Research Topics
| Wayne NewhauserSummaryAffiliation: The University of Texas Country: USA Publications
Research Grants
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Detail Information
Publications
Assessing the risk of second malignancies after modern radiotherapyWayne D Newhauser
MD Anderson Cancer Center Radiation Oncology, 1515 Holcombe Boulevard Houston, Texas 77030 4009, USA
Nat Rev Cancer 11:438-48. 2011..Therefore, there is a need to develop risk assessments based on our current knowledge of radiation-induced carcinogenesis...- The risk of developing a second cancer after receiving craniospinal proton irradiationWayne D Newhauser
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA
Phys Med Biol 54:2277-91. 2009..Simulations revealed that both passively scattered and scanned-beam proton therapies confer significantly lower risks of second cancers than 6 MV conventional and intensity-modulated photon therapies... - Can megavoltage computed tomography reduce proton range uncertainties in treatment plans for patients with large metal implants?Wayne D Newhauser
Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Phys Med Biol 53:2327-44. 2008..In this approach, the kVCT images provided good delineation of soft tissues due to high-contrast resolution, and the streak-free MVCT images provided smaller range uncertainties because they did not require artifact correction... 
Dosimetric impact of tantalum markers used in the treatment of uveal melanoma with proton beam therapyWayne D Newhauser
The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 94, Houston, TX 77030, USA
Phys Med Biol 52:3979-90. 2007..To avoid this situation, fiducials should be positioned laterally or distally with respect to the target volume...- Monte Carlo simulations for configuring and testing an analytical proton dose-calculation algorithmWayne Newhauser
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
Phys Med Biol 52:4569-84. 2007..The model presented here provided a means to reduce by several months the time required to prepare an analytical treatment planning system for patient treatments... - Monte Carlo simulations of the dosimetric impact of radiopaque fiducial markers for proton radiotherapy of the prostateWayne Newhauser
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Phys Med Biol 52:2937-52. 2007..A 0.9 mm diameter, 3.1 mm long cylindrical stainless steel marker provides good radiographic visibility yet perturbs the proton dose distribution in the prostate by less than 8% when using a parallel opposed lateral beam arrangement... - Monte Carlo simulations of a nozzle for the treatment of ocular tumours with high-energy proton beamsWayne Newhauser
The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA
Phys Med Biol 50:5229-49. 2005..The study revealed that, after a significant development effort, a Monte Carlo model of a proton therapy apparatus is sufficiently accurate and fast for commissioning a treatment planning system... - Dosimetry for ocular proton beam therapy at the Harvard Cyclotron Laboratory based on the ICRU Report 59W D Newhauser
Massachusetts General Hospital, Boston 02114, USA
Med Phys 29:1953-61. 2002..That difference is small compared with the experimental uncertainties and is clinically insignificant. In June of 1998, we adopted the IC-based method as our standard practice for the ocular beam... - Neutron radiation area monitoring system for proton therapy facilitiesW D Newhauser
The University of Texas M D Anderson Cancer Center Proton Therapy Center, 1515 Holcombe Boulevard, Unit 94, Houston, TX 77030, USA
Radiat Prot Dosimetry 115:149-53. 2005..The system performs with a mean time between failures of >6 months. Required data storage capabilities and application execution times are met with inexpensive off-the-shelf computer hardware... - Monte Carlo simulations of neutron spectral fluence, radiation weighting factor and ambient dose equivalent for a passively scattered proton therapy unitYuanshui Zheng
Department of Radiation Physics, Unit 94, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Phys Med Biol 53:187-201. 2008..Comparisons of in-air calculations with in-phantom calculations indicated that the in-air method yielded a conservative estimation of stray neutron radiation exposure for a prostate cancer patient... - Monte Carlo study of neutron dose equivalent during passive scattering proton therapyYuanshui Zheng
The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Phys Med Biol 52:4481-96. 2007..The analytical model predicted H/D values within 28% of those obtained in simulations; this value is within typical neutron measurement uncertainties... - Patient neutron dose equivalent exposures outside of the proton therapy treatment fieldJ C Polf
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 130, Houston, TX 77030, USA
Radiat Prot Dosimetry 115:154-8. 2005..35 and 0.60 mSv Gy(-1) from the simulations and measurements, respectively. At all locations, the predicted H/D values are within a factor of 2 and 3 of the measured result for no modulation and 8.2 cm of modulation, respectively... - Equivalent dose and effective dose from stray radiation during passively scattered proton radiotherapy for prostate cancerJonas Fontenot
The University of Texas Graduate School of Biomedical Sciences at Houston, Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 94, Houston, TX 77030, USA
Phys Med Biol 53:1677-88. 2008..Neutrons created in the nozzle predominated effective dose, though neutrons created in the patient contributed substantially to the equivalent dose in organs near the proton field. Photons contributed less than 15% to equivalent doses... 
