Research Topics
Genomes and Genes | Kazuko NishikuraSummaryAffiliation: The Wistar Institute Country: USA Publications
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Publications
Editor meets silencer: crosstalk between RNA editing and RNA interferenceKazuko Nishikura
The Wistar Institute, Department of Gene Expression and Regulation, 3601 Spruce Street, Philadelphia, Pennsylvania 19104 4268, USA
Nat Rev Mol Cell Biol 7:919-31. 2006..A-->I RNA editing therefore seems to have additional functions, including the regulation of retrotransposons and gene silencing, which adds a new urgency to the challenges of fully understanding ADAR functions...- Functions and regulation of RNA editing by ADAR deaminasesKazuko Nishikura
Department of Gene Expression and Regulation, The Wistar Institute, Philadelphia, Pennsylvania 19104 4268, USA
Annu Rev Biochem 79:321-49. 2010..Here, I review the recent findings that indicate new functions for A-->I editing in the regulation of noncoding RNAs and for interactions between RNA editing and RNA interference mechanisms... - Modulation of microRNA processing and expression through RNA editing by ADAR deaminasesWeidong Yang
The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Nat Struct Mol Biol 13:13-21. 2006..Consequently, mature miRNA-142 expression levels increased substantially in ADAR1 null or ADAR2 null mice. Our results demonstrate a new function of RNA editing in the control of miRNA biogenesis... - ADAR1 RNA deaminase limits short interfering RNA efficacy in mammalian cellsWeidong Yang
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 280:3946-53. 2005..These results identify ADAR1 as a cellular factor that limits the efficacy of siRNA in mammalian cells... - Redirection of silencing targets by adenosine-to-inosine editing of miRNAsYukio Kawahara
Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Science 315:1137-40. 2007.... - RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer-TRBP complexYukio Kawahara
The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
EMBO Rep 8:763-9. 2007..Our results indicate that A --> I conversion at two specific positions of the pre-miRNA foldback structure can affect its interaction with the Dicer-TRBP complex, showing a new regulatory role of A --> I RNA editing in miRNA biogenesis... - Adenosine-to-inosine RNA editingBoris Zinshteyn
The Wistar Institute, Gene Expression and Regulation, Philadelphia, PA 19104, USA
Wiley Interdiscip Rev Syst Biol Med 1:202-9. 2009..The vast majority of editing sites are in noncoding sequences. This includes microRNAs, as well as the introns and 3' untranslated regions of messenger RNAs, which play important roles in the RNA-mediated regulation of gene expression... - RNA binding-independent dimerization of adenosine deaminases acting on RNA and dominant negative effects of nonfunctional subunits on dimer functionsLouis Valente
Department of Gene Expression and Regulation, Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 282:16054-61. 2007.... 
ADAR gene family and A-to-I RNA editing: diverse roles in posttranscriptional gene regulationLouis Valente
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Prog Nucleic Acid Res Mol Biol 79:299-338. 2005- Substitutional A-to-I RNA editingBjorn Erik Wulff
Gene Expression and Regulation, The Wistar Institute, Philadelphia, PA, USA
Wiley Interdiscip Rev RNA 1:90-101. 2010..This includes microRNAs, small interfering RNAs, viral RNAs, and messenger RNAs with potential for recoding events and splice site modifications... 
