ....
  9. doi request reprint First report of warfarin dose requirements in patients possessing the CYP2C9*12 allele
    Travis J O'Brien
    The George Washington University, Department of Pharmacology and Physiology, Washington, DC, United States
    Clin Chim Acta 424:73-5. 2013
    ..Numerous variant alleles of CYP2C9 have been identified. The CYP2C9*12 (rs9332239) allele harbors a P489S substitution in CYP2C9 which has been shown to result in a 40% decline in catalytic activity in vitro...
  10. doi request reprint Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water
    Travis J O'Brien
    George Washington University, Department of Pharmacology and Physiology, Washington, DC 20037, United States
    Mutat Res 754:15-21. 2013
    ....
  11. doi request reprint The current and future state of pharmacogenomics medical education in the USA
    Tracey J Nickola
    Department of Pharmacology and Physiology, Pharmacogenomics Program, The George Washington University, Ross Hall Room 660A, 2300 Eye Street, NW Washington, DC 20037, USA
    Pharmacogenomics 13:1419-25. 2012
    ..Based on our experience as undergraduate and pharmacy PGx educators, we further reflect on our experience educating future healthcare professionals on PGx...