J J Nichols

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Deposition rates and lens care influence on galyfilcon A silicone hydrogel lenses
    Jason J Nichols
    The Ohio State University, College of Optometry, Columbus, Ohio 43210, USA
    Optom Vis Sci 83:751-7. 2006
  2. pmc Tear proteomics in keratoconus
    Catherine Pannebaker
    College of Optometry, The Ohio State University, Columbus, OH 43210, USA
    Mol Vis 16:1949-57. 2010
  3. ncbi request reprint The impact of hydrogel lens settling on the thickness of the tears and contact lens
    Jason J Nichols
    College of Optometry, Ohio State University, Columbus, 43218 2342, USA
    Invest Ophthalmol Vis Sci 45:2549-54. 2004
  4. ncbi request reprint An assessment of self-reported disease classification in epidemiological studies of dry eye
    Jason J Nichols
    The Ohio State University, 320 West 10th Avenue, PO Box 182342, Columbus, OH 43218 2342, USA
    Invest Ophthalmol Vis Sci 45:3453-7. 2004
  5. ncbi request reprint An assessment of grading scales for meibography images
    Jason J Nichols
    The Ohio State University, Columbus, 43218, USA
    Cornea 24:382-8. 2005
  6. ncbi request reprint Thinning rate of the precorneal and prelens tear films
    Jason J Nichols
    College of Optometry, Ohio State University, Columbus, Ohio 43218 2342, USA
    Invest Ophthalmol Vis Sci 46:2353-61. 2005
  7. ncbi request reprint Sensitivity of the National Eye Institute Refractive Error Quality of Life instrument to refractive surgery outcomes
    Jason J Nichols
    College of Optometry, Ohio State University, Columbus, Ohio 43218 2342, USA
    J Cataract Refract Surg 31:2313-8. 2005
  8. ncbi request reprint Tear film, contact lens, and patient-related factors associated with contact lens-related dry eye
    Jason J Nichols
    College of Optometry, The Ohio State University, Columbus, Ohio 43218 2342, USA
    Invest Ophthalmol Vis Sci 47:1319-28. 2006
  9. doi request reprint Hydrogel contact lens binding induced by contact lens rewetting drops
    Jason J Nichols
    The Ohio State University, College of Optometry, Columbus, Ohio 43210, USA
    Optom Vis Sci 85:236-40. 2008
  10. pmc Tear film, contact lens, and patient factors associated with corneal staining
    Jason J Nichols
    Ohio State University, College of Optometry, Columbus, Ohio, USA
    Invest Ophthalmol Vis Sci 52:1127-37. 2011

Research Grants

  1. The Contact Lens and Dry Eye Study
    Jason Nichols; Fiscal Year: 2006

Detail Information

Publications55

  1. ncbi request reprint Deposition rates and lens care influence on galyfilcon A silicone hydrogel lenses
    Jason J Nichols
    The Ohio State University, College of Optometry, Columbus, Ohio 43210, USA
    Optom Vis Sci 83:751-7. 2006
    ..The purpose of this study is to investigate the frequency of deposition and impact of various multipurpose care regimens on a silicone hydrogel contact lens material (galyfilcon A; Acuvue Advance, Vistakon, Inc.)...
  2. pmc Tear proteomics in keratoconus
    Catherine Pannebaker
    College of Optometry, The Ohio State University, Columbus, OH 43210, USA
    Mol Vis 16:1949-57. 2010
    ..The purpose of this work was to identify potential tear-film based proteins expressed in keratoconus...
  3. ncbi request reprint The impact of hydrogel lens settling on the thickness of the tears and contact lens
    Jason J Nichols
    College of Optometry, Ohio State University, Columbus, 43218 2342, USA
    Invest Ophthalmol Vis Sci 45:2549-54. 2004
    ..To investigate the effect of contact lens insertion on the thickness on the prelens tear film (PLTF), the contact lens, and the postlens tear film (PoLTF)...
