Randy Nelson

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Seasonal immune function and sickness responses
    Randy J Nelson
    Departments of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Trends Immunol 25:187-92. 2004
  2. ncbi request reprint Form over function?
    Randy J Nelson
    Department of Psychology, The Ohio State University, Columbus 43210, USA
    J Biol Rhythms 17:406-9; discussion 410-2. 2002
  3. ncbi request reprint Molecular basis of aggression
    R J Nelson
    Dept of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Trends Neurosci 24:713-9. 2001
  4. ncbi request reprint Neural mechanisms of aggression
    Randy J Nelson
    Department of Psychology, Institute for Behavioural Medicine Research, The Ohio State University, Columbus, Ohio 43210, USA
    Nat Rev Neurosci 8:536-46. 2007
  5. ncbi request reprint Pleiotropic contributions of nitric oxide to aggressive behavior
    Randy J Nelson
    Department of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Neurosci Biobehav Rev 30:346-55. 2006
  6. ncbi request reprint Leptin effects on immune function and energy balance are photoperiod dependent in Siberian hamsters (Phodopus sungorus)
    D L Drazen
    Department of Psychology, The Johns Hopkins University, Baltimore, Maryland 21218-2686, USA
    Endocrinology 142:2768-75. 2001
  7. ncbi request reprint Photoperiod alters the time course of brain cyclooxygenase-2 expression in Siberian hamsters
    S D Bilbo
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    J Neuroendocrinol 15:958-64. 2003
  8. ncbi request reprint Skeleton photoperiods alter delayed-type hypersensitivity responses and reproductive function of Siberian hamsters (Phodopus sungorus)
    M L Gatien
    Department of Psychology, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    J Neuroendocrinol 17:733-9. 2005
  9. ncbi request reprint Melatonin mediates seasonal adjustments in immune function
    R J Nelson
    Department of Psychology, Johns Hopkins University, Baltimore, MD 21218 2686, USA
    Reprod Nutr Dev 39:383-98. 1999
  10. ncbi request reprint Sex steroid hormones enhance immune function in male and female Siberian hamsters
    S D Bilbo
    Departments of Psychology and Neuroscience, Biochemistry and Molecular Biology, Reproductive Biology Division, The Johns Hopkins University, Baltimore, Maryland 21218 2686, USA
    Am J Physiol Regul Integr Comp Physiol 280:R207-13. 2001

Research Grants

  1. Photoperiod Brain and Behavior
    Randy Nelson; Fiscal Year: 2009
  2. Photoperiod, Melatonin, and Sickness Behaviors
    Randy Nelson; Fiscal Year: 2006
  3. ENVIRONMENT, BEHAVIOR, AND REPRODUCTION
    Randy Nelson; Fiscal Year: 2006
  4. ENVIRONMENT, BEHAVIOR, AND REPRODUCTION
    Randy Nelson; Fiscal Year: 2000
  5. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2010

Detail Information

Publications108 found, 100 shown here

  1. ncbi request reprint Seasonal immune function and sickness responses
    Randy J Nelson
    Departments of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Trends Immunol 25:187-92. 2004
  2. ncbi request reprint Form over function?
    Randy J Nelson
    Department of Psychology, The Ohio State University, Columbus 43210, USA
    J Biol Rhythms 17:406-9; discussion 410-2. 2002
  3. ncbi request reprint Molecular basis of aggression
    R J Nelson
    Dept of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Trends Neurosci 24:713-9. 2001
    ..Understanding the interactions between 5-HT receptor subtypes should lead to novel insights into the molecular mechanisms of aggression...
  4. ncbi request reprint Neural mechanisms of aggression
    Randy J Nelson
    Department of Psychology, Institute for Behavioural Medicine Research, The Ohio State University, Columbus, Ohio 43210, USA
    Nat Rev Neurosci 8:536-46. 2007
    ..This Review summarizes the complex interactions between genes, biological signals, neural circuits and the environment that influence the development and expression of aggressive behaviour...
  5. ncbi request reprint Pleiotropic contributions of nitric oxide to aggressive behavior
    Randy J Nelson
    Department of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Neurosci Biobehav Rev 30:346-55. 2006
    ..Lastly, the multiple, and often unanticipated, effects of targeted gene disruption on aggressive behavior are considered...
  6. ncbi request reprint Leptin effects on immune function and energy balance are photoperiod dependent in Siberian hamsters (Phodopus sungorus)
    D L Drazen
    Department of Psychology, The Johns Hopkins University, Baltimore, Maryland 21218-2686, USA
    Endocrinology 142:2768-75. 2001
    ..Additionally, leptin appears to act differentially, according to photoperiod, to regulate both immune and energetic parameters...
  7. ncbi request reprint Photoperiod alters the time course of brain cyclooxygenase-2 expression in Siberian hamsters
    S D Bilbo
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    J Neuroendocrinol 15:958-64. 2003
    ..We conclude that short photoperiods significantly altered the time course of central COX-2 protein expression in hamsters in a manner consistent with reduced fever duration...
