Robert A Newman

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander
    Dan Ni
    Pharmaceutical Development Center, University of Texas M D Anderson Cancer Center, 8000 El Rio, Houston, TX 77054, USA
    J Exp Ther Oncol 2:278-85. 2002
  2. doi request reprint Cardiac glycosides as novel cancer therapeutic agents
    Robert A Newman
    Department of Experimental Therapeutics and Pharmaceutical Development Center, University of Texas, M D Anderson Cancer Center, Houston, TX 77054, USA
    Mol Interv 8:36-49. 2008
  3. doi request reprint Phase II trial of curcumin in patients with advanced pancreatic cancer
    Navneet Dhillon
    Department of Investigational Cancer Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:4491-9. 2008
  4. ncbi request reprint Phase I trial of intoplicine (RP 60475) administered as a 72 h infusion every 3 weeks in patients with solid tumors
    R A Newman
    Division of Medicine, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Anticancer Drugs 10:889-94. 1999
  5. ncbi request reprint Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside
    Robert A Newman
    Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77054, USA
    Integr Cancer Ther 6:354-64. 2007
  6. ncbi request reprint Oleandrin-mediated oxidative stress in human melanoma cells
    Robert A Newman
    Department of Experimental Therapeutics, Univ Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    J Exp Ther Oncol 5:167-81. 2006
  7. ncbi request reprint Determination of endogenous tissue inflammation profiles by LC/MS/MS: COX- and LOX-derived bioactive lipids
    Peiying Yang
    Departments of Experimental Therapeutics, The University of Texas, M D Anderson Cancer Center, 8000 El Rio, Houston, TX 77054, USA
    Prostaglandins Leukot Essent Fatty Acids 75:385-95. 2006
  8. ncbi request reprint Evaluation of targeted arterial delivery of the branched chain fatty acid 12-methyltetradecanoic acid as a novel therapy for solid tumors
    Kenneth C Wright
    Section of Interventional Radiology, Department of Diagnostic Radiology, Unit 057, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    J Exp Ther Oncol 5:55-68. 2005
  9. doi request reprint Oleandrin-mediated inhibition of human tumor cell proliferation: importance of Na,K-ATPase alpha subunits as drug targets
    Peiying Yang
    Department of Experimental Therapeutics, The University of Texas, MD Anderson Cancer, Houston, Texas 77054, USA
    Mol Cancer Ther 8:2319-28. 2009
  10. ncbi request reprint Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells
    Peiying Yang
    Pharmaceutical Development Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    J Lipid Res 45:1030-9. 2004

Research Grants

Detail Information

Publications76

  1. ncbi request reprint Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander
    Dan Ni
    Pharmaceutical Development Center, University of Texas M D Anderson Cancer Center, 8000 El Rio, Houston, TX 77054, USA
    J Exp Ther Oncol 2:278-85. 2002
    ..The data suggest that components within oleander extract may enhance transport of oleandrin across the blood brain barrier...
  2. doi request reprint Cardiac glycosides as novel cancer therapeutic agents
    Robert A Newman
    Department of Experimental Therapeutics and Pharmaceutical Development Center, University of Texas, M D Anderson Cancer Center, Houston, TX 77054, USA
    Mol Interv 8:36-49. 2008
    ..This review focuses on recent findings on cellular pharmacology of cardiac glycosides as they relate to treatment of human cancer and attempts to explain why these agents have been overlooked in the past...
  3. doi request reprint Phase II trial of curcumin in patients with advanced pancreatic cancer
    Navneet Dhillon
    Department of Investigational Cancer Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:4491-9. 2008
    ..We evaluated the clinical biological effects of curcumin (diferuloylmethane), a plant-derived dietary ingredient with potent nuclear factor-kappaB (NF-kappaB) and tumor inhibitory properties, against advanced pancreatic cancer...
