K Nicolaou

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Total synthesis of abyssomicin C and atrop-abyssomicin C
    K C Nicolaou
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 45:3256-60. 2006
  2. pmc Synthesis of the WXYZA' domain of maitotoxin
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States
    J Am Chem Soc 133:220-6. 2011
  3. doi request reprint Total synthesis of the originally proposed and revised structures of palmerolide A and isomers thereof
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667
    J Am Chem Soc 130:3633-44. 2008
  4. ncbi request reprint Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 128:2258-67. 2006
  5. ncbi request reprint A facile method for the solution and solid-phase synthesis of substituted [3.3.1] bicycles
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Org Lett 1:807-10. 1999
  6. ncbi request reprint A new method for the stereoselective synthesis of alpha- and beta-glycosylamines using the Burgess reagent
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 126:6234-5. 2004
  7. ncbi request reprint Chemistry and biology of diazonamide A: first total synthesis and confirmation of the true structure
    K C Nicolaou
    Contribution from the Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 126:12888-96. 2004
  8. ncbi request reprint Design, synthesis, and biological properties of highly potent epothilone B analogues
    K C Nicolaou
    Department of Chemistry and, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 42:3515-20. 2003
  9. doi request reprint Total synthesis of (+)-cortistatin A
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences, Agency for Science, Technology, and Research, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667, Singapore
    Angew Chem Int Ed Engl 47:7310-3. 2008
  10. ncbi request reprint Second-generation total synthesis of azaspiracids-1, -2, and -3
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Asian J 1:245-63. 2006

Research Grants

  1. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 1999
  2. SYNTHESIS OF ANTIBIOTICS
    K Nicolaou; Fiscal Year: 2006
  3. TOTAL SYNTHESIS OF AZASPIRACIDS
    K Nicolaou; Fiscal Year: 2006
  4. SYNTHESIS OF ANTICANCER AGENTS
    K Nicolaou; Fiscal Year: 2006
  5. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2007
  6. SYNTHESIS OF ANTIBIOTICS
    K Nicolaou; Fiscal Year: 2007
  7. TOTAL SYNTHESIS OF KINAMYCINS AND LOMAIVITICINS
    K Nicolaou; Fiscal Year: 2007
  8. Synthesis of Marine Neurotoxins
    K Nicolaou; Fiscal Year: 2007
  9. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
  10. SYNTHESIS OF ANTICANCER AGENTS
    K Nicolaou; Fiscal Year: 2008

Detail Information

Publications156 found, 100 shown here

  1. ncbi request reprint Total synthesis of abyssomicin C and atrop-abyssomicin C
    K C Nicolaou
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 45:3256-60. 2006
  2. pmc Synthesis of the WXYZA' domain of maitotoxin
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States
    J Am Chem Soc 133:220-6. 2011
    ..The synthesized WXYZA' domain (7) of maitotoxin (1) exhibited the expected (13)C NMR chemical shifts, supporting the originally assigned structure of the corresponding region of the natural product...
  3. doi request reprint Total synthesis of the originally proposed and revised structures of palmerolide A and isomers thereof
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667
    J Am Chem Soc 130:3633-44. 2008
    ..The syntheses were completed by attachment of the enamide moiety through a copper-catalyzed coupling process...
  4. ncbi request reprint Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 128:2258-67. 2006
    ..Neither of the final products (1a,b) matched the natural substance by TLC or (1)H NMR spectroscopic analysis, suggesting one or more errors in the originally proposed structure for this notorious biotoxin...
  5. ncbi request reprint A facile method for the solution and solid-phase synthesis of substituted [3.3.1] bicycles
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Org Lett 1:807-10. 1999
    ..3.1]nonan-9-ones (II) both in solution and on solid support...
  6. ncbi request reprint A new method for the stereoselective synthesis of alpha- and beta-glycosylamines using the Burgess reagent
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 126:6234-5. 2004
    ..In this communication, we report an operationally simple method for the synthesis of both alpha- and beta-glycosylamines using the Burgess reagent that overcomes many of these limitations in a bare minimum of synthetic steps...
  7. ncbi request reprint Chemistry and biology of diazonamide A: first total synthesis and confirmation of the true structure
    K C Nicolaou
    Contribution from the Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 126:12888-96. 2004
    ....