  8. ncbi request reprint Skeleton photoperiods alter delayed-type hypersensitivity responses and reproductive function of Siberian hamsters (Phodopus sungorus)
    M L Gatien
    Department of Psychology, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    J Neuroendocrinol 17:733-9. 2005
    ..DTH responses were equivalent in both long-day groups. These results suggest that the influences of day length on immune function potentially are due to circadian photoperiodic time measurement systems...
  9. ncbi request reprint Melatonin mediates seasonal adjustments in immune function
    R J Nelson
    Department of Psychology, Johns Hopkins University, Baltimore, MD 21218 2686, USA
    Reprod Nutr Dev 39:383-98. 1999
    ..To summarize, melatonin may be part of an integrative system to coordinate reproductive, immunologic and other physiological processes to cope successfully with energetic stressors during winter...
  10. ncbi request reprint Sex steroid hormones enhance immune function in male and female Siberian hamsters
    S D Bilbo
    Departments of Psychology and Neuroscience, Biochemistry and Molecular Biology, Reproductive Biology Division, The Johns Hopkins University, Baltimore, Maryland 21218 2686, USA
    Am J Physiol Regul Integr Comp Physiol 280:R207-13. 2001
    ..Contrary to evidence in many species such as rats, mice, and humans, these data suggest that sex steroid hormones enhance immunity in both male and female Siberian hamsters...
  11. ncbi request reprint Photoperiod affects the expression of sex and species differences in leukocyte number and leukocyte trafficking in congeneric hamsters
    S D Bilbo
    Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA
    Psychoneuroendocrinology 28:1027-43. 2003
    ..Our results suggest that interactions among social factors and the environment play a significant role in modulating sex and seasonal alterations in leukocyte numbers and stress responses...
  12. ncbi request reprint Cognitive and behavioral assessment in experimental stroke research: will it prove useful?
    A C DeVries
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Neurosci Biobehav Rev 25:325-42. 2001
    ....
  13. ncbi request reprint Photoperiod alters hypothalamic cytokine gene expression and sickness responses following immune challenge in female Siberian hamsters (Phodopus sungorus)
    L M Pyter
    Department of Neuroscience, Institute of Behavioral Medicine Research, 48A Townshend Hall, Ohio State University, Columbus, OH 43210, USA
    Neuroscience 131:779-84. 2005
    ..These data suggest that differences in cytokine production in the hypothalamus may underlie the photoperiod-induced differences in sickness responses, and that these changes are not mediated by estradiol...
  14. pmc Photoperiod-mediated impairment of long-term potention and learning and memory in male white-footed mice
    J C Walton
    Department of Neuroscience, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Neuroscience 175:127-32. 2011
    ..Taken together, these results demonstrate a functional change in the hippocampus in male white-footed mice induced by day length...
  15. ncbi request reprint Photorefractoriness of immune function in male Siberian hamsters (Phodopus sungorus)
    B J Prendergast
    Departments of Psychology and Neuroscience, Ohio State University, Townshend Hall, Columbus, OH 43210, USA
    J Neuroendocrinol 14:318-29. 2002
    ..Together, these data indicate that, similar to the reproductive system, the immune system of male Siberian hamsters exhibits refractoriness to short days...
  16. ncbi request reprint Social, but not photoperiodic, influences on reproductive function in male Peromyscus aztecus
    G E Demas
    Department of Psychology, The Johns Hopkins University, Baltimore, Maryland 21218 2686, USA
    Biol Reprod 58:385-9. 1998
    ..aztecus. These results are consistent with the results found for other low-latitude rodent species and suggest that P. aztecus uses a flexible rather than obligatory breeding strategy...
  17. ncbi request reprint Photoperiodic polyphenisms in rodents: neuroendocrine mechanisms, costs, and functions
    B J Prendergast
    Department of Psychology, Ohio State University, Columbus, Ohio 43210, USA
    Q Rev Biol 76:293-325. 2001
    ..Several nonexclusive hypotheses are proposed to account for the maintenance of nonresponsive individuals in wild rodent populations...
  18. ncbi request reprint Photoperiodic and temporal influences on chemosensory induction of brain fos expression in female prairie voles
    J E Hairston
    Department of Psychology, The Johns Hopkins University, Baltimore, MD, USA
    J Neuroendocrinol 15:161-72. 2003
    ..These results identify a putative neural circuitry of oestrus induction in this species, and provide an approximate time line of activation in the brain circuit responsible for oestrus induction in prairie voles...
  19. ncbi request reprint 3-bromo-7-nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs maternal aggression and citrulline immunoreactivity in prairie voles
    S C Gammie
    Departments of Psychology and Neuroscience, 3400 N Charles St, Room 225, Ames Hall, Behavioral Neuroendocrinology Group, The Johns Hopkins University, 21218, Baltimore, MD, USA
    Brain Res 870:80-6. 2000
    ....
  20. ncbi request reprint Photoperiod modulates the inhibitory effect of in vitro melatonin on lymphocyte proliferation in female Siberian hamsters
    B J Prendergast
    Department of Psychology and Neuroscience, The Ohio State University, Columbus 43210, USA
    J Biol Rhythms 16:224-33. 2001
    ..These data support the hypothesis that melatonin acts directly on lymphocytes from long-day hamsters to suppress blastogenesis...