  4. ncbi request reprint An assessment of self-reported disease classification in epidemiological studies of dry eye
    Jason J Nichols
    The Ohio State University, 320 West 10th Avenue, PO Box 182342, Columbus, OH 43218 2342, USA
    Invest Ophthalmol Vis Sci 45:3453-7. 2004
    ..To evaluate the reliability of self-reported dry eye disease status and patient-related predictors of misclassification in contact lens wearers...
  5. ncbi request reprint An assessment of grading scales for meibography images
    Jason J Nichols
    The Ohio State University, Columbus, 43218, USA
    Cornea 24:382-8. 2005
    ..To evaluate the within- and between-reader reliability and the interrelation between 2 methods of grading meibography images...
  6. ncbi request reprint Thinning rate of the precorneal and prelens tear films
    Jason J Nichols
    College of Optometry, Ohio State University, Columbus, Ohio 43218 2342, USA
    Invest Ophthalmol Vis Sci 46:2353-61. 2005
    ..To apply interferometry as an in vivo measure of tear film thinning between blinks...
  7. ncbi request reprint Sensitivity of the National Eye Institute Refractive Error Quality of Life instrument to refractive surgery outcomes
    Jason J Nichols
    College of Optometry, Ohio State University, Columbus, Ohio 43218 2342, USA
    J Cataract Refract Surg 31:2313-8. 2005
    ..To evaluate scores from the National Eye Institute Refractive Error Quality of Life instrument (NEI-RQL) relative to refractive surgery outcomes in myopic patients...
  8. ncbi request reprint Tear film, contact lens, and patient-related factors associated with contact lens-related dry eye
    Jason J Nichols
    College of Optometry, The Ohio State University, Columbus, Ohio 43218 2342, USA
    Invest Ophthalmol Vis Sci 47:1319-28. 2006
    ..To examine tear film, contact lens, medical, and patient-related factors associated with self-reported contact lens-related dry eye...
  9. doi request reprint Hydrogel contact lens binding induced by contact lens rewetting drops
    Jason J Nichols
    The Ohio State University, College of Optometry, Columbus, Ohio 43210, USA
    Optom Vis Sci 85:236-40. 2008
    ..To investigate alterations in prelens tear film (PLTF), contact lens (CL), and postlens tear film (PoLTF) thicknesses and contact lens movement associated with boric acid-containing rewetting drops...
  10. pmc Tear film, contact lens, and patient factors associated with corneal staining
    Jason J Nichols
    Ohio State University, College of Optometry, Columbus, Ohio, USA
    Invest Ophthalmol Vis Sci 52:1127-37. 2011
    ..The purpose of this study was to examine ocular surface and tear film, contact lens, care solution, medical, and patient-related factors that are associated with corneal staining in contact lens wearers...
  11. doi request reprint Mass spectrometry-based proteomic analyses in contact lens-related dry eye
    Jason J Nichols
    Ohio State University, Columbus, 43210, USA
    Cornea 28:1109-17. 2009
    ..To identify potential protein biomarkers associated with dry eye in contact lens wearers...
  12. ncbi request reprint The assessment of automated measures of hydrogel contact lens refractive index
    Jason J Nichols
    College of Optometry, The Ohio State University, 320 West 10th Avenue, PO Box 182342, Columbus, OH 43218 2342, USA
    Ophthalmic Physiol Opt 23:517-25. 2003
    ..To investigate within- and between-operator reliability and validity of refractive index measures of hydrogel lenses...
  13. ncbi request reprint Overnight orthokeratology
    J J Nichols
    The Ohio State University, College of Optometry, Columbus 43210 1240, USA
    Optom Vis Sci 77:252-9. 2000
    ..The purpose of this study is to assess visual, refractive, topographic, and corneal thickness changes in subjects undergoing overnight orthokeratology...
