Garth L Nicolson
Affiliation: The Institute for Molecular Medicine
- High prevalence of Mycoplasma infections among European chronic fatigue syndrome patients. Examination of four Mycoplasma species in blood of chronic fatigue syndrome patientsJo Nijs
Department of Human Physiology, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, KRO Gebouw 1, Laarbeeklaan 101, 1090 Brussel, Belgium
FEMS Immunol Med Microbiol 34:209-14. 2002..2%). Compared to American CFS patients (M. pneumoniae>M. hominis>M. penetrans), a slightly different pattern of mycoplasmal infections was found in European CFS patients (M. hominis>M. pneumoniae, M. fermentansz.Gt;M. penetrans)...
- Lipid replacement therapy: a nutraceutical approach for reducing cancer-associated fatigue and the adverse effects of cancer therapy while restoring mitochondrial functionGarth L Nicolson
The Institute for Molecular Medicine, Huntington Beach, CA 92647, USA
Cancer Metastasis Rev 29:543-52. 2010..Recent clinical trials using cancer and non-cancer patients with chronic fatigue have shown the benefits of lipid replacement therapy in reducing fatigue and restoring mitochondrial electron transport function...
- Multiple co-infections (Mycoplasma, Chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: association with signs and symptomsG L Nicolson
The Institute for Molecular Medicine, Huntington Beach, California 92649, USA
APMIS 111:557-66. 2003..The results indicate that a large subset of CFS patients show evidence of bacterial and/or viral infection(s), and these infections may contribute to the severity of signs and symptoms found in these patients...
- Lipid replacement/antioxidant therapy as an adjunct supplement to reduce the adverse effects of cancer therapy and restore mitochondrial functionGarth L Nicolson
The Institute for Molecular Medicine, Huntington Beach, California, CA 92647, USA
Pathol Oncol Res 11:139-44. 2005..Dietary use of unoxidized membrane lipids plus antioxidants is recommended for patients undergoing cancer therapy to improve quality of life but should not be taken at the same time of day as the therapy...
- Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulationGarth L Nicolson
The Institute for Molecular Medicine, Huntington Beach, California 92649, USA
Clin Exp Metastasis 20:19-24. 2003..The results suggest that the MTA1 protein may serve multiple functions in cellular signaling, chromosome remodeling and transcription processes that are important in the progression, invasion and growth of metastatic epithelial cells...
- Metabolic syndrome and mitochondrial function: molecular replacement and antioxidant supplements to prevent membrane peroxidation and restore mitochondrial functionGarth L Nicolson
Department of Molecular Pathology, The Institute for Molecular Medicine, Huntington Beach, California 92647, USA
J Cell Biochem 100:1352-69. 2007..Thus LRT plus antioxidant supplements should be considered for metabolic syndrome patients who suffer to various degrees from fatigue...
- Evidence for Mycoplasma ssp., Chlamydia pneunomiae, and human herpes virus-6 coinfections in the blood of patients with autistic spectrum disordersGarth L Nicolson
The Institute for Molecular Medicine, Huntington Beach, California 92647, USA
J Neurosci Res 85:1143-8. 2007..The results indicate that a large subset of ASD patients shows evidence of bacterial and/or viral infections (odds ratio = 16.5, P < 0.001). The significance of these infections in ASD is discussed in terms of appropriate treatment...
- High frequency of systemic mycoplasmal infections in Gulf War veterans and civilians with Amyotrophic Lateral Sclerosis (ALS)Garth L Nicolson
Molecular Biology Laboratory, Department of General Surgery, University Hospital Muenster, Muenster, Germany
J Clin Neurosci 9:525-9. 2002..fermentans (P<0.001). The results support the suggestion that infectious agents may play a role in the pathogenesis and/or progression of ALS, or alternatively ALS patients are extremely susceptible to systemic mycoplasmal infections...
- Reversing mitochondrial dysfunction, fatigue and the adverse effects of chemotherapy of metastatic disease by molecular replacement therapyGarth L Nicolson
Department of Molecular Pathology, The Institute for Molecular Medicine, P O Box 9355, Laguna Beach, CA 92652, USA
Clin Exp Metastasis 25:161-9. 2008..Molecular replacement and antioxidant administration mitigates the damage to normal tissues, such as cardiac tissue, and reduces the adverse effects of cancer therapy without reduction in therapeutic results...
- Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoidsAnke von Sengbusch
Molecular Biology Lab, Department of General Surgery, University Hospital Munster, Waldeyerstrasse 1, 48149 Munster, Germany
Am J Pathol 166:585-96. 2005..This kinase may take part in the establishment of definitive adhesive interactions that enable adherent tumor cells to resist fluid shear forces, resulting in an organ-specific formation of distant metastases...
- Integrity of actin fibers and microtubules influences metastatic tumor cell adhesionTimo Korb
Molecular Biology Laboratory, Department of General Surgery, University Hospital Munster, Germany
Exp Cell Res 299:236-47. 2004....
- Immunization with a vaccine that combines the expression of MUC1 and B7 co-stimulatory molecules prolongs the survival of mice and delays the appearance of mouse mammary tumorsVitaly Vasilevko
Department of Molecular Immunology, The Institute for Molecular Medicine, Huntington Beach, California 92649 1041, USA
Clin Exp Metastasis 20:489-98. 2003..In addition, there were also significant delays in the appearance of measurable tumors and their growth in mice vaccinated by gene-gun immunization with plasmids encoding MUC1 and CD80 or CD86...
- Src protein kinase pp60c-src influences adhesion stabilization of HT-29 colon carcinoma cells to extracellular matrix components under dynamic conditions of laminar flowJörg Haier
Institute for Molecular Medicine, Huntington Beach, CA, USA
J Exp Ther Oncol 2:237-45. 2002..Our results suggest that pp60c-src may be involved in stabilization of dynamic HT-29 cell adhesion to ECM components, and this kinase appears to be part of a mechanosensory protein complex during integrin-mediated cell adhesion...
- PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flowJörg Haier
The Institute for Molecular Medicine 15162 Triton Lane, Huntington Beach, California, CA 92649, USA
Oncogene 21:1450-60. 2002..This phosphatase might play a role as a negative regulator for the formation of stable HT-29 cell adhesion to extracellular matrix...
- Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomasYasushi Toh
Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan
Int J Cancer 110:362-7. 2004..Thus, strategies involving inhibition of MTA1 function as well as inhibition of histone deacetylation could be novel approaches for the treatment of esophageal squamous cell carcinomas...
- Triterpenoids from Glycine max decrease invasiveness and induce caspase-mediated cell death in human SNB19 glioma cellsNiranjan Yanamandra
Division of Cancer Biology, Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine at Peoria, Peoria, Illinois 61605, USA
Clin Exp Metastasis 20:375-83. 2003..Our observations clearly demonstrate the pro-apoptotic and anti-invasive activities of the soyasapogenol B glycosides from soybeans...
- Characterization of 11 human sarcoma cell strains: evaluation of cytogenetics, tumorigenicity, metastasis, and production of angiogenic factorsMei Hu
Division of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 95:1569-76. 2002..A secondary purpose was to establish low passage cell strains for studying new therapeutic approaches...