  21. ncbi request reprint cFOS and pCREB activation and maternal aggression in mice
    S C Gammie
    Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, USA
    Brain Res 898:232-41. 2001
    ..These results complement previous studies of nitric oxide release during maternal aggression to create a possible map of the functional neural circuitry underlying maternal aggression...
  22. ncbi request reprint Maternal and mating-induced aggression is associated with elevated citrulline immunoreactivity in the paraventricular nucleus in prairie voles
    S C Gammie
    Department of Psychology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Comp Neurol 418:182-92. 2000
    ..In other regions of the brain, no changes in the number of citrulline-positive cells were observed. These results suggest that NO is released specifically in the PVN during both maternal and mating-induced aggression in prairie voles...
  23. ncbi request reprint Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice
    S L Klein
    Department of Psychology, Johns Hopkins University, Baltimore, MD 21218, USA
    Physiol Behav 60:1159-64. 1996
    ....
  24. ncbi request reprint Gonadal and photoperiodic influences on body mass regulation in adult male and female prairie voles
    L J Kriegsfeld
    Department of Psychology, Johns Hopkins University, Baltimore, Maryland 21218 2686, USA
    Am J Physiol 270:R1013-8. 1996
    ..Taken together, these studies suggest that male and female prairie voles use photoperiodic information to time seasonal changes in body mass...
  25. ncbi request reprint Reproductive and immune responses to photoperiod and melatonin are linked in Peromyscus subspecies
    G E Demas
    Department of Psychology, Johns Hopkins University, Baltimore, MD 21218, USA
    J Comp Physiol A 179:819-25. 1996
    ..These data also imply that melatonin may not possess universal immunoenhancing properties. Rather, the effectiveness of melatonin to influence immune responses may be constrained by reproductive responsiveness to this indole-amine...
  26. ncbi request reprint Aggressive behavior in male mice lacking the gene for neuronal nitric oxide synthase requires testosterone
    L J Kriegsfeld
    Department of Psychology, The Johns Hopkins University, Baltimore, MD 21205, USA
    Brain Res 769:66-70. 1997
    ..Testosterone replacement restored aggression to precastration levels in both genotypes. These data provide evidence that increased aggressive behavior of nNOS - /- mice, like aggression in WT mice, is testosterone-dependent...
  27. ncbi request reprint Short day lengths enhance skin immune responses in gonadectomised Siberian hamsters
    B J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    J Neuroendocrinol 17:18-21. 2005
    ..The data suggest that contemporary gonadal hormone secretion is neither necessary, nor sufficient to mediate the effects of short photoperiods on skin immune function...
  28. ncbi request reprint Maternal aggression is reduced in neuronal nitric oxide synthase-deficient mice
    S C Gammie
    Departments of Psychology and Neuroscience, Behavioral Neuroendocrinology Group, The Johns Hopkins University, Baltimore, MD 21218, USA
    J Neurosci 19:8027-35. 1999
    ..These results provide two indirect lines of evidence that NO release is associated with maternal aggression...
  29. ncbi request reprint Short photoperiod affects reproductive function but not dehydroepiandrosterone concentrations in male deer mice (Peromyscus maniculatus)
    L J Kriegsfeld
    Department of Psychology, The Johns Hopkins University, Baltimore, Maryland 21218 2686, USA
    J Pineal Res 25:101-5. 1998
    ..However, DHEA concentrations did not differ between short- and long-day mice. Taken together, these data suggest that short-day enhancement of immune function in deer mice is independent of DHEA concentrations...
  30. ncbi request reprint Lipopolysaccharide facilitates partner preference behaviors in female prairie voles
    S D Bilbo
    Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218 2686, USA
    Physiol Behav 68:151-6. 1999
    ..From a proximate perspective, this study provides evidence that sickness behaviors influence female, but not male, partner preference in prairie voles...
  31. ncbi request reprint In vitro melatonin treatment enhances splenocyte proliferation in prairie voles
    D L Drazen
    Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, USA
    J Pineal Res 28:34-40. 2000
    ..The findings also indicate that, irrespective of photoperiod, melatonin exerts direct effects on splenocytes to enhance immune function...
  32. ncbi request reprint Photoperiod affects neuronal nitric oxide synthase and aggressive behaviour in male Siberian hamsters (Phodopus sungorus)
    J C Wen
    Departments of Psychology and Neuroscience, Ohio State University, Columbus, OH 43210, USA
    J Neuroendocrinol 16:916-21. 2004
    ..Together, these results suggest that seasonal aggression in male Siberian hamsters is regulated by photoperiod, through mechanisms that are likely independent from gonadal steroid hormones...
  33. ncbi request reprint Short-day enhancement of immune function is independent of steroid hormones in deer mice (Peromyscus maniculatus)
    G E Demas
    Department of Psychology, Johns Hopkins University, Baltimore, MD 21218, USA
    J Comp Physiol B 168:419-26. 1998
    ..Additionally, short-day elevation in splenocyte proliferation appears to be independent of the influence of steroid hormones in this species...
  34. pmc Melatonin, immunity and cost of reproductive state in male European starlings
    G E Bentley
    Department of Psychology, Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Biol Sci 265:1191-5. 1998
    ..These data are, we believe, the first to indicate a direct effect of reproductive state on immune function that is independent of both photoperiod (i.e., changes in the duration of melatonin secretion) and gonadal steroids...