Dose perturbations from implanted helical gold markers in proton therapy of prostate cancerAnnelise Giebeler
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Appl Clin Med Phys 10:2875. 2009..Dose perturbation was not observed for the small markers, but these markers were deemed too fragile for transrectal implantation in the prostate...- Assessment of the accuracy of an MCNPX-based Monte Carlo simulation model for predicting three-dimensional absorbed dose distributionsU Titt
The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Phys Med Biol 53:4455-70. 2008..Hence, the Monte Carlo models of medium- and large-size double scattering proton-therapy nozzles were valid for proton beams in the 100 MeV-250 MeV interval... - Neutron shielding calculations in a proton therapy facility based on Monte Carlo simulations and analytical models: criterion for selecting the method of choiceU Titt
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 94, Houston, TX 77030, USA
Radiat Prot Dosimetry 115:144-8. 2005..In this study, the optimum rejection criterion of 10% was found. The mean ratio was 26, 62% of all receptor locations showed a ratio between 0.9 and 10, and 92% were between 1 and 100... - Design tools for proton therapy nozzles based on the double-scattering foil techniqueJ D Fontenot
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 130, Houston, TX 77030, USA
Radiat Prot Dosimetry 116:211-5. 2005..8 in the gonadal region (50 cm from isocentre) and 3.4 in the thyroid region (21 cm from isocentre). The global ratio of predicted-to-measured H/D is 2.6... - Therapeutic step and shoot proton beam spot-scanning with a multi-leaf collimator: a Monte Carlo studyM Bues
The University of Texas M D Anderson Cancer Center, Department of Radiation Physics, 1515 Holcombe Blvd, Unit 94, Houston, Texas 77030, USA
Radiat Prot Dosimetry 115:164-9. 2005..Multileaf collimation is compared with a differential spot-weighting technique of sharpening the lateral dose falloff... - Four-dimensional computed tomography-based treatment planning for intensity-modulated radiation therapy and proton therapy for distal esophageal cancerXiaodong Zhang
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 72:278-87. 2008.... - Calculations of neutron dose equivalent exposures from range-modulated proton therapy beamsJerimy C Polf
Department of Radiation Physics, Unit 130, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Phys Med Biol 50:3859-73. 2005..In general, H/D increased with increasing range modulation at all locations studied, and the maximum H/D exposures shifted away from isocentre... - Reducing stray radiation dose to patients receiving passively scattered proton radiotherapy for prostate cancerPhillip J Taddei
The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 94, Houston, TX 77030, USA
Phys Med Biol 53:2131-47. 2008.... - Monte Carlo calculations and measurements of absorbed dose per monitor unit for the treatment of uveal melanoma with proton therapyNicholas Koch
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Phys Med Biol 53:1581-94. 2008..It is thus feasible to use the Monte Carlo method as a routine absolute dose algorithm for ocular proton therapy... - Monte Carlo investigation of collimator scatter of proton-therapy beams produced using the passive scattering methodUwe Titt
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 94, Houston, TX 77030, USA
Phys Med Biol 53:487-504. 2008.... - Initial beam size study for passive scatter proton therapy. I. Monte Carlo verificationJerimy C Polf
Department of Radiation Physics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Med Phys 34:4213-8. 2007.... - Is a 3-mm intrafractional margin sufficient for daily image-guided intensity-modulated radiation therapy of prostate cancer?Adam D Melancon
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, USA
Radiother Oncol 85:251-9. 2007.... - Changes in the pelvic anatomy after an IMRT treatment fraction of prostate cancerRenaud de Crevoisier
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 68:1529-36. 2007..To quantify the three-dimensional variations of pelvic anatomy after a single treatment fraction... - Determination of output factors for small proton therapy fieldsJonas D Fontenot
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Med Phys 34:489-98. 2007..We conclude that measuring D/MU without the range compensator present provides more reliable results than measuring it with the range compensator in place... - Effect of anatomic motion on proton therapy dose distributions in prostate cancer treatmentXiaodong Zhang
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 67:620-9. 2007..To determine the dosimetric impact of interfraction anatomic movements in prostate cancer patients receiving proton therapy... - Proton beam dosimetry for radiosurgery: implementation of the ICRU Report 59 at the Harvard Cyclotron LaboratoryWayne D Newhauser
Massachusetts General Hospital, Northeast Proton Therapy Center, Department of Radiation Oncology, Boston, MA 02114, USA
Phys Med Biol 47:1369-89. 2002..The ionization chamber technique exhibited superior reproducibility and was adopted in our standard clinical practice for radiosurgery...
Research Grants
- Prediction of Second Cancer Risks for Children Treated with Proton - vs. - PhotonWayne D Newhauser; Fiscal Year: 2010..In the future, we expect that the lower-risk treatments will result in fewer second cancers and this will translate into longer, higher-quality lives for survivors of childhood cancer (presently 270,000 persons in the United States). ..