B R Oakley

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Gamma-tubulin at ten: progress and prospects
    B R Oakley
    Department of Molecular Genetics, The Ohio State University, 484 W 12th Ave, Columbus, OH 43210, USA
    Cell Struct Funct 24:365-72. 1999
  2. ncbi request reprint An abundance of tubulins
    B R Oakley
    Dept of Molecular Genetics, The Ohio State University, 484 W 12th Ave, Columbus, OH 43210, USA
    Trends Cell Biol 10:537-42. 2000
  3. ncbi request reprint Tubulins in Aspergillus nidulans
    Berl R Oakley
    Department of Molecular Genetics, Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA
    Fungal Genet Biol 41:420-7. 2004
  4. ncbi request reprint Mitosis in wild-type and beta-tubulin mutant strains of Aspergillus nidulans
    M K Jung
    Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, Ohio, 43210, USA
    Fungal Genet Biol 24:146-60. 1998
  5. pmc Gamma-tubulin and the C-terminal motor domain kinesin-like protein, KLPA, function in the establishment of spindle bipolarity in Aspergillus nidulans
    N L Prigozhina
    Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 12:3161-74. 2001
  6. pmc Alanine-scanning mutagenesis of Aspergillus gamma-tubulin yields diverse and novel phenotypes
    M K Jung
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Biol Cell 12:2119-36. 2001
  7. ncbi request reprint Gamma-tubulin is a component of the spindle pole body that is essential for microtubule function in Aspergillus nidulans
    B R Oakley
    Department of Molecular Genetics, Ohio State University, Colombus 43210
    Cell 61:1289-301. 1990
  8. ncbi request reprint The gamma-tubulin gene family in humans
    D O Wise
    Department of Molecular Genetics, The Ohio State University, 484 W 12th Avenue, Columbus, Ohio 43210, USA
    Genomics 67:164-70. 2000
  9. pmc gamma-tubulin plays an essential role in the coordination of mitotic events
    Natalie L Prigozhina
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Biol Cell 15:1374-86. 2004
  10. pmc TINA interacts with the NIMA kinase in Aspergillus nidulans and negatively regulates astral microtubules during metaphase arrest
    Aysha H Osmani
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Biol Cell 14:3169-79. 2003

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Gamma-tubulin at ten: progress and prospects
    B R Oakley
    Department of Molecular Genetics, The Ohio State University, 484 W 12th Ave, Columbus, OH 43210, USA
    Cell Struct Funct 24:365-72. 1999
    ..Finally, there is evidence that gamma-tubulin has important functions in addition to microtubule nucleation, and these functions are just beginning to be investigated...
  2. ncbi request reprint An abundance of tubulins
    B R Oakley
    Dept of Molecular Genetics, The Ohio State University, 484 W 12th Ave, Columbus, OH 43210, USA
    Trends Cell Biol 10:537-42. 2000
    ..delta-Tubulin has an important role in flagellar assembly in Chlamydomonas, but its role in other organisms is just beginning to be investigated, as are the functions of the recently discovered epsilon- and zeta-tubulins...
  3. ncbi request reprint Tubulins in Aspergillus nidulans
    Berl R Oakley
    Department of Molecular Genetics, Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA
    Fungal Genet Biol 41:420-7. 2004
    ..gamma-Tubulin localizes to the spindle pole body and is essential for mitotic spindle formation. The phenotypes of mipA mutants suggest, moreover, that gamma-tubulin has essential functions in addition to microtubule nucleation...
  4. ncbi request reprint Mitosis in wild-type and beta-tubulin mutant strains of Aspergillus nidulans
    M K Jung
    Department of Molecular Genetics, The Ohio State University, 484 West 12th Avenue, Columbus, Ohio, 43210, USA
    Fungal Genet Biol 24:146-60. 1998
    ..We also often observe abnormal spindle morphologies in strains carrying benA33. Another allele, benA31, causes arrest in mitosis with short mitotic spindles and, thus, appears to inhibit spindle elongation...
  5. pmc Gamma-tubulin and the C-terminal motor domain kinesin-like protein, KLPA, function in the establishment of spindle bipolarity in Aspergillus nidulans
    N L Prigozhina
    Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 12:3161-74. 2001
    ..These results indicate, surprisingly, that gamma-tubulin and the klpA kinesin have overlapping roles in the establishment of spindle bipolarity. We propose a model to account for these data...
  6. pmc Alanine-scanning mutagenesis of Aspergillus gamma-tubulin yields diverse and novel phenotypes
    M K Jung
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Biol Cell 12:2119-36. 2001
    ..We have also placed our mutations on a model of the structure of gamma-tubulin and these data give a good initial indication of the functionally important regions of the molecule...
  7. ncbi request reprint Gamma-tubulin is a component of the spindle pole body that is essential for microtubule function in Aspergillus nidulans
    B R Oakley
    Department of Molecular Genetics, Ohio State University, Colombus 43210
    Cell 61:1289-301. 1990
    ..We propose that gamma-tubulin attaches microtubules to the spindle pole body, nucleates microtubule assembly, and establishes microtubule polarity in vivo...
  8. ncbi request reprint The gamma-tubulin gene family in humans
    D O Wise
    Department of Molecular Genetics, The Ohio State University, 484 W 12th Avenue, Columbus, Ohio 43210, USA
    Genomics 67:164-70. 2000
    ..In addition, any pharmacological agents that target one human gamma-tubulin are likely to target both...
  9. pmc gamma-tubulin plays an essential role in the coordination of mitotic events
    Natalie L Prigozhina
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Biol Cell 15:1374-86. 2004
    ..These data reveal that gamma-tubulin has an essential role in the coordination of late mitotic events, and a microtubule-independent function in mitotic checkpoint control...
