ROZA INSAFETDINOVNA NURIEVA

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. doi request reprint T-cell tolerance in cancer
    Roza Nurieva
    Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77030, USA
    Immunotherapy 5:513-31. 2013
  2. pmc Bcl6 mediates the development of T follicular helper cells
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 325:1001-5. 2009
  3. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
  4. doi request reprint Understanding the development and function of T follicular helper cells
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Mol Immunol 7:190-7. 2010
  5. ncbi request reprint Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    Roza Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 448:480-3. 2007
  6. ncbi request reprint Regulation of immune and autoimmune responses by ICOS-B7h interaction
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center, 7455 Fannin, Unit 906, Houston, TX 77030, USA
    Clin Immunol 115:19-25. 2005
  7. pmc The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 32:670-80. 2010
  8. pmc B7h is required for T cell activation, differentiation, and effector function
    Roza I Nurieva
    Department of Immunology, University of Washington, Seattle, WA 98195 7650, USA
    Proc Natl Acad Sci U S A 100:14163-8. 2003
  9. doi request reprint Keeping autoimmunity in check: how to control a Th17 cell controller
    Roza I Nurieva
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 29:841-3. 2008
  10. ncbi request reprint Regulation of immune and autoimmune responses by ICOS
    Chen Dong
    Department of Immunology, University of Washington, 1959 NE Pacific Street, H466 HSC, Seattle, WA 98195 7650, USA
    J Autoimmun 21:255-60. 2003

Research Grants

  1. Regulation of T cell activation and tolerance by Grail
    ROZA INSAFETDINOVNA NURIEVA; Fiscal Year: 2010

Detail Information

Publications19

  1. doi request reprint T-cell tolerance in cancer
    Roza Nurieva
    Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77030, USA
    Immunotherapy 5:513-31. 2013
    ..Ultimately, understanding and manipulating T-cell tolerance will help to break the tolerance state in cancer...
  2. pmc Bcl6 mediates the development of T follicular helper cells
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Science 325:1001-5. 2009
    ..Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation...
  3. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
    ..This study thus demonstrates that Tfh is a distinct Th cell lineage...
  4. doi request reprint Understanding the development and function of T follicular helper cells
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Mol Immunol 7:190-7. 2010
    ..In this review, we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation, the relationship of Tfh cells to other CD4(+) T-cell lineages, and the role of Tfh cells in health and disease...
  5. ncbi request reprint Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    Roza Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 448:480-3. 2007
    ..IL-21 is therefore an autocrine cytokine that is sufficient and necessary for T(H)17 differentiation, and serves as a target for treating inflammatory diseases...
  6. ncbi request reprint Regulation of immune and autoimmune responses by ICOS-B7h interaction
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center, 7455 Fannin, Unit 906, Houston, TX 77030, USA
    Clin Immunol 115:19-25. 2005
    ..In this review, we summarize the latest data about inducible costimulator and its receptor and their roles in regulation of immune and autoimmune responses...
  7. pmc The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 32:670-80. 2010
    ..Our results indicate that GRAIL, by mediating TCR-CD3 degradation, regulates naive T cell tolerance induction and Treg cell function...
  8. pmc B7h is required for T cell activation, differentiation, and effector function
    Roza I Nurieva
    Department of Immunology, University of Washington, Seattle, WA 98195 7650, USA
    Proc Natl Acad Sci U S A 100:14163-8. 2003
    ..Therefore, B7h is required for proper Th cell activation, differentiation, and effector cytokine expression...
  9. doi request reprint Keeping autoimmunity in check: how to control a Th17 cell controller
    Roza I Nurieva
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 29:841-3. 2008
    ..In this issue of Immunity, Chen et al. (2008) show that IRF-4-binding protein is a critical negative regulator of IRF-4 function, regulating production of the cytokines IL-21 and IL-17...
  10. ncbi request reprint Regulation of immune and autoimmune responses by ICOS
    Chen Dong
    Department of Immunology, University of Washington, 1959 NE Pacific Street, H466 HSC, Seattle, WA 98195 7650, USA
    J Autoimmun 21:255-60. 2003
    ..Our work not only illustrates the complexity of immune regulation by costimulatory molecules, but also suggests novel therapeutic strategies for various autoimmune diseases...
  11. pmc Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease
    Joseph M Reynolds
    Department of Immunology and Center for Inflammation and Cancer, M D Anderson Cancer Center, Houston, TX 77054, USA
    Immunity 32:692-702. 2010
    ..This study thus reveals a critical role of a TLR in the direct regulation of adaptive immune response and pathogenesis of autoimmune diseases...
  12. pmc Yin-Yang of costimulation: crucial controls of immune tolerance and function
    Roza I Nurieva
    Department of Immunology, MD Anderson Cancer Center, Houston, TX, USA
    Immunol Rev 229:88-100. 2009
    ..Therefore, positive and negative costimulation are the two sides of the coin to fine tune T-cell receptor signaling to determine the outcome of T-cell receptor engagement-tolerance versus function...
  13. doi request reprint Regulation and function of proinflammatory TH17 cells
    Gustavo J Martinez
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Ann N Y Acad Sci 1143:188-211. 2008
    ..In this review, we summarize the latest discoveries on the cytokine-mediated regulation and transcriptional programming of TH17 cells and their roles in different immune responses and diseases...
  14. ncbi request reprint A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes
    Roza I Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 179:1096-103. 2007
    ..This work demonstrates an important role for costimulatory receptors in sustaining T cell activation programs leading to Nfatc1 gene transcription and has implications in our understanding of the immune response and tolerance...
  15. ncbi request reprint Transcriptional regulation of th2 differentiation by inducible costimulator
    Roza I Nurieva
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 18:801-11. 2003
    ..These data indicate that ICOS, by enhancing TcR signals at an early stage of T cell activation, regulates IL-4 transcription and T cell function in effector cells...
  16. pmc Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction
    Xikui Liu
    Department of Immunology, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 182:4516-20. 2009
    ..v. Finally, BTLA(-/-) OT-I cells caused autoimmune diabetes in RIP-mOVA recipient mice. Our results thus demonstrate an important role for BTLA in the induction of peripheral tolerance of both CD4(+) and CD8(+) T cells in vivo...
  17. pmc Inducible costimulator is essential for collagen-induced arthritis
    Roza I Nurieva
    Department of Immunology, and Department of Comparative Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    J Clin Invest 111:701-6. 2003
    ..These data indicate that ICOS is essential for collagen-induced arthritis and may suggest novel means for treating patients with rheumatoid arthritis...
  18. pmc MKP-1 is necessary for T cell activation and function
    Yongliang Zhang
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:30815-24. 2009
    ..Our results thus demonstrate that MKP-1 is a critical positive regulator of T cell activation and function and may be targeted in treatment of autoimmune diseases...
  19. ncbi request reprint Immune regulation by novel costimulatory molecules
    Chen Dong
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 7650, USA
    Immunol Res 28:39-48. 2003
    ..B7-H3 recognizes a putative costimulatory receptor on activated T-cells. Here we summarize the latest developments in the novel costimulatory molecules and their roles in regulating Th activation, differentiation, and function...

Research Grants2

  1. Regulation of T cell activation and tolerance by Grail
    ROZA INSAFETDINOVNA NURIEVA; Fiscal Year: 2010
    ..These proposed studies will greatly advance our knowledge on Grail function in T cells and will provide a novel and unique insight into proper T cell regulation that governs self tolerance and immune function. ..