Research Topics
Genomes and Genes | Robert A NewmanSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleanderDan Ni
Pharmaceutical Development Center, University of Texas M.D. Anderson Cancer Center, 8000 El Rio, Houston, TX 77054, USA
J Exp Ther Oncol 2:278-85. 2002..The data suggest that components within oleander extract may enhance transport of oleandrin across the blood brain barrier...
Cardiac glycosides as novel cancer therapeutic agentsRobert A Newman
Department of Experimental Therapeutics and Pharmaceutical Development Center, University of Texas, M D Anderson Cancer Center, Houston, TX 77054, USA
Mol Interv 8:36-49. 2008..This review focuses on recent findings on cellular pharmacology of cardiac glycosides as they relate to treatment of human cancer and attempts to explain why these agents have been overlooked in the past...- Phase II trial of curcumin in patients with advanced pancreatic cancerNavneet Dhillon
Department of Investigational Cancer Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 14:4491-9. 2008..We evaluated the clinical biological effects of curcumin (diferuloylmethane), a plant-derived dietary ingredient with potent nuclear factor-kappaB (NF-kappaB) and tumor inhibitory properties, against advanced pancreatic cancer... - Phase I trial of intoplicine (RP 60475) administered as a 72 h infusion every 3 weeks in patients with solid tumorsR A Newman
Division of Medicine, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
Anticancer Drugs 10:889-94. 1999..Intoplicine content measured in whole blood exceeded that found in plasma by 3- to 7-fold, indicating that red blood cells may serve as a drug reservoir. Preclinical cytotoxic concentrations were not achieved at the dose levels studied... - Oleandrin-mediated oxidative stress in human melanoma cellsRobert A Newman
Department of Experimental Therapeutics, Univ Texas M D Anderson Cancer Center, Houston, TX 77054, USA
J Exp Ther Oncol 5:167-81. 2006..These mechanisms play a role in cardiac glycoside mediated tumor cell injury. Conversely, incubation of NAC, a precursor to GSH, largely prevents oleandrin-mediated inhibition of proliferation and mitochondria structural changes... - Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycosideRobert A Newman
Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77054, USA
Integr Cancer Ther 6:354-64. 2007..The data provide insight into the mechanisms and role of a potent, lipid-soluble cardiac glycoside (oleandrin) in control of human pancreatic cancer proliferation... - Determination of endogenous tissue inflammation profiles by LC/MS/MS: COX- and LOX-derived bioactive lipidsPeiying Yang
Departments of Experimental Therapeutics, The University of Texas, M.D. Anderson Cancer Center, 8000 El Rio, Houston, TX 77054, USA
Prostaglandins Leukot Essent Fatty Acids 75:385-95. 2006.... - Oleandrin-mediated inhibition of human tumor cell proliferation: importance of Na,K-ATPase alpha subunits as drug targetsPeiying Yang
Department of Experimental Therapeutics, The University of Texas, MD Anderson Cancer, Houston, Texas 77054, USA
Mol Cancer Ther 8:2319-28. 2009..In conclusion, the relatively higher expression of alpha3 with the limited expression of alpha1 may help predict which human tumors are likely to be responsive to treatment with potent lipid-soluble cardiac glycosides such as oleandrin... - Evaluation of targeted arterial delivery of the branched chain fatty acid 12-methyltetradecanoic acid as a novel therapy for solid tumorsKenneth C Wright
Section of Interventional Radiology, Department of Diagnostic Radiology, Unit 057, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
J Exp Ther Oncol 5:55-68. 2005..Additional in vivo studies are warranted to elucidate 12-MTA's mechanism of action and further investigate the branched chain fatty acid's antitumor effects... - Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylationPeiying Yang
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 8000 El Rio Street, Houston, TX 77054, USA
Cancer Biol Ther 6:228-36. 2007.... 