  14. ncbi request reprint The performance of the contact lens dry eye questionnaire as a screening survey for contact lens-related dry eye
    Jason J Nichols
    Ohio State University College of Optometry, 320 West 10th Avenue, Rm 101, Columbus, OH 43210, USA
    Cornea 21:469-75. 2002
    ..In this report, we examine the CLDEQ as a screening survey for contact lens-related dry eye and compare it with McMonnies' questionnaire...
  15. ncbi request reprint Daily disposable vs. disposable extended wear: a contact lens clinical trial
    J J Nichols
    The Ohio State University, College of Optometry, Columbus 43210 1240, USA
    Optom Vis Sci 77:637-47. 2000
    ..The purpose of this work was to compare traditional standards of contact lens success and patient-reported preferences in the daily-disposable and disposable extended-wear contact lens modalities...
  16. ncbi request reprint Evaluation of tear film interference patterns and measures of tear break-up time
    Jason J Nichols
    The Ohio State University, College of Optometry, Columbus 43210, USA
    Optom Vis Sci 79:363-9. 2002
    ....
  17. ncbi request reprint Reliability and validity of refractive error-specific quality-of-life instruments
    Jason J Nichols
    College of Optometry, The Ohio State University, Columbus 43218, USA
    Arch Ophthalmol 121:1289-96. 2003
    ..To evaluate the reliability and validity of the National Eye Institute Refractive Error Quality of Life Instrument (NEI-RQL-42) and the Refractive Status and Vision Profile survey (RSVP)...
  18. ncbi request reprint Thickness of the pre- and post-contact lens tear film measured in vivo by interferometry
    Jason J Nichols
    Ohio State University College of Optometry, 320 West 10th Avenue, Room 101, Columbus, OH 43210 1240, USA
    Invest Ophthalmol Vis Sci 44:68-77. 2003
    ..The precision and accuracy of measuring postlens tear thickness is compared with a previous method based on optical pachymetry and mechanical measurement of contact lens thickness...
  19. ncbi request reprint Reliability of corneal thickness and endothelial cell density measures
    Jason J Nichols
    The Ohio State University, College of Optometry, Columbus, OH 43210, USA
    J Refract Surg 19:344-52. 2003
    ..The Konan was also used to study the reliability and agreement between endothelial cell density measures...
  20. ncbi request reprint The reliability and validity of hand-held refractometry water content measures of hydrogel lenses
    Jason J Nichols
    College of Optometry, The Ohio State University, 320 West 10th Avenue, PO Box 182342, Columbus, OH 43218 2342, USA
    Optom Vis Sci 80:447-53. 2003
    ..To investigate within- and between-examiner reliability and validity of hand-held refractometry water content measures of hydrogel lenses...
  21. ncbi request reprint The effect of eye closure on the post-lens tear film thickness during silicone hydrogel contact lens wear
    Jason J Nichols
    The Ohio State University College of Optometry, 320 West 10th Avenue, PO Box 182342, Columbus, OH 43218 2342, USA
    Cornea 22:539-44. 2003
    ..The purpose of this study was to investigate the effect of eye closure on the thickness on the post-lens tear film (POLTF) during silicone hydrogel contact lens wear...
  22. ncbi request reprint The performance of the refractive status and vision profile survey in a contact lens clinical trial
    J J Nichols
    The Ohio State University, College of Optometry, Columbus, Ohio 43218-2342, USA
    Ophthalmology 108:1160-6. 2001
    ..The instrument seems to lack sensitivity and discriminative validity in evaluating contact lens treatments...
  23. doi request reprint Contact lens material characteristics associated with hydrogel lens dehydration
    Padmapriya Ramamoorthy
    The Ohio State University, 320 West Tenth Avenue, Columbus, OH 43210, USA
    Ophthalmic Physiol Opt 30:160-6. 2010
    ..To determine the association between material dehydration and hydrogel contact lens material characteristics, including water content and ionicity...
  24. ncbi request reprint Corneal scarring and vision in keratoconus: a baseline report from the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study
    K Zadnik
    The Ohio State University College of Optometry, Columbus 43210 1240, USA
    Cornea 19:804-12. 2000
    ..We report on the correlation of corneal scarring with clinical and patient-reported variables at the baseline visit...