  4. ncbi request reprint Phase I trial of intoplicine (RP 60475) administered as a 72 h infusion every 3 weeks in patients with solid tumors
    R A Newman
    Division of Medicine, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Anticancer Drugs 10:889-94. 1999
    ..Intoplicine content measured in whole blood exceeded that found in plasma by 3- to 7-fold, indicating that red blood cells may serve as a drug reservoir. Preclinical cytotoxic concentrations were not achieved at the dose levels studied...
  5. ncbi request reprint Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside
    Robert A Newman
    Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77054, USA
    Integr Cancer Ther 6:354-64. 2007
    ..The data provide insight into the mechanisms and role of a potent, lipid-soluble cardiac glycoside (oleandrin) in control of human pancreatic cancer proliferation...
  6. ncbi request reprint Oleandrin-mediated oxidative stress in human melanoma cells
    Robert A Newman
    Department of Experimental Therapeutics, Univ Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    J Exp Ther Oncol 5:167-81. 2006
    ..These mechanisms play a role in cardiac glycoside mediated tumor cell injury. Conversely, incubation of NAC, a precursor to GSH, largely prevents oleandrin-mediated inhibition of proliferation and mitochondria structural changes...
  7. ncbi request reprint Determination of endogenous tissue inflammation profiles by LC/MS/MS: COX- and LOX-derived bioactive lipids
    Peiying Yang
    Departments of Experimental Therapeutics, The University of Texas, M D Anderson Cancer Center, 8000 El Rio, Houston, TX 77054, USA
    Prostaglandins Leukot Essent Fatty Acids 75:385-95. 2006
    ....
  8. ncbi request reprint Evaluation of targeted arterial delivery of the branched chain fatty acid 12-methyltetradecanoic acid as a novel therapy for solid tumors
    Kenneth C Wright
    Section of Interventional Radiology, Department of Diagnostic Radiology, Unit 057, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    J Exp Ther Oncol 5:55-68. 2005
    ..Additional in vivo studies are warranted to elucidate 12-MTA's mechanism of action and further investigate the branched chain fatty acid's antitumor effects...
  9. doi request reprint Oleandrin-mediated inhibition of human tumor cell proliferation: importance of Na,K-ATPase alpha subunits as drug targets
    Peiying Yang
    Department of Experimental Therapeutics, The University of Texas, MD Anderson Cancer, Houston, Texas 77054, USA
    Mol Cancer Ther 8:2319-28. 2009
    ..In conclusion, the relatively higher expression of alpha3 with the limited expression of alpha1 may help predict which human tumors are likely to be responsive to treatment with potent lipid-soluble cardiac glycosides such as oleandrin...
  10. ncbi request reprint Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells
    Peiying Yang
    Pharmaceutical Development Center, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    J Lipid Res 45:1030-9. 2004
    ..These data indicate that exposure of lung cancer cells to EPA results in a decrease in the COX-2-mediated formation of PGE(2), an increase in the level of PGE(3), and PGE(3)-mediated inhibition of tumor cell proliferation...
  11. ncbi request reprint Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation
    Peiying Yang
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 8000 El Rio Street, Houston, TX 77054, USA
    Cancer Biol Ther 6:228-36. 2007
    ....
  12. pmc Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epithelia
    Vemparala Subbarayan
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 7:280-93. 2005
    ..These results suggest that feedback mechanisms may contribute to the loss of 15-LOX-2 pathway components, which coincide with an increase in PPAR-gamma in many epithelial cancers...
  13. ncbi request reprint Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer
    Janos L Tanyi
    Departments of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:3534-45. 2003
    ..Thus, the LPA-rich environment of the ovarian cancer cell in vivo and the subsequent effects of cellular pathophysiology may be a consequence of both increased LPA production and decreased LPA metabolism by ovarian cancer cells...