Combination chemoprevention of HER2/neu-induced breast cancer using a cyclooxygenase-2 inhibitor and a retinoid X receptor-selective retinoidPowel H Brown
Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Cancer Prev Res (Phila) 1:208-14. 2008..Our data show that simultaneous blockade of COX/prostaglandin signaling and retinoid X receptor-dependent transcription confers potent anticancer efficacy, suggesting a novel avenue for clinical evaluation...- Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancerJanos L Tanyi
Departments of Molecular Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 9:3534-45. 2003..Thus, the LPA-rich environment of the ovarian cancer cell in vivo and the subsequent effects of cellular pathophysiology may be a consequence of both increased LPA production and decreased LPA metabolism by ovarian cancer cells... - Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cellsPeiying Yang
Pharmaceutical Development Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77054, USA
J Lipid Res 45:1030-9. 2004..These data indicate that exposure of lung cancer cells to EPA results in a decrease in the COX-2-mediated formation of PGE(2), an increase in the level of PGE(3), and PGE(3)-mediated inhibition of tumor cell proliferation... - Cyclooxygenase-2 induction and prostaglandin E2 accumulation in squamous cell carcinoma as a consequence of epidermal growth factor receptor activation by imatinib mesylateFaye M Johnson
Department of Thoracic and Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Exp Ther Oncol 4:317-25. 2004..COX-2 induction by imatinib in squamous tumors derived from the head and neck region is unique with respect to other target-specific agents and may represent one of the unintended toxic effects of imatinib described in some patients... - Inhibition of proliferation of PC3 cells by the branched-chain fatty acid, 12-methyltetradecanoic acid, is associated with inhibition of 5-lipoxygenasePeiying Yang
Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77090-1009, USA
Prostate 55:281-91. 2003..At relevant concentrations, 12-MTA can selectively inhibit the formation of 5-HETE, a metabolite of 5-lipoxygenase. This agent may be a novel adjunctive therapy for selected malignancies including prostate cancer... - Inverse relationship between 15-lipoxygenase-2 and PPAR-gamma gene expression in normal epithelia compared with tumor epitheliaVemparala Subbarayan
Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Neoplasia 7:280-93. 2005..These results suggest that feedback mechanisms may contribute to the loss of 15-LOX-2 pathway components, which coincide with an increase in PPAR-gamma in many epithelial cancers... - Comparative analysis of peritoneum and tumor eicosanoids and pathways in advanced ovarian cancerRalph S Freedman
Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230, USA
Clin Cancer Res 13:5736-44. 2007..To describe the eicosanoid profile and differentially expressed eicosanoid and arachidonic acid pathway genes in tissues from patients with advanced epithelial ovarian cancer (EOC)... - Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch modelPeiying Yang
Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
Carcinogenesis 29:2182-9. 2008..The study suggests that Zyflamend might prevent oral carcinogenesis at the post-initiation stage... - The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesisImad Shureiqi
Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Cancer Res 65:11486-92. 2005..Therefore, 15-LOX-1 down-regulation rather than a shift in the balance of LOXs is likely the dominant alteration in LOX metabolism which contributes to colorectal tumorigenesis by repressing apoptosis... - Suppression of prostate tumor cell growth by stromal cell prostaglandin D synthase-derived productsJeri Kim
Department of Genitourinary Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 65:6189-98. 2005.... - Curcumin inhibits COPD-like airway inflammation and lung cancer progression in miceS J Moghaddam
Department of Pulmonary Medicine, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1100, Houston, TX 77030, USA
Carcinogenesis 30:1949-56. 2009..These findings suggest that curcumin could be used to protract the premalignant phase and inhibit lung cancer progression in high-risk COPD patients... - Silk fibroin mediated delivery of liposomal emodin to breast cancer cellsSangeeta K Cheema
University of Texas M D Anderson Cancer Center, Departments of Biomedical Engineering and Plastic Surgery, Unit 602, P O Box 301402, Houston, TX 72230 1402, United States
Int J Pharm 341:221-9. 2007..This study demonstrates that silk fibroin coating enhanced emodin delivery in Her2/neu over-expressing breast cancer cells thereby increasing the overall efficacy of the drug... - Cell-autonomous induction of functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) contributes to replicative senescence of human prostate progenitor cellsBobby Bhatia
Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park-Research Division, 1808 Park Rd. 1C, Smithville, TX 78957, USA