Modulation of microRNA expression and function by ADARsBjorn Erik Wulff
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Curr Top Microbiol Immunol 353:91-109. 2012..This article reviews the recent attempts to identify miRNA editing sites and elucidate the effects of ADARs on miRNA expression and function...- A new function for the RNA-editing enzyme ADAR1Hisashi Iizasa
Department of Gene Expression and Regulation, Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Nat Immunol 10:16-8. 2009..ADAR1 catalyzes the deamination of adenosine to inosine in double-stranded RNA. This RNA-editing enzyme is now shown to be involved in hematopoiesis, where it acts to suppress interferon signaling and to block premature apoptosis... - Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine therapyWeidong Yang
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
Brain Res Mol Brain Res 124:70-8. 2004..Our results support the hypothesis that 5-HT(2C)R mRNA editing has causative relevance in the pathophysiology of depression associated with cytokine therapy... - Functional relevance of serotonin 2C receptor mRNA editing in antidepressant- and anxiety-like behaviorsCedric Mombereau
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Neuropharmacology 59:468-73. 2010..These data constitute the first in vivo demonstration of a role for 5-HT(2C)R mRNA editing in anxiety- and depression-related behaviors... - Elucidating the inosinome: global approaches to adenosine-to-inosine RNA editingBjorn Erik Wulff
The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Nat Rev Genet 12:81-5. 2011..This Progress article reviews some of these recent global studies and their results... - Extensive adenosine-to-inosine editing detected in Alu repeats of antisense RNAs reveals scarcity of sense-antisense duplex formationYukio Kawahara
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
FEBS Lett 580:2301-5. 2006..Our findings imply that sense and antisense RNAs form two separate intramolecular double-stranded RNAs consisting of inversely oriented Alu repeats, but rarely form intermolecular duplexes... - Editing of Epstein-Barr virus-encoded BART6 microRNAs controls their dicer targeting and consequently affects viral latencyHisashi Iizasa
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 285:33358-70. 2010..Mutation and A-to-I editing appear to be adaptive mechanisms that antagonize miR-BART6 activities... - Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat massYukio Kawahara
The Wistar Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 28:12834-44. 2008..Our results highlight the importance of regulated 5-HT(2C)R mRNA editing, because dysregulation could result in the pathological consequences such as growth retardation seen in VGV mice... - Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase geneQingde Wang
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 279:4952-61. 2004.... - TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencingThimmaiah P Chendrimada
The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Nature 436:740-4. 2005..These results support a role of the Dicer-TRBP complex not only in miRNA processing but also as a platform for RISC assembly... - Requirement of dimerization for RNA editing activity of adenosine deaminases acting on RNADan Sung C Cho
Wistar Institute, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 278:17093-102. 2003..Analysis of dimer complexes consisting of one wild-type and one mutant monomer suggests functional interactions between the two subunits during site-selective RNA editing... - A-to-I RNA editing and human diseaseStefan Maas
Department of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania 18015, USA
RNA Biol 3:1-9. 2006..Here we review the recent knowledge on where disturbances in A-to-I RNA editing have been correlated with human disease phenotypes... - Frequency and fate of microRNA editing in human brainYukio Kawahara
The Wistar Institute
Nucleic Acids Res 36:5270-80. 2008..Our studies predict that approximately 16% of human pri-miRNAs are subject to A-->I editing and, thus, miRNA editing could have a large impact on the miRNA-mediated gene silencing... - Editing the message from A to IKazuko Nishikura
Nat Biotechnol 22:962-3. 2004 - A-to-I RNA editing: recent news and residual mysteriesStefan Maas
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Biol Chem 278:1391-4. 2003 - Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing moleculesZhichao Wang
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
Proc Natl Acad Sci U S A 105:5477-82. 2008..These results in toto provide insights into the mechanism of DAI activation and reveal the complex regulatory mechanisms underlying DNA-mediated protective and pathologic immune responses...
Research Grants
- STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASEKazuko Nishikura; Fiscal Year: 2003..The information gained from the proposed experiments will allow us to better understand this intriguing RNA editing system and its role in the regulation of target gene expression. ..
- Functions of ADARI RNA Editase in ErythropoiesisKazuko Nishikura; Fiscal Year: 2005..Our research may reveal critical information leading to new strategies for therapeutic intervention for certain human dyserythropoietic disorders. ..
- STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASEKazuko Nishikura; Fiscal Year: 2007..Our research proposal will generate important information on regulation of apoptosis, which is highly relevant to many human diseases including cancer. ..
- Characterization of TRBP-containing complexesRUSSEL KAUFMAN; Fiscal Year: 2007..Aim 3 extends the work to the analysis of the large TRBP- containing complex, which is associated with the 60S ribosome subunit and the human Armitage protein involved in translational repression. ..
- STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASEKazuko Nishikura; Fiscal Year: 2009..Our research proposal will generate important information on regulation of apoptosis, which is highly relevent to many human diseases including cancer. ..
- Interaction between RNA interference and RNA editing pathwaysKazuko Nishikura; Fiscal Year: 2010..Our research focuses also on apoptosis, which is highly relevant to many human diseases including cancer. ..
- STRUCTURE AND FUNCTION OF DSRNA ADENOSINE DEAMINASEKazuko Nishikura; Fiscal Year: 1999..The information gained by the proposed experiments should lead to enhanced understanding of the full range of biological functions of this intriguing nuclear enzyme. ..
- RNA DUPLEX UNWINDASEKazuko Nishikura; Fiscal Year: 1993..reveal its homology to any other known gene or protein, and thereby direct us to an understanding of its physiological functions...
- Interaction between RNA interference and RNA editing pathwaysKazuko Nishikura; Fiscal Year: 2011..Our research focuses also on apoptosis, which is highly relevant to many human diseases including cancer. ..