KIM ERIKA NICHOLS

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint X-linked lymphoproliferative disease: genetics and biochemistry
    K E Nichols
    Department of Pediatric Oncology, Children s Hospital of Philadelphia, PA 19104, USA
    Rev Immunogenet 2:256-66. 2000
  2. ncbi request reprint Macrophage activation and Fcgamma receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors
    Kim E Nichols
    Pediatric Oncology, Children s Hospital of Philadelphia, PA 19104, USA
    J Leukoc Biol 75:541-52. 2004
  3. ncbi request reprint Molecular and cellular pathogenesis of X-linked lymphoproliferative disease
    Kim E Nichols
    Pediatric Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Immunol Rev 203:180-99. 2005
  4. ncbi request reprint Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing
    Regina A Clemens
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    J Immunol 178:4606-14. 2007
  5. ncbi request reprint Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules
    Cindy S Ma
    Garvan Institute of Medical Research, Darlinghurst, 2010, New South Wales, Australia
    Annu Rev Immunol 25:337-79. 2007
  6. pmc Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76
    Martha S Jordan
    Cancer Biology, Abramson Family Cancer Research Institute, 427 BRBII III, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA
    Immunity 28:359-69. 2008
  7. pmc Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in nonobese diabetic mice
    Denis V Baev
    Experimental Diabetes Unit, San Raffaele Scientific Institute, Milan, Italy
    J Immunol 181:869-77. 2008
  8. pmc Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells
    Cindy S Ma
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    J Clin Invest 115:1049-59. 2005
  9. pmc Differential requirement for the SAP-Fyn interaction during NK T cell development and function
    Selene Nunez-Cruz
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Immunol 181:2311-20. 2008
  10. ncbi request reprint Missense mutations in SH2D1A identified in patients with X-linked lymphoproliferative disease differentially affect the expression and function of SAP
    Nathan J Hare
    Lymphocyte Differentiation, Centenary Institute for Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, New South Wales 2042, Australia
    Int Immunol 18:1055-65. 2006

Research Grants

Collaborators

  • Cindy S Ma
  • Hao Shen
  • Stuart G Tangye
  • Jennifer L Cannons
  • Pamela L Schwartzberg
  • Gary Koretzky
  • K E Sullivan
  • James Riley
  • D E Tsai
  • H Jumaa
  • M Yurchenko
  • Andre Veillette
  • Martha S Jordan
  • Xiao Ping Zhong
  • Alejandro Malbran
  • Denis V Baev
  • Selene Nunez-Cruz
  • Regina A Clemens
  • Cheng hu Liu
  • Alexandra Filipovich
  • Nathan J Hare
  • Amanda K Cuss
  • Jonathan S Maltzman
  • Michael C Milone
  • Svitlana V Mikhalap
  • Jens M Chemnitz
  • Mark D Fleming
  • Jessica Elise T Austin
  • Marika Falcone
  • Jennifer Rothman
  • Margherita Coccia
  • Dominique Davidson
  • Hamid Bassiri
  • Jeremy C Burns
  • Marisa Juntilla
  • Jennifer E Smith
  • Anna C Aschenbrenner
  • Federica Facciotti
  • Simone Caielli
  • Francesca Ronchi
  • W C Janice Yeo
  • Priti Ojha
  • Rishu Guo
  • A Wesley Burks
  • Fabiana S Machado
  • Natalie Bezman
  • Laurie E Lenox
  • Julio C Aliberti
  • Taku Kambayashi
  • Li Jun Yu
  • Peter J Shaw
  • Danielle T Avery
  • Frank Alvaro
  • Mary Ellen Conley
  • Richard L Hodinka
  • Lewis B Silverman
  • Mariusz A Wasik
  • Olga V Yurchenko
  • Ivana Massud
  • Kathleen Haines
  • Beatriz Ruibal-Ares
  • MarĂ­a M de Bracco
  • Richard V Parry
  • Svetlana P Sidorenko
  • Ganna G Berdova
  • Cecilia Parodi
  • Carl H June
  • Larysa M Shlapatska
  • Patricia Bare
  • Richard Hodinka
  • Marta Felippo
  • Liliana Belmonte
  • Edward A Clark
  • David F Carpentieri
  • Stephen E Sallan
  • Sarah W Alexander
  • Jack L Pinkus
  • Ehmonie A Hainey
  • Benjamin A Olenchock
  • Geraldine S Pinkus
  • Carmen Tam
  • Barrett J Rollins
  • Marcia V Fournier
  • Massimo Loda