  35. ncbi request reprint A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice
    S Chiavegatto
    Department of Psychology, The Johns Hopkins University, Baltimore, Maryland, 21218, USA
    Exp Neurol 166:227-34. 2000
    ..1999. Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects. Proc. Natl. Acad. Sci. USA 96: 7532-7537), and may provide insights into the mechanisms underlying certain neural degenerative diseases...
  36. ncbi request reprint Maternal aggression in endothelial nitric oxide synthase-deficient mice
    S C Gammie
    Department of Psychology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Horm Behav 38:13-20. 2000
    ..Taken together, these results suggest that NO produced by eNOS neither facilitates nor inhibits maternal aggression and that NO produced by eNOS has a different role in maternal and male aggression...
  37. ncbi request reprint Photoperiod and population density interact to affect reproductive and immune function in male prairie voles
    R J Nelson
    Department of Psychology, Johns Hopkins University, Baltimore, Maryland 21218 2686, USA
    Am J Physiol 270:R571-7. 1996
    ..These results may be important in understanding arvicoline population fluctuations, as well as improving animal husbandry practices in the lab...
  38. ncbi request reprint In vitro melatonin treatment enhances cell-mediated immune function in male prairie voles (Microtus ochrogaster)
    L J Kriegsfeld
    Department of Psychology, The Johns Hopkins University, Baltimore, Maryland 21218-2686, USA
    J Pineal Res 30:193-8. 2001
    ..Taken together, the results of the present study suggest that melatonin is capable of enhancing immune function in male voles potentially by acting directly on immune cells...
  39. ncbi request reprint Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase
    R J Nelson
    Department of Psychology, Behavioral Neuroendocrinology Group, Johns Hopkins University, Baltimore, Maryland 21218 2686, USA
    Nature 378:383-6. 1995
    ..We now report a large increase in aggressive behaviour and excess, inappropriate sexual behaviour in nNOS- mice...
  40. ncbi request reprint Effects of nitric oxide on neuroendocrine function and behavior
    R J Nelson
    Department of Psychology, Johns Hopkins University, Baltimore, Maryland 21218 2686, USA
    Front Neuroendocrinol 18:463-91. 1997
    ..Learning and memory are also influenced by NO. Taken together, NO is emerging as an important chemical mediator of neuroendocrine function and behavior...
  41. ncbi request reprint Seasonal variation in human functional cerebral lateralization and free testosterone concentrations
    A B Wisniewski
    Behavioral Neuroendocrinology Group, Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, USA
    Brain Cogn 43:429-38. 2000
    ..These results illustrate that seasonal fluctuations in testosterone exposure do not directly influence seasonal changes in functional lateralization patterns...
  42. ncbi request reprint The effects of photoperiod and food intake on reproductive development in male deer mice (Peromyscus maniculatus)
    R J Nelson
    Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218 2686, USA
    Physiol Behav 62:945-50. 1997
    ..It does not appear that male deer mice escape from the inhibitory effects of food restriction to attain sexual development...
  43. ncbi request reprint Melatonin enhancement of splenocyte proliferation is attenuated by luzindole, a melatonin receptor antagonist
    D L Drazen
    Department of Psychology, The Johns Hopkins University, Baltimore, Maryland 21218 2686, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1476-82. 2001
    ....
  44. ncbi request reprint Behavioral phenotyping of transgenic and knockout animals: a cautionary tale
    S D Bilbo
    Department of Psychology, Johns Hopkins University, USA
    Lab Anim (NY) 30:24-9. 2001
    ..Knockout and transgenic mice are extremely useful for behavioral research, especially for linking specific genes with behaviors. The authors present caveats to be aware of when using such mice in research situations...
  45. ncbi request reprint Acute and chronic social defeat suppresses humoral immunity of male Syrian hamsters (Mesocricetus auratus)
    A M Jasnow
    Department of Psychology, Georgia State University, Atlanta, GA 30303, USA
    Horm Behav 40:428-33. 2001
    ..These data suggest that social defeat is an important, ecologically relevant model with which to examine stress-induced immune suppression in rodents...
  46. ncbi request reprint Reproductive function in female mice lacking the gene for endothelial nitric oxide synthase
    D L Drazen
    Departments of Psychology and Neuroscience, The Johns Hopkins University, Baltimore, Maryland, 21218, USA
    Nitric Oxide 3:366-74. 1999
    ..These data suggest that NO from endothelial sources might play a role in mediating rodent ovulation and may be involved in regulation of the timing of the estrous cycle...
  47. ncbi request reprint Behavior in mice with targeted disruption of single genes
    R J Nelson
    Department of Psychology, Johns Hopkins University, Baltimore, MD 21218 2686, USA
    Neurosci Biobehav Rev 22:453-62. 1998
    ..Impaired learning and memory have also been reported for mice with targeted disruption of specific genes. Taken together, the use of knockouts will provide an important new tool to understand the mechanisms underlying behavior...