  14. pmc Combination chemoprevention of HER2/neu-induced breast cancer using a cyclooxygenase-2 inhibitor and a retinoid X receptor-selective retinoid
    Powel H Brown
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Cancer Prev Res (Phila) 1:208-14. 2008
    ..Our data show that simultaneous blockade of COX/prostaglandin signaling and retinoid X receptor-dependent transcription confers potent anticancer efficacy, suggesting a novel avenue for clinical evaluation...
  15. doi request reprint Arachidonic acid metabolism in human prostate cancer
    Peiying Yang
    Department of General Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Int J Oncol 41:1495-503. 2012
    ..0.010 ng/mg protein, respectively; p=0.019). Our results suggest that LOX metabolites such as 12-HETE are critical in prostate cancer progression and that the LOX pathway may be a target for treating and preventing prostate cancer...
  16. pmc The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis
    Imad Shureiqi
    Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11486-92. 2005
    ..Therefore, 15-LOX-1 down-regulation rather than a shift in the balance of LOXs is likely the dominant alteration in LOX metabolism which contributes to colorectal tumorigenesis by repressing apoptosis...
  17. ncbi request reprint Inhibition of proliferation of PC3 cells by the branched-chain fatty acid, 12-methyltetradecanoic acid, is associated with inhibition of 5-lipoxygenase
    Peiying Yang
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77090 1009, USA
    Prostate 55:281-91. 2003
    ..Here we study 12-methyltetradecanoic acid (12-MTA), a branched-chain fatty acid, isolated from a sea cucumber extract, on the growth of prostate cancer cells and investigate the underlying mechanisms of its effect...
  18. ncbi request reprint Cyclooxygenase-2 induction and prostaglandin E2 accumulation in squamous cell carcinoma as a consequence of epidermal growth factor receptor activation by imatinib mesylate
    Faye M Johnson
    Department of Thoracic and Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Exp Ther Oncol 4:317-25. 2004
    ..COX-2 induction by imatinib in squamous tumors derived from the head and neck region is unique with respect to other target-specific agents and may represent one of the unintended toxic effects of imatinib described in some patients...
  19. pmc Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model
    Peiying Yang
    Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Carcinogenesis 29:2182-9. 2008
    ..The study suggests that Zyflamend might prevent oral carcinogenesis at the post-initiation stage...
  20. ncbi request reprint Comparative analysis of peritoneum and tumor eicosanoids and pathways in advanced ovarian cancer
    Ralph S Freedman
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230, USA
    Clin Cancer Res 13:5736-44. 2007
    ..To describe the eicosanoid profile and differentially expressed eicosanoid and arachidonic acid pathway genes in tissues from patients with advanced epithelial ovarian cancer (EOC)...
  21. ncbi request reprint Suppression of prostate tumor cell growth by stromal cell prostaglandin D synthase-derived products
    Jeri Kim
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 65:6189-98. 2005
    ....
  22. ncbi request reprint Cell-autonomous induction of functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) contributes to replicative senescence of human prostate progenitor cells
    Bobby Bhatia
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, 1808 Park Rd 1C, Smithville, TX 78957, USA
    Oncogene 24:3583-95. 2005
    ..Together, these data suggest that 15-LOX2 may represent an endogenous prostate senescence gene and its tumor-suppressing functions might be associated with its ability to induce cell senescence...
  23. ncbi request reprint Silk fibroin mediated delivery of liposomal emodin to breast cancer cells
    Sangeeta K Cheema
    University of Texas M D Anderson Cancer Center, Departments of Biomedical Engineering and Plastic Surgery, Unit 602, P O Box 301402, Houston, TX 72230 1402, United States
    Int J Pharm 341:221-9. 2007
    ..This study demonstrates that silk fibroin coating enhanced emodin delivery in Her2/neu over-expressing breast cancer cells thereby increasing the overall efficacy of the drug...
  24. pmc Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice
    S J Moghaddam
    Department of Pulmonary Medicine, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1100, Houston, TX 77030, USA
    Carcinogenesis 30:1949-56. 2009
    ..These findings suggest that curcumin could be used to protract the premalignant phase and inhibit lung cancer progression in high-risk COPD patients...
