Travis J O'Brien

Summary

Affiliation: The George Washington University
Country: USA

Publications

  1. ncbi DNA polymerase zeta is essential for hexavalent chromium-induced mutagenesis
    Travis J O'Brien
    Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA
    Mutat Res 663:77-83. 2009
  2. ncbi Development of an undergraduate pharmacogenomics curriculum
    Travis J O'Brien
    The George Washington University Medical Center, Ross Hall Room 660A, 2300 Eye Street, NW, Washington, DC 20037, USA
    Pharmacogenomics 10:1979-86. 2009
  3. ncbi Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells
    Travis J O'Brien
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC 20037, USA
    Mol Cell Biochem 279:85-95. 2005
  4. ncbi Incision of trivalent chromium [Cr(III)]-induced DNA damage by Bacillus caldotenax UvrABC endonuclease
    Travis J O'Brien
    Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, United States
    Mutat Res 610:85-92. 2006
  5. ncbi Excision repair is required for genotoxin-induced mutagenesis in mammalian cells
    Bradford Brooks
    Department of Pharmacology and Physiology, The George Washington University Medical Center, 2300 Eye Street Northwest, Washington, DC 20037, USA
    Carcinogenesis 29:1064-9. 2008
  6. ncbi Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass
    Gina Chun
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC 20037, USA
    Carcinogenesis 31:785-93. 2010
  7. ncbi Effects of hexavalent chromium on the survival and cell cycle distribution of DNA repair-deficient S. cerevisiae
    Travis J O'Brien
    Molecular and Cellular Oncology Program, Department of Pharmacology, The George Washington University Medical Center, Washington, DC 20037, USA
    DNA Repair (Amst) 1:617-27. 2002
  8. ncbi Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis
    Dongsoon Bae
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC, USA
    Mutat Res 660:40-6. 2009

Collaborators

  • Gina Chun
  • Dongsoon Bae
  • Steven R Patierno
  • Susan Ceryak
  • Bradford Brooks
  • Kristen Nickens
  • Madhu Lal
  • Tura C Camilli
  • Kristen Wright
  • Edward DeFabo
  • John Pierce Wise
  • Sandra S Wise

Detail Information

Publications8

  1. ncbi DNA polymerase zeta is essential for hexavalent chromium-induced mutagenesis
    Travis J O'Brien
    Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA
    Mutat Res 663:77-83. 2009
    ..This work provides novel information regarding the molecular mechanisms of Cr(VI)-induced mutagenesis and is the first report demonstrating a role for TLS in the fixation of mutations induced by a carcinogenic metal...
  2. ncbi Development of an undergraduate pharmacogenomics curriculum
    Travis J O'Brien
    The George Washington University Medical Center, Ross Hall Room 660A, 2300 Eye Street, NW, Washington, DC 20037, USA
    Pharmacogenomics 10:1979-86. 2009
    ..This course offers the advantage of exposing students to the concepts of pharmacogenomics prior to their enrollment in PhD, PharmD or MD/DO graduate programs...
  3. ncbi Nucleotide excision repair functions in the removal of chromium-induced DNA damage in mammalian cells
    Travis J O'Brien
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC 20037, USA
    Mol Cell Biochem 279:85-95. 2005
    ..Consequently, NER may represent an important mechanism for preventing Cr(VI)-induced mutagenesis and neoplastic transformation...
  4. ncbi Incision of trivalent chromium [Cr(III)]-induced DNA damage by Bacillus caldotenax UvrABC endonuclease
    Travis J O'Brien
    Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, United States
    Mutat Res 610:85-92. 2006
    ..Taken together, our data suggest that a sub-fraction of Cr(III)-DNA adducts is recognized and processed by the prokaryotic NER machinery and that ICLs are not necessarily the sole lesions generated by Cr(III) that are substrates for NER...
  5. ncbi Excision repair is required for genotoxin-induced mutagenesis in mammalian cells
    Bradford Brooks
    Department of Pharmacology and Physiology, The George Washington University Medical Center, 2300 Eye Street Northwest, Washington, DC 20037, USA
    Carcinogenesis 29:1064-9. 2008
    ..We postulate that, in the absence of ER, DNA damage is channeled into an error-free system of DNA repair or damage tolerance...
  6. ncbi Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass
    Gina Chun
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC 20037, USA
    Carcinogenesis 31:785-93. 2010
    ..Our studies highlight a role for Plk1 in the loss of checkpoint control, increased survival and mutagenesis after genotoxic exposure in normal cells, which in turn may lead to genomic instability and carcinogenesis...
  7. ncbi Effects of hexavalent chromium on the survival and cell cycle distribution of DNA repair-deficient S. cerevisiae
    Travis J O'Brien
    Molecular and Cellular Oncology Program, Department of Pharmacology, The George Washington University Medical Center, Washington, DC 20037, USA
    DNA Repair (Amst) 1:617-27. 2002
    ..Furthermore, only the combined inactivation of multiple excision repair genes affects cell growth after Cr(VI) treatment...
  8. ncbi Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis
    Dongsoon Bae
    Department of Pharmacology and Physiology, The George Washington University Medical Center, Washington, DC, USA
    Mutat Res 660:40-6. 2009
    ....