  8. ncbi request reprint Design, synthesis, and biological properties of highly potent epothilone B analogues
    K C Nicolaou
    Department of Chemistry and, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 42:3515-20. 2003
  9. doi request reprint Total synthesis of (+)-cortistatin A
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences, Agency for Science, Technology, and Research, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667, Singapore
    Angew Chem Int Ed Engl 47:7310-3. 2008
  10. ncbi request reprint Second-generation total synthesis of azaspiracids-1, -2, and -3
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Asian J 1:245-63. 2006
    ..These improved, second-generation routes confirm the absolute structures and render all three azaspiracids readily available for biological studies...
  11. doi request reprint Total synthesis of hopeahainol A and hopeanol
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667, Singapore
    Angew Chem Int Ed Engl 48:3440-3. 2009
    ..Their first total synthesis has now been achieved through a series of novel cascade reactions and skeletal rearrangements...
  12. ncbi request reprint Total synthesis and revised structure of biyouyanagin A
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 46:4708-11. 2007
  13. ncbi request reprint The total synthesis of coleophomones B, C, and D
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 127:8872-88. 2005
    ..The synthesis of coleophomone D (4) confirmed that it exists as a dynamic mixture of isomeric forms with a different aromatic substitution pattern from the other family members...
  14. pmc Recent advances in the chemistry and biology of naturally occurring antibiotics
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 48:660-719. 2009
    ....
  15. ncbi request reprint Total synthesis of the originally proposed and revised structures of palmerolide A
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences, Agency for Science, Technology, and Research, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667, Singapore
    Angew Chem Int Ed Engl 46:5896-900. 2007
  16. ncbi request reprint Total synthesis of everninomicin 13,384-1--Part 1: retrosynthetic analysis and synthesis of the A1B(A)C fragment
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Chemistry 6:3095-115. 2000
    ....
  17. ncbi request reprint Total synthesis of diazonamide A
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 41:3495-9. 2002
  18. ncbi request reprint Total synthesis of the proposed azaspiracid-1 structure, part 1: construction of the enantiomerically pure C1-C20, C21-C27, and C28-C40 fragments
    K C Nicolaou
    Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 42:3643-8. 2003
  19. ncbi request reprint Structural revision and total synthesis of azaspiracid-1, part 2: definition of the ABCD domain and total synthesis
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10 550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 43:4318-24. 2004
  20. doi request reprint Chemical synthesis and biological evaluation of palmerolide A analogues
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences ICES, Agency for Science, Technology and Research A STAR, Singapore
    J Am Chem Soc 130:10019-23. 2008
    ..These findings point the way to more focused structure activity relationship studies...
  21. pmc Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and haematoc
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 134:17320-32. 2012
    ..e., 46, 2,2'-epi-46, and 61) and several low-micromolar anti- Plasmodium falciparum lead compounds (i.e., 46, 2,2'-epi-46, 58, 61, and 1)...
  22. pmc An expedient procedure for the oxidative cleavage of olefinic bonds with PhI(OAc)2, NMO, and catalytic OsO4
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Org Lett 12:1552-5. 2010
    ..A more practical and clean protocol to effect oxidative cleavage of olefinic bonds involves NMO, OsO(4) (cat.), 2,6-lutidine, and PhI(OAc)(2)...
  23. ncbi request reprint Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system
    K C Nicolaou
    Department of Chemistry, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 44:3736-40. 2005
  24. ncbi request reprint Studies toward the synthesis of azadirachtin, part 1: total synthesis of a fully functionalized ABC ring framework and coupling with a norbornene domain
    K C Nicolaou
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 44:3443-7. 2005
  25. pmc Total synthesis of sporolide B and 9-epi-sporolide B
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 132:11350-63. 2010
    ....
  26. ncbi request reprint Molecular design and chemical synthesis of a highly potent epothilone
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    ChemMedChem 1:41-4. 2006
  27. pmc Inspirations, discoveries, and future perspectives in total synthesis
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Org Chem 74:951-72. 2009
    ..Indeed, the advent of chemical synthesis as a whole must be considered as one of the most influential developments of the twentieth century in terms of its impact on society...
  28. ncbi request reprint Metathesis reactions in total synthesis
    K C Nicolaou
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 44:4490-527. 2005
    ..Judging from their short but impressive history, the influence of these reactions in chemical synthesis is destined to increase...