  25. ncbi request reprint Eupalmerin acetate, a novel anticancer agent from Caribbean gorgonian octocorals, induces apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathway
    Arifumi Iwamaru
    Department of Neurosurgery, Unit BSRB1004, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 6:184-92. 2007
    ..01, on day 19). These results indicate that EPA is therapeutically effective against malignant glioma cells in vitro and in vivo and that it, or a similar marine-based compound, may hold promise as a clinical anticancer agent...
  26. ncbi request reprint Eicosanoid metabolism in squamous cell carcinoma cell lines derived from primary and metastatic head and neck cancer and its modulation by celecoxib
    Claudia P Schroeder
    Department of Thoracic, Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 3:847-52. 2004
    ..Our findings provide new informations about individual eicosanoids produced by HNSCC cells and their differential regulation by the selective COX-2 inhibitor celecoxib...
  27. doi request reprint Biological activity of celecoxib in the bronchial epithelium of current and former smokers
    Edward S Kim
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 3:148-59. 2010
    ..Celecoxib (400 mg twice daily) was biologically active in the bronchial epithelium of current and former smokers; additional studies on the efficacy of celecoxib in non-small cell lung cancer chemoprevention may be warranted...
  28. doi request reprint Regulation of prostaglandin transporters in colorectal neoplasia
    Vijaykumar R Holla
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 118, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 1:93-9. 2008
    ..Our collective data suggest that the existing model to explain increased PGE(2) in colorectal neoplasia should be modified to include the novel mechanism of coordinated up- and down-regulation of genes involved in PGE(2) transport...
  29. doi request reprint Zyflamend mediates therapeutic induction of autophagy to apoptosis in melanoma cells
    Suhendan Ekmekcioglu
    Department of Melanoma Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Nutr Cancer 63:940-9. 2011
    ..Based on the responsible molecular mechanisms of Zyflamend, our study highlights the importance of the use of herbal preparations for the prevention and treatment of cancer...
  30. pmc A classification model to predict synergism/antagonism of cytotoxic mixtures using protein-drug docking scores
    John C Boik
    Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    BMC Pharmacol 8:13. 2008
    ..Results were compared to models where explanatory variables were constructed using the pseudomolecule approach of Sheridan...
  31. ncbi request reprint Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice
    Bharat B Aggarwal
    Cytokine Research Laboratory and Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas, 77030, USA
    Clin Cancer Res 11:7490-8. 2005
    ..Overall, our results indicate that curcumin, which is a pharmacologically safe compound, has a therapeutic potential in preventing breast cancer metastasis possibly through suppression of NF-kappaB and NF-kappaB-regulated gene products...
  32. ncbi request reprint Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products
    Santosh K Sandur
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nutr Cancer 57:78-87. 2007
    ..Overall, our results indicate that Zyflamend suppresses osteoclastogenesis, inhibits invasion, and potentiates cytotoxicity through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products...
  33. pmc Silk-fibroin-coated liposomes for long-term and targeted drug delivery
    Andrea S Gobin
    University of Texas MD Anderson Cancer Center, Laboratory of Reparative Biology and Bioengineering, Plastic Surgery, Houston, TX 72230, USA
    Int J Nanomedicine 1:81-7. 2006
    ..SF-ELP also decreased survival rate of keloids that expressed high levels of RTK. These results demonstrated that SF-ELP enhanced emodin delivery by improved diffusion kinetics and specific cell targeting...
  34. ncbi request reprint Metabolism of homoharringtonine, a cytotoxic component of the evergreen plant Cephalotaxus harringtonia
    Dan Ni
    Department of Experimental Therapeutics, Unit 601, University of Texas M D Anderson Cancer Center, 8000 El Rio, Houston, TX 77054, USA
    J Exp Ther Oncol 3:47-52. 2003
    ..The lethal dose of HHT affecting 50% (LD50) of mice was 6.7 mg/kg, but HHT-acid produced no apparent toxic effects at doses up to 280 mg/kg...