Oncogene 24:3583-95. 2005..Together, these data suggest that 15-LOX2 may represent an endogenous prostate senescence gene and its tumor-suppressing functions might be associated with its ability to induce cell senescence... - Zyflamend mediates therapeutic induction of autophagy to apoptosis in melanoma cellsSuhendan Ekmekcioglu
Department of Melanoma Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA
Nutr Cancer 63:940-9. 2011..Based on the responsible molecular mechanisms of Zyflamend, our study highlights the importance of the use of herbal preparations for the prevention and treatment of cancer... - Regulation of prostaglandin transporters in colorectal neoplasiaVijaykumar R Holla
Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 118, Houston, TX 77030, USA
Cancer Prev Res (Phila) 1:93-9. 2008..Our collective data suggest that the existing model to explain increased PGE(2) in colorectal neoplasia should be modified to include the novel mechanism of coordinated up- and down-regulation of genes involved in PGE(2) transport... - Biological activity of celecoxib in the bronchial epithelium of current and former smokersEdward S Kim
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Prev Res (Phila) 3:148-59. 2010..Celecoxib (400 mg twice daily) was biologically active in the bronchial epithelium of current and former smokers; additional studies on the efficacy of celecoxib in non-small cell lung cancer chemoprevention may be warranted... - A classification model to predict synergism/antagonism of cytotoxic mixtures using protein-drug docking scoresJohn C Boik
Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
BMC Pharmacol 8:13. 2008..Results were compared to models where explanatory variables were constructed using the pseudomolecule approach of Sheridan... - Eicosanoid metabolism in squamous cell carcinoma cell lines derived from primary and metastatic head and neck cancer and its modulation by celecoxibClaudia P Schroeder
Department of Thoracic, Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Biol Ther 3:847-52. 2004..Our findings provide new informations about individual eicosanoids produced by HNSCC cells and their differential regulation by the selective COX-2 inhibitor celecoxib... - Eupalmerin acetate, a novel anticancer agent from Caribbean gorgonian octocorals, induces apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathwayArifumi Iwamaru
Department of Neurosurgery, Unit BSRB1004, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mol Cancer Ther 6:184-92. 2007..01, on day 19). These results indicate that EPA is therapeutically effective against malignant glioma cells in vitro and in vivo and that it, or a similar marine-based compound, may hold promise as a clinical anticancer agent... - Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinomaPremal H Thaker
Department of Gynecologic Oncology, University of Texas (U.T.) M.D. Anderson Cancer Center, 1155 Herman Pressler, Unit 1362, Houston, Texas 77030, USA
Nat Med 12:939-44. 2006..These data also suggest that blocking ADRB-mediated angiogenesis could have therapeutic implications for the management of ovarian cancer... - Silk-fibroin-coated liposomes for long-term and targeted drug deliveryAndrea S Gobin
University of Texas MD Anderson Cancer Center, Laboratory of Reparative Biology and Bioengineering, Plastic Surgery, Houston, TX 72230, USA
Int J Nanomedicine 1:81-7. 2006..SF-ELP also decreased survival rate of keloids that expressed high levels of RTK. These results demonstrated that SF-ELP enhanced emodin delivery by improved diffusion kinetics and specific cell targeting... - Metabolism of homoharringtonine, a cytotoxic component of the evergreen plant Cephalotaxus harringtoniaDan Ni
Department of Experimental Therapeutics, Unit 601, University of Texas M D Anderson Cancer Center, 8000 El Rio, Houston, TX 77054, USA
J Exp Ther Oncol 3:47-52. 2003..The lethal dose of HHT affecting 50% (LD50) of mice was 6.7 mg/kg, but HHT-acid produced no apparent toxic effects at doses up to 280 mg/kg... - Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude miceBharat B Aggarwal
Cytokine Research Laboratory and Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas, 77030, USA
Clin Cancer Res 11:7490-8. 2005..Overall, our results indicate that curcumin, which is a pharmacologically safe compound, has a therapeutic potential in preventing breast cancer metastasis possibly through suppression of NF-kappaB and NF-kappaB-regulated gene products... - Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene productsSantosh K Sandur
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Nutr Cancer 57:78-87. 2007..Overall, our results indicate that Zyflamend suppresses osteoclastogenesis, inhibits invasion, and potentiates cytotoxicity through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products... - Human tumor cell sensitivity to oleandrin is dependent on relative expression of Na+, K+ -ATPase subunitstYun Lin