  10. pmc TINA interacts with the NIMA kinase in Aspergillus nidulans and negatively regulates astral microtubules during metaphase arrest
    Aysha H Osmani
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Biol Cell 14:3169-79. 2003
    ....
  11. pmc In vivo analysis of the functions of gamma-tubulin-complex proteins
    Yi Xiong
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Sci 122:4218-27. 2009
    ..All GCPs localize normally in a GCPE deletion. We propose a model for the structure of the gamma-tubulin complex and its attachment to polar microtubule organizing centers...
  12. pmc The role of microtubules in rapid hyphal tip growth of Aspergillus nidulans
    Tetsuya Horio
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 16:918-26. 2005
    ..These data also reveal that A. nidulans exhibits a remarkable spatial regulation of microtubule disassembly within hyphal tip cells...
  13. pmc Identification and characterization of the asperthecin gene cluster of Aspergillus nidulans
    Edyta Szewczyk
    Department of Molecular Genetics, Ohio State University, 484 West 12th Avenue, Columbus, Ohio 43210, USA
    Appl Environ Microbiol 74:7607-12. 2008
    ..The identification of these genes allows us to propose a biosynthetic pathway for asperthecin...
  14. pmc Gamma-tubulin regulates the anaphase-promoting complex/cyclosome during interphase
    Tania Nayak
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 190:317-30. 2010
    ..Thus, gamma-tubulin functions to regulate this key mitotic and cell cycle regulatory complex...
  15. ncbi request reprint Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome
    Y Zheng
    Department of Molecular Genetics, Ohio State University, Columbus 43210 1292
    Cell 65:817-23. 1991
    ....
  16. pmc Spindle formation in Aspergillus is coupled to tubulin movement into the nucleus
    Yulia Ovechkina
    Department of Molecular Genetics, The Ohio State University, Columbus 43210, USA
    Mol Biol Cell 14:2192-200. 2003
    ..nidulans. They suggest that regulation of protein movement into the nucleoplasm may be important for regulating mitotic onset in organisms with intranuclear mitosis...
  17. pmc The tip growth apparatus of Aspergillus nidulans
    Naimeh Taheri-Talesh
    Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 19:1439-49. 2008
    ..Microtubules are important for delivering vesicles to the tip area and for holding the tip growth apparatus in position...
  18. ncbi request reprint Identification and analysis of essential Aspergillus nidulans genes using the heterokaryon rescue technique
    Aysha H Osmani
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210, USA
    Nat Protoc 1:2517-26. 2006
    ..Diagnostic PCR can be used to confirm deletions at the molecular level. This technique is suitable for large-scale gene-deletion programs and can be completed within 3 weeks...
  19. ncbi request reprint Fusion PCR and gene targeting in Aspergillus nidulans
    Edyta Szewczyk
    Department of Molecular Genetics, Ohio State University, 484 West 12th Avenue, Columbus, Ohio 43210, USA
    Nat Protoc 1:3111-20. 2006
    ..nidulans with fusion PCR products results in high frequencies of accurate gene targeting. Fusion PCR takes less than 2 d. Protoplast formation and transformation takes less than 1 d...
  20. pmc Cytoplasmic dynein's mitotic spindle pole localization requires a functional anaphase-promoting complex, gamma-tubulin, and NUDF/LIS1 in Aspergillus nidulans
    Shihe Li
    Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Mol Biol Cell 16:3591-605. 2005
    ....
  21. ncbi request reprint Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
    James E Galagan
    The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, Massachusetts 02142, USA
    Nature 438:1105-15. 2005
    ..These results enhance our understanding of these widely studied fungi as well as provide new insight into eukaryotic genome evolution and gene regulation...
  22. doi request reprint Sumoylation in Aspergillus nidulans: sumO inactivation, overexpression and live-cell imaging
    Koon Ho Wong
    Department of Genetics, The University of Melbourne, Grattan Street, Parkville, VIC 3010, Australia
    Fungal Genet Biol 45:728-37. 2008
    ..Localization of GFP-SumO is dynamic, accumulating in punctate spots within the nucleus during interphase, lost at the onset of mitosis and re-accumulating during telophase...
  23. pmc Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway
    Yi Ming Chiang
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Chem Biol 15:527-32. 2008
    ..From the sequences of the genes, we are able to deduce a biosynthetic pathway for the emericellamides. The identification of this biosynthetic pathway opens the door to engineering novel analogs of this structurally complex metabolite...
  24. pmc Expression of Arabidopsis gamma-tubulin in fission yeast reveals conserved and novel functions of gamma-tubulin
    Tetsuya Horio
    Department of Nutrition, The University of Tokushima School of Medicine, Kuramoto, Tokushima, 770 8503, Japan
    Plant Physiol 133:1926-34. 2003
    ....
  25. pmc Microtubule organization requires cell cycle-dependent nucleation at dispersed cytoplasmic sites: polar and perinuclear microtubule organizing centers in the plant pathogen Ustilago maydis
    Anne Straube
    Max Planck Institut fur terrestrische Mikrobiologie, Karl von Frisch Strabetae, D 35043 Marburg, Germany
    Mol Biol Cell 14:642-57. 2003
    ..Taken together, our data suggest that MT reorganization in U. maydis depends on cell cycle-specific nucleation at dispersed cytoplasmic sites, at a polar MTOC and the SPB...
  26. pmc Dual-Color imaging of nuclear division and mitotic spindle elongation in live cells of Aspergillus nidulans
    Wenqi Su
    Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Eukaryot Cell 3:553-6. 2004
    ..This system allows new details of mitosis and nuclear movement to be revealed...