  35. ncbi request reprint Human tumor cell sensitivity to oleandrin is dependent on relative expression of Na+, K+ -ATPase subunitst
    Yun Lin
    Department of Experimental Therapeutics, The Univ of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Exp Ther Oncol 8:271-86. 2010
    ..Its inhibition by cardiac glycosides may provide a strategy for effective cancer therapy...
  36. pmc Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic mice
    Qian Jia
    Department of Nutrition and Food Science, Intercollegiate Faculty of Nutrition, Texas A and M University, Houston, USA
    Cancer Res 68:3985-91. 2008
    ..05) CD3(+), CD4(+) T helper, and macrophage cell numbers per colon as compared with wt mice. These results suggest that the antitumorigenic effect of n-3 PUFA may be mediated, in part, via its anti-inflammatory properties...
  37. ncbi request reprint Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
    Premal H Thaker
    Department of Gynecologic Oncology, University of Texas U T M D Anderson Cancer Center, 1155 Herman Pressler, Unit 1362, Houston, Texas 77030, USA
    Nat Med 12:939-44. 2006
    ..These data also suggest that blocking ADRB-mediated angiogenesis could have therapeutic implications for the management of ovarian cancer...
  38. ncbi request reprint Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cells
    Peiying Yang
    Department of Experimental Therapeutics, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Anal Biochem 308:168-77. 2002
    ..Concomitantly, EPA increased formation of PGE(3) by 10-fold in A549 cells. This is the first report that unequivocally demonstrates that EPA can be converted to PGE(3) by cyclooxygenase in human cancer cells...
  39. ncbi request reprint Evaluation of in vitro drug interactions with karenitecin, a novel, highly lipophilic camptothecin derivative in phase II clinical development
    Judith A Smith
    Division of Pharmacy, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 90, Houston, TX 77030, USA
    J Clin Pharmacol 43:1008-14. 2003
    ..Future karenitecin clinical trials should include studies to monitor or evaluate the effects of these potential drug interactions on the overall toxicity of karenitecin when used in combination with other drugs...
  40. pmc Differential effects of pravastatin and simvastatin on the growth of tumor cells from different organ sites
    David G Menter
    Department of Cancer Biology, The University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 6:e28813. 2011
    ..In conclusion, the specific chemical properties of different classes of statins dictate mechanistic properties which may be relevant when evaluating biological responses to statins...
  41. pmc Structure-activity models of oral clearance, cytotoxicity, and LD50: a screen for promising anticancer compounds
    John C Boik
    Department of Experimental Therapeutics, University of Texas M, d, Anderson Cancer Center, 8000 El Rio, Houston, TX 77054, USA
    BMC Pharmacol 8:12. 2008
    ..Multitask learning is particularly useful when the number of available training records is small relative to the number of features, as was the case with the oral clearance data...
  42. pmc Profiling lipoxygenase metabolism in specific steps of colorectal tumorigenesis
    Imad Shureiqi
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, 77030 4009, USA
    Cancer Prev Res (Phila) 3:829-38. 2010
    ..15-LOX-1 inhibited interleukin-1beta expression. This study establishes that reduced 13-HODE levels are a specific alteration in the LOX product profile associated with human colorectal tumorigenesis...
  43. ncbi request reprint Final results of a phase I and pharmacokinetic study of gamma-methylene-10-deazaaminopterin (MDAM) administered intravenously daily for five consecutive days in patients with solid tumors
    Mary Johansen
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77054, USA
    Cancer Chemother Pharmacol 53:370-6. 2004
    ....
  44. ncbi request reprint Phase I and pharmacological study of oral 9-aminocamptothecin colloidal dispersion (NSC 603071) in patients with advanced solid tumors
    Henry Q Xiong
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:2066-71. 2003
    ..o. This Phase I trial was conducted to determine the toxicity profile, maximal tolerated dose, and pharmacokinetics profile, including bioavailability, of p.o. 9-ACCD in patients with advanced solid tumors...