Detail Information

Publications24

  1. ncbi request reprint X-linked lymphoproliferative disease: genetics and biochemistry
    K E Nichols
    Department of Pediatric Oncology, Children s Hospital of Philadelphia, PA 19104, USA
    Rev Immunogenet 2:256-66. 2000
    ..Future studies exploring the function of DSHP during lymphocyte proliferation and activation should improve our ability to diagnose and treat XLP and possibly other human diseases associated with EBV...
  2. ncbi request reprint Macrophage activation and Fcgamma receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors
    Kim E Nichols
    Pediatric Oncology, Children s Hospital of Philadelphia, PA 19104, USA
    J Leukoc Biol 75:541-52. 2004
    ..Taken together, these data suggest that neither SLP-76 nor SLP-65 is required during FcgammaR-dependent signaling and functional events in macrophages...
  3. ncbi request reprint Molecular and cellular pathogenesis of X-linked lymphoproliferative disease
    Kim E Nichols
    Pediatric Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Immunol Rev 203:180-99. 2005
    ..Further studies of SAP and the SLAM family receptors will provide insights into XLP and elucidate the signaling events regulating lymphocyte ontogeny and function...
  4. ncbi request reprint Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing
    Regina A Clemens
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    J Immunol 178:4606-14. 2007
    ..aureus but reduction in LPS-induced tissue damage and vascular injury...
  5. ncbi request reprint Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules
    Cindy S Ma
    Garvan Institute of Medical Research, Darlinghurst, 2010, New South Wales, Australia
    Annu Rev Immunol 25:337-79. 2007
    ....
  6. pmc Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76
    Martha S Jordan
    Cancer Biology, Abramson Family Cancer Research Institute, 427 BRBII III, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA
    Immunity 28:359-69. 2008
    ..Thus, the N-terminal tyrosines of SLP76 are required for thymocyte selection but can function on separate molecules to support TCR signaling...
  7. pmc Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in nonobese diabetic mice
    Denis V Baev
    Experimental Diabetes Unit, San Raffaele Scientific Institute, Milan, Italy
    J Immunol 181:869-77. 2008
    ..Our data suggest that the genetic Slamf1 defect in NOD mice also affects SLAM expression on other immune cells such as the mDC, thus critically impairing the peripheral differentiation of iNKT cells toward a regulatory NKT2 type...
  8. pmc Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells
    Cindy S Ma
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    J Clin Invest 115:1049-59. 2005
    ..Thus, insufficient IL-10 production may contribute to hypogammaglobulinemia in XLP. This finding suggests new strategies for treating this immunodeficiency...
  9. pmc Differential requirement for the SAP-Fyn interaction during NK T cell development and function
    Selene Nunez-Cruz
    Division of Oncology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Immunol 181:2311-20. 2008
    ..Thus, SAP appears to use differential signaling mechanisms in NKT cells, with optimal ontogeny requiring Fyn binding, while functional responses occur independently of this interaction...
  10. ncbi request reprint Missense mutations in SH2D1A identified in patients with X-linked lymphoproliferative disease differentially affect the expression and function of SAP
    Nathan J Hare
    Lymphocyte Differentiation, Centenary Institute for Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, New South Wales 2042, Australia
    Int Immunol 18:1055-65. 2006
    ....
  11. ncbi request reprint SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1
    Jennifer L Cannons
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 21:693-706. 2004
    ..SLAM engagement amplified PKC-theta recruitment in wt but not SAP- or Fyn-deficient cells, arguing that a SAP/Fyn-mediated pathway enhances PKC-theta/NF-kappaB1 activation and suggesting a role for this pathway in T(H)2 regulation...
  12. ncbi request reprint The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells
    Svitlana V Mikhalap
    Signal Transduction Laboratory, R E Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine, 45 Vasylkivska St, Kiev 03022, Ukraine
    Blood 104:4063-70. 2004
    ..Our data support the hypothesis that CD150 and SH2D1A are coexpressed during a narrow window of B-cell maturation and SH2D1A may be involved in regulation of B-cell differentiation via switching of CD150-mediated signaling pathways...
