Kenneth E Neet

Summary

Affiliation: The Chicago Medical School
Country: USA

Publications

  1. ncbi request reprint Biophysical characterization of proteins in the post-genomic era of proteomics
    Kenneth E Neet
    Department of Biochemistry and Molecular Biology, Finch University of Health Sciences Chicago Medical School, North Chicago, Illinois 60064, USA
    Mol Cell Proteomics 1:415-20. 2002
  2. ncbi request reprint Receptor binding, internalization, and retrograde transport of neurotrophic factors
    K E Neet
    Department of Biochemistry and Molecular Biology, Finch UHS Chicago Medical School, North Chicago, Illinois 60064, USA
    Cell Mol Life Sci 58:1021-35. 2001
  3. pmc Comparison of nerve growth factor receptor binding models using heterodimeric muteins
    Hrishikesh M Mehta
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois, USA
    J Neurosci Res 90:2259-71. 2012
  4. pmc Identification of critical residues within the conserved and specificity patches of nerve growth factor leading to survival or differentiation
    Sidharth Mahapatra
    Department of Biochemistry and Molecular Biology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Biol Chem 284:33600-13. 2009
  5. ncbi request reprint Activation of the mitogen-activated protein kinase pathway through p75NTR: a common mechanism for the neurotrophin family
    Shivanand P Lad
    Department of Biochemistry and Molecular Biology, Finch University of Health Sciences The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci Res 73:614-26. 2003
  6. ncbi request reprint Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modification mechanism of neurotrophin-induced tumor suppressor activation
    Houman Vaghefi
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science formerly Finch University of Health Sciences, The Chicago Medical School, 3333 Green Bay Rd, North Chicago, IL 60064, USA
    Oncogene 23:8078-87. 2004
  7. ncbi request reprint Nerve growth factor withdrawal-mediated apoptosis in naive and differentiated PC12 cells through p53/caspase-3-dependent and -independent pathways
    Houman Vaghefi
    Department of Biochemistry and Molecular Biology, The Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Biol Chem 279:15604-14. 2004
  8. ncbi request reprint Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site
    Shivanand P Lad
    Department of Biochemistry and Molecular Biology, University of Health Sciences The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Biol Chem 278:24808-17. 2003
  9. pmc Construction of a mutated pro-nerve growth factor resistant to degradation and suitable for biophysical and cellular utilization
    Promila C Pagadala
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    Proc Natl Acad Sci U S A 103:17939-43. 2006

Collaborators

  • R B Campenot
  • Daniel A Peterson
  • Houman Vaghefi
  • Shivanand P Lad
  • Hrishikesh M Mehta
  • Sang B Woo
  • Sidharth Mahapatra
  • Promila C Pagadala
  • Hrishikesh Mehta
  • Laura A Dvorak
  • Allison L Hughes
  • Ralph A Bradshaw

Detail Information

Publications9

  1. ncbi request reprint Biophysical characterization of proteins in the post-genomic era of proteomics
    Kenneth E Neet
    Department of Biochemistry and Molecular Biology, Finch University of Health Sciences Chicago Medical School, North Chicago, Illinois 60064, USA
    Mol Cell Proteomics 1:415-20. 2002
    ....
  2. ncbi request reprint Receptor binding, internalization, and retrograde transport of neurotrophic factors
    K E Neet
    Department of Biochemistry and Molecular Biology, Finch UHS Chicago Medical School, North Chicago, Illinois 60064, USA
    Cell Mol Life Sci 58:1021-35. 2001
    ..e., NGF, GDNF, and CNTF, has a set of receptors with specificity for individual members of the family and a common receptor without member specificity that, in some families, generates the cellular signal and retrograde transport...
  3. pmc Comparison of nerve growth factor receptor binding models using heterodimeric muteins
    Hrishikesh M Mehta
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois, USA
    J Neurosci Res 90:2259-71. 2012
    ..In the longstanding debate on the NGF receptor binding mechanism, our data support the ligand passing of NGF from p75 to TrkA involving a transient heteroreceptor complex of p75-NGF-TrkA...
  4. pmc Identification of critical residues within the conserved and specificity patches of nerve growth factor leading to survival or differentiation
    Sidharth Mahapatra
    Department of Biochemistry and Molecular Biology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Biol Chem 284:33600-13. 2009
    ....
  5. ncbi request reprint Activation of the mitogen-activated protein kinase pathway through p75NTR: a common mechanism for the neurotrophin family
    Shivanand P Lad
    Department of Biochemistry and Molecular Biology, Finch University of Health Sciences The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci Res 73:614-26. 2003
    ..The effect of this MAPK activation on cell survival is dependent on cell type. These results support the concept that signaling from the p75(NTR) receptor is more diverse and extensive than previously believed...
  6. ncbi request reprint Deacetylation of p53 after nerve growth factor treatment in PC12 cells as a post-translational modification mechanism of neurotrophin-induced tumor suppressor activation
    Houman Vaghefi
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science formerly Finch University of Health Sciences, The Chicago Medical School, 3333 Green Bay Rd, North Chicago, IL 60064, USA
    Oncogene 23:8078-87. 2004
    ..Finally, NGF or serum withdrawal did not lead to p53 deacetylation. A model is proposed in which the acetylation status of Lys 382 of p53 discriminates between cell cycle arrest and apoptosis...
  7. ncbi request reprint Nerve growth factor withdrawal-mediated apoptosis in naive and differentiated PC12 cells through p53/caspase-3-dependent and -independent pathways
    Houman Vaghefi
    Department of Biochemistry and Molecular Biology, The Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Biol Chem 279:15604-14. 2004
    ..These results suggest that p53 is important, but not essential, in factor withdrawal-mediated apoptosis. Parallel pathways of caspase-mediated apoptosis are activated later in the absence of functional p53...
  8. ncbi request reprint Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site
    Shivanand P Lad
    Department of Biochemistry and Molecular Biology, University of Health Sciences The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Biol Chem 278:24808-17. 2003
    ..In addition, a new interaction in the TrkA/p75NTR heteromeric receptor signal transduction network was revealed, namely that NGF-induced activation of the MAPK pathway appears to inhibit the parallel NGF-induced Akt pathway...
  9. pmc Construction of a mutated pro-nerve growth factor resistant to degradation and suitable for biophysical and cellular utilization
    Promila C Pagadala
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    Proc Natl Acad Sci U S A 103:17939-43. 2006
    ..This stable proNGF molecule demonstrated proapoptotic activity on rat pheocytochroma PC12 cells, PC12nnr cells, C6 glioblastoma cells, and RN22 schwannoma cells...