  45. ncbi request reprint In vitro enhancement of tumor cell radiosensitivity by a selective inhibitor of cyclooxygenase-2 enzyme: mechanistic considerations
    Uma Raju
    Department of Experimental Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 54:886-94. 2002
    ..In the present study, we investigated several possible mechanisms using a murine sarcoma cell culture system...
  46. doi request reprint Nerium oleander derived cardiac glycoside oleandrin is a novel inhibitor of HIV infectivity
    Shailbala Singh
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Fitoterapia 84:32-9. 2013
    ..These results support the potential utility of the Nerium oleander aqueous extract, containing the CG oleandrin as a novel candidate anti-HIV therapeutic...
  47. ncbi request reprint Quantifying synergism/antagonism using nonlinear mixed-effects modeling: a simulation study
    John C Boik
    Graduate School of Biomedical Sciences, University of Texas, Houston, TX, U S A
    Stat Med 27:1040-61. 2008
    ..The MixLow method can be used to quantify drug interactions in any fixed-ratio drug combination study that includes within-group and between-group replicates, and where responses follow a sigmoidal pattern...
  48. pmc Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies
    David S Hong
    Division of Cancer Medicine, Department of Investigational Therapeutics Phase 1 Program, Unit 455, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 15:7061-8. 2009
    ....
  49. ncbi request reprint Safety and pharmacokinetic effects of TNP-470, an angiogenesis inhibitor, combined with paclitaxel in patients with solid tumors: evidence for activity in non-small-cell lung cancer
    Roy S Herbst
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 20:4440-7. 2002
    ..TNP-470 was administered with paclitaxel to adults with solid tumors to define the safety and optimal dose of the combination regimen and to assess pharmacokinetic interactions...
  50. ncbi request reprint Bioavailability of curcumin: problems and promises
    Preetha Anand
    Cytokine Research Laboratory and Pharmaceutical Development Center, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Pharm 4:807-18. 2007
    ..Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease...
  51. pmc Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors
    Philippe Thuillier
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville 78957, USA
    Biochem J 366:901-10. 2002
    ..Ligand-binding studies revealed that the LOX inhibitors bind directly to PPARs and demonstrate a novel mechanism for these inhibitors in altering PPAR-mediated gene expression...
  52. ncbi request reprint 2004 Dr. Gary J. Becker Young Investigator Award: Relative thermosensitivity of cytotoxic drugs used in transcatheter arterial chemoembolization
    Kamran Ahrar
    Department of Interventional Radiology, The University of Texas M D Anderson Cancer Center, Unit 325, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    J Vasc Interv Radiol 15:901-5. 2004
    ..Therefore, in the present study, the relative thermosensitivity of cytotoxic drugs commonly used in TACE was studied...
  53. ncbi request reprint Use of microdialysis to study platinum anticancer agent pharmacokinetics in preclinical models
    Mary J Johansen
    Divisions of Pharmacy and Cancer Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Exp Ther Oncol 2:163-73. 2002
    ..v. administration, and variable tumor exposure with dose. Significant increases in hepatic carboplatin exposure with increasing dose suggest a possible mechanism for high-dose carboplatin-induced hepatic toxicity...
  54. ncbi request reprint The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer
    Janos L Tanyi
    Department of Molecular Therapeutics, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:1073-82. 2003
    ..Thus genetic or pharmacological manipulation of LPA metabolism, receptor activation, or downstream signaling is an attractive approach for therapy of ovarian cancer...
  55. ncbi request reprint Docetaxel secretion in tears: association with lacrimal drainage obstruction
    Bita Esmaeli
    Ophthalmology Section, Department of Plastic Surgery, Box 443, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Arch Ophthalmol 120:1180-2. 2002
    ..To test the hypothesis that docetaxel may be secreted in tears after intravenous infusion...
