Affiliation: The University of Texas
Country: USA


  1. Haymaker C, Hailemichael Y, Yang Y, Nurieva R. In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model. J Vis Exp. 2017;: pubmed publisher
    ..Overall, this protocol allows a quick assessment of killing function in vivo and can be adapted to any given antigen. ..
  2. Sahoo A, Wali S, Nurieva R. T helper 2 and T follicular helper cells: Regulation and function of interleukin-4. Cytokine Growth Factor Rev. 2016;30:29-37 pubmed publisher
    ..Understanding of the molecular mechanisms for IL-4 expression and function in both cell subsets will be beneficial for the development of future therapeutic interventions. ..
  3. Nurieva R, Chung Y. Understanding the development and function of T follicular helper cells. Cell Mol Immunol. 2010;7:190-7 pubmed publisher
    ..In this review, we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation, the relationship of Tfh cells to other CD4(+) T-cell lineages, and the role of Tfh cells in health and disease. ..
  4. request reprint
    Nurieva R, Yang X, Martinez G, Zhang Y, Panopoulos A, Ma L, et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature. 2007;448:480-3 pubmed
    ..IL-21 is therefore an autocrine cytokine that is sufficient and necessary for T(H)17 differentiation, and serves as a target for treating inflammatory diseases. ..
  5. Nurieva R, Chung Y, Hwang D, Yang X, Kang H, Ma L, et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity. 2008;29:138-49 pubmed publisher
    ..This study thus demonstrates that Tfh is a distinct Th cell lineage. ..
  6. Nurieva R, Chung Y, Martinez G, Yang X, Tanaka S, Matskevitch T, et al. Bcl6 mediates the development of T follicular helper cells. Science. 2009;325:1001-5 pubmed publisher
    ..Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation...
  7. Nurieva R, Zheng S, Jin W, Chung Y, Zhang Y, Martinez G, et al. The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity. 2010;32:670-80 pubmed publisher
    ..Our results indicate that GRAIL, by mediating TCR-CD3 degradation, regulates naive T cell tolerance induction and Treg cell function. ..
  8. Wali S, Sahoo A, Puri S, Alekseev A, Nurieva R. Insights into the development and regulation of T follicular helper cells. Cytokine. 2016;87:9-19 pubmed publisher
    ..In this review, we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation and their role in health and disease. ..
  9. Haymaker C, Yang Y, Wang J, Zou Q, Sahoo A, Alekseev A, et al. Absence of Grail promotes CD8+ T cell anti-tumour activity. Nat Commun. 2017;8:239 pubmed publisher
    ..Here the authors show Grail also limits IL-21 receptor expression and function in CD8+ T cells, is overactive in these cells in patients with lymphoma, and promotes tumour development in a lymphoma transplant mouse model. ..