  48. ncbi request reprint Nocturnal motor coordination deficits in neuronal nitric oxide synthase knock-out mice
    L J Kriegsfeld
    Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218, USA
    Neuroscience 89:311-5. 1999
    ..These previous studies were all conducted during the day (between 1400 and 1600, lights on at 0700). We now report striking, discrete abnormalities in balance and motor coordination in nNOS-mice reflected selectively at night...
  49. ncbi request reprint Spatial memory deficits in segmental trisomic Ts65Dn mice
    G E Demas
    Department of Psychology, Johns Hopkins University, Baltimore, MD 21218, USA
    Behav Brain Res 82:85-92. 1996
    ..Taken together, these results provide evidence for short- and long-term spatial memory deficits in Ts65Dn mice...
  50. pmc Spontaneous "regression" of enhanced immune function in a photoperiodic rodent Peromyscus maniculatus
    B J Prendergast
    Department of Psychology, The Ohio State University, Townshend Hall, Columbus, OH 43210, USA
    Proc Biol Sci 268:2221-8. 2001
    ..The results suggest that formal similarities and, possibly, common substrates exist among the photoperiodic timekeeping mechanisms that regulate seasonal transitions in reproductive and immune function...
  51. ncbi request reprint Enduring effects of photoperiod on affective behaviors in Siberian hamsters (Phodopus sungorus)
    Leah M Pyter
    Department of Neuroscience and Psychology, Ohio State University, Columbus, OH, USA
    Behav Neurosci 120:125-34. 2006
    ..The persistence of photoperiod-induced affective behaviors in rodents supports the hypothesis that symptoms of human affective disorders may reflect ancestral adaptations to seasonal environments...
  52. ncbi request reprint Short days increase hypothalamic-pituitary-adrenal axis responsiveness
    Leah M Pyter
    Department of Neuroscience, Institute of Behavioral Medicine Research, Ohio State University, Columbus, Ohio 43210, USA
    Endocrinology 148:3402-9. 2007
    ..Overall, these results suggest that photoperiod-evoked modification of the HPA axis and its potential behavioral consequences may be adaptive for winter survival...
  53. ncbi request reprint Perinatal photoperiod organizes adult immune responses in Siberian hamsters (Phodopus sungorus)
    Zachary M Weil
    Department of Neuroscience, and Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1714-9. 2006
    ....
  54. pmc HPA activity and neotic and anxiety-like behavior vary among Peromyscus species
    Lynn B Martin
    Departments of Psychology, Neuroscience, and Evolution, Ecology, and Organismal Biology, The Ohio State University, Columbus, OH 43210, USA
    Gen Comp Endocrinol 151:342-50. 2007
    ....
  55. pmc Photoperiod alters affective responses in collared lemmings
    Zachary M Weil
    Department of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Behav Brain Res 179:305-9. 2007
    ..Lemmings housed in long days reduced anxiety-like responses in the elevated plus maze. Depressive-like behaviours were decreased in the intermediate photoperiod relative to other photoperiod groups...
  56. ncbi request reprint Melatonin receptor (MT1) knockout mice display depression-like behaviors and deficits in sensorimotor gating
    Zachary M Weil
    Departments of Neuroscience and Institute for Behavioral Medicine Research, The Ohio State University, 09 Townshend Hall, Columbus, OH 43210, USA
    Brain Res Bull 68:425-9. 2006
    ..Taken together, MT1 receptor signaling may be important for normal brain and behavioral function...
  57. ncbi request reprint Immunological memory is compromised by food restriction in deer mice Peromyscus maniculatus
    Lynn B Martin
    Department of Psychology, The Ohio State University, Columbus, OH 43210 1287, USA
    Am J Physiol Regul Integr Comp Physiol 292:R316-20. 2007
    ..Together, these data imply that secondary antibody responses and the benefits of immunological memory are energetically costly in this species...
  58. ncbi request reprint D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice
    Alex S Huang
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 26:2814-9. 2006
    ..Therefore, Ddo is the endogenous enzyme that degrades D-aspartate, and Ddo-enriched organs, low in D-aspartate, may represent areas of high turnover where D-aspartate may be physiologically important...
  59. ncbi request reprint Testosterone and photoperiod interact to affect spatial learning and memory in adult male white-footed mice (Peromyscus leucopus)
    Leah M Pyter
    Department of Neuroscience, and Institute of Behavioural Medicine Research, Ohio State University, Columbus, 43210, USA
    Eur J Neurosci 23:3056-62. 2006
    ..These results suggest that photoperiod modulates the effects of testosterone on spatial learning performance by mechanisms indirect of the hippocampus...
  60. pmc Individual differences in estrogen receptor alpha in select brain nuclei are associated with individual differences in aggression
    Brian C Trainor
    Departments of Psychology and Neuroscience, Institute of Behavioral Medicine Research, Ohio State University, Columbus, OH 43210, USA
    Horm Behav 50:338-45. 2006
    ..These results suggest that estrogen acts in a specific subset of a complex network of nuclei to affect aggressive behavior...
  61. ncbi request reprint Maternal aggression persists following lipopolysaccharide-induced activation of the immune system
    Zachary M Weil
    Departments of Neuroscience and Psychology, and Institute of Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Physiol Behav 87:694-9. 2006
    ..These findings suggest that maternal aggression is not suppressed by LPS-evoked immune activation at doses that attenuate other aspects of maternal and social behavior...