  56. ncbi request reprint Plasma and cellular pharmacology of 8-chloro-adenosine in mice and rats
    Varsha Gandhi
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Cancer Chemother Pharmacol 50:85-94. 2002
    ..In addition, we sought to determine whether an inhibitor of adenosine deaminase, 2'-deoxycoformycin (dCF), could enhance intracellular formation of 8-Cl-ATP by preventing degradation of 8-Cl-Ado to 8-Cl-inosine (8-Cl-Ino)...
  57. doi request reprint BDNF Mediates Neuroprotection against Oxygen-Glucose Deprivation by the Cardiac Glycoside Oleandrin
    Michael J Van Kanegan
    Center for Drug Discovery and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27704, and Department of Experimental Therapeutics, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030
    J Neurosci 34:963-8. 2014
    ..Together, these findings support further investigation of cardiac glycosides in providing neuroprotection in the context of ischemic stroke. ..
  58. ncbi request reprint Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in mice
    Christina K Haston
    Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Mol Genet 11:1855-63. 2002
    ..A putative mechanism for the interaction between the two loci in males is that bleomycin hydrolase functions as an MHC class I epitope-processing protease...
  59. ncbi request reprint Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells
    Shaohua Tang
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    J Biol Chem 277:16189-201. 2002
    ..Taken together, these results suggest that 15-LOX2 could be a suppressor of prostate cancer development, which functions by restricting cell cycle progression...
  60. ncbi request reprint Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model
    Xiaoxin Chen
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, 164 Frelinghuysen Road, Piscataway 08854, USA
    Carcinogenesis 23:2095-102. 2002
    ..Inhibition of tumor formation by sulindac was correlated with lowered levels of PGE2. In conclusion, sulindac exerted its chemopreventive effect against the formation of EAC in the rat EGDA model possibly through its inhibition of Cox...
  61. ncbi request reprint A phase I trial to determine the optimal biological dose of celecoxib when combined with erlotinib in advanced non-small cell lung cancer
    Karen L Reckamp
    Department of Medicine, Division of Hematology Oncology, David Geffen School of Medicine at University of California at Los Angeles, 90095, USA
    Clin Cancer Res 12:3381-8. 2006
    ....
  62. ncbi request reprint Celecoxib inhibits prostate cancer growth: evidence of a cyclooxygenase-2-independent mechanism
    Manish I Patel
    Department of Medicine, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Clin Cancer Res 11:1999-2007. 2005
    ..The primary purpose of this study was to evaluate whether celecoxib or rofecoxib, two widely used selective COX-2 inhibitors, possess COX-2-independent antitumor activity...
  63. ncbi request reprint Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer
    Ephraim P Lansky
    Punisyn Pharmaceuticals Ltd, Haifa, Israel
    J Ethnopharmacol 109:177-206. 2007
    ....
  64. ncbi request reprint An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesis
    Eunjung Kim
    Science Park Research Division, University of Texas MD Anderson Cancer Center, 1808 Park Road 1C, PO Box 389, Smithville, TX 78957, USA
    Oncogene 24:1174-87. 2005
    ..Collectively, these data suggest that 8S-LOX plays a role as a prodifferentiating, antitumorigenic, and tumor suppressing gene in mouse skin carcinogenesis...
  65. ncbi request reprint Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell lines
    Claudia P Schroeder
    Department of Thoracic, Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center Houston, TX 77030, USA
    J Exp Ther Oncol 6:183-92. 2007
    ..Our data indicate that a triple drug combination of distinct inhibitors of the eicosanoid metabolism at clinically feasible concentrations were more effective than each agent alone suggesting further investigations...
  66. ncbi request reprint Clinical evaluation of the delivery and safety of aerosolized liposomal 9-nitro-20(s)-camptothecin in patients with advanced pulmonary malignancies
    Claire F Verschraegen
    Cancer Research and Treatment Center, University of New Mexico, Albequerque, New Mexico 87131, USA
    Clin Cancer Res 10:2319-26. 2004
    ....