  13. ncbi request reprint Summary of the 12th Nikolas Symposium dendritic cell differentiation: signals, signaling and functional consequences as clues to possible therapy
    Kim E Nichols
    Division of Pediatric Oncology, Children s of Hospital Philadelphia, Philadelphia, Pensilvania 19104, USA
    J Pediatr Hematol Oncol 25:193-7. 2003
  14. ncbi request reprint Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation
    Stuart G Tangye
    Centenary Institute for Cancer Medicine and Cell Biology, Newtown 2042, Sydney, New South Wales, Australia
    J Immunol 171:2485-95. 2003
    ..These results reveal a novel function of CD84 on human lymphocytes and suggest that CD84 can activate human T cells via a SAP-independent mechanism...
  15. ncbi request reprint Treatment of primary Epstein-Barr virus infection in patients with X-linked lymphoproliferative disease using B-cell-directed therapy
    Michael C Milone
    Department of Pathology and Laboratory Medicine, Hematologic Malignancies Program, University of Pennsylvania, Philadelphia, USA
    Blood 105:994-6. 2005
    ..These data suggest that the pre-emptive use of B-cell-directed therapy may reduce the morbidity and mortality of primary EBV infection in XLP-affected individuals...
  16. ncbi request reprint Coincident expression of the chemokine receptors CCR6 and CCR7 by pathologic Langerhans cells in Langerhans cell histiocytosis
    Mark D Fleming
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Blood 101:2473-5. 2003
    ..Histiocytes in Rosai-Dorfman disease and hemophagocytic syndrome also coexpressed CCR6 and CCR7, suggesting that this may be a general attribute of abnormal histiocytes...
  17. ncbi request reprint Enhanced T cell responses due to diacylglycerol kinase zeta deficiency
    Xiao Ping Zhong
    The Signal Transduction Program, The Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 4:882-90. 2003
    ..These results demonstrate the importance of DGKzeta as a physiological negative regulator of TCR signaling and T cell activation...
  18. pmc Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii
    Cheng hu Liu
    Department of Pediatrics Allergy and Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 204:781-92. 2007
    ....
  19. ncbi request reprint Loss of circulating CD27+ memory B cells and CCR4+ T cells occurring in association with elevated EBV loads in XLP patients surviving primary EBV infection
    Alejandro Malbran
    Departamento de Alergia e Inmunologia, Hospital Britanico, Buenos Aires, Argentina
    Blood 103:1625-31. 2004
    ..Despite an expanded number of CD3+CD8+ lymphocytes, increased EBV loads occurred in both patients without overt clinical symptoms of mononucleosis, lymphoproliferative disease, or lymphoma...
  20. ncbi request reprint X-linked lymphoproliferative syndrome: an X-cellent question
    Alexandra Filipovich
    Cincinnati Children s Hospital Medical Center, OH, USA
    Clin Immunol 119:241-4. 2006
  21. pmc Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease
    Cindy S Ma
    Lymphocyte Differentiation Laboratory, Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
    J Clin Invest 116:322-33. 2006
    ..Production of affinity-matured IgM by IgMCD27 B cells may protect against pathogens to which a normal immune response is elicited in XLP patients...
  22. ncbi request reprint Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity
    Amanda K Cuss
    Centenary Institute of Cancer Medicine and Cell Biology, New South Wales, Australia
    J Immunol 176:1506-16. 2006
    ..Further investigation of transitional B cells will improve our understanding of human B cell development and how alterations to this process may precipitate immunodeficiency or autoimmunity...
  23. ncbi request reprint SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation
    Jens M Chemnitz
    Abramson Family Cancer Research Institute and Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 173:945-54. 2004
    ..Despite this interaction, the ability of PD-1 to block T cell activation required receptor ligation, suggesting that colocalization of PD-1 with CD3 and/or CD28 may be necessary for inhibition of T cell activation...
  24. ncbi request reprint Regulation of NKT cell development by SAP, the protein defective in XLP
    Kim E Nichols
    Pediatric Oncology, Wood, 4th Floor, 3615 Civic Center Boulevard, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nat Med 11:340-5. 2005
    ..Thus, SAP is a crucial regulator of NKT cell ontogeny in humans and in mice. The absence of NKT cells may contribute to the phenotypes of SAP deficiency, including abnormal antiviral and antitumor immunity and hypogammaglobulinemia...

Research Grants4