  62. ncbi request reprint Exogenous pyruvate prevents stress-evoked suppression of mitogen-stimulated proliferation
    Gretchen N Neigh
    Departments of Neuroscience and Psychology, The Ohio State University, Columbus, OH 43210, USA
    Brain Behav Immun 18:425-33. 2004
    ....
  63. pmc Photoperiod reverses the effects of estrogens on male aggression via genomic and nongenomic pathways
    Brian C Trainor
    Department of Psychology, Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:9840-5. 2007
    ..These data demonstrate that the environment can dictate how hormones affect a complex behavior by altering the molecular pathways targeted by steroid receptors...
  64. pmc Food restriction compromises immune memory in deer mice (Peromyscus maniculatus) by reducing spleen-derived antibody-producing B cell numbers
    Lynn B Martin
    Department of Psychology, Ohio State University, Columbus, Ohio 43210, USA
    Physiol Biochem Zool 81:366-72. 2008
    ..These results further indicate that maintenance of immune memory is expensive and may be subject to trade-offs with other physiological processes...
  65. doi request reprint Maternal pinealectomy increases depressive-like responses in Siberian hamster offspring
    Joanna L Workman
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Behav Brain Res 189:387-91. 2008
    ..Maternal pinealectomy increased rearing behaviour and postnatal pinealectomy increased locomotor behaviour in the open field test. These results suggest that prenatal melatonin organizes adult affective responses...
  66. doi request reprint Sex-specific effects of glucose deprivation on cell-mediated immunity and reproduction in Siberian hamsters (Phodopus sungorus)
    Lynn B Martin
    Department of Psychology, Neuroscience, and Evolution, The Ohio State University, Columbus, OH 43210, USA
    J Comp Physiol B 178:623-8. 2008
    ....
  67. pmc 6-MBOA affects testis size, but not delayed-type hypersensitivity, in white-footed mice (Peromyscus leucopus)
    Lynn B Martin
    Department of Psychology, Neuroscience, and Evolution, The Ohio State University, Columbus, OH 43210, USA
    Comp Biochem Physiol A Mol Integr Physiol 149:181-7. 2008
    ..Other aspects of the immune system, especially in herbivorous rodents, may be affected by 6-MBOA and thus warrant further study...
  68. ncbi request reprint Immune defense and reproductive pace of life in Peromyscus mice
    Lynn B Martin
    Department of Psychology, Ohio State University, Columbus, Ohio 43210, USA
    Ecology 88:2516-28. 2007
    ..Importantly, our study indicates that species may not be differentially immunocompetent; rather, they use unique defense strategies to prevent infection...
  69. pmc Paternal aggression in a biparental mouse: parallels with maternal aggression
    Brian C Trainor
    Department of Psychology, University of California, Davis, CA 95616, USA
    Horm Behav 53:200-7. 2008
    ..These data suggest that, in biparental species, reproductive experience leads to the onset of paternal aggression that may be analogous to maternal aggression...
  70. pmc Rapid effects of estradiol on male aggression depend on photoperiod in reproductively non-responsive mice
    Brian C Trainor
    Department of Psychology, University of California, Davis, CA 95616, USA
    Horm Behav 53:192-9. 2008
    ..The rapid action of estradiol on aggression in short-day mice also suggests that nongenomic mechanisms mediate the effects of estrogens in short days...
  71. pmc Inhibition of neuronal nitric oxide reduces anxiety-like responses to pair housing
    Joanna L Workman
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Behav Brain Res 187:109-15. 2008
    ..This research suggests that NO may play an important role in mediating the effect social interactions have on anxiety...
  72. ncbi request reprint Urinary adrenalin and cortisol secretion patterns of social voles in response to adrenergic blockade under basal conditions
    Abed Elsalam Zubidat
    Department of Evolution and Environmental Biology, University of Haifa, Haifa 31905, Israel
    Physiol Behav 93:243-9. 2008
    ..The simultaneous decrease in adrenal hormones induced by PRAZ suggests that alpha(1)-adrenoceptors may contribute to the mechanism of integrated stress responses...
  73. pmc Stressor-specific alterations in corticosterone and immune responses in mice
    Stephanie L Bowers
    Departments of Psychology, Neuroscience, and Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Brain Behav Immun 22:105-13. 2008
    ..The variation observed in the measured immune responses may reflect differential glucocorticoid activation, differential metabolic adjustments, or both processes in response to specific stressors...
  74. pmc Photoperiod affects estrogen receptor alpha, estrogen receptor beta and aggressive behavior
    Brian C Trainor
    Department of Psychology, Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH 43210, USA
    Eur J Neurosci 26:207-18. 2007
    ..These data suggest that the effects of photoperiod on ERalpha and ERbeta expression may thus have important behavioral consequences...
  75. ncbi request reprint Photoperiod alters macrophage responsiveness, but not expression of Toll-like receptors in Siberian hamsters
    Kristen J Navara
    Departments of Psychology and Neuroscience, Institute of Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Comp Biochem Physiol A Mol Integr Physiol 148:354-9. 2007
    ....