  29. ncbi request reprint Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Med Chem 48:5613-38. 2005
  30. ncbi request reprint Biomimetically inspired total synthesis and structure activity relationships of 1-O-methyllateriflorone. 6 pi electrocyclizations in organic synthesis
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 126:5493-501. 2004
    ..Among the most active compounds against tumor cells are 2, 16b, 56, 58, and 59...
  31. pmc Total syntheses of (+/-)-platencin and (-)-platencin
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 131:15909-17. 2009
    ..The syntheses demonstrate the power of the cobalt-catalyzed asymmetric Diels-Alder reaction and the one-pot reductive rearrangement of [3.2.1] bicyclic ketones to [2.2.2] bicyclic olefins...
  32. pmc The art of total synthesis through cascade reactions
    K C Nicolaou
    The Scripps Research Institute, Department of Chemistry, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Soc Rev 38:2993-3009. 2009
    ..In this tutorial review, we highlight the design and execution of cascade reactions within the context of total synthesis as demonstrated with selected examples from these laboratories...
  33. ncbi request reprint The Diels--Alder reaction in total synthesis
    K C Nicolaou
    Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 41:1668-98. 2002
    ....
  34. ncbi request reprint Construction of highly functionalized medium-sized rings: synthesis of hyperforin and perforatumone model systems
    K C Nicolaou
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Angew Chem Int Ed Engl 44:3895-9. 2005
  35. ncbi request reprint Studies towards the synthesis of azadirachtin: enantioselective entry into the azadirachtin framework through cascade reactions
    K C Nicolaou
    Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 42:3637-42. 2003
  36. pmc How thiostrepton was made in the laboratory
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 51:12414-36. 2012
    ..In this Review the author narrates the long journey to success, not so dissimilar to Odysseus' return voyage to Ithaca, full of adventure, knowledge, and wisdom...
  37. pmc A practical sulfenylation of 2,5-diketopiperazines
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 USA Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 USA
    Angew Chem Int Ed Engl 51:728-32. 2012
    ..The reaction provides more or less complex epidithiodiketopiperazines (II) and bis-methylthiodiketopiperazines (III)...
  38. ncbi request reprint Total synthesis of colombiasin A and determination of its absolute configuration
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Chemistry 7:5359-71. 2001
    ....
  39. pmc Total syntheses and structural revision of alpha- and beta-diversonolic esters and total syntheses of diversonol and blennolide C
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 47:6579-82. 2008
  40. ncbi request reprint Synthesis of iso-epoxy-amphidinolide N and des-epoxy-caribenolide I structures. Revised strategy and final stages
    K C Nicolaou
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California 92037, USA
    Org Biomol Chem 4:2158-83. 2006
    ..Regio- and diastereo-selective epoxidation of the C6 methylene group in bicyclic acetal 84 provided access to iso-epoxy-amphidinolide N stereoisomer 89...
  41. ncbi request reprint Total synthesis of brevetoxin A
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 392:264-9. 1998
    ..The convergent synthesis reported here renders this scarce neurotoxin synthetically available and, more importantly, allows the design and synthesis of analogues for further biochemical studies...
  42. ncbi request reprint Total synthesis of everninomicin 13,384-1--Part 2: synthesis of the FGHA2 fragment
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Chemistry 6:3116-48. 2000
    ..Final success for the latter construction came when a novel 1,2-phenylseleno migration reaction was applied to couple rings G and H, followed by ketene acetal and orthoester formation...
  43. doi request reprint Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Chem Asian J 3:413-29. 2008
    ....
  44. ncbi request reprint Joys of molecules. 1. Campaigns in total synthesis
    K C Nicolaou
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Org Chem 70:7007-27. 2005
    ..Cope Award address, I recount some of the joys I have experienced and shared with my students during campaigns to synthesize some of Nature's most intriguing and complex molecules...
  45. ncbi request reprint Total synthesis and antibacterial properties of carbaplatensimycin
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 129:14850-1. 2007
    ..Carbaplatensimycin exhibited similar potency to the natural product as an antibacterial agent against a variety of strains, including methicilin- and vancomycin-resistant bacteria...