Department of Experimental Therapeutics, The Univ of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Exp Ther Oncol 8:271-86. 2010..Its inhibition by cardiac glycosides may provide a strategy for effective cancer therapy... - Differential effects of pravastatin and simvastatin on the growth of tumor cells from different organ sitesDavid G Menter
Department of Cancer Biology, The University of Texas, M D Anderson Cancer Center, Houston, Texas, USA
PLoS ONE 6:e28813. 2011..In conclusion, the specific chemical properties of different classes of statins dictate mechanistic properties which may be relevant when evaluating biological responses to statins... - Structure-activity models of oral clearance, cytotoxicity, and LD50: a screen for promising anticancer compoundsJohn C Boik
Department of Experimental Therapeutics, University of Texas M, d, Anderson Cancer Center, 8000 El Rio, Houston, TX 77054, USA
BMC Pharmacol 8:12. 2008..Multitask learning is particularly useful when the number of available training records is small relative to the number of features, as was the case with the oral clearance data... - Final results of a phase I and pharmacokinetic study of gamma-methylene-10-deazaaminopterin (MDAM) administered intravenously daily for five consecutive days in patients with solid tumorsMary Johansen
Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77054, USA
Cancer Chemother Pharmacol 53:370-6. 2004..Based on the results of this phase I study, stomatitis emerged as the dose-limiting toxicity and the recommended starting dose for phase II trials using this schedule and route of administration is 240 mg/m2 per day... - Profiling lipoxygenase metabolism in specific steps of colorectal tumorigenesisImad Shureiqi
Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, 77030 4009, USA
Cancer Prev Res (Phila) 3:829-38. 2010..15-LOX-1 inhibited interleukin-1beta expression. This study establishes that reduced 13-HODE levels are a specific alteration in the LOX product profile associated with human colorectal tumorigenesis... - Phase I and pharmacological study of oral 9-aminocamptothecin colloidal dispersion (NSC 603071) in patients with advanced solid tumorsHenry Q Xiong
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 9:2066-71. 2003..o. This Phase I trial was conducted to determine the toxicity profile, maximal tolerated dose, and pharmacokinetics profile, including bioavailability, of p.o. 9-ACCD in patients with advanced solid tumors... - Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cellsPeiying Yang
Department of Experimental Therapeutics, University of Texas, M. D. Anderson Cancer Center, Houston 77030, USA
Anal Biochem 308:168-77. 2002..Concomitantly, EPA increased formation of PGE(3) by 10-fold in A549 cells. This is the first report that unequivocally demonstrates that EPA can be converted to PGE(3) by cyclooxygenase in human cancer cells... - Reduced colitis-associated colon cancer in Fat-1 (n-3 fatty acid desaturase) transgenic miceQian Jia
Department of Nutrition and Food Science, Intercollegiate Faculty of Nutrition, Texas A and M University, Houston, USA
Cancer Res 68:3985-91. 2008..05) CD3(+), CD4(+) T helper, and macrophage cell numbers per colon as compared with wt mice. These results suggest that the antitumorigenic effect of n-3 PUFA may be mediated, in part, via its anti-inflammatory properties... - Quantifying synergism/antagonism using nonlinear mixed-effects modeling: a simulation studyJohn C Boik
Graduate School of Biomedical Sciences, University of Texas, Houston, TX, U S A
Stat Med 27:1040-61. 2008..The MixLow method can be used to quantify drug interactions in any fixed-ratio drug combination study that includes within-group and between-group replicates, and where responses follow a sigmoidal pattern... - Safety and pharmacokinetic effects of TNP-470, an angiogenesis inhibitor, combined with paclitaxel in patients with solid tumors: evidence for activity in non-small-cell lung cancerRoy S Herbst
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 20:4440-7. 2002..TNP-470 was administered with paclitaxel to adults with solid tumors to define the safety and optimal dose of the combination regimen and to assess pharmacokinetic interactions... - Bioavailability of curcumin: problems and promisesPreetha Anand
Cytokine Research Laboratory and Pharmaceutical Development Center, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mol Pharm 4:807-18. 2007..Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease... - Evaluation of in vitro drug interactions with karenitecin, a novel, highly lipophilic camptothecin derivative in phase II clinical developmentJudith A Smith
Division of Pharmacy, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 90, Houston, TX 77030, USA
J Clin Pharmacol 43:1008-14. 2003..Future karenitecin clinical trials should include studies to monitor or evaluate the effects of these potential drug interactions on the overall toxicity of karenitecin when used in combination with other drugs... - Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignanciesDavid S Hong