  76. ncbi request reprint Interaction of nitric oxide and serotonin in aggressive behavior
    Silvana Chiavegatto
    Department and Institute of Psychiatry and Laboratory of Genetics and Molecular Cardiology, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Horm Behav 44:233-41. 2003
    ..Taken together, NO appears to play an important role in normal brain 5-HT function and may have significant implications for the treatment of psychiatric disorders characterized by aggressive and impulsive behaviors...
  77. pmc Housing condition alters immunological and reproductive responses to day length in Siberian hamsters (Phodopus sungorus)
    Zachary M Weil
    Department of Psychology, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Horm Behav 52:261-6. 2007
    ..These data suggest that short day enhancement of immune function is independent of photoperiod-mediated changes in the reproductive system...
  78. pmc Impaired nitric oxide synthase signaling dissociates social investigation and aggression
    Brian C Trainor
    Department of Psychology, Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH 43210, USA
    Behav Neurosci 121:362-9. 2007
    ..These data suggest that further study of nNOS signaling is warranted in mental disorders characterized by social withdrawal and increased aggression...
  79. ncbi request reprint Low temperatures during early development influence subsequent maternal and reproductive function in adult female mice
    Zeynep Benderlioglu
    Departments of Psychology and Neuroscience, Institute for Behavioral Medicine Research, 09 Townshend Hall, Ohio State University, Columbus, OH 43210, USA
    Physiol Behav 87:416-23. 2006
    ..Our findings also suggest that chronic low temperatures experienced only after birth may have less deleterious effects than exposure to a combination of pre- and postnatal or prenatal treatments alone...
  80. ncbi request reprint Social interactions alter proinflammatory cytokine gene expression and behavior following endotoxin administration
    Zachary M Weil
    Department of Neuroscience, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Brain Behav Immun 20:72-9. 2006
    ..These results suggest that social interactions can adjust behavioral responses to infection although the ultimate cause of this adjustment remains unspecified...
  81. ncbi request reprint Photoperiodic regulation of circulating leukocytes in juvenile Siberian hamsters: mediation by melatonin and testosterone
    Brian J Prendergast
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    J Biol Rhythms 18:473-80. 2003
    ..These data indicate that juvenile Siberian hamsters are immunologically responsive to photoperiod and that the leukocyte responses to day length are the result of melatonin-mediated effects of photoperiod on testicular hormone secretion...
  82. ncbi request reprint Peripubertal immune challenges attenuate reproductive development in male Siberian hamsters (Phodopus sungorus)
    Brian J Prendergast
    Departments of Psychology and Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
    Biol Reprod 70:813-20. 2004
    ..The data also underscore the importance of seasonally dependent life history factors in assessing physiological tradeoffs...
  83. ncbi request reprint Photoperiod influences the effects of exercise and food restriction on an antigen-specific immune response in Siberian hamsters
    Staci D Bilbo
    Department of Psychology, The Ohio State University, Columbus, OH 43210 1222, USA
    Endocrinology 145:556-64. 2004
    ..In sum, moderate energetic deficiency suppressed DTH in SD (but not LD) hamsters, and this suggests that hamsters may have evolved to enhance immune responses during winter in preparation for increased metabolic stressors...
  84. ncbi request reprint Sex differences in photoperiodic and stress-induced enhancement of immune function in Siberian hamsters
    Staci D Bilbo
    Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA
    Brain Behav Immun 17:462-72. 2003
    ..Furthermore, interactions among reproductive status and stress responses appear to mediate the expression of sex differences in immune responses in hamsters...
  85. ncbi request reprint Photoperiod modulates the effects of norepinephrine on lymphocyte proliferation in Siberian hamsters
    Gregory E Demas
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Am J Physiol Regul Integr Comp Physiol 285:R873-9. 2003
    ..Collectively, these results provide further support that photoperiodic changes in immunity are influenced by changes in SNS activity...
  86. ncbi request reprint Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase
    Staci D Bilbo
    Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, MD 21218, USA
    J Neuroimmunol 140:41-8. 2003
    ..Neuronal NO appears to be involved in the neuroendocrine-immune response to stress, perhaps via glucocorticoid regulation...
  87. ncbi request reprint Photoperiod and stress affect wound healing in Siberian hamsters
    Steven G Kinsey
    Departments of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Physiol Behav 78:205-11. 2003
    ..In nature, enhanced wound healing coincident with the breeding season and territorial defense may be adaptive...
  88. ncbi request reprint Photoperiodic adjustments in immune function protect Siberian hamsters from lethal endotoxemia
    Brian J Prendergast
    Department of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    J Biol Rhythms 18:51-62. 2003
    ..Adaptation to short days induces changes in immune parameters that affect survival in the face of immune challenges...
  89. pmc Hypothalamic gene expression in reproductively photoresponsive and photorefractory Siberian hamsters
    Brian J Prendergast
    Departments of Psychology and Neuroscience, and Biochemistry and Medical Biochemistry and Neurobiotechnology Center, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 99:16291-6. 2002
    ....