  25. pmc Impact of a rinse step on protein removal from silicone hydrogel contact lenses
    Andrew D Pucker
    The Ohio State University College of Optometry, Columbus, Ohio 43218 2342, USA
    Optom Vis Sci 86:943-7. 2009
    ..To determine the impact of the rinse step in "no rub" contact lens care systems relative to its ability to assist in removing loosely associated and bound tear film proteins from a worn silicone hydrogel lens...
  26. pmc Treatment, material, care, and patient-related factors in contact lens-related dry eye
    Padmapriya Ramamoorthy
    College of Optometry, The Ohio State University, 320 West 10th Avenue, Columbus, OH 43210, USA
    Optom Vis Sci 85:764-72. 2008
    ..To examine the effect of general contact lens and material characteristics, care solutions, treatment, and patient-related factors on contact lens-related dry eye...
  27. ncbi request reprint Proteins identified from care solution extractions of silicone hydrogels
    Andrew J Emch
    College of Optometry, The Ohio State University, Columbus, Ohio 43210, USA
    Optom Vis Sci 86:E123-31. 2009
    ..The purpose of this study was to investigate the quantity and identify the proteins extracted from two different types of silicone hydrogel contact lenses by several multipurpose care solutions after 1 day of wear...
  28. doi request reprint The impact of punctal occlusion on soft contact lens wearing comfort and the tear film
    Julia R Geldis
    Ohio State University, College of Optometry, Columbus, OH 43210, USA
    Eye Contact Lens 34:261-5. 2008
    ..The purpose of this report is to describe the impact of punctal occlusion in symptomatic dry eye contact lens wearers and the relation between subjective and objective outcomes...
  29. ncbi request reprint Reliability of grading lissamine green conjunctival staining
    David A Berntsen
    Ohio State University College of Optometry, Columbus, OH 43210, USA
    Cornea 25:695-700. 2006
    ..To assess the reliability of a lissamine green grading scale for conjunctival images...
  30. pmc The relation between disease asymmetry and severity in keratoconus
    J J Nichols
    Ohio State University, College of Optometry, Columbus, OH 43210, USA
    Br J Ophthalmol 88:788-91. 2004
    ..The purpose of the study was to examine the relation between disease asymmetry and severity in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study cohort...
  31. doi request reprint Contributions of evaporation and other mechanisms to tear film thinning and break-up
    P Ewen King-Smith
    College of Optometry, The Ohio State University, 338 W 10th Avenue, Columbus, OH 43210, USA
    Optom Vis Sci 85:623-30. 2008
    ..It is argued that most of the observed tear film thinning between blinks is due to evaporation, rather than tangential flow, and that large "pool" break-up regions are the result of evaporation over an extended area...
  32. ncbi request reprint Gas permeable and soft contact lens wear in children
    Lisa A Jones-Jordan
    The Ohio State University College of Optometry, Columbus, Ohio 43210, USA
    Optom Vis Sci 87:414-20. 2010
    ..To compare children's reports of comfort, vision, and contact lens-related issues in gas permeable (GP) and soft (SCL) contact lens wearers...
  33. doi request reprint The contribution of lipid layer movement to tear film thinning and breakup
    P Ewen King-Smith
    College of Optometry, Ohio State University, Columbus, Ohio, USA
    Invest Ophthalmol Vis Sci 50:2747-56. 2009
    ..To investigate whether the tear film thinning between blinks is caused by evaporation or by tangential flow of the tear film along the surface of the cornea. Tangential flow was studied by measuring the movement of the lipid layer...
  34. doi request reprint Prevention of UV-induced damage to the anterior segment using class I UV-absorbing hydrogel contact lenses
    Heather L Chandler
    Ohio State University, College of Optometry, Columbus, Ohio, USA
    Invest Ophthalmol Vis Sci 51:172-8. 2010
    ..To determine whether class I ultraviolet (UV) light-blocking contact lenses prevent UV-induced pathologic changes in a rabbit model...