  46. doi request reprint Synthesis of the sporolide ring framework through a cascade sequence involving an intramolecular [4+2] cycloaddition reaction of an o-quinone
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 47:1432-5. 2008
  47. ncbi request reprint Stereocontrolled synthesis of model core systems of lomaiviticins A and B
    K C Nicolaou
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 45:2076-81. 2006
  48. pmc Total synthesis and biological evaluation of (+)- and (-)-bisanthraquinone antibiotic BE-43472B and related compounds
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA
    J Am Chem Soc 131:14812-26. 2009
    ..Interestingly, the unnatural enantiomer [(-)-1] of antibiotic BE-43472B exhibited antibacterial properties comparable to those of the natural enantiomer [(+)-1]...
  49. ncbi request reprint Cascade reactions involving formal [2+2] thermal cycloadditions: total synthesis of artochamins F, H, I, and J
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 46:7501-5. 2007
  50. ncbi request reprint Construction of the "left domain" of haplophytine
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research A STAR, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667, Singapore
    Angew Chem Int Ed Engl 46:4715-8. 2007
  51. ncbi request reprint Total synthesis and stereochemistry of uncialamycin
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 46:4704-7. 2007
  52. pmc Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 130:13110-9. 2008
    ..These findings refine our present understanding of the platensimycin pharmacophore and establish certain structure-activity relationships from which the next generation of designed analogues of this new antibiotic may emerge...
  53. ncbi request reprint Total synthesis and biological evaluation of cortistatins A and J and analogues thereof
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences ICES, Agency for Science, Technology and Research ASTAR, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667
    J Am Chem Soc 131:10587-97. 2009
    ....
  54. pmc Samarium diiodide mediated reactions in total synthesis
    K C Nicolaou
    Department of Chemistry, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 48:7140-65. 2009
    ..The examples discussed are both illustrative of the power of this reagent in the construction of complex molecules and inspirational for the design of synthetic strategies toward such targets, both natural and designed...
  55. pmc Total synthesis of sporolide B
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 48:3449-53. 2009
    ..The key steps involve a ruthenium-catalyzed [2+2+2] cycloaddition to assemble the indene structural motif and a thermally induced Diels-Alder-type reaction to forge the macrocycle (see scheme)...
  56. doi request reprint A concise asymmetric total synthesis of aspidophytine
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 130:14942-3. 2008
    ..A highly convergent strategy involving the sequential annulation of vinyl iodide 5 with indole 6 exploits varying modes of indole reactivity to provide aspidophytine in 23% over six steps from 5...
  57. ncbi request reprint Synthesis of iso-epoxy-amphidinolide N and des-epoxy-caribenolide I structures. Initial forays
    K C Nicolaou
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, California 92037, USA
    Org Biomol Chem 4:2119-57. 2006
    ..Despite these setbacks, the information gleaned from these endeavours was to prove invaluable in laying the foundation for the eventual successful approach to the macrocyclic structures of amphidinolide N (1) and caribenolide I (2)...
  58. ncbi request reprint Studies toward the synthesis of azadirachtin, part 2: construction of fully functionalized ABCD ring frameworks and unusual intramolecular reactions induced by close-proximity effects
    K C Nicolaou
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10 550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 44:3447-52. 2005
  59. ncbi request reprint Total synthesis of apoptolidin: completion of the synthesis and analogue synthesis and evaluation
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 125:15443-54. 2003
    ..The developed synthetic technology was applied to the construction of several analogues including 74, 75, and 77 which exhibit significant bioactivity against tumor cells...
  60. ncbi request reprint Stereocontrolled total synthesis of apicularen A and its delta(17,18) Z isomer
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 41:3701-4; 3523. 2002
  61. ncbi request reprint Synthetic studies on thiostrepton: construction of thiostrepton analogues with the thiazoline-containing macrocycle
    K C Nicolaou
    Department of Chemistry and, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 42:3418-24. 2003
  62. ncbi request reprint The second total synthesis of diazonamide A
    K C Nicolaou
    Department of Chemistry and, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 42:1753-8. 2003
  63. pmc Bio-inspired synthesis and biological evaluation of a colchicine-related compound library
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 22:3776-80. 2012
    ..Biological evaluation revealed that some of the synthesized products had significant cytotoxic properties against the colon cancer cell line HT-29...
  64. pmc Enantioselective dichlorination of allylic alcohols
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Am Chem Soc 133:8134-7. 2011
    ..Reaction optimization, exploration of the substrate scope, and a model for stereoinduction are presented...