  90. pmc Short day lengths attenuate the symptoms of infection in Siberian hamsters
    Staci D Bilbo
    Department of Psychology, The Johns Hopkins University, Baltimore, MD 21218 2686, USA
    Proc Biol Sci 269:447-54. 2002
    ..Taken together, short day lengths attenuated the symptoms of infection, presumably to optimize energy expenditure and survival outcome...
  91. ncbi request reprint Exposure to short days, but not short-term melatonin, enhances humoral immunity of male Syrian hamsters (Mesocricetus auratus)
    Deborah L Drazen
    Department of Psychology, Johns Hopkins University, Baltimore, MD, USA
    J Pineal Res 33:118-24. 2002
    ..These results confirm previous findings of photoperiodic changes in immunity in rodents and suggest that changes in humoral immunity are not due to short-term changes in melatonin...
  92. ncbi request reprint Melatonin regulates energy balance and attenuates fever in Siberian hamsters
    Staci D Bilbo
    Department of Psychological and Brain Sciences, The Johns Hopkins University, Baltimore, Maryland 21218 2686, USA
    Endocrinology 143:2527-33. 2002
    ....
  93. ncbi request reprint Nyctohemeral differences in response to restraint stress in CD-1 and C57BL/6 mice
    Andrew K Hotchkiss
    Department of Psychology, The Ohio State University, 48A Townshend Hall, 1885 Neil Avenue Mall, Columbus, OH 43210, USA
    Physiol Behav 80:441-7. 2004
    ..These results suggest that the physiological response to restraint is similar in both strains. However, corticosterone responses to both restraint and food deprivation were highest during the transitional and dark phases...
  94. ncbi request reprint Effects of photoperiod history on immune responses to intermediate day lengths in Siberian hamsters (Phodopus sungorus)
    Brian J Prendergast
    Departments of Psychology and Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    J Neuroimmunol 149:31-9. 2004
    ..The data suggest that photoperiodic mechanisms that enhance and suppress several aspects of immunity in young-adult hamsters are not responsive to prenatally communicated photoperiod history information...
  95. ncbi request reprint Season of birth and fluctuating asymmetry
    Zeynep Benderlioglu
    Departments of Psychology and Neuroscience, The Ohio State University, Columbus Ohio 43210, USA
    Am J Hum Biol 16:298-310. 2004
    ..Our results generally confirm previous research on seasonal variation in adult longevity and neurological and psychiatric disorders, suggesting that winter and spring births are at risk for asymmetric developmental trajectory...
  96. ncbi request reprint 3-aminobenzamide prevents restraint-evoked immunocompromise
    Gretchen N Neigh
    Department of Psychology, Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA
    Brain Behav Immun 19:351-6. 2005
    ..These data suggest that PARP inhibitors may be useful to prevent compromised immune function in response to stressors...
  97. ncbi request reprint Short photoperiods impair spatial learning and alter hippocampal dendritic morphology in adult male white-footed mice (Peromyscus leucopus)
    Leah M Pyter
    Department of Neuroscience and Institute of Behavioral Medicine Research, Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 25:4521-6. 2005
    ..Understanding the mechanisms mediating these photoperiod-induced alterations may provide insight for treatment of seasonal cognitive and affective disorders...
  98. ncbi request reprint Melatonin and immune function: hype or hypothesis?
    Andrew K Hotchkiss
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Crit Rev Immunol 22:351-71. 2002
    ..Further, we also examine mounting evidence that the pattern of melatonin secretion, mediated by photoperiod, directly influences immune function...
  99. ncbi request reprint Affective responses to changes in day length in Siberian hamsters (Phodopus sungorus)
    Brian J Prendergast
    Department of Psychology, University of Chicago, Chicago, IL 60637, USA
    Psychoneuroendocrinology 30:438-52. 2005
    ..Together the results indicate that adaptation to short photoperiods is associated with increased expression of anxiety- and depressive-like behaviors relative to those observed under LD photoperiod conditions...
  100. ncbi request reprint Photoperiod-induced differential expression of angiogenesis genes in testes of adult Peromyscus leucopus
    Leah M Pyter
    Neuroscience and Psychology, Ohio State University, Columbus, OH 43210, USA
    Reproduction 129:201-9. 2005
    ....
  101. ncbi request reprint Digit length ratios predict reactive aggression in women, but not in men
    Zeynep Benderlioglu
    Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
    Horm Behav 46:558-64. 2004
    ..Taken together, these data confirm the predominantly right-sided influence of androgens on digit length and suggest that digit length ratios may be associated with female reactive aggression when sufficient provocation is present...

Research Grants13

  1. Photoperiod Brain and Behavior
    Randy Nelson; Fiscal Year: 2009
    ....
  2. Photoperiod, Melatonin, and Sickness Behaviors
    Randy Nelson; Fiscal Year: 2006
    ..6) To determine if photoperiod influences the extent to which stress compromises immune function. Taken together, these studies may reveal novel therapeutic uses of melatonin on fever and anorexia. ..
  3. ENVIRONMENT, BEHAVIOR, AND REPRODUCTION
    Randy Nelson; Fiscal Year: 2006
    ..abstract_text> ..
  4. ENVIRONMENT, BEHAVIOR, AND REPRODUCTION
    Randy Nelson; Fiscal Year: 2000
    ....
  5. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2010
    ....