Kazuko Nishikura

Summary

Affiliation: The Wistar Institute
Country: USA

Publications

  1. pmc Functions and regulation of RNA editing by ADAR deaminases
    Kazuko Nishikura
    Department of Gene Expression and Regulation, The Wistar Institute, Philadelphia, Pennsylvania 19104 4268, USA
    Annu Rev Biochem 79:321-49. 2010
  2. pmc Editor meets silencer: crosstalk between RNA editing and RNA interference
    Kazuko Nishikura
    The Wistar Institute, Department of Gene Expression and Regulation, 3601 Spruce Street, Philadelphia, Pennsylvania 19104 4268, USA
    Nat Rev Mol Cell Biol 7:919-31. 2006
  3. pmc ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing
    Hiromitsu Ota
    The Wistar Institute, Philadelphia, PA 19104, USA
    Cell 153:575-89. 2013
  4. pmc ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells
    Weidong Yang
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 280:3946-53. 2005
  5. pmc Modulation of microRNA processing and expression through RNA editing by ADAR deaminases
    Weidong Yang
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nat Struct Mol Biol 13:13-21. 2006
  6. pmc Redirection of silencing targets by adenosine-to-inosine editing of miRNAs
    Yukio Kawahara
    Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Science 315:1137-40. 2007
  7. pmc RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer-TRBP complex
    Yukio Kawahara
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    EMBO Rep 8:763-9. 2007
  8. pmc RNA binding-independent dimerization of adenosine deaminases acting on RNA and dominant negative effects of nonfunctional subunits on dimer functions
    Louis Valente
    Department of Gene Expression and Regulation, Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:16054-61. 2007
  9. pmc Adenosine-to-inosine RNA editing
    Boris Zinshteyn
    The Wistar Institute, Gene Expression and Regulation, Philadelphia, PA 19104, USA
    Wiley Interdiscip Rev Syst Biol Med 1:202-9. 2009
  10. doi request reprint A-to-I editing of protein coding and noncoding RNAs
    Arka Mallela
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Crit Rev Biochem Mol Biol 47:493-501. 2012

Research Grants

  1. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2011
  2. STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASE
    Kazuko Nishikura; Fiscal Year: 2003
  3. Functions of ADARI RNA Editase in Erythropoiesis
    Kazuko Nishikura; Fiscal Year: 2005
  4. STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASE
    Kazuko Nishikura; Fiscal Year: 2007
  5. Characterization of TRBP-containing complexes
    RUSSEL KAUFMAN; Fiscal Year: 2007
  6. STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASE
    Kazuko Nishikura; Fiscal Year: 2009
  7. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2010
  8. STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASE
    Kazuko Nishikura; Fiscal Year: 1999
  9. RNA DUPLEX UNWINDASE
    Kazuko Nishikura; Fiscal Year: 1993