  65. ncbi request reprint Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, La Jolla, California 92037, USA
    Chemistry 7:3798-823. 2001
    ..In addition to aiding these investigations, the solid-phase chemistry described herein is expected to enhance the power of combinatorial chemistry and facilitate chemical biology and medicinal chemistry studies...
  66. pmc Synthesis of the carboline disaccharide domain of shishijimicin A
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Org Lett 13:3924-7. 2011
    ....
  67. pmc Bioinspired synthesis of hirsutellones A, B, and C
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Org Lett 13:5708-10. 2011
    ..The sequence proceeded via labile intermediate 17,1'-dehydrohirsutellone B (5) and delivered, in addition to the natural products (1-3), hirsutellone analogue 1',2',17-epi-hirsutellone C (1',2',17-epi-3)...
  68. pmc Synthesis of the QRSTU domain of maitotoxin and its 85-epi- and 86-epi-diastereoisomers
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 132:9900-7. 2010
    ..13)C NMR spectroscopic analysis of synthesized fragments 4, 5, and 6 and comparisons with maitotoxin provided strong support for the originally assigned structure of the QRSTU domain of the natural product...
  69. ncbi request reprint Solid phase synthesis of complex natural products and libraries thereof
    K C Nicolaou
    Department of Chemistry, and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Biopolymers 60:171-93. 2001
    ..Issues such as target selection, library design, linker development, automation, and library characterization are addressed...
  70. ncbi request reprint A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 44:1378-82. 2005
  71. ncbi request reprint Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 130:7466-76. 2008
    ..The (13)C NMR chemical shifts of synthetic 3 matched closely those corresponding to the same domain of the natural product providing strong evidence for the correctness of the originally proposed structure of maitotoxin ( 1)...
  72. ncbi request reprint Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Chemistry 6:2783-800. 2000
    ....
  73. ncbi request reprint Studies toward diazonamide A: development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 126:10174-82. 2004
    ..In addition, preliminary biological studies with intermediates and simplified analogues obtained via the developed sequences are also described...
  74. ncbi request reprint Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Angew Chem Int Ed Engl 43:5092-7. 2004
  75. ncbi request reprint Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones
    K C Nicolaou
    Department of Chemistry The Skaggs Institute for Chemical Biology The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Chem Biol 5:365-72. 1998
    ..The development of detailed structure-activity relationships for these compounds and the further elucidation of their mechanism of action is of high priority...
  76. pmc Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents
    Kyriacos C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Org Biomol Chem 11:4154-63. 2013
    ....
  77. pmc General synthetic approach to functionalized dihydrooxepines
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States
    Org Lett 15:1994-7. 2013
    ..This approach features a regioselective Baeyer-Villiger oxidation and subsequent functionalization via the corresponding enol phosphate intermediate...
  78. pmc Synthesis of the C'D'E'F' domain of maitotoxin
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States
    J Am Chem Soc 133:214-9. 2011
    ..X-ray crystallographic analysis of 6 provided unambiguous proof of its structure...
  79. doi request reprint The emergence of the structure of the molecule and the art of its synthesis
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 52:131-46. 2013
    ..This Essay traces the understanding of the structure of the molecule, the emergence of organic synthesis, and the art of total synthesis from the 19th century to the present day...
  80. ncbi request reprint A total synthesis trilogy: calicheamicin γ1(I), Taxol®, and brevetoxin A
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, USA
    Chem Rec 12:407-41. 2012
    ..Detailed behind-the-scenes accounts of the total syntheses of calicheamicin γ(1)(I), Taxol(®), and brevetoxin A are discussed with particular emphasis placed on strategies and tactics employed in these campaigns...
  81. pmc Synthesis of macroheterocycles through intramolecular oxidative coupling of furanoid β-ketoesters
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 51:4726-30. 2012
  82. doi request reprint Total synthesis of platencin
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 47:1780-3. 2008
  83. pmc From nature to the laboratory and into the clinic
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC408, La Jolla, CA 92037, USA
    Bioorg Med Chem 17:2290-303. 2009
    ..e., dynemicin A (8), uncialamycin (9), eleutherobin (10), sarcodictyin A (11), azaspiracid-1 (12), thiostrepton (13), abyssomicin C (14), platensimycin (15), platencin (16), and palmerolide A (17)]...