  35. pmc Investigation of the human tear film proteome using multiple proteomic approaches
    Kari B Green-Church
    Mass Spectrometry and Proteomics Facility, The Ohio State University, Columbus, OH 43210, USA
    Mol Vis 14:456-70. 2008
    ....
  36. pmc Mass spectrometry-based proteomic analyses of contact lens deposition
    Kari B Green-Church
    Campus Chemical Instrument Center Mass Spectrometry and Proteomics Facility, The Ohio State University, Columbus, OH 43210, USA
    Mol Vis 14:291-7. 2008
    ..The purpose of this report is to describe the contact lens deposition proteome associated with two silicone hydrogel contact lenses and care solutions using a mass spectrometric-based approach...
  37. ncbi request reprint The Contact Lens and Tear Film Laboratory, the Ohio State University College of Optometry
    Kelly K Nichols
    Ohio State University College of Optometry, Columbuc, OH, USA
    Ocul Surf 5:259-61. 2007
  38. ncbi request reprint Between-eye asymmetry in keratoconus
    Karla Zadnik
    Ohio State University College of Optometry, Columbus 43210 1240, USA
    Cornea 21:671-9. 2002
    ....
  39. ncbi request reprint The relation between tear film tests in patients with dry eye disease
    Kelly K Nichols
    The Ohio State University, College of Optometry, 320 West 10th Avenue PO Box 182342, Columbus, OH 43218 2342, USA
    Ophthalmic Physiol Opt 23:553-60. 2003
    ..The purpose of this report was to investigate the relation between dry eye diagnostic tests...
  40. ncbi request reprint The reliability and validity of McMonnies Dry Eye Index
    Kelly K Nichols
    Ohio State University College of Optometry, Columbus, OH 43218 2342, USA
    Cornea 23:365-71. 2004
    ..The purpose of this report was to investigate the psychometric properties of the McMonnies questionnaire for dry eye disease...
  41. ncbi request reprint Characteristics of corneal ectasia after LASIK for myopia
    Michael D Twa
    College of Optometry, Ohio State University, Columbus, 43210 1240, USA
    Cornea 23:447-57. 2004
    ..We conducted a retrospective analysis of published case reports to describe common characteristics of this postoperative event and compared them with findings from a group of successful LASIK patients...
  42. ncbi request reprint The lack of association between signs and symptoms in patients with dry eye disease
    Kelly K Nichols
    College of Optometry, The Ohio State University, Columbus, OH 43218 2342, USA
    Cornea 23:762-70. 2004
    ..The purpose of this report was to examine the relation between clinical tests and dry eye symptoms in patients with dry eye disease...
  43. ncbi request reprint Self-reported dry eye disease across refractive modalities
    Jason J Nichols
    Ohio State University, Columbus, 43218, USA
    Invest Ophthalmol Vis Sci 46:1911-4. 2005
    ..To compare self-reported dry eye disease across contact lens wearers, spectacles wearers, and clinical emmetropes (i.e., those not requiring refractive correction)...
  44. ncbi request reprint The impact of contact lens care solutions on the thickness of the tear film and contact lens
    Jason J Nichols
    College of Optometry, The Ohio State University, Columbus, OH 43218 2342, USA
    Cornea 24:825-32. 2005
    ..To determine the impact of compositional differences in contact lens care solutions on the thickness of the tear film during contact lens wear...
  45. ncbi request reprint The reliability of the Lanthony Desaturated D-15 test
    Gregory W Good
    The Ohio State University College of Optometry, Columbus, 43210, USA
    Optom Vis Sci 82:1054-9. 2005
    ..This study investigated the test-retest reliability of the test using an intertest interval of approximately 1 month...