Collaborators

Detail Information

Publications28

  1. pmc Functions and regulation of RNA editing by ADAR deaminases
    Kazuko Nishikura
    Department of Gene Expression and Regulation, The Wistar Institute, Philadelphia, Pennsylvania 19104 4268, USA
    Annu Rev Biochem 79:321-49. 2010
    ..Here, I review the recent findings that indicate new functions for A-->I editing in the regulation of noncoding RNAs and for interactions between RNA editing and RNA interference mechanisms...
  2. pmc Editor meets silencer: crosstalk between RNA editing and RNA interference
    Kazuko Nishikura
    The Wistar Institute, Department of Gene Expression and Regulation, 3601 Spruce Street, Philadelphia, Pennsylvania 19104 4268, USA
    Nat Rev Mol Cell Biol 7:919-31. 2006
    ..A-->I RNA editing therefore seems to have additional functions, including the regulation of retrotransposons and gene silencing, which adds a new urgency to the challenges of fully understanding ADAR functions...
  3. pmc ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing
    Hiromitsu Ota
    The Wistar Institute, Philadelphia, PA 19104, USA
    Cell 153:575-89. 2013
    ..As expected, the expression of miRNAs is globally inhibited in ADAR1(-/-) mouse embryos, which, in turn, alters the expression of their target genes and might contribute to their embryonic lethal phenotype...
  4. pmc ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cells
    Weidong Yang
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 280:3946-53. 2005
    ..These results identify ADAR1 as a cellular factor that limits the efficacy of siRNA in mammalian cells...
  5. pmc Modulation of microRNA processing and expression through RNA editing by ADAR deaminases
    Weidong Yang
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nat Struct Mol Biol 13:13-21. 2006
    ..Consequently, mature miRNA-142 expression levels increased substantially in ADAR1 null or ADAR2 null mice. Our results demonstrate a new function of RNA editing in the control of miRNA biogenesis...
  6. pmc Redirection of silencing targets by adenosine-to-inosine editing of miRNAs
    Yukio Kawahara
    Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Science 315:1137-40. 2007
    ....
  7. pmc RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer-TRBP complex
    Yukio Kawahara
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    EMBO Rep 8:763-9. 2007
    ....
  8. pmc RNA binding-independent dimerization of adenosine deaminases acting on RNA and dominant negative effects of nonfunctional subunits on dimer functions
    Louis Valente
    Department of Gene Expression and Regulation, Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:16054-61. 2007
    ....
  9. pmc Adenosine-to-inosine RNA editing
    Boris Zinshteyn
    The Wistar Institute, Gene Expression and Regulation, Philadelphia, PA 19104, USA
    Wiley Interdiscip Rev Syst Biol Med 1:202-9. 2009
    ..The vast majority of editing sites are in noncoding sequences. This includes microRNAs, as well as the introns and 3' untranslated regions of messenger RNAs, which play important roles in the RNA-mediated regulation of gene expression...
  10. doi request reprint A-to-I editing of protein coding and noncoding RNAs
    Arka Mallela
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Crit Rev Biochem Mol Biol 47:493-501. 2012
    ..Such editing has a wide range of physiological effects, including modification of targets in the brain and in disease states...
  11. ncbi request reprint ADAR gene family and A-to-I RNA editing: diverse roles in posttranscriptional gene regulation
    Louis Valente
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Prog Nucleic Acid Res Mol Biol 79:299-338. 2005
  12. pmc Substitutional A-to-I RNA editing
    Bjorn Erik Wulff
    Gene Expression and Regulation, The Wistar Institute, Philadelphia, PA, USA
    Wiley Interdiscip Rev RNA 1:90-101. 2010
    ..This includes microRNAs, small interfering RNAs, viral RNAs, and messenger RNAs with potential for recoding events and splice site modifications...
  13. doi request reprint Modulation of microRNA expression and function by ADARs
    Bjorn Erik Wulff
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Curr Top Microbiol Immunol 353:91-109. 2012
    ..This article reviews the recent attempts to identify miRNA editing sites and elucidate the effects of ADARs on miRNA expression and function...
  14. pmc Elucidating the inosinome: global approaches to adenosine-to-inosine RNA editing
    Bjorn Erik Wulff
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Genet 12:81-5. 2011
    ..This Progress article reviews some of these recent global studies and their results...
  15. ncbi request reprint Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine therapy
    Weidong Yang
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Brain Res Mol Brain Res 124:70-8. 2004
    ..Our results support the hypothesis that 5-HT(2C)R mRNA editing has causative relevance in the pathophysiology of depression associated with cytokine therapy...
  16. pmc Extensive adenosine-to-inosine editing detected in Alu repeats of antisense RNAs reveals scarcity of sense-antisense duplex formation
    Yukio Kawahara
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    FEBS Lett 580:2301-5. 2006
    ..Our findings imply that sense and antisense RNAs form two separate intramolecular double-stranded RNAs consisting of inversely oriented Alu repeats, but rarely form intermolecular duplexes...
  17. pmc Functional relevance of serotonin 2C receptor mRNA editing in antidepressant- and anxiety-like behaviors
    Cedric Mombereau
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropharmacology 59:468-73. 2010
    ..These data constitute the first in vivo demonstration of a role for 5-HT(2C)R mRNA editing in anxiety- and depression-related behaviors...
  18. pmc A new function for the RNA-editing enzyme ADAR1
    Hisashi Iizasa
    Department of Gene Expression and Regulation, Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 10:16-8. 2009
    ..ADAR1 catalyzes the deamination of adenosine to inosine in double-stranded RNA. This RNA-editing enzyme is now shown to be involved in hematopoiesis, where it acts to suppress interferon signaling and to block premature apoptosis...
  19. pmc Editing of Epstein-Barr virus-encoded BART6 microRNAs controls their dicer targeting and consequently affects viral latency
    Hisashi Iizasa
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 285:33358-70. 2010
    ..Mutation and A-to-I editing appear to be adaptive mechanisms that antagonize miR-BART6 activities...
  20. pmc Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass
    Yukio Kawahara
    The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 28:12834-44. 2008
    ..Our results highlight the importance of regulated 5-HT(2C)R mRNA editing, because dysregulation could result in the pathological consequences such as growth retardation seen in VGV mice...
  21. ncbi request reprint Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene
    Qingde Wang
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 279:4952-61. 2004
    ....
  22. pmc TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
    Thimmaiah P Chendrimada
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nature 436:740-4. 2005
    ..These results support a role of the Dicer-TRBP complex not only in miRNA processing but also as a platform for RISC assembly...
  23. ncbi request reprint Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNA
    Dan Sung C Cho
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:17093-102. 2003
    ..Analysis of dimer complexes consisting of one wild-type and one mutant monomer suggests functional interactions between the two subunits during site-selective RNA editing...
  24. pmc Frequency and fate of microRNA editing in human brain
    Yukio Kawahara
    The Wistar Institute
    Nucleic Acids Res 36:5270-80. 2008
    ..Our studies predict that approximately 16% of human pri-miRNAs are subject to A-->I editing and, thus, miRNA editing could have a large impact on the miRNA-mediated gene silencing...
  25. ncbi request reprint Editing the message from A to I
    Kazuko Nishikura
    Nat Biotechnol 22:962-3. 2004
  26. pmc A-to-I RNA editing and human disease
    Stefan Maas
    Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
    RNA Biol 3:1-9. 2006
    ..Here we review the recent knowledge on where disturbances in A-to-I RNA editing have been correlated with human disease phenotypes...
  27. ncbi request reprint A-to-I RNA editing: recent news and residual mysteries
    Stefan Maas
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 278:1391-4. 2003
  28. pmc Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules
    Zhichao Wang
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:5477-82. 2008
    ..These results in toto provide insights into the mechanism of DAI activation and reveal the complex regulatory mechanisms underlying DNA-mediated protective and pathologic immune responses...