  84. doi request reprint Synthesis of functionalized maoecrystal V core structures
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research, 11 Biopolis Way, The Helios Block 03 08, Singapore
    Chem Commun (Camb) 46:70-2. 2010
    ..Two strategies toward the total synthesis of maoecrystal V (1) culminating in the construction of core structures 2 and 3 are described...
  85. doi request reprint An expedient strategy for the synthesis of tryptamines and other heterocycles
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 47:4217-20. 2008
  86. pmc Total synthesis, revised structure, and biological evaluation of biyouyanagin A and analogues thereof
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 130:11114-21. 2008
    ..Biological investigations with the synthesized biyouyangagins A (2-11) and hyperolactones C (12-16) revealed that the activity of biyouyanagin A most likely resides in its hyperolactone C structural domain...
  87. ncbi request reprint Total synthesis and biological evaluation of the resveratrol-derived polyphenol natural products hopeanol and hopeahainol A
    K C Nicolaou
    Chemical Synthesis Laboratory at Biopolis, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667
    J Am Chem Soc 132:7540-8. 2010
    ..Biological evaluation of the synthesized compounds confirmed the reported acetylcholinesterase inhibitory activity of hopeahainol A (3) but not the reported cytotoxic potencies of hopeanol (2)...
  88. pmc Synthesis of the ABCDEFG ring system of maitotoxin
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 132:6855-61. 2010
    ....
  89. pmc Total synthesis and structural revision of vannusals A and B: synthesis of the true structures of vannusals A and B
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 132:7153-76. 2010
    ....
  90. pmc Total synthesis and structural revision of vannusals A and B: synthesis of the originally assigned structure of vannusal B
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 132:7138-52. 2010
    ..These investigations led to the discovery and development of a number of new synthetic technologies that set the stage for the solution of the vannusal structural conundrum...
  91. pmc Total synthesis and absolute configuration of the bisanthraquinone antibiotic BE-43472B
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 48:3444-8. 2009
    ..Key transformations in the pivotal cascade sequence include a Diels-Alder reaction, a hemiketal formation, and a nucleophilic aromatic ipso substitution...
  92. ncbi request reprint Total synthesis of englerin A
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences ICES, Agency for Science, Technology and Research A STAR, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667
    J Am Chem Soc 132:8219-22. 2010
    ....
  93. pmc Design, synthesis, and biological evaluation of a biyouyanagin compound library
    K C Nicolaou
    Department of Chemistry, Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:6715-20. 2011
    ....
  94. doi request reprint Total synthesis of echinopines A and B
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667
    J Am Chem Soc 132:3815-8. 2010
    ..Their total synthesis involves a novel intramolecular rhodium-catalyzed cyclopropanation (4 --> 16) and a samarium diiodide-mediated ring closure (3 --> 37)...
  95. pmc The continuing saga of the marine polyether biotoxins
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 47:7182-225. 2008
    ..The Review ends with a discussion of the, as yet unfinished, story of maitotoxin, and projects into the future of this area of research...
  96. pmc Total synthesis of epicoccin G
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Am Chem Soc 133:8150-3. 2011
    ..An expedient enantioselective total synthesis of epicoccin G and related dithiodiketopiperazines through a strategy featuring direct two-directional sulfenylation, photooxygenation, and Kornblum-DeLaMare rearrangement is described...
  97. ncbi request reprint An expedient asymmetric synthesis of platencin
    K C Nicolaou
    Chemical Synthesis Institute of Chemical and Engineering Sciences ICES, Agency for Science, Technology and Research ASTAR, 11 Biopolis Way, The Helios Block, 03 08, Singapore 138667
    J Am Chem Soc 130:11292-3. 2008
    ..A short and efficient synthesis of enone 3, a key intermediate in the total synthesis of platencin (2), based on an intramolecular Diels-Alder reaction is described...
  98. pmc Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Bioorg Med Chem 19:5648-69. 2011
    ..0 μM) and HxB2 (IC(50)=2.4 μM). These findings render bridged nucleosides as credible leads for drug discovery in the anti-HIV area of research...
  99. pmc Total synthesis of platensimycin and related natural products
    K C Nicolaou
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 131:16905-18. 2009
    ..The rhodium-catalyzed asymmetric reaction involving a terminal acetylene was developed as a general method for the asymmetric cycloisomerization of terminal enynes...