Division of Cancer Medicine, Department of Investigational Therapeutics Phase 1 Program, Unit 455, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Clin Cancer Res 15:7061-8. 2009.... - In vitro enhancement of tumor cell radiosensitivity by a selective inhibitor of cyclooxygenase-2 enzyme: mechanistic considerationsUma Raju
Department of Experimental Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 54:886-94. 2002..In the present study, we investigated several possible mechanisms using a murine sarcoma cell culture system... - Use of microdialysis to study platinum anticancer agent pharmacokinetics in preclinical modelsMary J Johansen
Divisions of Pharmacy and Cancer Medicine, University of Texas M D Anderson Cancer Center, Houston, TX, USA
J Exp Ther Oncol 2:163-73. 2002..v. administration, and variable tumor exposure with dose. Significant increases in hepatic carboplatin exposure with increasing dose suggest a possible mechanism for high-dose carboplatin-induced hepatic toxicity... - 2004 Dr. Gary J. Becker Young Investigator Award: Relative thermosensitivity of cytotoxic drugs used in transcatheter arterial chemoembolizationKamran Ahrar
Department of Interventional Radiology, The University of Texas M D Anderson Cancer Center, Unit 325, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
J Vasc Interv Radiol 15:901-5. 2004..Therefore, in the present study, the relative thermosensitivity of cytotoxic drugs commonly used in TACE was studied... - Plasma and cellular pharmacology of 8-chloro-adenosine in mice and ratsVarsha Gandhi
Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Cancer Chemother Pharmacol 50:85-94. 2002..Further development of 8-Cl-Ado is recommended... - The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancerJanos L Tanyi
Department of Molecular Therapeutics, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 63:1073-82. 2003..Thus genetic or pharmacological manipulation of LPA metabolism, receptor activation, or downstream signaling is an attractive approach for therapy of ovarian cancer... - Docetaxel secretion in tears: association with lacrimal drainage obstructionBita Esmaeli
Ophthalmology Section, Department of Plastic Surgery, Box 443, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Arch Ophthalmol 120:1180-2. 2002..To test the hypothesis that docetaxel may be secreted in tears after intravenous infusion... - Bleomycin hydrolase and a genetic locus within the MHC affect risk for pulmonary fibrosis in miceChristina K Haston
Department of Experimental Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Hum Mol Genet 11:1855-63. 2002..A putative mechanism for the interaction between the two loci in males is that bleomycin hydrolase functions as an MHC class I epitope-processing protease... - Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cellsShaohua Tang
Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
J Biol Chem 277:16189-201. 2002..Taken together, these results suggest that 15-LOX2 could be a suppressor of prostate cancer development, which functions by restricting cell cycle progression... - Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancerEphraim P Lansky
Punisyn Pharmaceuticals Ltd, Haifa, Israel
J Ethnopharmacol 109:177-206. 2007.... - Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitorsPhilippe Thuillier
Department of Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Smithville 78957, USA
Biochem J 366:901-10. 2002..Ligand-binding studies revealed that the LOX inhibitors bind directly to PPARs and demonstrate a novel mechanism for these inhibitors in altering PPAR-mediated gene expression... - Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cellsAtsuko Deguchi
Department of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
Cancer Res 65:8442-7. 2005..Taken together, these results provide evidence that the cGMP/PKG pathway can play an important role in the induction of 15-LOX-1 expression by nonsteroidal antiinflammatory drugs and related agents... - Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitorsZheng Sun
Cancer Research Program, Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, NC 27707, USA
Carcinogenesis 27:1902-8. 2006..In summary, our studies have demonstrated that 5-Lox/LTA4H pathway is one of the major AA-metabolizing pathways involved in DMBA-induced oral carcinogenesis in hamsters, and may be targeted for chemoprevention... - A phase I trial to determine the optimal biological dose of celecoxib when combined with erlotinib in advanced non-small cell lung cancerKaren L Reckamp
Department of Medicine, Division of Hematology Oncology, David Geffen School of Medicine at University of California at Los Angeles, 90095, USA
Clin Cancer Res 12:3381-8. 2006.... - Celecoxib inhibits prostate cancer growth: evidence of a cyclooxygenase-2-independent mechanismManish I Patel
Department of Medicine, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
Clin Cancer Res 11:1999-2007. 2005..CONCLUSIONS: Two clinically available selective COX-2 inhibitors possess different COX-2-independent anticancer properties. The anticancer activity of celecoxib may reflect COX-2-independent in addition to COX-2-dependent effects... - Clinical evaluation of the delivery and safety of aerosolized liposomal 9-nitro-20(s)-camptothecin in patients with advanced pulmonary malignanciesClaire F Verschraegen