Research Grants26

  1. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2011
    ..Our research focuses also on apoptosis, which is highly relevant to many human diseases including cancer. ..
  2. STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASE
    Kazuko Nishikura; Fiscal Year: 2003
    ..The information gained from the proposed experiments will allow us to better understand this intriguing RNA editing system and its role in the regulation of target gene expression. ..
  3. Functions of ADARI RNA Editase in Erythropoiesis
    Kazuko Nishikura; Fiscal Year: 2005
    ..Our research may reveal critical information leading to new strategies for therapeutic intervention for certain human dyserythropoietic disorders. ..
  4. STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASE
    Kazuko Nishikura; Fiscal Year: 2007
    ..Our research proposal will generate important information on regulation of apoptosis, which is highly relevant to many human diseases including cancer. ..
  5. Characterization of TRBP-containing complexes
    RUSSEL KAUFMAN; Fiscal Year: 2007
    ..Aim 3 extends the work to the analysis of the large TRBP- containing complex, which is associated with the 60S ribosome subunit and the human Armitage protein involved in translational repression. ..
  6. STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASE
    Kazuko Nishikura; Fiscal Year: 2009
    ..Our research proposal will generate important information on regulation of apoptosis, which is highly relevent to many human diseases including cancer. ..
  7. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2010
    ..Our research focuses also on apoptosis, which is highly relevant to many human diseases including cancer. ..
  8. STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASE
    Kazuko Nishikura; Fiscal Year: 1999
    ..The information gained by the proposed experiments should lead to enhanced understanding of the full range of biological functions of this intriguing nuclear enzyme. ..
  9. RNA DUPLEX UNWINDASE
    Kazuko Nishikura; Fiscal Year: 1993
    ..reveal its homology to any other known gene or protein, and thereby direct us to an understanding of its physiological functions...