  46. ncbi request reprint Interferometric imaging of the full thickness of the precorneal tear film
    P Ewen King-Smith
    College of Optometry, The Ohio State University, 338 West 10th Avenue, Columbus, 43210, USA
    J Opt Soc Am A Opt Image Sci Vis 23:2097-104. 2006
    ..This method has the potential for evaluating the role of both tear film flow and evaporation in tear film thinning and breakup. It therefore may be applied to the analysis of dry eye disease...
  47. pmc Application of a novel interferometric method to investigate the relation between lipid layer thickness and tear film thinning
    P Ewen King-Smith
    College of Optometry, The Ohio State University, Columbus, OH 43210, USA
    Invest Ophthalmol Vis Sci 51:2418-23. 2010
    ..The purpose of this study was to investigate the relation between tear film thinning and lipid layer thickness before and after instillation of an emulsion eye drop...
  48. ncbi request reprint Relation between mood and self-reported dry eye in contact lens wearers
    Jason J Nichols
    Ohio State University, Columbus, OH 43218 2342, USA
    Cornea 25:937-42. 2006
    ..Recent evidence from other disciplines has shown a relation between self-rated mood and symptom reporting, and the purpose of this work was to explore the relation between self-rated mood and dry eye symptoms...
  49. ncbi request reprint Identification of fatty acids and fatty acid amides in human meibomian gland secretions
    Kelly K Nichols
    College of Optometry, The Ohio State University, Columbus, OH 43210, USA
    Invest Ophthalmol Vis Sci 48:34-9. 2007
    ..Although classes of lipids found in the tear film have been reported, individual lipid species are currently being studied with more sophisticated...
  50. doi request reprint Mucins in contact lens wear and dry eye conditions
    Padmapriya Ramamoorthy
    College of Optometry, The Ohio State University, 338 W 10th Avenue, Columbus, OH 43210, USA
    Optom Vis Sci 85:631-42. 2008
    ..In view of the mucin involvement in dry eye conditions, stimulation of mucus secretion pathways may hold promise in the pharmaceutical treatment of dry eye...
  51. ncbi request reprint Frequency of and factors associated with contact lens dissatisfaction and discontinuation
    Kathryn Richdale
    Ohio State University, Columbus, OH 43210, USA
    Cornea 26:168-74. 2007
    ..To determine the frequency of and factors associated with contact lens dissatisfaction and discontinuation...
  52. pmc Enzymatic quantification of cholesterol and cholesterol esters from silicone hydrogel contact lenses
    Andrew D Pucker
    Ohio State University, Columbus, Ohio 43218 2342, USA
    Invest Ophthalmol Vis Sci 51:2949-54. 2010
    ..The purpose of this work was to develop an enzymatic method of quantification of cholesterol and cholesterol esters derived from contact lenses, both in vitro and ex vivo...
  53. ncbi request reprint The thickness of the post-lens tear film measured by interferometry
    Jason J Nichols
    College of Optometry, The Ohio State University, Columbus, Ohio, USA
    Adv Exp Med Biol 506:929-33. 2002
  54. doi request reprint The influence of gender and hormone status on the severity and progression of keratoconus
    Barbara A Fink
    College of Optometry, The Ohio State University, Columbus, OH 43210 1240, USA
    Cornea 29:65-72. 2010
    ..To assess the effects of gender and hormone status on the severity and progression of keratoconus in patients enrolled in the Collaborative Longitudinal Evaluation of Keratoconus Study...
  55. pmc Dry eye and designer ophthalmics
    Gordon W Laurie
    Department of Cell Biology, University of Virginia, Charlottesville, VA, USA
    Optom Vis Sci 85:643-52. 2008
    ..Some differ and a couple overlap, suggesting that disease-specific signatures could be identified. Future dry eye treatment might include recombinant tear protein rescue as a personalized ophthalmic approach to ocular surface disease...

Research Grants1

  1. The Contact Lens and Dry Eye Study
    Jason Nichols; Fiscal Year: 2006
    ..The long-term objective of this research is to contribute to a better understanding of the etiology and risk factors for contact lens-related dry eye so that progress can be made toward its prevention. ..