Research Topics
| JAMES M O'BRIENSummaryAffiliation: The Ohio State University Country: USA Publications
Research Grants
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Detail Information
Publications
SepsisJAMES M O'BRIEN
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, The Ohio State University Medical Center, Columbus 43210, USA
Am J Med 120:1012-22. 2007..Better description of the molecular basis of the disease process also will allow for more targeted therapies...
The association between body mass index, processes of care, and outcomes from mechanical ventilation: a prospective cohort studyJAMES M O'BRIEN
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Critical Care, The Ohio State University Medical Center, College of Public Health, The Ohio State University, Columbus, OH, USA
Crit Care Med 40:1456-63. 2012..To determine the association between excess weight and processes of care and outcomes for critically ill adults...- Will performance measurement lead to better patient outcomes? What are the roles of the National Quality Forum and Medical Specialty Societies?JAMES M O'BRIEN
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Critical Care, Ohio State University Medical Center, Columbus, OH 43210, USA
Chest 141:300-7. 2012.... 
Delta inflation: a bias in the design of randomized controlled trials in critical care medicineScott K Aberegg
Department of Critical Care, Jordan Valley Medical Center, 3580 West 9000 South, West Jordan, Utah 84088, USA
Crit Care 14:R77. 2010..The reasons for this are unknown...- Results from the National Sepsis Practice Survey: use of drotrecogin α (activated) and other therapeutic decisionsJAMES M O'BRIEN
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Critical Care, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH 43210, USA
J Crit Care 25:658.e7-15. 2010..We sought to evaluate factors associated with choices about provided care for patients with septic shock, including the use of drotrecogin α (activated) (DAA)... - Results from the national sepsis practice survey: predictions about mortality and morbidity and recommendations for limitation of care ordersJAMES M O'BRIEN
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH 43210, USA
Crit Care 13:R96. 2009..Little is known about patient and clinician factors which influence these predictions. The association between these predictions and recommendations for continued aggressive care is also understudied... - Insurance type and sepsis-associated hospitalizations and sepsis-associated mortality among US adults: a retrospective cohort studyJAMES M O'BRIEN
Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Critical Care, The Ohio State University Medical Center, Columbus, OH 43221, USA
Crit Care 15:R130. 2011..We hypothesized that patients with Medicare and/or Medicaid or without health insurance have a higher risk of sepsis-associated hospitalization or sepsis-associated death than those with private health insurance... - Year in review 2007: Critical Care--multiple organ failure and sepsisJAMES M O'BRIEN
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Critical Care, The Ohio State University Medical Center, 201 Davis HLRI, 473 West 12th Avenue, Columbus, OH 43210, USA
Crit Care 12:228. 2008..The present review summarizes the findings and implications of the papers published on sepsis and multiorgan failure and places the research in the context of other work in the field... - Acquired weakness, handgrip strength, and mortality in critically ill patientsNaeem A Ali
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Ohio State University, 473 W 12th Avenue, Columbus, OH 43221, USA
Am J Respir Crit Care Med 178:261-8. 2008..However, it is unclear whether ICUAP is independently associated with mortality, as sicker patients are more prone and existing studies have not adjusted for this... - Glucose variability and mortality in patients with sepsisNaeem A Ali
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine and Center for Critical Care, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, Ohio, USA
Crit Care Med 36:2316-21. 2008..Our objective was to determine the association between glucose variability and hospital mortality in septic patients and the expression of glucose variability that best reflects this risk... - Continuity of care in intensive care units: a cluster-randomized trial of intensivist staffingNaeem A Ali
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Indiana University, Indianapolis, Indiana, USA
Am J Respir Crit Care Med 184:803-8. 2011..Little is known about the consequences of intensivists’ work schedules, or intensivist continuity of care... - Hyperglycemia in patients with acute myeloid leukemia is associated with increased hospital mortalityNaeem A Ali
Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Ohio State University, Columbus, Ohio 43210, USA
Cancer 110:96-102. 2007..The authors hypothesized that hyperglycemia may be associated with adverse outcomes in patients with acute myeloid leukemia (AML) and sought to determine whether this association exists in this population... - The normalization heuristic: an untested hypothesis that may misguide medical decisionsScott K Aberegg
The Ohio State University College of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, 201 Davis Heart Lung Research Institute, 473 West 12th Avenue, Columbus, Ohio 43210, USA
Med Hypotheses 72:745-8. 2009..We review historical and contemporaneous examples of normalization practices as empirical evidence for the normalization heuristic and to highlight its frailty as a guide for clinical decision making... - Obesity and acute lung injuryJennifer W McCallister
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Critical Care, The Ohio State University Medical Center, Columbus, OH 43210, USA
Clin Chest Med 30:495-508, viii. 2009..The few studies that have examined the influence of obesity on the outcomes from ALI/ARDS are inconclusive. Furthermore, observed results could be biased by disparities in provided care... - Factors associated with elevated plateau pressure in patients with acute lung injury receiving lower tidal volume ventilationHallie C Prescott
Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, USA
Crit Care Med 41:756-64. 2013.... - The search-inference framework: a proposed strategy for novice clinical problem solvingScott K Aberegg
The Ohio State University College of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Columbus, Ohio, USA
Med Educ 42:389-95. 2008..Before novice problem solvers develop these illness scripts, pattern recognition may not be effective for solving clinical problems...
Research Grants
- The Obese Critical III: Process and Outcome DisparitiesJames O Brien; Fiscal Year: 2007..These studies will describe the effect of excess body weight on critical illness and produce a new type of independent investigator - the ICU health services researcher. ..