  67. doi request reprint Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth
    Hitoshi Funahashi
    Hirshberg Laboratories for Pancreatic Cancer Research, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Pancreas 36:353-62. 2008
    ..The aim of this study was to evaluate the effects of n-6 and n-3 PUFAs on the growth of pancreatic cancer...
  68. ncbi request reprint Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitors
    Zheng Sun
    Cancer Research Program, Julius L Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, NC 27707, USA
    Carcinogenesis 27:1902-8. 2006
    ..In summary, our studies have demonstrated that 5-Lox/LTA4H pathway is one of the major AA-metabolizing pathways involved in DMBA-induced oral carcinogenesis in hamsters, and may be targeted for chemoprevention...
  69. ncbi request reprint Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells
    Atsuko Deguchi
    Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
    Cancer Res 65:8442-7. 2005
    ..Taken together, these results provide evidence that the cGMP/PKG pathway can play an important role in the induction of 15-LOX-1 expression by nonsteroidal antiinflammatory drugs and related agents...
  70. ncbi request reprint HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice
    Louise R Howe
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, NY, USA
    Cancer Res 65:10113-9. 2005
    ..This finding may help to explain the reduced risk of breast cancer associated with regular use of nonsteroidal anti-inflammatory drugs...
  71. pmc 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis
    Seung Jae Myung
    Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 103:12098-102. 2006
    ....
  72. ncbi request reprint Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trials
    Keith I Block
    Institute for Integrative Cancer Research and Education, 1800 Sherman Avenue, Suite 350, Evanston, IL 60201, USA
    Cancer Treat Rev 33:407-18. 2007
    ..The objective of this study is to systematically review the literature in order to compile results from randomized trials that evaluate concurrent use of antioxidants with chemotherapy...
  73. ncbi request reprint The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissue
    Xingya Wang
    Department of Human Nutrition and Molecular Carcinogenesis and Chemoprevention Program, The Ohio State University Comprehensive Cancer Center, The Ohio State University, 325 Campbell Hall, 1787 Neil Avenue, Columbus, OH 43210, USA
    Carcinogenesis 29:120-8. 2008
    ..Collectively, our results suggest that COX-2 may not play a tumorigenic role during prostate carcinogenesis in the TRAMP model...
  74. doi request reprint Quantitative determination of fluorinated caffeic acid phenethyl ester derivative from rat blood plasma by liquid chromatography-electrospray ionization tandem mass spectrometry
    Xinyu Wang
    Pharmaceutics Division, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 867:138-43. 2008
    ..2% and 9.5%, respectively. Data are presented to illustrate the practicality of the method for the pharmacokinetic evaluation of CAPE and FCAPE after intravenous administration to rats...
  75. ncbi request reprint Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants
    Bobby Bhatia
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville 78957, USA
    J Biol Chem 278:25091-100. 2003
    ..Together, these results suggest that both 15-LOX2 and 15-LOX2sv-b suppress prostate tumor development, and the tumor-suppressive functions apparently do not necessarily depend on AA-metabolizing activity and nuclear localization...
  76. doi request reprint Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials
    Keith I Block
    Institute for Integrative Cancer Research and Education, Suite 350, Evanston, IL, USA
    Int J Cancer 123:1227-39. 2008
    ..However, well-designed studies evaluating larger populations of patients given specific antioxidants defined by dose and schedule relative to chemotherapy are warranted...

Research Grants1

  1. Relevance of fish oil derived PGE3 to lung cancer
    Robert Newman; Fiscal Year: 2004
    ..To evaluate the relative efficacy of EPA, DHA and fish oil (containing both fatty acids) in prevention of tumor growth and its correlation to alteration of eicosanoid metabolism in a mouse model of human lung cancer. ..