Cancer Research and Treatment Center, University of New Mexico, Albequerque, New Mexico 87131, USA
Clin Cancer Res 10:2319-26. 2004.... - Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical modelXiaoxin Chen
Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, 164 Frelinghuysen Road, Piscataway 08854, USA
Carcinogenesis 23:2095-102. 2002..Inhibition of tumor formation by sulindac was correlated with lowered levels of PGE2. In conclusion, sulindac exerted its chemopreventive effect against the formation of EAC in the rat EGDA model possibly through its inhibition of Cox... - An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesisEunjung Kim
Science Park Research Division, University of Texas MD Anderson Cancer Center, 1808 Park Road 1C, PO Box 389, Smithville, TX 78957, USA
Oncogene 24:1174-87. 2005..Collectively, these data suggest that 8S-LOX plays a role as a prodifferentiating, antitumorigenic, and tumor suppressing gene in mouse skin carcinogenesis... - Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growthHitoshi Funahashi
Hirshberg Laboratories for Pancreatic Cancer Research, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Pancreas 36:353-62. 2008..The aim of this study was to evaluate the effects of n-6 and n-3 PUFAs on the growth of pancreatic cancer... - Simultaneous inhibition of COX-2 and 5-LOX activities augments growth arrest and death of premalignant and malignant human lung cell linesClaudia P Schroeder
Department of Thoracic, Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center Houston, TX 77030, USA
J Exp Ther Oncol 6:183-92. 2007..Our data indicate that a triple drug combination of distinct inhibitors of the eicosanoid metabolism at clinically feasible concentrations were more effective than each agent alone suggesting further investigations... - HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout miceLouise R Howe
Department of Cell and Developmental Biology, Weill Medical College of Cornell University, NY, USA
Cancer Res 65:10113-9. 2005..This finding may help to explain the reduced risk of breast cancer associated with regular use of nonsteroidal anti-inflammatory drugs... - Quantitative determination of fluorinated caffeic acid phenethyl ester derivative from rat blood plasma by liquid chromatography-electrospray ionization tandem mass spectrometryXinyu Wang
Pharmaceutics Division, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, United States
J Chromatogr B Analyt Technol Biomed Life Sci 867:138-43. 2008..2% and 9.5%, respectively. Data are presented to illustrate the practicality of the method for the pharmacokinetic evaluation of CAPE and FCAPE after intravenous administration to rats... - Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variantsBobby Bhatia
Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville 78957, USA
J Biol Chem 278:25091-100. 2003..Together, these results suggest that both 15-LOX2 and 15-LOX2sv-b suppress prostate tumor development, and the tumor-suppressive functions apparently do not necessarily depend on AA-metabolizing activity and nuclear localization... - 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesisSeung Jae Myung
Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 103:12098-102. 2006.... - Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trialsKeith I Block
Institute for Integrative Cancer Research and Education, Suite 350, Evanston, IL, USA
Int J Cancer 123:1227-39. 2008..However, well-designed studies evaluating larger populations of patients given specific antioxidants defined by dose and schedule relative to chemotherapy are warranted... - Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trialsKeith I Block
Institute for Integrative Cancer Research and Education, 1800 Sherman Avenue, Suite 350, Evanston, IL 60201, USA
Cancer Treat Rev 33:407-18. 2007..The objective of this study is to systematically review the literature in order to compile results from randomized trials that evaluate concurrent use of antioxidants with chemotherapy... - The resistance to the tumor suppressive effects of COX inhibitors and COX-2 gene disruption in TRAMP mice is associated with the loss of COX expression in prostate tissueXingya Wang
Department of Human Nutrition and Molecular Carcinogenesis and Chemoprevention Program, The Ohio State University Comprehensive Cancer Center, The Ohio State University, 325 Campbell Hall, 1787 Neil Avenue, Columbus, OH 43210, USA
Carcinogenesis 29:120-8. 2008..Collectively, our results suggest that COX-2 may not play a tumorigenic role during prostate carcinogenesis in the TRAMP model...
Research Grants
- Relevance of fish oil derived PGE3 to lung cancerRobert Newman; Fiscal Year: 2004..To evaluate the relative efficacy of EPA, DHA and fish oil (containing both fatty acids) in prevention of tumor growth and its correlation to alteration of eicosanoid metabolism in a mouse model of human lung cancer. ..