  100. ncbi request reprint Novel strategies to construct the gamma-hydroxy lactone moiety of the CP molecules. Synthesis of the CP-225,917 core skeleton
    K C Nicolaou
    Department of Chemistry, Scripps Research Institute, La Jolla, California, USA
    Org Lett 1:63-6. 1999
    ....
  101. ncbi request reprint Total synthesis and biological evaluation of (-)apicularen A and analogues thereof
    K C Nicolaou
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Chemistry 9:6177-91. 2003
    ....

Research Grants37

  1. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 1999
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  2. SYNTHESIS OF ANTIBIOTICS
    K Nicolaou; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  3. TOTAL SYNTHESIS OF AZASPIRACIDS
    K Nicolaou; Fiscal Year: 2006
    ..g. lung, liver, spleen and lymphocyte damage as well as cancer) health hazards. The project is also expected to advance our knowledge in chemical synthesis and impact favorably the drug discovery and development process. ..
  4. SYNTHESIS OF ANTICANCER AGENTS
    K Nicolaou; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  5. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2007
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  6. SYNTHESIS OF ANTIBIOTICS
    K Nicolaou; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  7. TOTAL SYNTHESIS OF KINAMYCINS AND LOMAIVITICINS
    K Nicolaou; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  8. Synthesis of Marine Neurotoxins
    K Nicolaou; Fiscal Year: 2007
    ..The project is also expected to significantly advance our knowledge in chemical synthesis, chemical biology, and medicine ..
  9. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  10. SYNTHESIS OF ANTICANCER AGENTS
    K Nicolaou; Fiscal Year: 2008
    ..abstract_text> ..
  11. SYNTHESIS OF ANTIBIOTICS
    K Nicolaou; Fiscal Year: 2008
    ..abstract_text> ..
  12. Synthesis of Marine Neurotoxins
    K Nicolaou; Fiscal Year: 2008
    ..The project is also expected to significantly advance our knowledge in chemical synthesis, chemical biology, and medicine ..
  13. SYNTHESIS OF ANTICANCER AGENTS
    K Nicolaou; Fiscal Year: 2009
    ..abstract_text> ..
  14. SYNTHESIS OF ANTIBIOTICS
    K Nicolaou; Fiscal Year: 2009
    ..abstract_text> ..
  15. Synthesis of Marine Neurotoxins
    K Nicolaou; Fiscal Year: 2009
    ..The project is also expected to significantly advance our knowledge in chemical synthesis, chemical biology, and medicine ..
  16. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  17. SYNTHESIS OF ANTIBIOTICS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  18. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2006
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  19. TOTAL SYNTHESIS OF AZASPIRACIDS
    K Nicolaou; Fiscal Year: 2005
    ..g. lung, liver, spleen and lymphocyte damage as well as cancer) health hazards. The project is also expected to advance our knowledge in chemical synthesis and impact favorably the drug discovery and development process. ..
  20. TOTAL SYNTHESIS OF THIOSTREPTON
    K Nicolaou; Fiscal Year: 2005
    ..The disease areas likely to benefit most from the proposed investigations are bacterial-caused diseases and malaria. ..
  21. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2000
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  22. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2001
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  23. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2001
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  24. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2002
    ..abstract_text> ..
  25. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2002
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  26. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  27. TOTAL SYNTHESIS OF THIOSTREPTON
    K Nicolaou; Fiscal Year: 2002
    ..The disease areas likely to benefit most from the proposed investigations are bacterial-caused diseases and malaria. ..
  28. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2003
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  29. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2003
    ..abstract_text> ..
  30. TOTAL SYNTHESIS OF THIOSTREPTON
    K Nicolaou; Fiscal Year: 2003
    ..The disease areas likely to benefit most from the proposed investigations are bacterial-caused diseases and malaria. ..
  31. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  32. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2004
    ..abstract_text> ..
  33. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  34. TOTAL SYNTHESIS OF THIOSTREPTON
    K Nicolaou; Fiscal Year: 2004
    ..The disease areas likely to benefit most from the proposed investigations are bacterial-caused diseases and malaria. ..
  35. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2005
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  36. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  37. Synthesis of Marine Neurotoxins
    K C Nicolaou; Fiscal Year: 2010
    ..The project is also expected to significantly advance our knowledge in chemical synthesis, chemical biology, and medicine ..